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Patients in this study had a mean age of 44 years, so were very much part of the young, working-age population. Only 18% had been hospitalised with COVID-19, meaning organ damage may occur even after a non-severe infection.

Another piece of early research (awaiting peer review) suggests that SARS-CoV-2 could also have a long-term impact on people’s organs.

Perhaps unsurprisingly, people with more severe disease initially – characterised by more than five symptoms – seem to be at increased risk of long COVID. Older age and being female also appear to be risk factors for having prolonged symptoms, as is having a higher body mass index.

Rather harder to explore is the symptom of fatigue. Another recent large-scale study has shown that this symptom is common after COVID-19 – occurring in more than half of cases – and appears unrelated to the severity of the early illness.

While men are at increased risk of severe infection, that women seem to be more affected by long COVID may reflect their different or changing hormone status.

Some symptoms of long COVID overlap with menopausal symptoms, and hormone replacement using medication may be one route to reducing the impact of symptoms.

What is clear, however, is that long-term symptoms after COVID-19 are common, and that research into the causes and treatments of long COVID will likely be needed long after the outbreak itself has subsided.

it’s unclear whether infectious virus can persist in blood or stool

the infection can spread through the mucous membranes, from the nose down to the rectum.

while the virus appears to zero in on the lungs, it may also be able to infect cells in the gastrointestinal system, experts say. This may be why some patients have symptoms like diarrhea or indigestion

“The virus will actually land on organs like the heart, the kidney, the liver, and may cause some direct damage to those organs,

some patients in China recovered but got sick again, apparently because they had damaged and vulnerable lung tissue that was subsequently attacked by bacteria in their body.

As the body’s immune system shifts into high gear to battle the infection, the resulting inflammation may cause those organs to malfunction, he said.

About 80 percent of people infected with the new coronavirus have relatively mild symptoms. But about 20 percent of people become more seriously ill and in about 2 percent of patients in China, which has had the most cases, the disease has been fatal.

the effects appear to depend on how robust or weakened a person’s immune system is. Older people or those with underlying health issues, like diabetes or another chronic illness, are more likely to develop severe symptoms

the course a patient’s coronavirus will take is not yet fully understood.

Some patients can remain stable for over a week and then suddenly develop pneumonia, Dr. Diaz said. Some patients seem to recover but then develop symptoms again.

more than half of 121 patients in China had normal CT scans early in their disease.

Coronavirus particles have spiked proteins sticking out from their surfaces, and these spikes hook onto cell membranes, allowing the virus’s genetic material to enter the human cell.

That genetic material proceeds to “hijack the metabolism of the cell and say, in effect, ‘Don’t do your usual job. Your job now is to help me multiply and make the virus,’

As copies of the virus multiply, they burst out and infect neighboring cells. The symptoms often start in the back of the throat with a sore throat and a dry cough.

The virus then “crawls progressively down the bronchial tubes,”

That can damage the alveoli or lung sacs and they have to work harder to carry out their function of supplying oxygen to the blood

The swelling and the impaired flow of oxygen can cause those areas in the lungs to fill with fluid, pus and dead cells. Pneumonia, an infection in the lung, can occur

Some people have so much trouble breathing they need to be put on a ventilator

The trendlines are obvious: Asked the same questions at about the same points in their lives, Americans are, over time, experiencing worse and worse symptoms associated with anxiety and depression.

there’s an interesting recent wrinkle to this trajectory. In a paper published in 2014 in Social Indicators Research, Twenge tracked the results of the Monitoring the Future (MtF) survey, “a nationally representative sample of U.S. 12th graders [administered] every year since 1976,” between 1982 and 2013. Like the MMPI, the MtF asks students about symptoms in a manner that should be generally resistant to cultural change: The somatic items Twenge examined asked about trouble sleeping, remembering things, thinking/concentrating, and learning, as well as shortness of breath. An interesting recent pattern emerged on these measures:

All the items end up significantly higher than where they started, but for many of them most of the increase happens over the first half of the time period in question. From the late 1990s or so until 2013, many of the items bounce around a bit but ultimately remain flat, or flat-ish.

drugs — Prozac and Lexapro, among others — have been prescribed to millions of people who experience these symptoms, many of whom presumably saw some improvement once the drugs kicked in, so this explanation at least makes intuitive sens

there are likely other factors leading to the plateau as well, said Twenge. For one thing, the “crime rate is lower [today] than it was when it peaked in the early 1990s,” and dealing with crime can lead to anxiety and depression symptoms. Other indicators of youth well-being, like teen pregnancy, were also significantly higher back then, and could have accounted for the trajectory visible on the graphs.“For whatever reason,” said Twenge, “if you look at what was going on back then, the early 1990s were not a good time, particularly for young people.”

