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Plato and Aristotle: What an accident of history that two such contrasting orientations toward the physical world, animated by two such different aesthetic sensibilities, should have been pedagogically entangled with each other.

To read some semblance of our science into these ancients requires charitably imaginative interpretations that clarify their obscurities with insights toward which they were themselves, perhaps, groping. Some of us are prepared to extend such interpretations toward Plato. Leroi extends them toward Aris­totle, so much so that he would vehemently reject my statement that Aristotle, like Plato, was not the finished scientific article.

Leroi follows closely in the footsteps of such generous elucidators. The modern understanding of genetically encoded information is applied not only to Aristotle’s formal cause, his “eidos,” and to his notion that all change is potentiality actualized, but also to his notion of the soul. “Aristotle’s belief that we should attend less to the matter than to the informational structure of living things makes him seem like a molecular geneticist avant la lettre.”

“I have kept Aristotle’s theos in the shadows. It may even be that I have done so deliberately; that I have been reluctant to reveal the degree to which my hero’s scientific system is riddled with religion. Yet it is.”

“In an individual person, the contributions of genes and the environment are inestimable,” she explained, “but on a population basis we can estimate how much person-to-person variation is explained by genetic and environmental differences.”

He hypothesizes that the process involves one or more molecules released by the nervous system — perhaps small RNAs, perhaps something secreted like a hormone. But somehow those germ cells then influence the behavior of the next generation and seem to circumvent the normal need for rde-4 in the production of the small RNAs for chemotaxis in the progeny.

“I believe that today, there is not a single solid paper showing that only small RNAs are involved in epigenetic inheritance,” said Isabelle Mansuy, a neuroepigenetics researcher at the Swiss Federal Institute of Technology Zurich and the University of Zurich who studies the inheritance of trauma in humans and mice. In the mouse model she works with, she knows that small RNAs are not sufficient because if she injects small RNAs alone into fertilized mouse eggs, the resulting animals do not show the RNA-associated trait.

“If we can ingest a chemical from our environment that changes the epigenomes of the egg or sperm, why couldn’t our brain make a similar molecule that does the same thing?”

Perinatal Depression

Seasonal Affective Disorder (SAD):

Psychotic Depression:

Depression can occur along with other serious illnesses, such as diabetes, cancer, heart disease, and Parkinson’s disease. Depression can make these conditions worse and vice versa.

Depression affects different people in different ways.

Medications called antidepressants can work well to treat depression.

Maybe Rogers's muscle cells are normal, and he experiences pain as most of us do but chooses to disregard it when he feels in command.

An illusion is a perception that does not match the physical reality. Is pain, then, as with illusions, a mind construct that some people can decide to turn off? As you will see in the studies that follow, pain varies as a function of mood, attentiveness and circumstances, lending support to the theory that pain is an emotion.

When scientists ask: “How old do you feel, most of the time?” the answer tends to reflect the state of people’s physical and mental health. “This simple question seems to be particularly powerful,” says Antonio Terracciano, a professor of geriatrics at Florida State University College of Medicine in Tallahassee.Sign up for the Well NewsletterGet the best of Well, with the latest on health, fitness and nutrition.Sign Up* Captcha is incomplete. Please try again.Thank you for subscribingYou can also view our other newsletters or visit your account to opt out or manage email preferences.An error has occurred. Please try again later.You are already subscribed to this email.View all New York Times newsletters.

Scientists are finding that people who feel younger than their chronological age are typically healthier and more psychologically resilient than those who feel older. They perform better on memory tasks and are at lower risk of cognitive decline.

If you’re over 40, chances are you feel younger than your driver’s license suggests. Some 80 percent of people do, according to Dr. Stephan. A small fraction of people — fewer than 10 percent — feel older.

At age 50, people may feel about five years, or 10 percent, younger, but by the time they’re 70 they may feel 15 percent or even 20 percent younger.

In a 2018 German study, investigators asked people in their 60s, 70s and early 80s how old they felt, then measured their walking speed in two settings. Participants walked 20 feet in the laboratory while being observed and timed. They also wore belts containing an accelerometer while out and about in their daily lives. Those who reported feeling younger tended to walk faster during the lab assessment. But feeling younger had no impact on their walking speed in real life.

