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What the rise of the BRICs symbolizes to both panicked individuals in the West and optimistic ones elsewhere is a radical shift in the geography of power -- a catch-up or reversal of the Western global dominance that was established with the Industrial Revolution.

developing countries won't be able to follow the West's path to becoming rich, because that path required certain things that were largely particular to that one period in history.

The challenge ahead for the BRICs, then, is to figure out how to maintain growth in a world where the vast new frontier opened up by the Industrial Revolution appears to be closing. The BRICs can play the West's game better than the West, both through technological innovation and population growth, but only for so long. The whole world has to figure out a way of dealing with energy and agriculture.

DJ: Of the basic values of French liberalism—liberty, equality, and fraternity—the last, fraternity, always seems to get short shrift. Your book, by contrast, argues that religious tolerance and liberalism in general can only flourish if people cultivate active respect, civility, and civic friendship with their fellow citizens. If this is so crucial, why do traditional liberals fail to make it more central to their program?

MN: I think liberals associate the cultivation of public emotion with fascism and other illiberal ideologies. But if they study history more closely they will find many instances in which emotions are deliberately cultivated in the service of liberal ideals. My next book, Political Emotions, will study all of this in great detail. Any political principles that ask people to go beyond their own self-interest for the sake of justice requires the cultivation of emotion.

we should confront sexism by argument and persuasion, and that to render all practices that objectify women illegal would be both too difficult (who would judge?) and too tyrannical.

critics of the burqa typically look at the practices of others and find sexism and “objectification” of women there, while failing to look at the practices of the dominant culture, which are certainly suffused with sexism and objectification. I was one of the feminist philosophers who wrote about objectification as a fundamental problem, and what we were talking about was the portrayal of women as commodities for male use and control in violent pornography, in a great deal of our media culture, and in other cultural practices, such as plastic surgery. I would say that this type of objectification is not on the retreat but may even be growing. Go to a high school dance—even at a high-brow school such as the John Dewey Laboratory School on our campus [at the University of Chicago]—and you will see highly individual and intelligent teenage girls marketing themselves for male consumption in indistinguishable microskirts, prior to engaging in a form of group dancing that mimes sex, and effaces their individuality. (Boys wear regular and not particularly sexy clothing.)

Lots of bad things are and will remain legal: unkindness, emotional blackmail, selfishness. And though I think the culture of pornographic objectification does great damage to personal relations, I don’t think that legal bans are the answer.

In the history of philosophy this was well understood, and figures as diverse as [Jean-Jacques] Rousseau, [Johann Gottfried von] Herder, [Giuseppe] Mazzini, Auguste Comte, John Stuart Mill, and John Rawls had a lot to say about the issue. In Mill’s case, he set about solving the problem posed by the confluence of liberalism and emotion: how can a society that cultivates emotion to support its political principles also preserve enough space for dissent, critique, and experimentation? My own proposal in the forthcoming book follows the lead of Mill—and, in India, of Rabindranath Tagore—and tries to show how a public culture of emotions, supporting the stability of good political principles, can also be liberal and protective of dissent. Some of the historical figures I study in this regard are Franklin Delano Roosevelt, Martin Luther King, Jr., Gandhi, and Nehru.

the Palin reaction was a whole lot better than the standard reaction in Europe, which is that we should just ban things that we fear. It is really unbelievable, having just lectured on this topic here in Germany: my views, which are pretty mainstream in America, are found “extreme” and even “offensive” in Germany, and all sorts of quite refined people think that Islam poses a unique problem and that the law should be dragged in to protect the culture.

The problem with these Europeans is that they don’t want to ban platform shoes or spike heels either; they just want to ban practices of others which they have never tried to understand.

STEIN: The brain connections of people whose microbes are dominated by one species of bacteria look different than those of people whose microbes are dominated by another species. That suggests that the specific mix of microbes in our guts helps determine what kinds of brains we have, how our brain circuits develop, how they're wired.

STEIN: It worked the other way around too. The bold mice became timid when they got the microbes of anxious ones. Aggressive mice also calmed down when the scientists altered their microbes by changing their diet, feeding them probiotics, or dosing them with antibiotics.

This could help explain why some people are born with brains that don't work the way they're supposed to, causing problems like autism, anxiety, depression.