“Obviously there’s a lot of good things about societal and technological progress,” she said, “and in a lot of ways our lives are much easier than, say, our grandparents’ or great-grandparents’ lives. But there’s a paradox here that we seem to have so much ease and relative economic prosperity compared to previous centuries, yet there’s this dissatisfaction, there’s this unhappiness, there are these mental health issues in terms of depression and anxiety.

She thinks the primary problem is that “modern life doesn’t give us as many opportunities to spend time with people and connect with them, at least in person, compared to, say, 80 years ago or 100 years ago. Families are smaller, the divorce rate is higher, people get married much later in life.”

it may simply be the case that many people who lived in less equal, more “traditional” times were forced into close companionship with a lot of other people, and that this shielded them from certain psychological problems, whatever else was going on in their lives.

She was virtually never alone — and that can be a bad thing, clearly, but from a mental health perspective being surrounded by people is a good thing.”

the shift away from this sort of life has also brought with it a shift in values, and Twenge thinks that this, too, can account for the increase in anxiety and depression. “There’s clear evidence that the focus on money, fame, and image has gone up,

“and there’s also clear evidence that people who focus on money, fame, and image are more likely to be depressed and anxious.”

“It’s so tempting to say the world is going to hell in a handbasket and everything’s bad, but there are so many good things about modern life,” she said. So maybe the key message here is that while there’s no way to go back to family farms and young marriage and parenthood — and, from an equality standpoint,we wouldn’t want to anyway — modern life needs to do a better job of connecting people to one another, and encouraging them to adopt the sorts of goals and outlooks that will make them happy.

‘I was so happy to read about this, because my doctor thought I was crazy when I mentioned tinnitus and now I know I’m not the only one.’”

A study published late last year in the journal Frontiers in Public Health surveyed 3,100 people with tinnitus and found that 40 percent of the 237 respondents who had contracted Covid-19 reported that their symptoms were “significantly exacerbated” following the infection.

A very small group of people in Dr. Beukes’s study — seven — reported that Covid-19 brought on tinnitus for the first time. Just over half of people with tinnitus said the illness had left their symptoms unchanged.

COVID-19 survivors, found that 36% of people with long-haul symptoms noticed improvements in their condition after vaccination. About 50% remained the same. Other unofficial surveys have also estimated that about a third of patients with long COVID feel better after getting a vaccine.

“We don’t know who gets PASC, who avoids it, what exactly is causing it, or how to even diagnose it effectively,” said William Li, a vascular biologist and medical director of the Angiogenesis Foundation. Without those answers, it’s difficult to clearly see how the vaccines impact long-haulers, for better or worse.

These devices can measure a person’s temperature, heart rate, level of activity and other biometrics. With this information, researchers have been able to track and detect COVID-19 infections even before people notice they have any symptoms.

Wearables can detect symptoms of COVID-19 or other illnesses before symptoms are noticeable. While they have proved to be capable of detecting sickness early, the symptoms wearables detect are not unique to COVID-19.

So a logical way to look for new drugs to treat a specific disease is to study individual genes and proteins that are directly affected by that disease.

But this idea of mapping the protein interactions of diseases to look for novel drug targets doesn’t apply just to the coronavirus. We have now used this approach on other pathogens as well as other diseases including cancer, neurodegenerative and psychiatric disorders.

We know that rumination (dwelling on personal problems) and social isolation are common features of depression. However, we don’t know whether these findings reflect differences in attention or thinking style. Does depression cause people to focus on themselves, or do people who focus on themselves get symptoms of depression?

Crucially, those who have previously had depressive symptoms are more likely to have them again. Therefore, their greater tendency for absolutist thinking, even when there are currently no symptoms of depression, is a sign that it may play a role in causing depressive episodes. The same effect is seen in use of pronouns, but not for negative emotion words.

