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Matthew Marshall

Dengue - 0 views

bmb.oxfordjournals.org/...161.full

Dengue DENV DHF DSS ADE Eva Harris

shared by Matthew Marshall on 27 Nov 12 - Cached
  • Matthew Marshall on 27 Nov 12
     
    Follow up research subsequent to viewing Dr. Eva Harris's Lecture, Dengue Fever: Breaking Epidemic Cycles. Research focused on mechanisms behind severe dengue forms DHF and DSS.
Matthew Marshall

Dengue: a continuing global threat : Article : Nature Reviews Microbiology - 0 views

www.nature.com/...nrmicro2460.html

Dengue DENV DHF DSS Eva Harris Transmission

shared by Matthew Marshall on 27 Nov 12 - Cached
  • Matthew Marshall on 27 Nov 12
     
    Follow up research subsequent to viewing Dr. Eva Harris's Lecture, Dengue Fever: Breaking Epidemic Cycles. Research focused on mechanisms behind severe dengue forms DHF and DSS. Figure 1 in paper is from this article.
Casey Finnerty

Discussion Ebola Research Needs | Video | C-SPAN.org - 2 views

www.c-span.org/video

ebolavirus

shared by Casey Finnerty on 24 Nov 14 - No Cached
  • Casey Finnerty on 24 Nov 14
     
    This panel has the best overview of the research needs for Ebola virus that I have seen. It includes the presentation by CJ Peters that I discussed in class.
Casey Finnerty

Great Lakes fish hatcheries could benefit from new test for deadly VHS virus | Great La... - 0 views

greatlakesecho.org/...m-new-tests-for-a-deadly-virus

research virology

shared by Casey Finnerty on 29 Aug 12 - No Cached
  • Genetics researchers at the Lake Erie Research Center at the University of Toledo are working on a test that will speed up that diagnosis to a matter of hours.
Casey Finnerty

The Quest to End the Flu - Carl Zimmer - The Atlantic - 0 views

www.theatlantic.com/...354677

influenza virology vaccination

shared by Casey Finnerty on 21 Nov 13 - No Cached
  • Fauci is more excited about something called a recombinant protein vaccine, which does not rely on growing viruses, even though it is cell-based. At Protein Sciences, a small Connecticut biotech firm, researchers isolate the gene for the flu virus’s surface proteins and insert it into an entirely different species of virus, called a baculovirus. The baculovirus infects insect cells and causes them to make huge amounts of the surface proteins, which the company uses to make Flublok, the only recombinant protein flu vaccine currently available.
  • The researchers have tried various methods, including the same one used to make Flublok—insect cells churning out surface proteins.
  • “The eggs should be long gone,” grumbles Michael Osterholm, the director of the Center for Infectious Disease Research and Policy at the University of Minnesota.
  • ...1 more annotation...
  • Manufacturers for the most part still make flu vaccines the way they did in World War II: in chicken eggs.
jiyoung yoon

Genomic Characterization of a Novel Virus of the Family Tymoviridae Isolated from Mosqu... - 3 views

www.plosone.org/...10.1371%2Fjournal.pone.0039845

virus tymoviridae virology

shared by jiyoung yoon on 27 Sep 12 - No Cached
  • jiyoung yoon on 27 Sep 12
     
    in this article we can know about unique novel tymoviridae virus. they are characterising about this new virus. one of the most unique feature about them is they can replicate even in mosquitoes!in consider that no mosquitoes have been reported as vectores of plant viruse,this research is quite suprising thing! but something i want to recommend is ...first At the result, it said cell lysates did not react with antisera to known only a few arboviruses of the genera. And said this virus is an uncommon arbovirus . I think the author should define more specially about the subject. and second, this research said that CuTLV virus may be transferred to male mosquitoes feed on plant juices and can started to replicate in the insect also. Because marifviruses can potentially replicate both in plants and in insects but, I can't figure out how this viruse can move into human,(animal) different kinds of species , can make a disease even by male ! I think the writer should more explain about that route. the last thing is There is many pictures .but some of them ,like figure 4&figure 5, are too massy to be hard recognized or unneeded thing. So I think they need more arrangement about picture.
Matthew Marshall

Viral carcinogenesis: revelation of molecular mechanisms and etiology of human disease - 0 views

carcin.oxfordjournals.org/...405.full

Joseph DeRisi Viral Oncogenesis Oncovirus

shared by Matthew Marshall on 27 Nov 12 - Cached
  • Matthew Marshall on 27 Nov 12
     
    Research subsequent to Dr. Joseph DeRisi's lecture The Virus Hunter's Toolkit, pertaining to investigation of his comment "about 15% of cancers are caused by viruses."
Casey Finnerty

mBio - September/October 2012, 3 (5) - 0 views

mbio.asm.org/5.toc

virology influenza H5N1

shared by Casey Finnerty on 04 Dec 12 - No Cached
  • Casey Finnerty on 04 Dec 12
     
