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Javier E

Health Experts Warily Eye XBB.1.5, the Latest Omicron Subvariant - The New York Times - 0 views

www.nytimes.com/...ovid-omicron-variants-xbb.html

pandemic policy history variants

shared by Javier E on 07 Jan 23 - No Cached
  • Most recombinant SARS-CoV-2 viruses have dwindled away in a matter of weeks or months, unable to outcompete other lineages. XBB, on the other hand, got a winning ticket in the genetic lottery.
  • From one parent, it gained a set of mutations that helped it evade antibodies from previous infections and vaccinations. From the other parent, it gained a separate set of mutations that made it even more evasive.
  • “XBB literally picked up the most possible mutations that it could possibly pick up from those two parents,” said Thomas Peacock, a virologist at Imperial College London. The new combination made XBB one of the most evasive Omicron subvariants in existence last summer.
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  • Recent experiments suggest that XBB paid a steep price for its power to evade immunity. The mutations allow it to escape antibodies by altering the shape of the protein, called spike, that covers its surface. But some of those mutations also make it harder for XBB spike proteins to grab tightly to cells — the first step required for an infection.
  • That loose grip may have lessened XBB’s advantage against other forms of the virus. In late 2022, it jostled alongside a number of other Omicron subvariants. In Singapore, XBB caused a surge in October, for example, while remaining rare in many other parts of the world.
  • As XBB multiplied, it continued to mutate into new forms. The earliest samples of XBB.1.5 were isolated in October in New York. The new subvariant gained one crucial mutation, known as F486P.
  • Yunlong Cao of Peking University and his colleagues tested out XBB.1.5 in dishes of cells, comparing how it fared against earlier forms of XBB. The researchers found that the F486P mutation allowed XBB.1.5 to grab tightly to cells again. But the new subvariant could still evade antibodies as well as earlier forms of XBB.
  • In Connecticut, for example, Nathan Grubaugh at Yale University and his colleagues found that by mid-December, other Omicron subvariants were falling. Only XBB.1.5 cases were growing. Dr. Grubaugh estimates that it is about 20 percent more transmissible than BQ.1, which had been the dominant form.
  • How severe XBB.1.5 infections are compared with other forms of the coronavirus is not yet clear. “It’s serious,” Dr. Grubaugh said. “I just don’t necessarily know if it’s really more serious than some of the other Omicron lineages in terms of the overall impact.”
  • XBB.1.5 has already spread to other countries, and is growing rapidly in Germany, Denmark and elsewhere in Europe
  • Scientists are already scanning new sequences being uploaded to an international database called GISAID in the hopes of spotting an upgraded version of XBB.1.5. But their job is getting harder because governments are pulling back on sequencing efforts. “Worldwide, sequencing has taken a real hit,” Dr. Peacock said.
  • The United States, which once lagged behind other nations, has managed to maintain a fairly strong sequencing effort. Without it, Dr. Peacock said, XBB.1.5 might have stayed below the radar for much longer. If XBB.1.5’s next generation is evolving somewhere with little sequencing, it may go undetected for some time to come.
  • Dr. Lemieux said that paring back on sequencing was a mistake, given how many infections and deaths the virus is still causing. “This is a part of public health,” he said.
Javier E