From the outset, we predicted that those with depression will have a more black and white view of the world, and that this would manifest in their style of language.

Our lab recently conducted a big data text analysis of 64 different online mental health forums, examining over 6,400 members. “Absolutist words” – which convey absolute magnitudes or probabilities, such as “always”, “nothing” or “completely” – were found to be better markers for mental health forums than either pronouns or negative emotion words.

But as the World Health Organisation estimates that more than 300m people worldwide are now living with depression, an increase of more than 18% since 2005, having more tools available to spot the condition is certainly important to improve health and prevent tragic suicides such as those of Plath and Cobain.

onic constipation, a functional bowel disorder, affects approximately 14% of adults worldwide [1]. Slow transit constipation (STC) is the major cause of chronic constipation which is characterized by markedly prolonged colonic transit time as a result of the colonic motility function disorde

Usually, patients with STC suffer from a common sense of abdominal pain, nausea, depression and sickness, which seriously influence their social ability and health-related quality of life [4–6

Current clinical treatments include cathartics, prokinetics and aggressive surgery which can increase bowel movement frequency to a certain degree.

However, pharmacological interventions is prone to drug dependency and relapse after drug withdrawal [3]

Surgical treatments such as subtotal colectomy and total colectomy in STC patients may adversely affect the quality of life due to the risk of postoperative diarrhea or incontinence, and result in a heavy healthcare burden

The enteric nervous system (ENS), located in the intestinal wall, regulates various functions including contraction of intestine, homeostasis and blood flow [10]. As the ‘second brain’, the ENS contains large amounts of neurons working independently from the central nervous system [11]. Researches have identified that STCs are mostly caused by disorders of the relevant nerves, especially the ENS [12,13].

McCallum et al. [35] found that gastric electrical stimulation in combination with pharmacological treatment could also enhance emptying in patients with gastroparesis. Especially, gastric electrical stimulation has been approved as a clinical therapy method for gastroparesis and obesity in European and American countries [36].

we employed pulse train stimulation and implanted electrodes at the proximal colon in dogs.

After CES treatment, we observed the colonic transit time of the sham treatment group was longer than that of CES treatment and control groups, and electrical stimulation significantly enhanced the colonic electromyogram (EMG) signal.

histopathology and TEM analysis showed increased ganglia and synaptic vesicles existing in the colon myenteric plexus of the CES treatment group as compared with that of the sham CES group

Our results suggested that CES might reduce the degeneration of the myenteric plexus neurons, thereby contributing to the therapeutic effect on STC beagles.

the defecating frequency and the feces characteristics of STC beagles returned to normal after CES treatment. The result indicated that CES could improve the symptoms of STC.

The colonic EMG signal was strongly promoted by CES

Especially, the colonic EMG signal of the beagles with STC was remarkably enhanced by CES (Figure 3), indicating that CES could not only improve the colonic content emptying, but also enhance the EMG signal to promote colonic motility.

Colonic electrical stimulation (CES), a valuable alternative for the treatment of STC, was reported to improve the colon motility by adjusting the bioelectrical activity in animal models or patients with STC [17]. However, little report focuses on the underlying nervous mechanism to normalize the delayed colonic emptying and relieve symptoms. We hypothesized that CES may also repair the disorders of the relevant nerves and then improve the colonic motility.

The first study regarding the CES to modulate colonic motility was performed by Hughes et al. [37]. Since then, many researchers employed short-pulse CES in canine descending colon or pig cecum [20,21,38]. Researchers also applied long-pulse CES to stimulate the colon of human or animals [39]

Recently, studies showed that the prokinetic effect of pulse train CES is better than that of short-pulse CES or long-pulse CES [25]

Our study indicated that CES could enhance the colonic motility, and then accelerate the colonic content emptying. Thereafter, we investigated the underlying mechanism and presumed that CES might improve the STC symptom through the repairment of the ENS.