Indeed, in cultures where elders are respected for their wisdom and experience, people don’t even understand the concept of subjective age, he said. When a graduate student of Dr. Weiss’s did research in Jordan, the people he spoke with “would say, ‘I’m 80. I don’t know what you mean by ‘How old do I feel?’”

As we age, we tend to become generally happier and more satisfied, said Dr. Tracey Gendron, a gerontologist at Virginia Commonwealth University who questions the whole notion of subjective age research

“Older age is a time that we can actually look forward to. People really just enjoy themselves more and are at peace with who they are. I would love for everyone to say their age at every year and celebrate it.”

Graduate students will inevitably encounter failed experiments, failed teachable moments in the classroom, and time spent on research that never gets funded or never comes to fruition. Wilson counsels patience: “A strong work ethic is absolutely essential. There must be an ability to pass long hours in study and research with pleasure even though some of the effort will inevitably lead to dead ends.”

Scientists, he claims, tend to be introverted and prone to daydreaming. They reject authority and therefore dislike being told what to do. Their attention wanders. This pigeonholing made me uncomfortable, because I think science benefits from incorporating a diversity of personalities

Williams ceded the microphone, and Padilla was able to speak. “Here’s what I have to say about the vision of classics that you outlined,” he said. “I want nothing to do with it. I hope the field dies that you’ve outlined, and that it dies as swiftly as possible.”

“I believe in merit. I don’t look at the color of the author.” She pointed a finger in Padilla’s direction. “You may have got your job because you’re Black,” Williams said, “but I would prefer to think you got your job because of merit.”

What he did find was a slim blue-and-white textbook titled “How People Lived in Ancient Greece and Rome.” “Western civilization was formed from the union of early Greek wisdom and the highly organized legal minds of early Rome,” the book began. “The Greek belief in a person’s ability to use his powers of reason, coupled with Roman faith in military strength, produced a result that has come to us as a legacy, or gift from the past.” Thirty years later, Padilla can still recite those opening lines.

In 2017, he published a paper in the journal Classical Antiquity that compared evidence from antiquity and the Black Atlantic to draw a more coherent picture of the religious life of the Roman enslaved. “It will not do merely to adopt a pose of ‘righteous indignation’ at the distortions and gaps in the archive,” he wrote. “There are tools available for the effective recovery of the religious experiences of the enslaved, provided we work with these tools carefully and honestly.”

Padilla sensed that his pursuit of classics had displaced other parts of his identity, just as classics and “Western civilization” had displaced other cultures and forms of knowledge. Recovering them would be essential to dismantling the white-supremacist framework in which both he and classics had become trapped. “I had to actively engage in the decolonization of my mind,” he told me.

He also gravitated toward contemporary scholars like José Esteban Muñoz, Lorgia García Peña and Saidiya Hartman, who speak of race not as a physical fact but as a ghostly system o

In response to rising anti-immigrant sentiment in Europe and the United States, Mary Beard, perhaps the most famous classicist alive, wrote in The Wall Street Journal that the Romans “would have been puzzled by our modern problems with migration and asylum,” because the empire was founded on the “principles of incorporation and of the free movement of people.”

In November 2015, he wrote an essay for Eidolon, an online classics journal, clarifying that in Rome, as in the United States, paeans to multiculturalism coexisted with hatred of foreigners. Defending a client in court, Cicero argued that “denying foreigners access to our city is patently inhumane,” but ancient authors also recount the expulsions of whole “suspect” populations, including a roundup of Jews in 139 B.C., who were not considered “suitable enough to live alongside Romans.”

The job of classicists is not to “point out the howlers,” he said on a 2017 panel. “To simply take the position of the teacher, the qualified classicist who knows things and can point to these mistakes, is not sufficient.”

Dismantling structures of power that have been shored up by the classical tradition will require more than fact-checking; it will require writing an entirely new story about antiquity, and about who we are today

To find that story, Padilla is advocating reforms that would “explode the canon” and “overhaul the discipline from nuts to bolts,” including doing away with the label “classics” altogether.

. “What I want to be thinking about in the next few weeks,” he told them, “is how we can be telling the story of the early Roman Empire not just through a variety of sources but through a variety of persons.” He asked the students to consider the lives behind the identities he had assigned them, and the way those lives had been shaped by the machinery of empire, which, through military conquest, enslavement and trade, creates the conditions for the large-scale movement of human beings.

ultimately, he decided that leaving enslaved characters out of the role play was an act of care. “I’m not yet ready to turn to a student and say, ‘You are going to be a slave.’”