COLLINS: And this resulted in a change in behavior. The mice became a little bit less anxious, a little bit more gregarious.

They did things like replace the gut bacteria of anxious mice with bacteria from fearless mice.

STEIN: Finally, these scientists figured out how the microbes in the guts of the mice were communicating with their brains - by sending signals up a big nerve known as the vagus nerve.

All this is raising the possibility that scientists could create drugs that mimic these signals. Or just give people the good bacteria - probiotics - to prevent or treat problems involving the brain.

is Chinese the language of the future?

So which one should you, or your children, learn? If you take a glance at advertisements in New York or A-level options in Britain, an answer seems to leap out: Mandarin.

The practical reasons are just as compelling. In business, if the team on the other side of the table knows your language but you don’t know theirs, they almost certainly know more about you and your company than you do about them and theirs—a bad position to negotiate from.

This factor is the Chinese writing system (which Japan borrowed and adapted centuries ago). The learner needs to know at least 3,000-4,000 characters to make sense of written Chinese, and thousands more to have a real feel for it. Chinese, with all its tones, is hard enough to speak. But  the mammoth feat of memory required to be literate in Mandarin is harder still. It deters most foreigners from ever mastering the system—and increasingly trips up Chinese natives.

If you were to learn ten languages ranked by general usefulness, Japanese would probably not make the list. And the key reason for Japanese’s limited spread will also put the brakes on Chinese.

A recent survey reported in the People’s Daily found 84% of respondents agreeing that skill in Chinese is declining.

Fewer and fewer native speakers learn to produce characters in traditional calligraphy. Instead, they write their language the same way we do—with a computer. And not only that, but they use the Roman alphabet to produce Chinese characters: type in wo and Chinese language-support software will offer a menu of characters pronounced wo; the user selects the one desired. (Or if the user types in wo shi zhongguo ren, “I am Chinese”, the software detects the meaning and picks the right characters.) With less and less need to recall the characters cold, the Chinese are forgetting them

As long as China keeps the character-based system—which will probably be a long time, thanks to cultural attachment and practical concerns alike—Chinese is very unlikely to become a true world language, an auxiliary language like English, the language a Brazilian chemist will publish papers in, hoping that they will be read in Finland and Canada. By all means, if China is your main interest, for business or pleasure, learn Chinese. It is fascinating, and learnable—though Moser’s online essay, “Why Chinese is so damn hard,” might discourage the faint of heart and the short of time.

But if I was asked what foreign language is the most useful, and given no more parameters (where? for what purpose?), my answer would be French. Whatever you think of France, the language is much less limited than many people realise.

French ranks only 16th on the list of languages ranked by native speakers. But ranked above it are languages like Telegu and Javanese that no one would call world languages. Hindi does not even unite India. Also in the top 15 are Arabic, Spanish and Portuguese, major languages to be sure, but regionally concentrated. If your interest is the Middle East or Islam, by all means learn Arabic. If your interest is Latin America, Spanish or Portuguese is the way to go. Or both; learning one makes the second quite easy.

if you want another truly global language, there are surprisingly few candidates, and for me French is unquestionably top of the list. It can enhance your enjoyment of art, history, literature and food, while giving you an important tool in business and a useful one in diplomacy. It has native speakers in every region on earth. And lest we forget its heartland itself, France attracts more tourists than any other country—76.8m in 2010, according to the World Tourism Organisation, leaving America a distant second with 59.7m

there could be more subtle problems at work, like the proliferation of grade inflation in the humanities and social sciences, which provides another incentive for students to leave STEM majors. It is no surprise that grades are lower in math and science, where the answers are clear-cut and there are no bonus points for flair. Professors also say they are strict because science and engineering courses build on one another, and a student who fails to absorb the key lessons in one class will flounder in the next.

The National Science Board, a public advisory body, warned in the mid-1980s that students were losing sight of why they wanted to be scientists and engineers in the first place. Research confirmed in the 1990s that students learn more by grappling with open-ended problems, like creating a computer game or designing an alternative energy system, than listening to lectures. While the National Science Foundation went on to finance pilot courses that employed interactive projects, when the money dried up, so did most of the courses. Lecture classes are far cheaper to produce, and top professors are focused on bringing in research grants, not teaching undergraduates.

