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Duncan H

Study Weakens Case for Preventive Mastectomy - WSJ.com - 0 views

  • Stanford University researchers affirmed that women with mothers and sisters who carry one of the BRCA gene mutations but who aren't carriers themselves don't have an especially heightened risk of breast cancer.
  • The findings run counter to an influential 2007 study, which found that such women could have as much as a five-fold higher risk of developing the disease as the general population, even if they tested negative for the two genetic mutations known as BRCA1 and BRCA2.
  • a negative BRCA test didn't necessarily mean women had escaped the risk associated with the mutations, which significantly raise a woman's risk of breast and ovarian cancer. Some women who test positive opt for prophylactic surgery to remove their breasts or ovaries.
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    How do you think these findings will change what people believe and do, if at all?
Duncan H

Raising the Chance of Some Cancers With Two Drinks a Day - WSJ.com - 0 views

  • Regularly drinking, even in moderation, raises the long-term risk of many kinds of cancer. A burgeoning body of research links alcohol to cancers of the breast, liver, colon, pancreas, mouth, throat, larynx and esophagus. A large new study last week added lung cancer to the list—even for people who have never smoked cigarettes.
  • For some of these cancers, such as lung, larynx and colorectal, the cancer risk only sets in when people drink heavily—three or four drinks a day on a regular basis. But just one drink a day raises the risk for cancers of the mouth and esophagus, several studies show.
  • "It's the repeated exposure to alcohol over a long period of time that will cause damage and it has a cumulative effect."
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  • One study found that men who consumed eight to 14 drinks a week had a 59% lower risk of heart failure compared with those who didn't drink.
  • But experts warn that regularly drinking more than that can cause cardiovascular damage instead, raising blood pressure, increasing the risk of hemorrhagic stroke and leading to cardiomyopathy, a dangerous enlargement of the heart.
  • Benefits of moderate drinking, defined as one drink a day for women, two for men. •Reduces the risk of coronary heart disease by 30% to 35%. Increases HDL 'good' cholesterol. •Prevents platelets from sticking together, reducing blood clots, and lowers the risk of congestive heart failure. •Cuts the risk of heart attack by 40% to 50% in healthy men. •Reduces the risk of stroke and dementia.
  • Cancer risks linked to drinking. (Risks vary with the amount of alcohol consumed.)•Raises the risk of oral and pharyngeal cancer by 20% and risk of breast cancer by 8% among people who have one or fewer drinks a day. •Raises risk of oral cancers 73%, risk of liver cancer 20% and risk of breast cancer 31% among people who have two to three drinks per day. •Associated with a fivefold increase in risk of oral, pharyngeal and esophageal cancers in people who have four or more drinks per day. •Raises the risk of colorectal cancer by 52%, pancreatic cancer by 22%, breast cancer by 46%.
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    Should adults drink in moderation then? How should the risks and benefits be balanced.
Duncan H

Study Suggests Way to Delay Age-Related Changes - WSJ.com - 0 views

  • Article Video Comments (54) more in Health & Wellness | Find New $LINKTEXTFIND$ »
  • Scientists may have found a way to put off some conditions of aging, according to a study in which they postponed or even prevented such afflictions as cataracts and wrinkle-inducing fat loss in mice by removing cells that had stopped dividing.
  • Most young, healthy cells divide continuously in order to keep body tissues and organs functioning properly, but eventually stop splitting—a state called senescence—and are replaced by others. Senescence occurs throughout life, but people's ability to clear such cells from their bodies decreases with age, leading to a buildup.
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  • "If you could clear senescent cells, you perhaps could treat age-related diseases as a group rather than individually," said Jan van Deursen, senior author of the paper and a professor in the departments of biochemistry and pediatric and adolescent medicine at Mayo.
  • When cells become senescent, they produce harmful compounds such as those that cause inflammation. Chronic tissue inflammation with aging is thought to underlie dementia, atherosclerosis and diabetes, among other ills,
  • Because senescence is believed to have developed as a defense against cancer, in which cells divide uncontrollably, simply halting the process could be dangerous. But scientists have wondered for decades if the damage inflicted by senescent cells could be stopped if they were removed from the body altogether, or if the harmful substances they produced were neutralized.
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    This seems like a question of a lesser of two evils, but it will be interesting to see where the research goes from here.
Duncan H