Privately, even some sympathetic classicists worry that Padilla’s approach will only hasten the field’s decline. “I’ve spoken to undergrad majors who say that they feel ashamed to tell their friends they’re studying classics,”

“I very much admire Dan-el’s work, and like him, I deplore the lack of diversity in the classical profession,” Mary Beard told me via email. But “to ‘condemn’ classical culture would be as simplistic as to offer it unconditional admiration.”

In a 2019 talk, Beard argued that “although classics may become politicized, it doesn’t actually have a politics,” meaning that, like the Bible, the classical tradition is a language of authority — a vocabulary that can be used for good or ill by would-be emancipators and oppressors alike.

Over the centuries, classical civilization has acted as a model for people of many backgrounds, who turned it into a matrix through which they formed and debated ideas about beauty, ethics, power, nature, selfhood, citizenship and, of course, race

Anthony Grafton, the great Renaissance scholar, put it this way in his preface to “The Classical Tradition”: “An exhaustive exposition of the ways in which the world has defined itself with regard to Greco-Roman antiquity would be nothing less than a comprehensive history of the world.”

Classics as we know it today is a creation of the 18th and 19th centuries. During that period, as European universities emancipated themselves from the control of the church, the study of Greece and Rome gave the Continent its new, secular origin story. Greek and Latin writings emerged as a competitor to the Bible’s moral authority, which lent them a liberatory power

Historians stress that such ideas cannot be separated from the discourses of nationalism, colorism and progress that were taking shape during the modern colonial period, as Europeans came into contact with other peoples and their traditions. “The whiter the body is, the more beautiful it is,” Winkelmann wrote.

While Renaissance scholars were fascinated by the multiplicity of cultures in the ancient world, Enlightenment thinkers created a hierarchy with Greece and Rome, coded as white, on top, and everything else below.

Jefferson, along with most wealthy young men of his time, studied classics at college, where students often spent half their time reading and translating Greek and Roman texts. “Next to Christianity,” writes Caroline Winterer, a historian at Stanford, “the central intellectual project in America before the late 19th century was classicism.

Of the 2.5 million people living in America in 1776, perhaps only 3,000 had gone to college, but that number included many of the founders

They saw classical civilization as uniquely educative — a “lamp of experience,” in the words of Patrick Henry, that could light the path to a more perfect union. However true it was, subsequent generations would come to believe, as Hannah Arendt wrote in “On Revolution,” that “without the classical example … none of the men of the Revolution on either side of the Atlantic would have possessed the courage for what then turned out to be unprecedented action.”

Comparisons between the United States and the Roman Empire became popular as the country emerged as a global power. Even after Latin and Greek were struck from college-entrance exams, the proliferation of courses on “great books” and Western civilization, in which classical texts were read in translation, helped create a coherent national story after the shocks of industrialization and global warfare.

even as the classics were pulled apart, laughed at and transformed, they continued to form the raw material with which many artists shaped their visions of modernity.

Over the centuries, thinkers as disparate as John Adams and Simone Weil have likened classical antiquity to a mirror. Generations of intellectuals, among them feminist, queer and Black scholars, have seen something of themselves in classical texts, flashes of recognition that held a kind of liberatory promise

The language that is used to describe the presence of classical antiquity in the world today — the classical tradition, legacy or heritage — contains within it the idea of a special, quasi-genetic relationship. In his lecture “There Is No Such Thing as Western Civilization,” Kwame Anthony Appiah (this magazine’s Ethicist columnist) mockingly describes the belief in such a kinship as the belief in a “golden nugget” of insight — a precious birthright and shimmering sign of greatness — that white Americans and Europeans imagine has been passed down to them from the ancients.

To see classics the way Padilla sees it means breaking the mirror; it means condemning the classical legacy as one of the most harmful stories we’ve told ourselves

Padilla is wary of colleagues who cite the radical uses of classics as a way to forestall change; he believes that such examples have been outmatched by the field’s long alliance with the forces of dominance and oppression.