    This issue of mBio has several updates and opinion pieces on the H5N1 research moratorium.
jiyoung yoon

The Identification of an Adenovirus Receptor by - 0 views

masspec.scripps.edu/...105_art.pdf

virology therapy microbiology

shared by jiyoung yoon on 12 Oct 12 - No Cached
  • jiyoung yoon on 12 Oct 12
     
    from that research , we can know not only traditional ways to identify virus, but also a up to date way to identify them. it Identify an Adenovirus Receptor by using affinity capture and mass spectrometry. it is quite complicated but really cool. i can bet it include really important information !! the one thing thought about more about this research is this up to date method is definately cool but includes too handful and laborious jobs. also, the reaseacher on this paper was really lucky. because they didn't demonstrate Adenovirus use glycoprotein receptor. most of case, receptor is consisted of glycoprotein . not all case.also, it means this method can be used when host cell has only glycoprotein receptors ! but , it is worth to being a few way to identify receptor quite specifically and identifying plycoprotein, most receptor included, scientifically.
Casey Finnerty

We Now Have the Cure for Hepatitis C, but Can We Afford It? - Scientific American - 13 views

www.scientificamerican.com/...patitis-c-but-can-we-afford-it

hepatitis medicine antiviral HCV

shared by Casey Finnerty on 09 Dec 14 - No Cached
  • Later this year the U.S. Food and Drug Administration is expected to approve a new pill that can cure hepatitis C
  • It will contain two drugs, one of which is already available at $1,000 per dose, or $84,000 for a complete 12-week course. The dual-drug combination will likely cost even more
  • They also determined that the virus's genes mutate very fast—a process that has generated several equally successful varieties, called genotypes, and rendered an effective vaccine impossible to create so far.
  • ...7 more annotations...
  • its genetic material, which is made up of RNA
  • After several false starts, researchers at Vertex Pharmaceuticals, in collaboration with others, developed a protease inhibitor known as telaprevir, while scientists at Schering-Plough (which merged with Merck in 2009), created one called boceprevir.
  • The medications had harsh side effects and worked only for those patients with a particular genetic variant of the virus known as genotype 1
  • What scientists had learned from their earlier research, however, was that inactivating an enzyme or protein was not enough. To stop hepatitis C, any effective drug also had to incorporate itself into the virus's genetic code, where it would need to halt the virus's ability to make new copies of its genes and thus to make new virus.
  • Michael Sofia, then at Pharmasset, solved the problems by adding two compounds known as esters to the analogue.
  • During sofosbuvir's development, they had studied other drugs that inhibited different viral proteins and that might eliminate the need for continued use of interferon and ribavirin.
  • It is this combination, mixed in a single daily pill, that industry watchers expect the FDA to approve by October 2014. It heralds a new era of curative treatment for patients with hepatitis C. Similar drugs that work equally well for all genotypes are now in the final stages of clinical development.
Casey Finnerty

Chicagoan follows father's footsteps to Purdue, discovers new virus - chicagotribune.com - 0 views

www.chicagotribune.com/...virus-20110428,0,4612783.story

microbiology virology

shared by Casey Finnerty on 29 Aug 12 - No Cached
  • Casey Finnerty on 29 Aug 12
     
    "National Genomics Research Initiative"
Casey Finnerty

Judy Mikovits in Prison: What Does It Mean for Research on Chronic Fatigue Syndrome? - ... - 0 views

www.slate.com/...chronic_fatigue_syndrome_.html

research microbiology virology

shared by Casey Finnerty on 29 Aug 12 - No Cached
  • This created a climate of mistrust that breeds hero-worship and conspiracy theories and that can cast a scientist simultaneously as a savior and a villain.
Casey Finnerty

Judy Mikovits in Prison: What Does It Mean for Research on Chronic Fatigue Syndrome? - ... - 0 views

www.slate.com/..._fatigue_syndrome_.single.html

research microbiology virology

shared by Casey Finnerty on 29 Aug 12 - No Cached
  • This created a climate of mistrust that breeds hero-worship and conspiracy theories and that can cast a scientist simultaneously as a savior and a villain.
Casey Finnerty

What Would Keep Ebola from Spreading in the US? Investing in Simple Research Years Ago.... - 0 views

www.wired.com/...ebola-ic-research

ebolavirus

shared by Casey Finnerty on 16 Oct 14 - No Cached
  • Casey Finnerty on 16 Oct 14
     
    Maryn McKenna writes frequently and eloquently on infectious disease in her blog "Superbug". I recommend you check out her latest post on the Ebola cases in the US.
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