Matt Ridley on How the Population Explosion Never Happened | Mind & Matter - WSJ.com - 0 views

  • According to demographers, nobody knows the exact population of the world to within 100 million.
  • the occasion will provide an excuse for yet another round of Malthusian gnashing of teeth about overpopulation. But we shouldn't let it obscure the real story of the past 50 years, which is not how much faster than expected, but how much slower, population has been growing.
  • The growth rate of world population has halved since the '60s and is now expected to hit zero around 2070, with population around 10 billion, though some news outlets prefer to focus on the U.N.'s "high" estimate that it "could" reach 15 billion. The truth is, nobody can know, but if it's below 10 billion in 2100, we will have only increased in numbers by 1.5 times in the 21st century, compared with a fourfold increase in the 20th.
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  • This "demographic transition" to lower birth rates began in Western Europe in the 19th century and later spread to North America, then Latin America, Asia and now Africa. In 1955, the birth rates per woman in Yemen, Iran, Bangladesh, Nigeria, Brazil and China were, respectively, 8.3, 7.0, 6.8, 6.5, 6.1 and 5.6. Today they are 5.1, 1.7, 2.7, 5.2, 1.8 and 1.7. Notice: The poorer a country has remained, the slower the fall.
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    Even if the population does not grow as much as we feared, can the earth still support the billions of us that live here as we continue to consume more and more? Will we have to collectively sacrifice consumption, or are some people simply going to be denied the opportunity to live a first-world life?
Javier E

Andrew Weil's Spontaneous Happiness: Our Nature-Deficit Disorder - The Daily Beast - 0 views

  • In my experience, the more people have, the less likely they are to be contented. Indeed, there is abundant evidence that depression is a “disease of affluence,” a disorder of modern life in the industrialized world. People who live in poorer countries have a lower risk of depression than those in industrialized nations. In general, countries with lifestyles that are furthest removed from modern standards have the lowest rates of depression.
  • there seems to be something about modern life that creates fertile soil for depression.”
  • Behaviors strongly associated with depression—reduced physical activity and human contact, overconsumption of processed food, seeking endless distraction—are the very behaviors that more and more people now can do, are even forced to do by the nature of their sedentary, indoor jobs.
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  • More and more of us are sedentary, spending most of our time indoors. We eat industrial food much altered from its natural sources, and there is reason for concern about how our changed eating habits are affecting our brain activity and our moods. We are deluged by an unprecedented overload of information and stimulation in this age of the Internet, email, mobile phones, and multimedia, all of which favor social isolation and certainly affect our emotional (and physical) health.
  • e we are gathering scientific evidence for the benefits of living close to nature, not simply for enjoying its beauty or getting spiritual sustenance but for keeping our brains and nervous systems in good working order.
  • It may seem baffling, but the explanation is simple: the human body was never designed for the modern postindustrial environment.”
  • I believ
  • Human beings evolved to thrive in natural environments and in bonded social groups. Few of us today can enjoy such a life and the emotional equilibrium it engenders, but our genetic predisposition for it has not changed.
  • Possibly, the deterioration of emotional well-being characteristic of contemporary urban life represents a cumulative effect of lifestyle changes that have been occurring over many years, an effect that is now suddenly obvious.
  • Not only do we suffer from nature deficit, we are experiencing information surfeit. Many people today spend much of their waking time surfing the Internet, texting and talking on mobile phones, attending to email, watching television, and being stimulated by other new media—experiences never available until now.
  • The allure of synthetic entertainment—television, the Internet—is eerily reminiscent of the false promise of industrial food. It seems like a distillation of the good aspects of a social life, always entertaining yet easy to abandon when it becomes tedious or challenging. But, like junk food, it is ultimately unsatisfying and potentially harmful. Our brains, genetically adapted to help us negotiate a successful course through complex, changing, and often hazardous natural environments, are suddenly confronted with an overload of information and stimulation independent of physical reality.
Javier E

