Study Weakens Case for Preventive Mastectomy - WSJ.com - 0 views
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Stanford University researchers affirmed that women with mothers and sisters who carry one of the BRCA gene mutations but who aren't carriers themselves don't have an especially heightened risk of breast cancer.
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The findings run counter to an influential 2007 study, which found that such women could have as much as a five-fold higher risk of developing the disease as the general population, even if they tested negative for the two genetic mutations known as BRCA1 and BRCA2.
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a negative BRCA test didn't necessarily mean women had escaped the risk associated with the mutations, which significantly raise a woman's risk of breast and ovarian cancer. Some women who test positive opt for prophylactic surgery to remove their breasts or ovaries.