Since becoming Notre Dame’s dean in 2008, Dr. Kilpatrick has revamped and expanded a freshman design course that had gotten “a little bit stale.” The students now do four projects. They build Lego robots and design bridges capable of carrying heavy loads at minimal cost. They also create electronic circuit boards and dream up a project of their own.

Some new students do not have a good feel for how deeply technical engineering is. Other bright students may have breezed through high school without developing disciplined habits. By contrast, students in China and India focus relentlessly on math and science from an early age.

“If I were teaching this in a course,” said Merilee Grindle, president of the Latin American Studies Association and director of the David Rockefeller Center for Latin American Studies at Harvard, “I would take his comments, add them in and use them to generate a far more interesting discussion about how we see and interpret events at different points in time.” And that seems to be exactly what many professors plan to do.

“Open Veins” has been translated into more than a dozen languages and has sold more than a million copies. In its heyday, its influence extended throughout what was then called the third world, including Africa and Asia, until the economic rise of China and India and Brazil seemed to undercut parts of its thesis.In the United States, “Open Veins” has been widely taught on university campuses since the 1970s, in courses ranging from history and anthropology to economics and geography. But Mr. Galeano’s unexpected takedown of his own work has left scholars wondering how to deal with the book in class.

“Reality has changed a lot, and I have changed a lot,” he said in Brazil, adding: “Reality is much more complex precisely because the human condition is diverse. Some political sectors close to me thought such diversity was a heresy. Even today, there are some survivors of this type who think that all diversity is a threat. Fortunately, it is not.”

In the mid-1990s, three advocates of free-market policies — the Colombian writer and diplomat Plinio Apuleyo Mendoza, the exiled Cuban author Carlos Alberto Montaner and the Peruvian journalist and author Álvaro Vargas Llosa — reacted to Mr. Galeano with a polemic of their own, “Guide to the Perfect Latin American Idiot.” They dismissed “Open Veins” as “the idiot’s bible,” and reduced its thesis to a single sentence: “We’re poor; it’s their fault.”

Mr. Montaner responded to Mr. Galeano’s recent remarks with a blog post titled “Galeano Corrects Himself and the Idiots Lose Their Bible.” In Brazil, Rodrigo Constantino, the author of “The Caviar Left,” took an even harsher tone, blaming Mr. Galeano’s analysis and prescription for many of Latin America’s ills. “He should feel really guilty for the damage he caused,”

Because cells are connected in a network, brain activity produces a synchronised pulse of electrical activity, which is called a “brain wave”.

Brainwaves are detected using a technique known as electroencephalography (EEG),

The pattern of activity is then recorded and interpreted using computer software.

The electrical nature of the brain allows not only for sending of signals, but also for the receiving of electrical pulses

Studies published in the last two years have reported direct transmission of brain activity between two animals, between two humans and even between a human and a rat.

The connection was reinforced by giving both rats a reward when the receiver rat performed the task correctly.

By combining EEG and TMS, scientists have transmitted the thought of moving a hand from one person to a separate individual, who actually moved their hand.

including EEG, the Internet and TMS – the team of researchers was able to transmit a thought all the way from India to France.

Words were first coded into binary notation

Now that these BBI technologies are becoming a reality, they have a huge potential to impact the way we interact with other humans. And maybe even the way we communicate with animals through direct transmission of thought.

Such technologies have obvious ethical and legal implications, however. So it is important to note that the success of BBIs depends upon the conscious coupling of the subjects.

What has exploded in India over the past few decades, but also everywhere else in the world, is information about other people. As we watch television, surf the Internet and follow events around the world, we become intimately aware of other ways of living and of others who are richer and more powerful. We place ourselves in a vast social order in which most of us are ants. It may truly be a depressing reflection.

We know that social position affects both when you die and how sick you get: The higher your social position, the healthier you are. It turns out that your sense of relative social rank — where you draw a line on an abstract ladder to show where you are with respect to others — predicts many health outcomes, including depression, sometimes even more powerfully than your objective socioeconomic status.

cities also break traditions and fracture families, and they breed psychiatric illness. In a city you are more likely to be depressed, to fall ill with schizophrenia, and to use alcohol and drugs. Poverty and rapid urbanization sharpen these effects.

