Skip to main content

Home/ TOK Friends/ Group items tagged doctors

Rss Feed Group items tagged

8More

Van Gogh: Artist experienced 'delirium from alcohol withdrawal' - BBC News - 0 views

  • Van Gogh dismissed the episode as "a simple artist's bout of craziness" and later a "mental or nervous fever".But research in the Netherlands has thrown new light on his mental state.
  • Van Gogh dismissed the episode as "a simple artist's bout of craziness" and later a "mental or nervous fever".But research in the Netherlands has thrown new light on his mental state.
    • lucieperloff
       
      How have they learned more about this?
  • In Van Gogh's case, the epileptic activity could have been caused by brain damage as a result of his lifestyle. Alcohol abuse, malnutrition, poor sleep and mental exhaustion could all have been factors, researchers say.
  • ...2 more annotations...
  • Van Gogh is thought to have suffered from a combination of psychiatric disorders, most likely bipolar and borderline personality, but his suspected illnesses have never been diagnosed. According to this new research, it is unlikely that the Dutch painter had schizophrenia. As to whether he suffered from epilepsy, a diagnosis established by his own doctors, the researchers believe it was most likely "masked epilepsy".
    • lucieperloff
       
      A lot more to him than we initially thought
  • Van Gogh's creativity is sometimes attributed to his mental health issues, but art experts argue that his achievements were rooted in the skills of his craft, which he worked hard to develop over many years.
    • lucieperloff
       
      His artistry isn't solely based in his mental health issues
12More

Even Non-Amputees Can Feel a Phantom Limb | Invisible Hand | Live Science - 0 views

  • Amputees often suffer from a phenomenon known as phantom limb syndrome, but researchers now say that non-amputees can also be made to feel phantom limbs, and even pain, when knives are jabbed into nonexistent hands.
  • In phantom limb syndrome, people suffer from the illusion that a limb exists even if it is missing
  • Phantom limbs occur in 95 percent of amputees who lose an arm or leg
    • caelengrubb
       
      I didn't know that it was this common
  • ...8 more annotations...
  • Doctors have known of this syndrome since the 16th century. (After Lord Horatio Nelson lost part of his right arm during a battle in 1797, he said he felt fingers pressing into his missing palm, sensations the admiral cited as direct evidence for the existence of a soul.)
  • Not only can the mind fool people into thinking a missing limb is there when it is not, but experiments prove that people can be fooled into thinking another object is part of them. The deception is known as the rubber hand illusion.
  • To play this trick, start with a table with a screen running up its middle, and sit in front of the table so the right arm is hidden from view. A fake right arm is visible on the table. If both the right hand and the rubber hand are simultaneously stroked with a brush for a few minutes, a 1998 study found eight of 10 volunteers experienced the disarming illusion that the dummy hand was their hand.
  • In another experiment, the volunteers were asked to close their eyes and quickly point with their left hand to where they perceived their right hand was. Those experiencing the invisible hand illusion would point at the invisible hand rather than their real hand.
  • The scientists had previously found objects that did not resemble body parts, such as a block of wood, cannot be experienced as one's own hand, "so we were extremely surprised to find that the brain can accept an invisible hand as part of the body,
  • "We believe that the crucial difference lies in that we are very used to feeling our hands without seeing them, and we can move our hands in empty space but not through solid objects," Guterstam said. "The empty space close to the body represents an array of potential locations for the limbs."
  • The researchers scanned the brains of 14 volunteers using functional magnetic resonance imaging (fMRI). Perceiving the invisible-hand illusion led to increased activity in the same parts of the brain that are normally active when individuals see their real hand being touched or when participants experience a prosthetic hand as their own.
  • There could be important differences between the invisible hand illusion and phantom sensations, Ehrsson said. "For example, signals from damaged nerves could contribute to phantom limbs and phantom pain in a way that would be different from our illusion in limbed-individuals," Ehrsson said.
14More

Opinion | Why Fox News Is Still in a Coronavirus Bubble - The New York Times - 0 views