Classics and whiteness are the bones and sinew of the same body; they grew strong together, and they may have to die together. Classics deserves to survive only if it can become “a site of contestation” for the communities who have been denigrated by it in the past.

if classics fails his test, Padilla and others are ready to give it up. “I would get rid of classics altogether,” Walter Scheidel, another of Padilla’s former advisers at Stanford, told me. “I don’t think it should exist as an academic field.”

One way to get rid of classics would be to dissolve its faculties and reassign their members to history, archaeology and language departments.

many classicists are advocating softer approaches to reforming the discipline, placing the emphasis on expanding its borders. Schools including Howard and Emory have integrated classics with Ancient Mediterranean studies, turning to look across the sea at Egypt, Anatolia, the Levant and North Africa. The change is a declaration of purpose: to leave behind the hierarchies of the Enlightenment and to move back toward the Renaissance model of the ancient world as a place of diversity and mixture.

Ian Morris put it more bluntly. “Classics is a Euro-American foundation myth,” Morris said to me. “Do we really want that sort of thing?”

There’s a more interesting story to be told about the history of what we call the West, the history of humanity, without valorizing particular cultures in it,” said Josephine Quinn, a professor of ancient history at Oxford. “It seems to me the really crucial mover in history is always the relationship between people, between cultures.”

“In some moods, I feel that this is just a moment of despair, and people are trying to find significance even if it only comes from self-accusation,” he told me. “I’m not sure that there is a discipline that is exempt from the fact that it is part of the history of this country. How distinctly wicked is classics? I don’t know that it is.”

“One of the dubious successes of my generation is that it did break the canon,” Richlin told me. “I don’t think we could believe at the time that we would be putting ourselves out of business, but we did.” She added: “If they blew up the classics departments, that would really be the end.”

Padilla, like Douglass, now sees the moment of absorption into the classical, literary tradition as simultaneous with his apprehension of racial difference; he can no longer find pride or comfort in having used it to bring himself out of poverty.

“Claiming dignity within this system of structural oppression,” Padilla has said, “requires full buy-in into its logic of valuation.” He refuses to “praise the architects of that trauma as having done right by you at the end.”

Last June, as racial-justice protests unfolded across the nation, Padilla turned his attention to arenas beyond classics. He and his co-authors — the astrophysicist Jenny Greene, the literary theorist Andrew Cole and the poet Tracy K. Smith — began writing their open letter to Princeton with 48 proposals for reform. “Anti-Blackness is foundational to America,” the letter began. “Indifference to the effects of racism on this campus has allowed legitimate demands for institutional support and redress in the face of microaggression and outright racist incidents to go long unmet.”

Padilla believes that the uproar over free speech is misguided. “I don’t see things like free speech or the exchange of ideas as ends in themselves,” he told me. “I have to be honest about that. I see them as a means to the end of human flourishing.”

“There is a certain kind of classicist who will look on what transpired and say, ‘Oh, that’s not us,’” Padilla said when we spoke recently. “What is of interest to me is why is it so imperative for classicists of a certain stripe to make this discursive move? ‘This is not us.’

Joel Christensen, the Brandeis professor, now feels that it is his “moral and ethical and intellectual responsibility” to teach classics in a way that exposes its racist history. “Otherwise we’re just participating in propaganda,”

Christensen, who is 42, was in graduate school before he had his “crisis of faith,” and he understands the fear that many classicists may experience at being asked to rewrite the narrative of their life’s work. But, he warned, “that future is coming, with or without Dan-el.”

On Jan. 6, Padilla turned on the television minutes after the windows of the Capitol were broken. In the crowd, he saw a man in a Greek helmet with TRUMP 2020 painted in white. He saw a man in a T-shirt bearing a golden eagle on a fasces — symbols of Roman law and governance — below the logo 6MWE, which stands for “Six Million Wasn’t Enough,

“When did it become taboo in this country to talk about getting healthy?” my friend Bill Maher asked in a recent monologue. “Fat shaming doesn’t need to end; it needs to make a comeback. Some amount of shame is good. We shamed people out of smoking and into wearing seat belts. We shamed them out of littering and most of them out of racism.”

