Vitamin D-induced up-regulation of tumour necrosis factor alpha (TNF-alpha) in prostate cancer cells.
Golovko O, Nazarova N, Tuohimaa P.
Life Sci. 2005 Jun 17;77(5):562-77. Epub 2005 Feb 25.
PMID: 15904673
doi:10.1016/j.lfs.2004.10.072
Combined addition of human recombinant TNF-alpha with calcitriol or CB1093 cause enhanced effect in induction of apoptosis. We conclude that under physiological conditions vitamin D activates only the transcription of TNF-alpha gene, for TNF-alpha protein synthesis additional cofactors are required. Therefore a cooperation of vitamin D and TNF-alpha may play an important role in the control of cell growth in prostate cancer.
Vitamin D and depressive symptoms in women during the winter: a pilot study.
Shipowick CD, Moore CB, Corbett C, Bindler R.
Appl Nurs Res. 2009 Aug;22(3):221-5.
PMID: 19616172
doi:10.1016/j.apnr.2007.08.001
ESULTS: Vitamin D supplementation was associated not only with an increase in the serum D levels by an average of 27 ng/ml but also with a decline in the BDI-II scores of an average of 10 points. DISCUSSION: This study suggests that supplemental vitamin D3 reduces depressive symptoms.