Elon Musk's Text Messages Explain Everything - The Atlantic - 0 views

www.theatlantic.com/...672595

billionaire silicon valley groupthink sycophant twitter musk

shared by Javier E on 29 Dec 22 - No Cached
  • I’ve begun to think of Exhibit H as a skeleton key for the final, halcyon days of the tech boom—unlocking an understanding of the cultural brain worms and low-interest-rate hubris that defined the industry in 2022. What we see in Exhibit H is only a tiny snapshot of a very important inbox, but it’s enough to make this one of the most revealing documents in a year that’s been absolutely overflowing with tech disclosures
  • the Musk texts demonstrate a decadence, an unearned confidence, and a boy’s-club mentality that coincide with the cultural disillusionment regarding the genius-innovator narrative.
  • I snarkily coined the Elon Musk School of Management to describe the petulant way that some tech founders, such as Musk and Coinbase’s Brian Armstrong, seemed to use confrontational, culture-warring, Twitter-addled thought leadership as a business tactic. The Musk School revolves around two principles: running a company in an authoritarian manner, and ensuring that every management decision is optimized to make news and hijack the attention of those following along on social media
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  • The Musk messages also reveal how some of the richest and most powerful men in the world treat actual billions of dollars with a level of care more appropriate for a 3-year-old tossing around Monopoly cash.
  • Oracle’s founder, Larry Ellison, essentially writes Musk a blank check over text, pledging, “A billion … or whatever you recommend.” The venture capitalist Marc Andreessen unsolicitedly offers Musk “$250M with no additional work required.” And Michael Grimes, a top investment banker at Morgan Stanley, proposes a meeting with Bankman-Fried as a way to “get us $5bn equity in an hour.”
  • The blitheness is the point. It is a total power move to talk about getting “$5bn in equity in an hour” the same way we mere mortals talk about Venmo-ing a friend $15 for lunch. The texts make it clear that these men are fundamentally alienated from the rest of the world by their wealth.
  • “These are absolutely not normal people with a normal understanding of the world.”
  • The men in Musk’s phone also appear wildly confident in their own abilities and those of their peers. Mathias Döpfner, the CEO of the media conglomerate Axel Springer, infamously texted Musk his bullet-pointed plan for Twitter, which began with the line item “1.),, Solve Free Speech.”
  • They teach us what happens when a small group of people with too much money come to view that money not just as a reward for success, but as its own form of merit—a specious achievement that totally alienates them from reality.
  • Ultimately, Exhibit H documents the loneliness and isolation of being the world’s richest man. As told via the texts, the seed of Musk’s Twitter purchase was planted by sycophants deferential to the billionaire who will never give him hard, truthful advice, because they wish to stay close to him.
  • the one time he receives actual, honest feedback from Agrawal, Musk behaves aggressively and impulsively, sealing his fate.
Javier E