On one side are helpless victims, who react to any debate with cries of oppression, and take no responsibility for their own physical destiny; on the other are brutal realists, with a callous touch, often refusing to see the genetic, social, and psychological complexity of fatness, or that serious health issues are not universal among heavier types

This is our reality. We are neither angels nor beasts, but we partake of both. We can rarely make the ugly beautiful, and if we do, it’s a moral achievement. However much we try, we will never correct the core natural inequalities and differences of our mammalian existence. But we can hazard a moral middle, seeing beauty in many ways, acknowledging the humanity of all shapes and sizes, while managing our health and weight in ways that are not totally subject to the gaze of others.

is to grapple with complexity in a way that can be rigorously empirical and yet also humane.

We are all driven by instinctive attraction, but men are particularly subject to fixed and crude notions of hotness. Beauty will thereby always be the source of extraordinary and extraordinarily unfair advantage, even if it captures only a tiny slice of what being human is about.

the two stances reflect our two ideological poles — not so much left and right anymore as nurture and nature. One pole argues nature doesn’t independently exist and everything is social; and one blithely asserts that nature determines everything. Both are ruinous attempts to bludgeon uncomfortable reality into satisfying ideology.

What we needed, in some ways, for our collective mental health, was a catalyst for greater physical socialization, more human contact, and more meaningful community. What we’re getting, I fear, is the opposite

one of the leading modelers, Gabriela Gomes, suggested the entire area of research was being effectively blackballed out of fear it might encourage a relaxation of pandemic vigilance. “This is the very sad reason for the absence of more optimistic projections on the development of this pandemic in the scientific literature,” she wrote on Twitter. “Our analysis suggests that herd-immunity thresholds are being achieved despite strict social-distancing measures.”

Gomes suggested, herd immunity could happen with as little as one quarter of the population of a community exposed — or perhaps just 20 percent. “We just keep running the models, and it keeps coming back at less than 20 percent,” she told Hamblin. “It’s very striking.” Such findings, if they held up, would be very instructive, as Hamblin writes: “It would mean, for instance, that at 25 percent antibody prevalence, New York City could continue its careful reopening without fear of another major surge in cases.”

But for those hoping that 25 percent represents a true ceiling for pandemic spread in a given community, well, it almost certainly does not, considering that recent serological surveys have shown that perhaps 93 percent of the population of Iquitos, Peru, has contracted the disease; as have more than half of those living in Indian slums; and as many as 68 percent in particular neighborhoods of New York City

overshoot of that scale would seem unlikely if the “true” threshold were as low as 20 or 25 percent.

But, of course, that threshold may not be the same in all places, across all populations, and is surely affected, to some degree, by the social behavior taken to protect against the spread of the disease.

we probably err when we conceive of group immunity in simplistically binary terms. While herd immunity is a technical term referring to a particular threshold at which point the disease can no longer spread, some amount of community protection against that spread begins almost as soon as the first people are exposed, with each case reducing the number of unexposed and vulnerable potential cases in the community by one

you would not expect a disease to spread in a purely exponential way until the point of herd immunity, at which time the spread would suddenly stop. Instead, you would expect that growth to slow as more people in the community were exposed to the disease, with most of them emerging relatively quickly with some immune response. Add to that the effects of even modest, commonplace protections — intuitive social distancing, some amount of mask-wearing — and you could expect to get an infection curve that tapers off well shy of 60 percent exposure.

Looking at the data, we see that transmissions in many severely impacted states began to slow down in July, despite limited interventions. This is especially notable in states like Arizona, Florida, and Texas. While we believe that changes in human behavior and changes in policy (such as mask mandates and closing of bars/nightclubs) certainly contributed to the decrease in transmission, it seems unlikely that these were the primary drivers behind the decrease. We believe that many regions obtained a certain degree of temporary herd immunity after reaching 10-35 percent prevalence under the current conditions. We call this 10-35 percent threshold the effective herd immunity threshold.

Indeed, that is more or less what was recently found by Youyang Gu, to date the best modeler of pandemic spread in the U.S

he cautioned again that he did not mean to imply that the natural herd-immunity level was as low as 10 percent, or even 35 percent. Instead, he suggested it was a plateau determined in part by better collective understanding of the disease and what precautions to take

Gu estimates national prevalence as just below 20 percent (i.e., right in the middle of his range of effective herd immunity), it still counts, I think, as encouraging — even if people in hard-hit communities won’t truly breathe a sigh of relief until vaccines arrive.

