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Matti Narkia

Novel role of the vitamin D receptor in maintaining the integrity of the intestinal muc... - 0 views

ajpgi.physiology.org/...G208

2008 January study research in_vivo animal_study vitamin_D VDR genotype polymorphism genetics IBD Crohn's deficiency tight_junction mucosal barrier tight junction medline

shared by Matti Narkia on 30 Aug 09 - Cached
  • Matti Narkia on 30 Aug 09
     
    Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Kong J, Zhang Z, Musch MW, Ning G, Sun J, Hart J, Bissonnette M, Li YC. Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G208-16. Epub 2007 Oct 25. PMID: 17962355 These observations suggest that VDR plays a critical role in mucosal barrier homeostasis by preserving the integrity of junction complexes and the healing capacity of the colonic epithelium. Therefore, vitamin D deficiency may compromise the mucosal barrier, leading to increased susceptibility to mucosal damage and increased risk of IBD.
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