The neuropathy in ENS is considered to be responsible for various kinds of disordered motility including STC and the related pathophysiologic symptoms [40]. In agreement with this view, our study discovered the decreased number of ganglia in the myenteric plexus, as well as the destruction of the enteric nerve axon terminals and synaptic vesicles in the sham CES group beagles

The present study proves that CES with pulse trains has curative effects on the colonic motility and content emptying in STC beagles. The up-regulation of intestinal nerve related proteins such as SYP, PGP9.5, CAD and S-100B in the colonic myenteric plexus suggests that CES might reduce the degeneration of the myenteric plexus neurons, thereby producing the therapeutic effect on STC beagles. Further investigation for the underlying mechanism of nerve regeneration is necessary to better understand how CES promotes the recovery of delayed colonic motility induced by STC.

the trends persisted, across several years and a series of national surveys. The changes weren’t just in degree, but in kind.

The biggest difference between the Millennials and their predecessors was in how they viewed the world; teens today differ from the Millennials not just in their views but in how they spend their time. The experiences they have every day are radically different from those of the generation that came of age just a few years before them.

it was exactly the moment when the proportion of Americans who owned a smartphone surpassed 50 percent.

theirs is a generation shaped by the smartphone and by the concomitant rise of social media. I call them iGen

Born between 1995 and 2012, members of this generation are growing up with smartphones, have an Instagram account before they start high school, and do not remember a time before the internet.

iGen’s oldest members were early adolescents when the iPhone was introduced, in 2007, and high-school students when the iPad entered the scene, in 2010. A 2017 survey of more than 5,000 American teens found that three out of four owned an iPhone.

The arrival of the smartphone has radically changed every aspect of teenagers’ lives, from the nature of their social interactions to their mental health. These changes have affected young people in every corner of the nation and in every type of household

More comfortable in their bedrooms than in a car or at a party, today’s teens are physically safer than teens have ever been. They’re markedly less likely to get into a car accident and, having less of a taste for alcohol than their predecessors, are less susceptible to drinking’s attendant ills.

Psychologically, however, they are more vulnerable than Millennials were: Rates of teen depression and suicide have skyrocketed since 2011. It’s not an exaggeration to describe iGen as being on the brink of the worst mental-health crisis in decades. Much of this deterioration can be traced to their phones.

the twin rise of the smartphone and social media has caused an earthquake of a magnitude we’ve not seen in a very long time, if ever. There is compelling evidence that the devices we’ve placed in young people’s hands are having profound effects on their lives—and making them seriously unhappy.

But the allure of independence, so powerful to previous generations, holds less sway over today’s teens, who are less likely to leave the house without their parents. The shift is stunning: 12th-graders in 2015 were going out less often than eighth-graders did as recently as 2009.

Today’s teens are also less likely to date. The initial stage of courtship, which Gen Xers called “liking” (as in “Ooh, he likes you!”), kids now call “talking”—an ironic choice for a generation that prefers texting to actual conversation. After two teens have “talked” for a while, they might start dating.

only about 56 percent of high-school seniors in 2015 went out on dates; for Boomers and Gen Xers, the number was about 85 percent.

The decline in dating tracks with a decline in sexual activity. The drop is the sharpest for ninth-graders, among whom the number of sexually active teens has been cut by almost 40 percent since 1991. The average teen now has had sex for the first time by the spring of 11th grade, a full year later than the average Gen Xer

The teen birth rate hit an all-time low in 2016, down 67 percent since its modern peak, in 1991.

Nearly all Boomer high-school students had their driver’s license by the spring of their senior year; more than one in four teens today still lack one at the end of high school.

In conversation after conversation, teens described getting their license as something to be nagged into by their parents—a notion that would have been unthinkable to previous generations.

In the late 1970s, 77 percent of high-school seniors worked for pay during the school year; by the mid-2010s, only 55 percent did. The number of eighth-graders who work for pay has been cut in half.

Beginning with Millennials and continuing with iGen, adolescence is contracting again—but only because its onset is being delayed. Across a range of behaviors—drinking, dating, spending time unsupervised— 18-year-olds now act more like 15-year-olds used to, and 15-year-olds more like 13-year-olds. Childhood now stretches well into high school.

In an information economy that rewards higher education more than early work history, parents may be inclined to encourage their kids to stay home and study rather than to get a part-time job. Teens, in turn, seem to be content with this homebody arrangement—not because they’re so studious, but because their social life is lived on their phone. They don’t need to leave home to spend time with their friends.

eighth-, 10th-, and 12th-graders in the 2010s actually spend less time on homework than Gen X teens did in the early 1990s.