If you can get real protection starting at 35 percent, it means that even a mediocre vaccine, administered much more haphazardly to a population with some meaningful share of vaccination skeptics, could still achieve community protection pretty quickly. And that is really significant — making both the total lack of national coordination on rollout and the likely “vaccine wars” much less consequential.

At least 20 percent of the public, and perhaps 50 percent, had some preexisting, cross-protective T-cell response to SARS-CoV-2, according to one much-discussed recent paper. An earlier paper had put the figure at between 40 and 60 percent. And a third had found an even higher prevalence: 81 percent.

The T-cell story is similarly encouraging in its big-picture implications without being necessarily paradigm-changing

These numbers suggest their own heterogeneity — that different populations, with different demographics, would likely exhibit different levels of cross-reactive T-cell immune response

The most optimistic interpretation of the data was given to me by Francois Balloux, a somewhat contrarian disease geneticist and the director of the University College of London’s Genetics Institute

According to him, a cross-reactive T-cell response wouldn’t prevent infection, but would probably mean a faster immune response, a shorter period of infection, and a “massively” reduced risk of severe illness — meaning, he guessed, that somewhere between a third and three-quarters of the population carried into the epidemic significant protection against its scariest outcomes

the distribution of this T-cell response could explain at least some, and perhaps quite a lot, of COVID-19’s age skew when it comes to disease severity and mortality, since the young are the most exposed to other coronaviruses, and the protection tapers as you get older and spend less time in environments, like schools, where these viruses spread so promiscuously.

Balloux told me he believed it was also possible that the heterogeneous distribution of T-cell protection also explains some amount of the apparent decline in disease severity over time within countries on different pandemic timelines — a phenomenon that is more conventionally attributed to infection spreading more among the young, better treatment, and more effective protection of the most vulnerable (especially the old).

Going back to Youyang Gu’s analysis, what he calls the “implied infection fatality rate” — essentially an estimated ratio based on his modeling of untested cases — has fallen for the country as a whole from about one percent in March to about 0.8 percent in mid-April, 0.6 percent in May, and down to about 0.25 percent today.

even as we have seemed to reach a second peak of coronavirus deaths, the rate of death from COVID-19 infection has continued to decline — total deaths have gone up, but much less than the number of cases

In other words, at the population level, the lethality of the disease in America has fallen by about three-quarters since its peak. This is, despite everything that is genuinely horrible about the pandemic and the American response to it, rather fantastic.

there may be some possible “mortality displacement,” whereby the most severe cases show up first, in the most susceptible people, leaving behind a relatively protected population whose experience overall would be more mild, and that T-cell response may play a significant role in determining that susceptibility.

That, again, is Balloux’s interpretation — the most expansive assessment of the T-cell data offered to me

The most conservative assessment came from Sarah Fortune, the chair of Harvard’s Department of Immunology

Fortune cautioned not to assume that cross-protection was playing a significant role in determining severity of illness in a given patient. Those with such a T-cell response, she told me, would likely see a faster onset of robust response, yes, but that may or may not yield a shorter period of infection and viral shedding

Most of the scientists, doctors, epidemiologists, and immunologists I spoke to fell between those two poles, suggesting the T-cell cross-immunity findings were significant without necessarily being determinative — that they may help explain some of the shape of pandemic spread through particular populations, but only some of the dynamics of that spread.

he told me he believed, in the absence of that data, that T-cell cross-immunity from exposure to previous coronaviruses “might explain different disease severity in different people,” and “could certainly be part of the explanation for the age skew, especially for why the very young fare so well.”

the headline finding was quite clear and explicitly stated: that preexisting T-cell response came primarily via the variety of T-cells called CD4 T-cells, and that this dynamic was consistent with the hypothesis that the mechanism was inherited from previous exposure to a few different “common cold” coronaviruses

“This potential preexisting cross-reactive T-cell immunity to SARS-CoV-2 has broad implications,” the authors wrote, “as it could explain aspects of differential COVID-19 clinical outcomes, influence epidemiological models of herd immunity, or affect the performance of COVID-19 candidate vaccines.”

“This is at present highly speculative,” they cautioned.

“The curriculum covers topics from causal modeling and probability to game theory and cognitive science,” read a website promising teens a summer of Rationalist learning. “How can we understand our own reasoning, behavior, and emotions? How can we think more clearly and better achieve our goals?”