The Book Bench: Is Self-Knowledge Overrated? : The New Yorker - 1 views

  • It’s impossible to overstate the influence of Kahneman and Tversky. Like Darwin, they helped to dismantle a longstanding myth of human exceptionalism. Although we’d always seen ourselves as rational creatures—this was our Promethean gift—it turns out that human reason is rather feeble, easily overwhelmed by ancient instincts and lazy biases. The mind is a deeply flawed machine.
  • there is a subtle optimism lurking in all of Kahneman’s work: it is the hope that self-awareness is a form of salvation, that if we know about our mental mistakes, we can avoid them. One day, we will learn to equally weigh losses and gains; science can help us escape from the cycle of human error. As Kahneman and Tversky noted in the final sentence of their classic 1974 paper, “A better understanding of these heuristics and of the biases to which they lead could improve judgments and decisions in situations of uncertainty.” Unfortunately, such hopes appear to be unfounded. Self-knowledge isn’t a cure for irrationality; even when we know why we stumble, we still find a way to fall.
  • self-knowledge is surprisingly useless. Teaching people about the hazards of multitasking doesn’t lead to less texting in the car; learning about the weakness of the will doesn’t increase the success of diets; knowing that most people are overconfident about the future doesn’t make us more realistic. The problem isn’t that we’re stupid—it’s that we’re so damn stubborn
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  • Kahneman has given us a new set of labels for our shortcomings. But his greatest legacy, perhaps, is also his bleakest: By categorizing our cognitive flaws, documenting not just our errors but also their embarrassing predictability, he has revealed the hollowness of a very ancient aspiration. Knowing thyself is not enough. Not even close.
Duncan H

Why Our Candidates Disappoint Us - NYTimes.com - 0 views

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    What do you guys think about the generalizations made about liberals and conservatives?
Duncan H

Cancer Screening May Be More Popular Than Useful - NYTimes.com - 0 views

  • Now expert groups are proposing less screening for prostate, breast and cervical cancer and have emphasized that screening comes with harms as well as benefits.
  • the influential United States Preventive Services Task Force, which evaluates evidence and publishes screening guidelines, said that women in their 40s do not appear to benefit from mammograms and that women ages 50 to 74 should consider having them every two years inst
  • Two recent clinical trials of prostate cancer screening cast doubt on whether many lives — or any — are saved. And it said that screening often leads to what can be disabling treatments for men whose cancer otherwise would never have harmed them. A new analysis of mammography concluded that while mammograms find cancer in 138,000 women each year, as many as 120,000 to 134,000 of those women either have cancers that are already lethal or have cancers that grow so slowly they do not need to be treated.
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  • But these concepts are difficult for many to swallow. Specialists like urologists, radiologists and oncologists, who see patients who are sick and dying from cancer, often resist the idea of doing less screening. General practitioners, who may agree with the new guidelines, worry about getting involved in long conversations with patients trying to explain why they might reconsider having a mammogram every year or a P.S.A. test at all. Some doctors fear lawsuits if they do not screen and a patient develops a fatal cancer. Patients often say they will take their chances with screening’s harms if a test can save their lives.
  • And comments like Dr. Brawley’s give rise to other questions as well. Is all this happening now because of worries over costs? And in any case, is all this simply an academic argument, since most doctors, faced with real patients, still suggest frequent screening and their patients agree?
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    Who should get screening and when?
Duncan H

