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Researchers Create 'Model Embryos' To Study Human Fertility : Shots - Health News : NPR - 0 views

  • For decades, science has been trying to unlock the mysteries of how a single cell becomes a fully formed human being and what goes wrong to cause genetic diseases, miscarriages and infertility.Now, scientists have created living entities in their labs that resemble human embryos; the results of two new experiments are the most complete such "model embryos" developed to date.
  • The goal of the experiments is to gain important insights into early human development and find new ways to prevent birth defects and miscarriages and treat fertility problems.But the research, which was published in two separate papers Wednesday in the journal Nature Portfolio, raises sensitive moral and ethical concerns.
  • Crucial periods of embryonic development are hidden inside women's bodies during pregnancies and therefore inaccessible to study. And conducting experiments on human embryos in the laboratory is difficult and controversial.
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  • So in recent years, scientists started creating structures that resemble human embryos in the lab by using chemical signals to coax cells into forming themselves into entities that look like very primitive human embryos.
  • Now, Wu's team and another international team of scientists have gone further than ever before. They created hollow balls of cells that closely resemble embryos at the stage when they usually implant in the womb, which are known as blastocysts. The new laboratory-made embryos have been dubbed "blastoids."
  • Now with this technique we can make hundreds of these structures. So this will allow us to scale up our understanding of very early human development. We think this will be very important." Some other scientists are hailing the research.
  • The blastoids appear to have enough differences from naturally formed embryos to prevent them ever becoming a viable fetus or baby. But they appear to be very close.
  • The two experiments started with different cells to get similar results. Wu's group created his blastoids from human embryonic stem cells, and from "induced pluripotent stem cells," which are made from adult cells. Polo's group started with adult skin cells.
  • Hyun agrees the research is very important and could lead to a many other advances. But Hyun says it's important to come up with clear guidelines about how scientists can responsibly be permitted to pursue this kind of research.
  • Hyun favors revising a guideline known as the 14-day rule, which prohibits experiments on human embryos in the lab beyond two weeks of their existence. Hyun says exceptions should be allowed under certain carefully reviewed conditions.
  • But others worry about easing the 14-day rule.That could mean "we could just keep growing these sort-of humans in a test tube and not even considering the fact that they're so close to being human, right?"
  • In fact, another team of scientists at the Weizmann Institute of Science in Israel figured out how to grow mouse embryos outside the womb — a step toward creating an "artificial womb," according to report published Wednesday in the journal Nature.
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From sex selection to surrogates, American IVF clinics provide services outlawed elsewh... - 0 views

  • This freewheeling approach has been good for business; the U.S. fertility industry is estimated to be worth as much as $5.8 billion this year. But as technological advances outpace any social consensus on such forms of reproductive intervention, discomfort with the hands-off status quo is rising.
  • National Institutes of Health Director Francis Collins condemned the gene-editing experiment as an “epic scientific misadventure,” and said he is seeking to establish a forum for oversight and public debate about the technology and related areas of science.
  • Collins said he also is concerned about the rise in the screening of embryos for characteristics such as intelligence, physical appearance and gender. Although editing a baby’s DNA is fundamentally different from picking and choosing among embryos created by nature, the procedures raise similar ethical questions about ma­nipu­la­ting human reproduction
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  • Amid this tumult, a panel of scientists, legal experts and ethicists convened by NIH released a report in 1994 on research involving human embryos. The report called for federal funding to explore this “sensitive and vital area of biomedical science.” It also emphasized the need for regulation and voiced “serious ethical concerns” about sex selection in IVF.
  • in 1995, then-Reps. Jay Woodson Dickey Jr. (R-Ark.) and Roger Wicker (R-Miss.) added a provision to an appropriations bill that did the opposite of what the NIH paper proposed. Instead of supporting research and government regulation, it prohibited the expenditure of federal funds for any research that involves the creation or destruction of human embryos. The amendment was intended to help skittish lawmakers navigate a touchy issue, allowing them to vote against public funding for embryo research while permitting such research to continue in the private sphere.
  • The ban, which remains in effect, “laid the backdrop for a more hands-off regulatory approach,” said Michelle Bayefsky, a former bioethics fellow at NIH who has written a book about PGD.
  • Like the United States, Britain put together an expert panel to study assisted reproduction. The panel suggested the establishment of a public body to oversee human embryo research, regulate fertility clinics and take the lead on debates about new technologies. Parliament concurred and in 1990 established the Human Fertilization and Embryology Authority, the first statutory body of its kind and a model emulated by other countries.
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Embryos That Are Part Monkey, Part Human Raise Ethical Concerns : Shots - Health News :... - 0 views

  • For the first time, scientists have created embryos that are a mix of human and monkey cells.
  • Thousands of people die every year in the United States waiting for an organ transplant, Hyun noted. So, in recent years, some researchers in the U.S. and beyond have been injecting human stem cells into sheep and pig embryos to see if th
  • "This knowledge will allow us to go back now and try to re-engineer these pathways that are successful for allowing appropriate development of human cells in these other animals,
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  • ey might eventually grow human organs in such animals for transplantation.
  • Another concern is that using human cells in this way could produce animals that have human sperm or eggs.
  • The notion of using organs from animals for transplants has also long raised concerns about spreading viruses from animals to humans. So, if the current research comes to fruition, steps would have to be taken to reduce that infection risk, scientists said, such as carefully sequestering animals used for that purpose and screening any organs used for transplantation.
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Fertility clinic informs hundreds of patients their eggs may have been damaged - The Wa... - 0 views

  • A long-established San Francisco fertility clinic experienced a liquid nitrogen failure in a storage tank holding thousands of frozen eggs and embryos for future use, jeopardizing tissue hundreds of women had stored in hopes of having children.
  • “We can’t say definitively nothing like this has ever happened, but we are certainly not aware of anything,” said Sean Tipton, the association’s chief policy, advocacy and development officer. “Now that we have a second incident, it becomes very important that we learn as much as we can about both, to search for commonalities and see if there are . . . risks that have now come to light that need to be addressed.”
  • On Saturday night, the half-dozen doctors who work at Pacific Fertility were finally able to begin making phone calls to some 400 patients who had all their eggs or embryos stored in storage tank No. 4.
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  • Herbert said the extent of the damage is not yet clear. When clinic staff thawed a few eggs affected by the malfunction, they found that the tissue remained viable. Staff have not checked any of the embryos, he said.
  • For affected patients who are still eager to use their eggs or embryos to try to become pregnant, Herbert said the clinic plans to first thaw them and check for viability. If the tissue is not viable, he said, “we are going to make our patients happy one way or another.”
  • The emergencies mentioned in the guidance are fires, floods, power failures and terrorist attacks — but do not include instances in which a clinic’s own equipment fails.
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