Some lived in group houses. Some practiced polyamory. “They are basically just hippies who talk a lot more about Bayes’ theorem than the original hippies,” said Scott Aaronson, a University of Texas professor who has stayed in one of the group houses.

For Kelsey Piper, who embraced these ideas in high school, around 2010, the movement was about learning “how to do good in a world that changes very rapidly.”

Yes, the community thought about A.I., she said, but it also thought about reducing the price of health care and slowing the spread of disease.

Slate Star Codex, which sprung up in 2013, helped her develop a “calibrated trust” in the medical system. Many people she knew, she said, felt duped by psychiatrists, for example, who they felt weren’t clear about the costs and benefits of certain treatment.

That was not the Rationalist way.

“There is something really appealing about somebody explaining where a lot of those ideas are coming from and what a lot of the questions are,” she said.

Sam Altman, chief executive of OpenAI, an artificial intelligence lab backed by a billion dollars from Microsoft. He was effusive in his praise of the blog.It was, he said, essential reading among “the people inventing the future” in the tech industry.

Mr. Altman, who had risen to prominence as the president of the start-up accelerator Y Combinator, moved on to other subjects before hanging up. But he called back. He wanted to talk about an essay that appeared on the blog in 2014.The essay was a critique of what Mr. Siskind, writing as Scott Alexander, described as “the Blue Tribe.” In his telling, these were the people at the liberal end of the political spectrum whose characteristics included “supporting gay rights” and “getting conspicuously upset about sexists and bigots.”

But as the man behind Slate Star Codex saw it, there was one group the Blue Tribe could not tolerate: anyone who did not agree with the Blue Tribe. “Doesn’t sound quite so noble now, does it?” he wrote.

Mr. Altman thought the essay nailed a big problem: In the face of the “internet mob” that guarded against sexism and racism, entrepreneurs had less room to explore new ideas. Many of their ideas, such as intelligence augmentation and genetic engineering, ran afoul of the Blue Tribe.

Mr. Siskind was not a member of the Blue Tribe. He was not a voice from the conservative Red Tribe (“opposing gay marriage,” “getting conspicuously upset about terrorists and commies”). He identified with something called the Grey Tribe — as did many in Silicon Valley.

The Grey Tribe was characterized by libertarian beliefs, atheism, “vague annoyance that the question of gay rights even comes up,” and “reading lots of blogs,” he wrote. Most significantly, it believed in absolute free speech.

The essay on these tribes, Mr. Altman told me, was an inflection point for Silicon Valley. “It was a moment that people talked about a lot, lot, lot,” he said.

And in some ways, two of the world’s prominent A.I. labs — organizations that are tackling some of the tech industry’s most ambitious and potentially powerful projects — grew out of the Rationalist movement.

In 2005, Peter Thiel, the co-founder of PayPal and an early investor in Facebook, befriended Mr. Yudkowsky and gave money to MIRI. In 2010, at Mr. Thiel’s San Francisco townhouse, Mr. Yudkowsky introduced him to a pair of young researchers named Shane Legg and Demis Hassabis. That fall, with an investment from Mr. Thiel’s firm, the two created an A.I. lab called DeepMind.

Like the Rationalists, they believed that A.I could end up turning against humanity, and because they held this belief, they felt they were among the only ones who were prepared to build it in a safe way.

In 2014, Google bought DeepMind for $650 million. The next year, Elon Musk — who also worried A.I. could destroy the world and met his partner, Grimes, because they shared an interest in a Rationalist thought experiment — founded OpenAI as a DeepMind competitor. Both labs hired from the Rationalist community.

Mr. Aaronson, the University of Texas professor, was turned off by the more rigid and contrarian beliefs of the Rationalists, but he is one of the blog’s biggest champions and deeply admired that it didn’t avoid live-wire topics.

“It must have taken incredible guts for Scott to express his thoughts, misgivings and questions about some major ideological pillars of the modern world so openly, even if protected by a quasi-pseudonym,” he said

In late June of last year, not long after talking to Mr. Altman, the OpenAI chief executive, I approached the writer known as Scott Alexander, hoping to get his views on the Rationalist way and its effect on Silicon Valley. That was when the blog vanished.