The time that seniors spend on activities such as student clubs and sports and exercise has changed little in recent years. Combined with the decline in working for pay, this means iGen teens have more leisure time than Gen X teens did, not less.

So what are they doing with all that time? They are on their phone, in their room, alone and often distressed.

despite spending far more time under the same roof as their parents, today’s teens can hardly be said to be closer to their mothers and fathers than their predecessors were. “I’ve seen my friends with their families—they don’t talk to them,” Athena told me. “They just say ‘Okay, okay, whatever’ while they’re on their phones. They don’t pay attention to their family.” Like her peers, Athena is an expert at tuning out her parents so she can focus on her phone.

The number of teens who get together with their friends nearly every day dropped by more than 40 percent from 2000 to 2015; the decline has been especially steep recently.

It’s not only a matter of fewer kids partying; fewer kids are spending time simply hanging out

The roller rink, the basketball court, the town pool, the local necking spot—they’ve all been replaced by virtual spaces accessed through apps and the web.

The results could not be clearer: Teens who spend more time than average on screen activities are more likely to be unhappy, and those who spend more time than average on nonscreen activities are more likely to be happy.

There’s not a single exception. All screen activities are linked to less happiness, and all nonscreen activities are linked to more happiness

Eighth-graders who spend 10 or more hours a week on social media are 56 percent more likely to say they’re unhappy than those who devote less time to social media

If you were going to give advice for a happy adolescence based on this survey, it would be straightforward: Put down the phone, turn off the laptop, and do something—anything—that does not involve a screen

Social-networking sites like Facebook promise to connect us to friends. But the portrait of iGen teens emerging from the data is one of a lonely, dislocated generation. Teens who visit social-networking sites every day but see their friends in person less frequently are the most likely to agree with the statements “A lot of times I feel lonely,” “I often feel left out of things,” and “I often wish I had more good friends.” Teens’ feelings of loneliness spiked in 2013 and have remained high since.

This doesn’t always mean that, on an individual level, kids who spend more time online are lonelier than kids who spend less time online.

Teens who spend more time on social media also spend more time with their friends in person, on average—highly social teens are more social in both venues, and less social teens are less so.

The more time teens spend looking at screens, the more likely they are to report symptoms of depression.

Eighth-graders who are heavy users of social media increase their risk of depression by 27 percent, while those who play sports, go to religious services, or even do homework more than the average teen cut their risk significantly.

Teens who spend three hours a day or more on electronic devices are 35 percent more likely to have a risk factor for suicide, such as making a suicide plan. (That’s much more than the risk related to, say, watching TV.)

Since 2007, the homicide rate among teens has declined, but the suicide rate has increased. As teens have started spending less time together, they have become less likely to kill one another, and more likely to kill themselves. In 2011, for the first time in 24 years, the teen suicide rate was higher than the teen homicide rate.

For all their power to link kids day and night, social media also exacerbate the age-old teen concern about being left out.

Today’s teens may go to fewer parties and spend less time together in person, but when they do congregate, they document their hangouts relentlessly—on Snapchat, Instagram, Facebook. Those not invited to come along are keenly aware of it. Accordingly, the number of teens who feel left out has reached all-time highs across age groups.

Forty-eight percent more girls said they often felt left out in 2015 than in 2010, compared with 27 percent more boys. Girls use social media more often, giving them additional opportunities to feel excluded and lonely when they see their friends or classmates getting together without them.

Social media levy a psychic tax on the teen doing the posting as well, as she anxiously awaits the affirmation of comments and likes. When Athena posts pictures to Instagram, she told me, “I’m nervous about what people think and are going to say. It sometimes bugs me when I don’t get a certain amount of likes on a picture.”

Girls have also borne the brunt of the rise in depressive symptoms among today’s teens. Boys’ depressive symptoms increased by 21 percent from 2012 to 2015, while girls’ increased by 50 percent—more than twice as much

The rise in suicide, too, is more pronounced among girls. Although the rate increased for both sexes, three times as many 12-to-14-year-old girls killed themselves in 2015 as in 2007, compared with twice as many boys

Social media give middle- and high-school girls a platform on which to carry out the style of aggression they favor, ostracizing and excluding other girls around the clock.