Some of these figures might simply reflect more willingness to label an experience as a symptom. For example, until recently, most Japanese understood intense fatigue as sacrifice for one’s work and suicide as an act of reasoned will. In her book “Depression in Japan,” the anthropologist Junko Kitanaka writes that partly as a result of aggressive pharmaceutical marketing, many Japanese began to think of their fatigue and suicidal thoughts as symptoms created by a disease. The number of diagnoses of depression in that country more than doubled between 1999 and 2008.

Smith had a particular example in mind when he talked about market integration between continents: Europe and America.

Kevin O’Rourke and Jeffrey Williamson argued in a 2002 paper that globalisation only really began in the nineteenth century when a sudden drop in transport costs allowed the prices of commodities in Europe and Asia to converge

But there is one important market that Mssrs O’Rourke and Williamson ignore in their analysis: that for silver. As European currencies were generally based on the value of silver, any change in its value would have had big effects on the European price level.

The impact of what historians have called the resulting “price revolution” dramatically changed the face of Europe. Historians attribute everything from the dominance of the Spanish Empire in Europe to the sudden increase in witch hunts around the sixteenth century to the destabilising effects of inflation on European society. And if it were not for the sudden increase of silver imports from Europe to China and India during this period, European inflation would have been much worse than it was. Price rises only stopped in about 1650 when the price of silver coinage in Europe fell to such a low level that it was no longer profitable to import it from the Americas.

The German historical economist, Andre Gunder Frank, has argued that the start of globalisation can be traced back to the growth of trade and market integration between the Sumer and Indus civilisations of the third millennium BC. Trade links between China and Europe first grew during the Hellenistic Age, with further increases in global market convergence occuring when transport costs dropped in the sixteenth century and more rapidly in the modern era of globalisation, which Mssrs O’Rourke and Williamson describe as after 1750.

it is clear that globalisation is not simply a process that started in the last two decades or even the last two centuries. It has a history that stretches thousands of years, starting with Smith’s primitive hunter-gatherers trading with the next village, and eventually developing into the globally interconnected societies of today. Whether you think globalisation is a “good thing” or not, it appears to be an essential element of the economic history of mankind.

Although he already speaks English well, he says meeting native speakers has been helpful for picking up new phrases and mastering the art of both British and American slang.

Language teachers aren’t surprised by the trend, and see it as a natural progression given improved access to technology in countries like India. “In a developing country many people don’t have the disposable income to invest in self-improvement with things like language lessons. But access to the internet creates opportunities for self-directed study and to learn from the wealth of English language [content] available,”

“Smart learning is all about learning the English you need to deal with day-to-day situations that you may encounter. The instant gratification of learning something and being able to apply it in a meaningful way is a huge motivator,”

Some jobs will be displaced, but 100 percent of jobs will be augmented by A.I.,” added Rometty. Technology companies “are inventing these technologies, so we have the responsibility to help people adapt to it — and I don’t mean just giving them tablets or P.C.s, but lifelong learning systems.”

Each time work gets outsourced or tasks get handed off to a machine, “we must reach up and learn a new skill or in some ways expand our capabilities as humans in order to fully realize our collaborative potential,” McGowan said.

Therefore, education needs to shift “from education as a content transfer to learning as a continuous process where the focused outcome is the ability to learn and adapt with agency as opposed to the transactional action of acquiring a set skill,

“Instructors/teachers move from guiding and accessing that transfer process to providing social and emotional support to the individual as they move into the role of driving their own continuous learning.”

By trial and error, Ms. Oakley had learned how to learn: “The higher I went, it started to gradually make more and more sense.”

“The way you learn intensively for a language is very similar to learning well in math and science,”

“In learning math and science through K-12, it’s long been held that practice and repetition will kill your creativity,” she says. “One mistake we make in the school system is we emphasize understanding. But if you don’t build those neural circuits with practice, it’ll all slip away. You can understand out the wazoo, but it’ll just disappear if you’re not practicing with it.”

In places like China and India, “practice and repetition and rote and memorization are really important parts of education.” She sees value in both methods: “There are real benefits for Western approaches—that it really does help with creativity. And there are also real benefits to Asian approaches—that it builds a solid foundation in the most difficult disciplines, math and science.

The best education would actually be a combination of both approaches.”

She defines a “mindshift” as “a change in your outlook that occurs through intensive learning”—such as her own mastery of math and engineering.