How Bad Are Ultraprocessed Foods, Really? - The New York Times - 0 views

www.nytimes.com/...ssed-foods-harmful-health.html

UPFs food diet processed health risks history culture

shared by Javier E on 07 May 24 - No Cached
  • scientists have found associations between UPFs and a range of health conditions, including heart disease, Type 2 diabetes, obesity, gastrointestinal diseases and depression, as well as earlier death.
  • That’s concerning, experts say, since ultraprocessed foods have become a major part of people’s diets worldwide. They account for 67 percent of the calories consumed by children and teenagers in the United States
  • What are ultraprocessed foods, exactly? And how strong is the evidence that they’re harmful? We asked experts to answer these
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  • Dr. Monteiro and his colleagues developed a food classification system called Nova, named after the Portuguese and Latin words for “new.” It has since been adopted by researchers across the world.
  • Unprocessed or minimally processed foods, like fresh or frozen fruits and vegetables, beans, lentils, meat, poultry, fish, eggs, milk, plain yogurt, rice, pasta, corn meal, flour, coffee, tea and herbs and spices.
  • Processed culinary ingredients, such as cooking oils, butter, sugar, honey, vinegar and salt.
  • If you look at the ingredient list and you see things that you wouldn’t use in home cooking, then that’s probably an ultraprocessed food,”
  • his group includes freshly baked bread, most cheeses and canned vegetables, beans and fish. These foods may contain preservatives that extend shelf life.
  • Ultraprocessed foods made using industrial methods and ingredients you wouldn’t typically find in grocery stores — like high-fructose corn syrup, hydrogenated oils and concentrated proteins like soy isolate.
  • They often contain additives like flavorings, colorings or emulsifiers to make them appear more attractive and palatable.
  • Think sodas and energy drinks, chips, candies, flavored yogurts, margarine, chicken nuggets, hot dogs, sausages, lunch meats, boxed macaroni and cheese, infant formulas and most packaged breads, plant milks, meat substitutes and breakfast cereals.
  • Processed foods made by combining foods from Category 1 with the ingredients of Category 2 and preserving or modifying them with relatively simple methods like canning, bottling, fermentation and baking
  • That has led to debate among nutrition experts about whether it’s useful for describing the healthfulness of a food, partly since many UPFs — like whole grain breads, flavored yogurts and infant formulas — can provide valuable nutrients
  • Most research linking UPFs to poor health is based on observational studies, in which researchers ask people about their diets and then track their health over many years.
  • Why might UPFs be harmful?
  • In a large review of studies that was published in 2024, scientists reported that consuming UPFs was associated with 32 health problems, with the most convincing evidence for heart disease-related deaths, Type 2 diabetes and common mental health issues like anxiety and depression.
  • Such studies are valuable, because they can look at large groups of people — the 2024 review included results from nearly 10 million — over the many years it can take for chronic health conditions to develop
  • She added that the consistency of the link between UPFs and health issues increased her confidence that there was a real problem with the foods.
  • But the observational studies also have limitations,
  • It’s true that there is a correlation between these foods and chronic diseases, she said, but that doesn’t mean that UPFs directly cause poor health.
  • Dr. O’Connor questioned whether it’s helpful to group such “starkly different” foods — like Twinkies and breakfast cereals — into one category. Certain types of ultraprocessed foods, like sodas and processed meats, are more clearly harmful than others
  • UPFs like flavored yogurts and whole grain breads, on the other hand, have been associated with a reduced risk of developing Type 2 diabetes.
  • Clinical trials are needed to test if UPFs directly cause health problems, Dr. O’Connor said. Only one such study, which was small and had some limitations, has been done, s
  • In that study, published in 2019, 20 adults with a range of body sizes lived in a research hospital at the National Institutes of Health for four weeks. For two weeks, they ate mainly unprocessed or minimally processed foods, and for another two weeks, they ate mainly UPFs. The diets had similar amounts of calories and nutrients, and the participants could eat as much as they wanted at each meal.
  • During their two weeks on the ultraprocessed diet, participants gained an average of two pounds and consumed about 500 calories more per day than they did on the unprocessed diet
  • During their time on the unprocessed diet, they lost about two pounds.
  • That finding might help explain the link between UPFs, obesity and other metabolic conditions
  • The Nova system notably doesn’t classify foods based on nutrients like fat, fiber, vitamins or minerals. It’s “agnostic to nutrition,”
  • There are many “strong opinions” about why ultraprocessed foods are unhealthy, Dr. Hall said. “But there’s actually not a lot of rigorous science” on what those mechanisms are
  • Because UPFs are often cheap, convenient and accessible, they’re probably displacing healthier foods from our diets
  • the foods could be having more direct effects on health. They can be easy to overeat — maybe because they contain hard-to-resist combinations of carbohydrates, sugars, fats and salt, are high-calorie and easy to chew
  • It’s also possible that resulting blood sugar spikes may damage arteries or ramp up inflammation, or that certain food additives or chemicals may interfere with hormones, cause a “leaky” intestine or disrupt the gut microbiome.
  • Researchers, including Dr. Hall and Dr. Davy, are beginning to conduct small clinical trials that will test some of these theories.
  • most researchers think there are various ways the foods are causing harm. “Rarely in nutrition is there a single factor that fully explains the relationship between foods and some health outcome,”
  • In 2014, Dr. Monteiro helped write new dietary guidelines for Brazil that advised people to avoid ultraprocessed foods.
  • Other countries like Mexico, Israel and Canada have also explicitly recommended avoiding or limiting UPFs or “highly processed foods.”
  • The U.S. dietary guidelines contain no such advice, but an advisory committee is currently looking into the evidence on how UPFs may affect weight gain, which could influence the 2025 guidelines.
  • It’s difficult to know what to do about UPFs in the United States, where so much food is already ultraprocessed and people with lower incomes can be especially dependent on them,
  • “At the end of the day, they are an important source of food, and food is food,” Dr. Mattei added. “We really cannot vilify them,”
  • While research continues, expert opinions differ on how people should approach UPFs.
  • the safest course is to avoid them altogether
  • to swap flavored yogurt for plain yogurt with fruit, for example, or to buy a fresh loaf from a local bakery instead of packaged bread, if you can afford to do so
  • Dr. Vadiveloo suggested a more moderate strategy, focusing on limiting UPFs that don’t provide valuable nutrients, like soda and cookies
  • She also recommended eating more fruits, vegetables, whole grains (ultraprocessed or not), legumes, nuts and seeds.
  • Cook at home as much as you can, using minimally processed foods
Javier E