What’s at stake isn’t just how kids experience adolescence. The constant presence of smartphones is likely to affect them well into adulthood. Among people who suffer an episode of depression, at least half become depressed again later in life. Adolescence is a key time for developing social skills; as teens spend less time with their friends face-to-face, they have fewer opportunities to practice them

the smartphone is cutting into teens’ sleep: Many now sleep less than seven hours most nights. Sleep experts say that teens should get about nine hours of sleep a night; a teen who is getting less than seven hours a night is significantly sleep deprived

Fifty-seven percent more teens were sleep deprived in 2015 than in 1991. In just the four years from 2012 to 2015, 22 percent more teens failed to get seven hours of sleep.

Two national surveys show that teens who spend three or more hours a day on electronic devices are 28 percent more likely to get less than seven hours of sleep than those who spend fewer than three hours, and teens who visit social-media sites every day are 19 percent more likely to be sleep deprived.

Teens who read books and magazines more often than the average are actually slightly less likely to be sleep deprived—either reading lulls them to sleep, or they can put the book down at bedtime.

Sleep deprivation is linked to myriad issues, including compromised thinking and reasoning, susceptibility to illness, weight gain, and high blood pressure. It also affects mood: People who don’t sleep enough are prone to depression and anxiety.

correlations between depression and smartphone use are strong enough to suggest that more parents should be telling their kids to put down their phone.

I asked my undergraduate students at San Diego State University what they do with their phone while they sleep. Their answers were a profile in obsession. Nearly all slept with their phone, putting it under their pillow, on the mattress, or at the very least within arm’s reach of the bed. They checked social media right before they went to sleep, and reached for their phone as soon as they woke up in the morning

Significant effects on both mental health and sleep time appear after two or more hours a day on electronic devices. The average teen spends about two and a half hours a day on electronic devices. Some mild boundary-setting could keep kids from falling into harmful habits.

“But the job market is going to be constrained, and opportunities to build your life are going to be slimmer.”

there is a tally that experts say is harder to track: the psychological toll of months of isolation and global suffering, which for some has proved fatal.

Mental health experts say prolonged symptoms of depression and anxiety may prompt risky behaviors that lead to self-harm, accidents, or even death, especially among young people.

the psychological fallout of the pandemic could unfold for months, or even years, public health officials say, with young people among the most affected.

“Mental health has become a buzzword during the pandemic, and we need to keep it that way,”

restrictions were hitting disadvantaged groups, including many young people, harder.

“It’s not just people dying in a hospital — it’s people dying inside.”

“They may be tempted to consume more drugs or drink more alcohol, and may have less physical activity, all of which can contribute to symptoms of depression, anxiety and poor sleep.”

‘Depressed? I don’t know what depressed is, I don’t think I am. I feel bored, but I don’t feel depressed,’”

Mr. Remmers said his son’s death was caused by a combination of carbon monoxide poisoning and drugs.

But the pandemic, he added, “provided a context in which things become possible, and which may have otherwise not happened.”

It is unclear, the organization says, whether this is a sign of more people experiencing more suicidal thoughts or symptoms of mental health issues, or if people now feel more comfortable reaching out for help.

“Lockdown put Lily in physical and emotional situations she would never have in normal times,”

“It’s OK for a young child to fall over and let their parents know that their knee hurts,” Ms. Arkwright said. “This same attitude needs to be extended to mental health.”

“Even the need to reach out to a help-line shows resilience,”

For many affected patients, brain function improves as they recover. But some are likely to face long-term disability,

The injuries resembled those from a series of tiny strokes occurring in many different areas of the brain,

Some patients also suffer brain damage when their lungs can no longer provide enough oxygen.

"What we found was that the very small blood vessels in the brain were leaking,"

To understand other, less obvious mechanisms, though, scientists needed brain tissue from patients with COVID-19 who died.

What's more, the inflammation and leaky blood vessels associated with all these symptoms may make a person's brain more vulnerable to another type of damage."We know that those are important in Alzheimer's disease and we're seeing them play a key role here in COVID-19,"

Researchers will assess patients' "behavior, their memory, their overall function" at six-month intervals, she says.