The issue, it was clear to me, was that I told him I could not guarantee him the anonymity he’d been writing with. In fact, his real name was easy to find because people had shared it online for years and he had used it on a piece he’d written for a scientific journal. I did a Google search for Scott Alexander and one of the first results I saw in the auto-complete list was Scott Alexander Siskind.

More than 7,500 people signed a petition urging The Times not to publish his name, including many prominent figures in the tech industry. “Putting his full name in The Times,” the petitioners said, “would meaningfully damage public discourse, by discouraging private citizens from sharing their thoughts in blog form.” On the internet, many in Silicon Valley believe, everyone has the right not only to say what they want but to say it anonymously.

I spoke with Manoel Horta Ribeiro, a computer science researcher who explores social networks at the Swiss Federal Institute of Technology in Lausanne. He was worried that Slate Star Codex, like other communities, was allowing extremist views to trickle into the influential tech world. “A community like this gives voice to fringe groups,” he said. “It gives a platform to people who hold more extreme views.”

I assured her my goal was to report on the blog, and the Rationalists, with rigor and fairness. But she felt that discussing both critics and supporters could be unfair. What I needed to do, she said, was somehow prove statistically which side was right.

When I asked Mr. Altman if the conversation on sites like Slate Star Codex could push people toward toxic beliefs, he said he held “some empathy” for these concerns. But, he added, “people need a forum to debate ideas.”

In August, Mr. Siskind restored his old blog posts to the internet. And two weeks ago, he relaunched his blog on Substack, a company with ties to both Andreessen Horowitz and Y Combinator. He gave the blog a new title: Astral Codex Ten. He hinted that Substack paid him $250,000 for a year on the platform. And he indicated the company would give him all the protection he needed.

Why some people can shake off the impulse to eat, and other people stay mired in thoughts about food, is “the million-dollar question,”

There’s another theoretical framework for why Ozempic might quash food noise: Semaglutide activates receptors for a hormone called GLP-1. Studies in animals have shown those receptors are found in cells in regions of the brain that are particularly important for motivation and reward, pointing to one potential way semaglutide could influence cravings and desires.

Ms. Klemmer said she worried about the potential long-term side effects of a medication she might be on for the rest of her life. But she thinks the trade-off — the end of food noise — is worth it. “It’s worth every bad side effect that I’d have to go through to have what I feel now,” she said: “not caring about food.”

In November 2020, the AI group DeepMind announced it had developed a program called AlphaFold that could rapidly predict this information using an algorithm. Since then, it has been crunching through the genetic codes of every organism that has had its genome sequenced, and predicting the structures of the hundreds of millions of proteins they collectively contain.

Last year, DeepMind published the protein structures for 20 species – including nearly all 20,000 proteins expressed by humans – on an open database. Now it has finished the job, and released predicted structures for more than 200m proteins.

“Essentially, you can think of it as covering the entire protein universe. It includes predictive structures for plants, bacteria, animals, and many other organisms, opening up huge new opportunities for AlphaFold to have an impact on important issues, such as sustainability, food insecurity, and neglected diseases,”

In May, researchers led by Prof Matthew Higgins at the University of Oxford announced they had used AlphaFold’s models to help determine the structure of a key malaria parasite protein, and work out where antibodies that could block transmission of the parasite were likely to bind.

“Previously, we’d been using a technique called protein crystallography to work out what this molecule looks like, but because it’s quite dynamic and moves around, we just couldn’t get to grips with it,” Higgins said. “When we took the AlphaFold models and combined them with this experimental evidence, suddenly it all made sense. This insight will now be used to design improved vaccines which induce the most potent transmission-blocking antibodies.”

AlphaFold’s models are also being used by scientists at the University of Portsmouth’s Centre for Enzyme Innovation, to identify enzymes from the natural world that could be tweaked to digest and recycle plastics. “It took us quite a long time to go through this massive database of structures, but opened this whole array of new three-dimensional shapes we’d never seen before that could actually break down plastics,” said Prof John McGeehan, who is leading the work. “There’s a complete paradigm shift. We can really accelerate where we go from here

“AlphaFold protein structure predictions are already being used in a myriad of ways. I expect that this latest update will trigger an avalanche of new and exciting discoveries in the months and years ahead, and this is all thanks to the fact that the data are available openly for all to use.”