The book is filled with advice for people who are considering a career change or who seek to develop “an attitude of lifelong learning,” even in retirement.

Her progression from desultory student to respected scholar led her to a sideline in the study of learning itself. She’s published two books on the subject, “A Mind for Numbers: How to Excel at Math and Science (Even if You Flunked Algebra)” (2014) and the new “Mindshift: Break Through Obstacles to Learning and Discover Your Hidden Potential.

they developed a massive open online course, “Learning How to Learn,” which by some measures is the world’s most popular MOOC

There are genres whose principal business is fact—journalism, history, popular science—but the essay has never been one of them. If the form possesses a defining characteristic, it is that the essay makes an argument

That argument can rest on fact, but it can also rest on anecdote, or introspection, or cultural interpretation, or some combination of all these and more

what makes a personal essay an essay and not just an autobiographical narrative is precisely that it uses personal material to develop, however speculatively or intuitively, a larger conclusion.

Nonfiction is the source of the narcissistic injury that seems to drive him. “Nonfiction,” he suggests, is like saying “not art,” and if D’Agata, who has himself published several volumes of what he refers to as essays, desires a single thing above all, it is to be known as a maker of art.

D’Agata tells us that the term has been in use since about 1950. In fact, it was coined in 1867 by the staff of the Boston Public Library and entered widespread circulation after the turn of the 20th century. The concept’s birth and growth, in other words, did coincide with the rise of the novel to literary preeminence, and nonfiction did long carry an odor of disesteem. But that began to change at least as long ago as the 1960s, with the New Journalism and the “nonfiction novel.”

What we really seem to get in D’Agata’s trilogy, in other words, is a compendium of writing that the man himself just happens to like, or that he wants to appropriate as a lineage for his own work.

What it’s like is abysmal: partial to trivial formal experimentation, hackneyed artistic rebellion, opaque expressions of private meaning, and modish political posturing

If I bought a bag of chickpeas and opened it to find that it contained some chickpeas, some green peas, some pebbles, and some bits of goat poop, I would take it back to the store. And if the shopkeeper said, “Well, they’re ‘lyric’ chickpeas,” I would be entitled to say, “You should’ve told me that before I bought them.”

when he isn’t cooking quotes or otherwise fudging the record, he is simply indifferent to issues of factual accuracy, content to rely on a mixture of guesswork, hearsay, and his own rather faulty memory.

His rejoinders are more commonly a lot more hostile—not to mention juvenile (“Wow, Jim, your penis must be so much bigger than mine”), defensive, and in their overarching logic, deeply specious. He’s not a journalist, he insists; he’s an essayist. He isn’t dealing in anything as mundane as the facts; he’s dealing in “art, dickhead,” in “poetry,” and there are no rules in art.

D’Agata replies that there is something between history and fiction. “We all believe in emotional truths that could never hold water, but we still cling to them and insist on their relevance.” The “emotional truths” here, of course, are D’Agata’s, not Presley’s. If it feels right to say that tae kwon do was invented in ancient India (not modern Korea, as Fingal discovers it was), then that is when it was invented. The term for this is truthiness.

D’Agata clearly wants to have it both ways. He wants the imaginative freedom of fiction without relinquishing the credibility (and for some readers, the significance) of nonfiction. He has his fingers crossed, and he’s holding them behind his back. “John’s a different kind of writer,” an editor explains to Fingal early in the book. Indeed he is. But the word for such a writer isn’t essayist. It’s liar.

he point of all this nonsense, and a great deal more just like it, is to advance an argument about the essay and its history. The form, D’Agata’s story seems to go, was neglected during the long ages that worshiped “information” but slowly emerged during the 19th and 20th centuries as artists learned to defy convention and untrammel their imaginations, coming fully into its own over the past several decades with the dawning recognition of the illusory nature of knowledge.

Most delectable is when he speaks about “the essay’s traditional ‘five-paragraph’ form.” I almost fell off my chair when I got to that one. The five-paragraph essay—introduction, three body paragraphs, conclusion; stultifying, formulaic, repetitive—is the province of high-school English teachers. I have never met one outside of a classroom, and like any decent college writing instructor, I never failed to try to wean my students away from them. The five-paragraph essay isn’t an essay; it’s a paper.