Whitty, who has appeared alongside Johnson at many of the daily press conferences held at Downing Street in the past two weeks, said he would spend the next week at home. "After experiencing symptoms compatible with COVID-19 last night, in line with the guidance, I will be self-isolating at home for the next seven days. I will be continuing to advise the Government on the medical response to Coronavirus, supported by my deputies," Whitty wrote on his Twitter page.

people their favorite color, and in most parts of the world roughly half will say blue, a figure three to four times the support accorded common second-place finishers like purple or green

t young patients preferred nurses wearing blue uniforms to those in white or yellow.

blue’s basic emotional valence is calmness and open-endedness, in contrast to the aggressive specificity associated with red. Blue is sea and sky, a pocket-size vacation.

computer screen color affected participants’ ability to solve either creative problems —

blue can also imply coldness, sorrow and death. On learning of a good friend’s suicide in 1901, Pablo Picasso fell into a severe depression, and he began painting images of beggars, drunks, the poor and the halt, all famously rendered in a palette of blue.

association arose from the look of the body when it’s in a low energy, low oxygen state. “The lips turn blue, there’s a blue pallor to the complexion,” she said. “It’s the opposite of the warm flushing of the skin that we associate with love, kindness and affection.”

A blue glow makes food look very unappetizing.”

That blue can connote coolness and tranquillity is one of nature’s little inside jokes. Blue light is on the high-energy end of the visible spectrum, and the comparative shortness of its wavelengths explains why the blue portion of the white light from the sun is easily scattered by the nitrogen and oxygen molecules in our atmosphere, and thus why the sky looks blue.

I have never seen this (brain) pathology in someone under the age of 30"

he had more than 10 concussions

He lost consciousness, suffered headaches, neck pain, insomnia and anxiety. He couldn't remember things or concentrate.

ventually saw a neurologist, who prescribed him a muscle relaxant and anti-seizure medication, but they did little and the symptoms continued

he stopped playing football because the symptoms were so strong

he had great opportunities, and he had to turn these opportunities down because of something that was taking over his brain

teach proper technique

Keck believed he suffered from CTE, but it cannot be diagnosed in living people.

Keck died from cardiac arrest in 2013, and it does appear his life was lost to CTE.

Usually there's a latent period. He seemed to develop it while he was playing. Even after he quit playing, it seemed to get worse."

factors such as environment and genetics may have a role.

I think its becoming more and more clear that the developing brain is more susceptible to concussion; it has a delayed recovery from concussion,"

"We really need to limit the amount of head contact that young children and adolescents are experiencing

became increasingly depressed and suicidal

We are taking out unnecessary head contact out of the sport, out of practice. We're enforcing rule changes

“In America, you almost need an excuse for knocking on a neighbor’s door,” Dr. Tang told me. “We want to break down those barriers.”

“You don’t need a playmate every day,” Dr. Tang said. “But knowing you’re valued and a contributing member of society is incredibly reaffirming.” Advertisement Continue reading the main story

A great paradox of our hyper-connected digital age is that we seem to be drifting apart. Increasingly, however, research confirms our deepest intuition: Human connection lies at the heart of human well-being. It’s up to all of us — doctors, patients, neighborhoods and communities — to maintain bonds where they’re fading, and create ones where they haven’t existed.

The creators of the D.S.M. in the 1960s and ’70s “were real heroes at the time,” said Dr. Steven E. Hyman, a psychiatrist and neuroscientist at the Broad Institute and a former director at the National Institute of Mental Health. “They chose a model in which all psychiatric illnesses were represented as categories discontinuous with ‘normal.’ But this is totally wrong in a way they couldn’t have imagined. So in fact what they produced was an absolute scientific nightmare. Many people who get one diagnosis get five diagnoses, but they don’t have five diseases — they have one underlying condition.”

Dr. Insel is one of a growing number of scientists who think that the field needs an entirely new paradigm for understanding mental disorders, though neither he nor anyone else knows exactly what it will look like.