  • Humans will do figure eights to make facts suit their fictions.
  • Back in the 1950s, the psychologist Leon Festinger came up with cognitive dissonance theory, which can essentially be described as the very human desire to reconcile the irreconcilable.
  • Our brains, he realized, will go to baroque lengths — do magic tricks, even — to preserve the integrity of our worldview, even when the facts inconveniently club us over the head with a two-by-four.
  • ...11 more annotations...
  • Today, perhaps the best case study of cognitive dissonance theory can be found in the prime-time lineup on Fox News, where Donald Trump’s most dedicated supporters are struggling mightily to make sense of the president’s Covid-19 diagnosis.
  • just as Festinger’s work predicts, they are doubling down on their beliefs, interpreting recent events as incontrovertible proof that they were right from the start.
  • the figure-eight logic we resort to when our stories don’t align with reality.
  • Later in her program, Ingraham even managed to find a doctor who challenged the efficacy of masks.
  • Everyone reckons with cognitive dissonance.
  • On his Friday show, Sean Hannity was reckoning with his own set of contradictions. He repeated, at almost metronomic intervals, that the president had been admitted to the hospital “out of an abundance of caution.” But in his outrage segment, during which he and his choir of the incensed (rightly) condemned those who wished the president harm, he didn’t blink when Geraldo Rivera said: “I hate when I hear that B.S. cliché ‘an abundance of caution.’ The headline here is that the president of the United States and the first lady of the United States have been diagnosed with Covid disease — a wicked, dangerous, deadly disease that’s already claimed 208,000 American lives.”
  • People will do a great deal to justify their belief systems, even if it means tolerating a thousand tiny inconsistencies.
  • And Fox News is especially adept at giving people scripts they can use to minimize their discomfort with bothersome, disconfirming facts.
  • It was notable, I thought, that a few of Trump’s supporters were wearing masks outside Walter Reed National Military Medical Center.
  • But I don’t feel much hope. It requires a pretty thick hide to say you disagree with your former self
  • For those who’ve dismissed or downplayed the threat of the coronavirus, now is a good time to reconsider that position. And for those who’ve prayed for such a conversion, now is a good time simply to be thankful, and not to judge.
7More

China 'gay conversion': Accounts of shocks and pills - BBC News - 0 views

  • Verbal abuse is the tip of the iceberg, according to the report.
  • They just told me they were supposed to be good for me and help with the progress of the 'treatment'," he explained.
  • How does family pressure lead to 'treatment'? All of those interviewed told Human Rights Watch that they were forcefully taken to "conversion" therapy. This often occurred within days of coming out to their parents, who felt "ashamed" that their children were gay.
  • ...4 more annotations...
  • What do doctors say about diseases like Aids?Most of those forced to undergo therapy say they were subjected to verbal harassment and insults during treatment.
  • What's the situation of LGBT people in China?There is growing awareness of LGBT issues in China. Homosexuality was decriminalised in 1997 and removed from an official list of mental disorders in 2001. Big cities have lively gay scenes, and in June, Shanghai held a gay pride parade.However, advocacy groups say that millions of gay people in China have married heterosexual partners rather than come out as gay as a result of pressure from families. Last year a judge ruled that a gay couple could not register as married, the first case of its kind in China.
  • In July, a gay man in central China won an apology and compensation from a mental hospital over forced "conversion therapy".
  • Platonic love relationship: Find an "elegant and caring" member of the opposite sex. Establish a relationship as friends initially. Then hope it becomes something else.2. Repulsion therapy: Induce nausea with forced vomiting or fear of electrocution when thoughts of having a lover of the same sex emerge.3. Shock therapy: Cause major shock to your lifestyle by moving to an entirely new environment in order to sever connection with previous friends, etc.4. Sexual orientation transfer:
10More