What he fails to understand is that facts and the essay are not antagonists but siblings, offspring of the same historical moment

—by ignoring the actual contexts of his selections, and thus their actual intentions—D’Agata makes the familiar contemporary move of imposing his own conceits and concerns upon the past. That is how ethnography turns into “song,” Socrates into an essayist, and the whole of literary history into a single man’s “emotional truth.”

The history of the essay is indeed intertwined with “facts,” but in a very different way than D’Agata imagines. D’Agata’s mind is Manichaean. Facts bad, imagination good

When he refers to his selections as essays, he does more than falsify the essay as a genre. He also effaces all the genres that they do belong to: not only poetry, fiction, journalism, and travel, but, among his older choices, history, parable, satire, the sermon, and more—genres that possess their own particular traditions, conventions, and expectation

one needs to recognize that facts themselves have a history.

Facts are not just any sort of knowledge, such as also existed in the ancient and medieval worlds. A fact is a unit of information that has been established through uniquely modern methods

Fact, etymologically, means “something done”—that is, an act or deed

It was only in the 16th century—an age that saw the dawning of a new empirical spirit, one that would issue not only in modern science, but also in modern historiography, journalism, and scholarship—that the word began to signify our current sense of “real state of things.”

It was at this exact time, and in this exact spirit, that the essay was born. What distinguished Montaigne’s new form—his “essays” or attempts to discover and publish the truth about himself—was not that it was personal (precursors like Seneca also wrote personally), but that it was scrupulously investigative. Montaigne was conducting research into his soul, and he was determined to get it right.

His famous motto, Que sais-je?—“What do I know?”—was an expression not of radical doubt but of the kind of skepticism that fueled the modern revolution in knowledge.

It is no coincidence that the first English essayist, Galileo’s contemporary Francis Bacon, was also the first great theorist of science.

That knowledge is problematic—difficult to establish, labile once created, often imprecise and always subject to the limitations of the human mind—is not the discovery of postmodernism. It is a foundational insight of the age of science, of fact and information, itself.

The point is not that facts do not exist, but that they are unstable (and are becoming more so as the pace of science quickens). Knowledge is always an attempt. Every fact was established by an argument—by observation and interpretation—and is susceptible to being overturned by a different one

A fact, you might say, is nothing more than a frozen argument, the place where a given line of investigation has come temporarily to rest.

Sometimes those arguments are scientific papers. Sometimes they are news reports, which are arguments with everything except the conclusions left out (the legwork, the notes, the triangulation of sources—the research and the reasoning).

When it comes to essays, though, we don’t refer to those conclusions as facts. We refer to them as wisdom, or ideas

the essay draws its strength not from separating reason and imagination but from putting them in conversation. A good essay moves fluidly between thought and feeling. It subjects the personal to the rigors of the intellect and the discipline of external reality. The truths it finds are more than just emotional.

He also called on his audience to “soul search” about their own relationship to social media. “Your behaviors, you don’t realize it, but you are being programmed,” he said. “It was unintentional, but now you gotta decide how much you’re going to give up, how much of your intellectual independence.”

Palihapitiya referenced a case from the Indian state of Jharkhand this spring, when false WhatsApp messages warning of a group of kidnappers led to the lynching of seven people. WhatsApp is owned by Facebook. “That’s what we’re dealing with,” Palihapitiya said. “Imagine when you take that to the extreme where bad actors can now manipulate large swaths of people to do anything you want. It’s just a really, really bad state of affairs.”

transportation experts are scrambling to figure out how to better adapt public transit to the needs of riders as cities begin to emerge from the pandemic.

In India, a company that sells secondhand cars online saw sales swell in 2020 and its own value as a company jump to $1 billion, according to news reports. Elsewhere, bike sales have grown, suggesting that people are pedaling a bit more.

Both London and Paris sought to use lockdowns to expand bike lanes.

ridership was just over half of normal in the first two months of this year.

Most importantly, if transit systems continue to lose passenger fare revenues, they will not be able to make the investments necessary to be efficient, safe and attractive to commuters.

The city transit agency, which had once projected a budget surplus for 2020, has instead been relying on government bailouts since the pandemic hit.

“only travel when absolutely necessary.”

There’s even more distress in cities where people rely in large part on private bus companies.