It's Consumer Spending, Stupid - NYTimes.com - 0 views

  • using business profits to increase productivity and output — doesn’t actually drive economic growth. Consumer debt and government spending do. Private investment isn’t even necessary to promote growth.
  • Economists will tell you that private business investment causes growth because it pays for the new plant or equipment that creates jobs, improves labor productivity and increases workers’ incomes. As a result, you’ll hear politicians insisting that more incentives for private investors — lower taxes on corporate profits — will lead to faster and better-balanced growth.
  • But history shows that this is wrong.
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  • Between 1900 and 2000, real gross domestic product per capita (the output of goods and services per person) grew more than 600 percent. Meanwhile, net business investment declined 70 percent as a share of G.D.P. What’s more, in 1900 almost all investment came from the private sector — from companies, not from government — whereas in 2000, most investment was either from government spending (out of tax revenues) or “residential investment,” which means consumer spending on housing, rather than business expenditure on plants, equipment and labor.
  • over the course of the last century, net business investment atrophied while G.D.P. per capita increased spectacularly. And the source of that growth? Increased consumer spending, coupled with and amplified by government outlays.
  • President George W. Bush’s tax cuts had similar effects between 2001 and 2007: real growth in the absence of new investment.
  • According to the Organization for Economic Cooperation and Development, retained corporate earnings that remain uninvested are now close to 8 percent of G.D.P., a staggering sum in view of the unemployment crisis we face.
  • So corporate profits do not drive economic growth — they’re just restless sums of surplus capital, ready to flood speculative markets at home and abroad. In the 1920s, they inflated the stock market bubble, and then caused the Great Crash. Since the Reagan revolution, these superfluous profits have fed corporate mergers and takeovers, driven the dot-com craze, financed the “shadow banking” system of hedge funds and securitized investment vehicles, fueled monetary meltdowns in every hemisphere and inflated the housing bubble.
  • we doubt the moral worth of consumer culture. Like the abstemious ant who scolds the feckless grasshopper as winter approaches, we think that saving is the right thing to do. Even as we shop with abandon, we feel that if only we could contain our unruly desires, we’d be committing ourselves to a better future. But we’re wrong.
  • Consumer spending is not only the key to economic recovery in the short term; it’s also necessary for balanced growth in the long term. If our goal is to repair our damaged economy, we should bank on consumer culture — and that entails a redistribution of income away from profits toward wages, enabled by tax policy and enforced by government spending.
Javier E

Hearing Bilingual - How Babies Tell Languages Apart - NYTimes.com - 4 views

  • In one recent study, Dr. Werker and her collaborators showed that babies born to bilingual mothers not only prefer both of those languages over others — but are also able to register that the two languages are different. In addition to this ability to use rhythmic sound to discriminate between languages, Dr. Werker has studied other strategies that infants use as they grow, showing how their brains use different kinds of perception to learn languages, and also to keep them separate.
  • Over the past decade, Ellen Bialystok, a distinguished research professor of psychology at York University in Toronto, has shown that bilingual children develop crucial skills in addition to their double vocabularies, learning different ways to solve logic problems or to handle multitasking, skills that are often considered part of the brain’s so-called executive function. These higher-level cognitive abilities are localized to the frontal and prefrontal cortex in the brain. “Overwhelmingly, children who are bilingual from early on have precocious development of executive function,” Dr. Bialystok said. Dr. Kuhl calls bilingual babies “more cognitively flexible” than monolingual infants.
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    I had no idea that language could play such a huge role in the development of an infant! This makes me wonder as to what other external social factors can come into consequence, like music or visual perceptions.
Javier E

Don't Blink! The Hazards of Confidence - NYTimes.com - 0 views

  • people who face a difficult question often answer an easier one instead, without realizing it. We were required to predict a soldier’s performance in officer training and in combat, but we did so by evaluating his behavior over one hour in an artificial situation. This was a perfect instance of a general rule that I call WYSIATI, “What you see is all there is.” We had made up a story from the little we knew but had no way to allow for what we did not know about the individual’s future, which was almost everything that would actually matter.
  • the exaggerated expectation of consistency is a common error. We are prone to think that the world is more regular and predictable than it really is, because our memory automatically and continuously maintains a story about what is going on, and because the rules of memory tend to make that story as coherent as possible and to suppress alternatives. F
  • The confidence we experience as we make a judgment is not a reasoned evaluation of the probability that it is right. Confidence is a feeling, one determined mostly by the coherence of the story and by the ease with which it comes to mind, even when the evidence for the story is sparse and unreliable. The bias toward coherence favors overconfidence. An individual who expresses high confidence probably has a good story, which may or may not be true.
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  • When a compelling impression of a particular event clashes with general knowledge, the impression commonly prevails. And this goes for you, too. The confidence you will experience in your future judgments will not be diminished by what you just read, even if you believe every word.
Javier E