Opinion | How Covid Changed America in 2020 - The New York Times - 0 views

www.nytimes.com/...vid-2020-recovery-society.html

pandemic history crisis culture cause trust solidarity policy loneliness cooperation

shared by Javier E on 31 Jan 24 - No Cached
  • It’s only now becoming clear how little we understood what the United States experienced during that unforgettable year and how deeply it shaped us
  • I’ve come to think of our current condition as a kind of long Covid, a social disease that intensified a range of chronic problems and instilled the belief that the institutions we’d been taught to rely on are unworthy of our trust
  • On a wide range of outcomes, including many that were less visible at the time, this country fared much worse during the Covid pandemic than comparable nations did. Distrust, division and disorganized leadership contributed to the scale of our negative health outcomes.
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  • As for our continuing distress, the standard explanation is a uniquely American loneliness. The surgeon general, Vivek Murthy, declared it an epidemic in its own right.
  • The truth, however, is there’s no good evidence that Americans are lonelier than ever
  • a major recent poll shows that older Americans are now significantly less lonely than they were three years ago; a recent peer-reviewed study reports that middle-aged Americans describe themselves as less lonely than they were 20 years ag
  • Loneliness is more pervasive among younger Americans, but there too, the rates have also plummeted since 2020
  • Logically, we should be feeling better. Why can’t we shake this thing?
  • loneliness was never the core problem. It was, rather, the sense among so many different people that they’d been left to navigate the crisis on their own. How do you balance all the competing demands of health, money, sanity?
  • The answer was always the same: Figure it out.
  • while other countries built trust and solidarity, America — both during and after 2020 — left millions to fend for themselves.
  • For millions of Americans, distrust feels like the most rational state.
  • The very different people I spoke with that year all had one thing in common: a feeling that in the wake of Covid, all the larger institutions they had been taught to trust had failed them. At the most precarious times in their lives, they found there was no system in place to help.
  • four years later, the situation is, if anything, worse.
  • Nursing homes across the country, where poor labor conditions were linked to higher Covid mortality levels, remain understaffed, leaving old, frail residents more vulnerable than they should be. Hunger and food insecurity remain wrenching emergencies.
  • Students haven’t fully returned to school. Congress passed the Child Poverty Reduction Act of 2021, one of the most effective antipoverty measures in decades. Then a year later, Congress ended it, pushing some five million young people back down into extreme financial need.
  • When everything was uncertain and everyone’s future was on the line, we walked right up to the precipice of a moral breakthrough, and then we turned back.
  • Look at the way we all accustomed ourselves to the term “essential worker,” an ostensible term of respect that instead condemned people to work in manifestly dangerous conditions. The adoption of that term made visible something we now cannot unsee: In the United States the people we rely on most to keep our world functioning are the people we treated as disposable.
  • we might call the bigger problem structural isolation: abandoned by employers, deprived of shared purpose, denied care. The combined effect sent a strong message that individual lives weren’t worth as much anymore.
  • People treated one another accordingly. We all remember the viral videos of people screaming at one another in supermarkets and on public transportation. Violent crime spiked. Even reckless driving surged — but it happened only in the United States.
  • The reasons for that American exceptionalism become only more urgent in an election year, when, as in a public health crisis, presidents can try to bring people together or try to turn them against one another.
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