Strikes by bus drivers have made bus travel even slower and more chaotic.

efficient bus system is critical for Rio to not only reduce its carbon emissions but also to clean its air. “It’s not just an environmental issue, but a public health issue,” Ms. Celidonio said.

“Those cities that were investing, they will get out stronger,”

"The passing of this bill shows that once again New Zealand is leading the way for progressive and compassionate legislation, becoming only the second country in the world to provide leave for miscarriage and stillbirth,"

The other country that provides such leave is India, which allows women to take six weeks of leave after a miscarriage,

Washington, D.C., recently expanded its bereavement leave for public employees who lose a child, including those mourning a stillborn baby,

D.C.'s new policy offers two weeks of paid leave to city employees who lose a child under the age of 21, including stillbirths.

"You get three days' paid leave, maybe you bury your baby or you have a service, and then you go back to work, and you carry on — and then what? That's my concern,"

"I'm celebrating it," she said, "but I want to see us keeping this compassion going, and looking further into the needs of these parents."

Globally, the numbers can be even worse, and the stakes often higher. “Say a person comes into the hospital in Sierra Leone with a fever and flulike symptoms,” DeRisi says. “After a few days, or a week, they die. What caused that illness? Most of the time, we never find out. Because if the cause isn’t something that we can culture and test for” — like hepatitis, or strep throat — “it basically just stays a mystery.”

It would be better, DeRisi says, to watch for rare cases of mystery illnesses in people, which often exist well before a pathogen gains traction and is able to spread.

Based on a retrospective analysis of blood samples, scientists now know that H.I.V. emerged nearly a dozen times over a century, starting in the 1920s, before it went global.

Zika was a relatively harmless illness before a single mutation, in 2013, gave the virus the ability to enter and damage brain cells.

The beauty of this approach” — running blood samples from people hospitalized all over the world through his system, known as IDseq — “is that it works even for things that we’ve never seen before, or things that we might think we’ve seen but which are actually something new.”

In this scenario, an undiscovered or completely new virus won’t trigger a match but will instead be flagged. (Even in those cases, the mystery pathogen will usually belong to a known virus family: coronaviruses, for instance, or filoviruses that cause hemorrhagic fevers like Ebola and Marburg.)

And because different types of bacteria require specific conditions in order to grow, you also need some idea of what you’re looking for in order to find it.

The same is true of genomic sequencing, which relies on “primers” designed to match different combinations of nucleotides (the building blocks of DNA and RNA).

Even looking at a slide under a microscope requires staining, which makes organisms easier to see — but the stains used to identify bacteria and parasites, for instance, aren’t the same.

The practice that DeRisi helped pioneer to skirt this problem is known as metagenomic sequencing

Unlike ordinary genomic sequencing, which tries to spell out the purified DNA of a single, known organism, metagenomic sequencing can be applied to a messy sample of just about anything — blood, mud, seawater, snot — which will often contain dozens or hundreds of different organisms, all unknown, and each with its own DNA. In order to read all the fragmented genetic material, metagenomic sequencing uses sophisticated software to stitch the pieces together by matching overlapping segments.

The assembled genomes are then compared against a vast database of all known genomic sequences — maintained by the government-run National Center for Biotechnology Information — making it possible for researchers to identify everything in the mix

Traditionally, the way that scientists have identified organisms in a sample is to culture them: Isolate a particular bacterium (or virus or parasite or fungus); grow it in a petri dish; and then examine the result under a microscope, or use genomic sequencing, to understand just what it is. But because less than 2 percent of bacteria — and even fewer viruses — can be grown in a lab, the process often reveals only a tiny fraction of what’s actually there. It’s a bit like planting 100 different kinds of seeds that you found in an old jar. One or two of those will germinate and produce a plant, but there’s no way to know what the rest might have grown into.

Such studies have revealed just how vast the microbial world is, and how little we know about it

“The selling point for researchers is: ‘Look, this technology lets you investigate what’s happening in your clinic, whether it’s kids with meningitis or something else,’” DeRisi said. “We’re not telling you what to do with it. But it’s also true that if we have enough people using this, spread out all around the world, then it does become a global network for detecting emerging pandemics

Metagenomic sequencing is especially good at what scientists call “environmental sampling”: identifying, say, every type of bacteria present in the gut microbiome, or in a teaspoon of seawater.