Who You Are - NYTimes.com - 1 views

  • Before Kahneman and Tversky, people who thought about social problems and human behavior tended to assume that we are mostly rational agents. They assumed that people have control over the most important parts of their own thinking. They assumed that people are basically sensible utility-maximizers and that when they depart from reason it’s because some passion like fear or love has distorted their judgment.
  • Kahneman and Tversky conducted experiments. They proved that actual human behavior often deviates from the old models and that the flaws are not just in the passions but in the machinery of cognition. They demonstrated that people rely on unconscious biases and rules of thumb to navigate the world, for good and ill. Many of these biases have become famous: priming, framing, loss-aversion.
  • We are dual process thinkers. We have two interrelated systems running in our heads. One is slow, deliberate and arduous (our conscious reasoning). The other is fast, associative, automatic and supple (our unconscious pattern recognition). There is now a complex debate over the relative strengths and weaknesses of these two systems. In popular terms, think of it as the debate between “Moneyball” (look at the data) and “Blink” (go with your intuition).
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  • We are not blank slates. All humans seem to share similar sets of biases. There is such a thing as universal human nature. The trick is to understand the universals and how tightly or loosely they tie us down.
  • We are players in a game we don’t understand. Most of our own thinking is below awareness. Fifty years ago, people may have assumed we are captains of our own ships, but, in fact, our behavior is often aroused by context in ways we can’t see. Our biases frequently cause us to want the wrong things. Our perceptions and memories are slippery, especially about our own mental states. Our free will is bounded. We have much less control over ourselves than we thought.
  • They also figured out ways to navigate around our shortcomings. Kahneman champions the idea of “adversarial collaboration” — when studying something, work with people you disagree with. Tversky had a wise maxim: “Let us take what the terrain gives.” Don’t overreach. Understand what your circumstances are offer
Laurel Brown

Faster than the speed of light - 0 views

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    this reminded me of the conversation we had in class about the neutrinos and the new discovery
Javier E

Amazon Rewrites the Rules of Book Publishing - NYTimes.com - 0 views

  • “The Hangman’s Daughter” was an e-book hit. Amazon bought the rights to the historical novel by a first-time writer, Oliver Pötzsch, and had it translated from German. It has now sold 250,000 digital copies.
Javier E

The Evangelical Rejection of Reason - NYTimes.com - 1 views

  • THE Republican presidential field has become a showcase of evangelical anti-intellectualism. Herman Cain, Rick Perry and Michele Bachmann deny that climate change is real and caused by humans. Mr. Perry and Mrs. Bachmann dismiss evolution as an unproven theory.
  • The rejection of science seems to be part of a politically monolithic red-state fundamentalism, textbook evidence of an unyielding ignorance on the part of the religious. As one fundamentalist slogan puts it, “The Bible says it, I believe it, that settles it.”
  • Fundamentalism appeals to evangelicals who have become convinced that their country has been overrun by a vast secular conspiracy; denial is the simplest and most attractive response to change.
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  • In response, many evangelicals created what amounts to a “parallel culture,” nurtured by church, Sunday school, summer camps and colleges, as well as publishing houses, broadcasting networks, music festivals and counseling groups.
  • But in fact their rejection of knowledge amounts to what the evangelical historian Mark A. Noll, in his 1994 book, “The Scandal of the Evangelical Mind,” described as an “intellectual disaster.” He called on evangelicals to repent for their neglect of the mind, decrying the abandonment of the intellectual heritage of the Protestant Reformation. “The scandal of the evangelical mind,” he wrote, “is that there is not much of an evangelical mind.”
  • Scholars like Dr. Collins and Mr. Noll, and publications like Books & Culture, Sojourners and The Christian Century, offer an alternative to the self-anointed leaders. They recognize that the Bible does not condemn evolution and says next to nothing about gay marriage. They understand that Christian theology can incorporate Darwin’s insights and flourish in a pluralistic society.
Duncan H

Where Did Global Warming Go? - 0 views

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    It's interesting to me how people seem to talk about the threats posed by global warming, yet politically the issue is ignored. Seems to me the unreasonable rhetoric on both sides has really turned people off from even discussing the topic.
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