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Casey Finnerty

The Virus That Learns - Phenomena: The Loom - 0 views

phenomena.nationalgeographic.com/...the-virus-that-learns

microbiology CRISPR

shared by Casey Finnerty on 07 Mar 13 - No Cached
  • Likewise, restriction enzymes are a dangerous defense, because they can chop up the distinctive stretches of DNA in a bacterium’s own genes. It avoids attacking itself by capping those sequences in its own DNA, so that the restriction enzymes can’t reach them.
  • Some species can muck up the production of new viruses, stealing their proteins before they can form shells. Others commit suicide upon infection, so as to avoid becoming an incubator for new viruses that would then kill their nearby relatives.
  • CRISPR genes can produce RNA molecules with a matching sequence. They grab onto the virus’s RNA and prevent them from being turned into proteins. The virus factory grinds to a halt.
  • ...6 more annotations...
  • The bacteria hold onto an invading virus’s DNA, so that they are now prepared for a fresh attack. And over time, bacteria can build up little libraries of these virus barcodes. 
  • Last year, scientists at Indiana University surveyed the bacteria in people’s mouths and discovered 8,000 different viral barcodes–many of them corresponding to viruses scientists have yet to discover.
  • But if you build up a healthy store of antibodies to various strains of flu, smallpox, and other diseases, all that knowledge dies with you.
  • Not so for bacteria. When a microbe reproduces, it passes down its CRISPR genes and all of their viral barcodes to its descendants–including the ones it acquired in its own lifetime.
  • Last fall, for example, University of Cambridge scientists discovered viruses that carry an antidote for the suicide toxin made by their hosts. When the bacteria want to die, the virus forces them to live on. And just last month, University of Toronto scientists even discovered anti-CRISPR genes in viruses, which the viruses use to shut down the production of virus-killing molecules.
  • the scientists demonstrated that the ICP1 virus uses its CRISPR immune system to attack its host’s virus-attacking genes.
Katelyn Madigan

The RNA Helicase Lgp2 Inhibits TLR-Independent Sensing of Viral Replication by Retinoic... - 0 views

www.jimmunol.org/...5260.short

shared by Katelyn Madigan on 30 Apr 13 - No Cached
  • Katelyn Madigan on 30 Apr 13
     
    Supplemental paper for presentation.
Alletia DeMartino

Protein synthesis: an epic on the cellular level - YouTube - 0 views

www.youtube.com/watch

RNA

shared by Alletia DeMartino on 20 Feb 13 - Cached
  • Casey Finnerty on 20 Feb 13
     
    With Loryn's help, I beat Alletia to this.
  • Alletia DeMartino on 20 Feb 13
     
    This is the video we are all talking about. go to 3 ish minutes. Such a great studying tool if you like humor!!
  • Alletia DeMartino on 20 Feb 13
     
    aww man i didnt see this!! well here it is haha.
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