After the Biohub opened in 2016, one of DeRisi’s goals was to turn metagenomics from a rarefied technology used by a handful of elite universities into something that researchers around the world could benefit from

metagenomics requires enormous amounts of computing power, putting it out of reach of all but the most well-funded research labs. The tool DeRisi created, IDseq, made it possible for researchers anywhere in the world to process samples through the use of a small, off-the-shelf sequencer, much like the one DeRisi had shown me in his lab, and then upload the results to the cloud for analysis.

he’s the first to make the process so accessible, even in countries where lab supplies and training are scarce. DeRisi and his team tested the chemicals used to prepare DNA for sequencing and determined that using as little as half the recommended amount often worked fine. They also 3-D print some of the labs’ tools and replacement parts, and offer ongoing training and tech support

The metagenomic analysis itself — normally the most expensive part of the process — is provided free.

But DeRisi’s main innovation has been in streamlining and simplifying the extraordinarily complex computational side of metagenomics

IDseq is also fast, capable of doing analyses in hours that would take other systems weeks.

“What IDseq really did was to marry wet-lab work — accumulating samples, processing them, running them through a sequencer — with the bioinformatic analysis,”

“Without that, what happens in a lot of places is that the researcher will be like, ‘OK, I collected the samples!’ But because they can’t analyze them, the samples end up in the freezer. The information just gets stuck there.”

Meningitis itself isn’t a disease, just a description meaning that the tissues around the brain and spinal cord have become inflamed. In the United States, bacterial infections can cause meningitis, as can enteroviruses, mumps and herpes simplex. But a high proportion of cases have, as doctors say, no known etiology: No one knows why the patient’s brain and spinal tissues are swelling.

When Saha and her team ran the mystery meningitis samples through IDseq, though, the result was surprising. Rather than revealing a bacterial cause, as expected, a third of the samples showed signs of the chikungunya virus — specifically, a neuroinvasive strain that was thought to be extremely rare. “At first we thought, It cannot be true!” Saha recalls. “But the moment Joe and I realized it was chikungunya, I went back and looked at the other 200 samples that we had collected around the same time. And we found the virus in some of those samples as well.”

Until recently, chikungunya was a comparatively rare disease, present mostly in parts of Central and East Africa. “Then it just exploded through the Caribbean and Africa and across Southeast Asia into India and Bangladesh,” DeRisi told me. In 2011, there were zero cases of chikungunya reported in Latin America. By 2014, there were a million.

Chikungunya is a mosquito-borne virus, but when DeRisi and Saha looked at the results from IDseq, they also saw something else: a primate tetraparvovirus. Primate tetraparvoviruses are almost unknown in humans, and have been found only in certain regions. Even now, DeRisi is careful to note, it’s not clear what effect the virus has on people. “Maybe it’s dangerous, maybe it isn’t,” DeRisi says. “But I’ll tell you what: It’s now on my radar.

it reveals a landscape of potentially dangerous viruses that we would otherwise never find out about. “What we’ve been missing is that there’s an entire universe of pathogens out there that are causing disease in humans,” Imam notes, “ones that we often don’t even know exist.”

“The plan was, Let’s let researchers around the world propose studies, and we’ll choose 10 of them to start,” DeRisi recalls. “We thought we’d get, like, a couple dozen proposals, and instead we got 350.”

One study found more than 1,000 different kinds of viruses in a tiny amount of human stool; another found a million in a couple of pounds of marine sediment. And most were organisms that nobody had seen before.

“When you draw blood from someone who has a fever in Ghana, you really don’t know very much about what would normally be in their blood without fever — let alone about other kinds of contaminants in the environment. So how do you interpret the relevance of all the things you’re seeing?”

Such criticisms have led some to say that metagenomics simply isn’t suited to the infrastructure of developing countries. Along with the problem of contamination, many labs struggle to get the chemical reagents needed for sequencing, either because of the cost or because of shipping and customs holdups

we’re less likely to be caught off-guard. “With Ebola, there’s always an issue: Where’s the virus hiding before it breaks out?” DeRisi explains. “But also, once we start sampling people who are hospitalized more widely — meaning not just people in Northern California or Boston, but in Uganda, and Sierra Leone, and Indonesia — the chance of disastrous surprises will go down. We’ll start seeing what’s hidden.”