Airborne Transmission of Influenza A/H5N1 Virus Between Ferrets - 12 views
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The MBCS in HA can be cleaved by ubiquitously expressed host proteases; this cleavage facilitates systemic virus replication and results in mortality of up to 100% in poultry (9, 10).
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Although limited A/H5N1 virus transmission between persons in close contact has been reported, sustained human-to-human transmission of HPAI A/H5N1 virus has not been detected (13–15).
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Could this not be happening?
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The viruses that caused the major pandemics of the past century emerged upon reassortment (that is, genetic mixing) of animal and human influenza viruses (22).
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How many pandemics are they talking about? Put another way, for how many pandemics in human history, do we have the virus on hand to analyze?
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This is the H5N1 mammal transmissibility paper from the Fouchier group.