Decades of spending on neuroscience have taught scientists mostly what they do not know, undermining some of their most elemental assumptions. Genetic glitches that appear to increase the risk of schizophrenia in one person may predispose others to autism-like symptoms, or bipolar disorder. The mechanisms of the field’s most commonly used drugs — antidepressants like Prozac, and antipsychosis medications like Zyprexa — have revealed nothing about the causes of those disorders. And major drugmakers have scaled back psychiatric drug development, having virtually no new biological “targets” to shoot for.

Dr. Hyman, Dr. Insel and other experts said they hoped that the science of psychiatry would follow the direction of cancer research, which is moving from classifying tumors by where they occur in the body to characterizing them by their genetic and molecular signatures.

Dr. Insel said in the interview that his motivation was not to disparage the D.S.M. as a clinical tool, but to encourage researchers and especially outside reviewers who screen proposals for financing from his agency to disregard its categories and investigate the biological underpinnings of disorders instead.

What has exploded in India over the past few decades, but also everywhere else in the world, is information about other people. As we watch television, surf the Internet and follow events around the world, we become intimately aware of other ways of living and of others who are richer and more powerful. We place ourselves in a vast social order in which most of us are ants. It may truly be a depressing reflection.

We know that social position affects both when you die and how sick you get: The higher your social position, the healthier you are. It turns out that your sense of relative social rank — where you draw a line on an abstract ladder to show where you are with respect to others — predicts many health outcomes, including depression, sometimes even more powerfully than your objective socioeconomic status.

cities also break traditions and fracture families, and they breed psychiatric illness. In a city you are more likely to be depressed, to fall ill with schizophrenia, and to use alcohol and drugs. Poverty and rapid urbanization sharpen these effects.

Some of these figures might simply reflect more willingness to label an experience as a symptom. For example, until recently, most Japanese understood intense fatigue as sacrifice for one’s work and suicide as an act of reasoned will. In her book “Depression in Japan,” the anthropologist Junko Kitanaka writes that partly as a result of aggressive pharmaceutical marketing, many Japanese began to think of their fatigue and suicidal thoughts as symptoms created by a disease. The number of diagnoses of depression in that country more than doubled between 1999 and 2008.

Given the poor quality of the typical American diet, this fortification is far from superfluous. In fact, for products like milk and flour, where fortification and enrichment have occurred for so long that they’ve become invisible, it would be almost irresponsible not to add synthetic vitamins.

synthetic vitamins are as essential to food companies as they are to us. To be successful in today’s market, food manufacturers must create products that can be easily transported over long distances and stored for extended periods.

They also need to be sure that their products offer some nutritional value so that customers don’t have to go elsewhere to meet their vitamin needs. But the very processing that’s necessary to create long shelf lives destroys vitamins, among other important nutrients. It’s nearly impossible to create foods that can sit for months in a supermarket that are also naturally vitamin-rich.

Today, it would be easy to blame food marketers for using vitamins to deceive us into buying their products. But our blindness is largely our own fault.

we’ve entered into a complicit agreement with them: They depend on us to buy their products, and we depend on the synthetic vitamins they add to those products to support eating habits that might otherwise leave us deficient

extra vitamins do not protect us from the long-term “diseases of civilization” that are currently ravaging our country, including obesity, heart disease and Type 2 diabetes — many of which are strongly associated with diet.

natural foods contain potentially protective substances such as phytochemicals and polyunsaturated fat that also are affected by processing, but that are not usually replaced. If these turn out to be as important as many researchers suspect, then our exclusive focus on vitamins could mean we’re protecting ourselves against the wrong dangers. It’s as if we’re taking out earthquake insurance policies in an area more at risk for floods.

And adding back vitamins after the fact ignores the issue of synergy: how nutrients work naturally as opposed to when they are isolated. A 2011 study on broccoli, for example, found that giving subjects fresh broccoli florets led them to absorb and metabolize seven times more of the anticancer compounds known as glucosinolates, present in broccoli and other cruciferous vegetables

And yet we refuse to change our eating habits in the ways that would actually protect us, which would require refocusing our diets on minimally processed foods that are naturally nutrient-rich.

The popularity of dietary supplements and vitamin-enhanced processed “health” foods means that even those of us who try to do right by our health are often getting it wrong.

we mustn’t let it distract us from an even more fundamental question: how we’ve allowed the word “vitamin” to become synonymous with “health.”