10 People With Photographic Memories | Mental Floss - 0 views

  • there are plenty of people who have claimed to possess eidetic memory
  • he had no problem memorizing entire books, but also experienced random, blinding flashes of light that were sometimes accompanied by hallucinations.
  • had detailed flashbacks to earlier parts of his life and could visualize his inventions in astonishing, complicated detail before he even started
  • ...7 more annotations...
  • Teddy Roosevelt could recite entire newspaper pages—not just articles—as if they were sitting in front of him.
  • is reported to have read two or three books a day.
  • was said to have memorized every word of every book he had ever read, estimated at around 9000. It took him up to just 12 seconds to read one page, and each eye could read a page independently.
  • "Kim's story tells us that the human brain is far more flexible than we had thought,"
  • "Like many other savants, he has suffered disability in one area of his brain, but has compensated by acquiring remarkable new abilities in other areas. This shows we all have considerable hidden intellectual potential."
  • may have had a type of photographic memory that helped him memorize sheet music with astonishing speed.
  • Russian composer Alexander Siloti would give him complicated and demanding works to learn and Rachmaninov (also spelled Rachmaninoff) would have them completely memorized to perfection a day or two later.
4More

Coronavirus deals blow to Putin's plans to stay in power until 2036 - CNN - 0 views

  • Russian President Vladimir Putin has long provided other world leaders with a template for authoritarian rule. Now he faces a new test: Whether his top-down system can survive the coronavirus pandemic.
  • "Let's not rely on our Russian luck," he said. "Please do not think, as we often do: 'Oh, this will not touch me.' It can touch everyone. And then what is happening today in many Western countries, both in Europe and overseas, could become our immediate future."
  • "We'll evaluate the situation and based only on the recommendations from doctors and specialists we will decide on a new date," Putin said.
  • ...1 more annotation...
  • On Tuesday, the Russian leader paid a visit to the main Moscow hospital for monitoring suspected coronavirus patients, donning protective gear to visit the hospital in the city's suburb of Kommunarka. It was the kind of costume play we're used to seeing from the Kremlin, and reminiscent of one of his earliest moves as Russia's acting president: flying to the war-torn republic of Chechnya in 2000 in the co-pilot's seat of an Su-27 fighter jet.
5More

Coronavirus economic impact: Australia could be among world's hardest hit nations | Wor... - 0 views

  • Australia could be one of the countries worst affected by the economic impact of the coronavirus outbreak as factories in China remain shuttered and millions of people are confined to their homes and banned from travelling.
  • But evidence is mounting that China is suffering a significant slowdown. S&P has downgraded its growth forecast for the world’s second biggest economy to 5% this year from 5.75%, predicting that the impact would spread around the world, while it seems clear that China’s lockdown is set to deprive Australia of billions of dollars in revenue from big spending tourists and students.
  • “When you look at how this will affect other countries, what their exposure is to China, how big the economy is, what type of companies it has, then Australia ticks a lot of the boxes,” he said. “In terms of which countries will be most affected, we’re right up there.”
  • ...2 more annotations...
  • “It’s not just the numbers of tourists – it’s that they spend quite a lot because of the way they travel with packages, how they get around and spending on shopping,” he says. “If that gets cut off it’s a material impact on the economy in Australia.”
  • However, some partial data released on Friday suggests the scale of the problem that is emerging, with figures showing that property sales in China’s so-called first-tier cities fell by 93% on 3-5 February compared with the same days last year. Railway passenger traffic was down 89% on 5 February.
11More

Humans Are the World's Best Pattern-Recognition Machines, But for How Long? - Big Think - 0 views

  • Not only are machines rapidly catching up to — and exceeding — humans in terms of raw computing power, they are also starting to do things that we used to consider inherently human
  • Quite simply, humans are amazing pattern-recognition machines. They have the ability to recognize many different types of patterns - and then transform these "recursive probabalistic fractals" into concrete, actionable steps.
  • Intelligence, then, is really just a matter of being able to store more patterns than anyone else
  • ...8 more annotations...
  • Artificial intelligence pioneer Ray Kurzweil was among the first to recognize how the link between pattern recognition and human intelligence could be used to build the next generation of artificially intelligent machines.
  • where human "expertise" has always trumped machine "expertise."
  • It turns out patterns matter, and they matter a lot.
  • The more you think about it, the more you can see patterns all around you. Getting to work on time in the morning is the result of recognizing patterns in your daily commute
  • it's really just a matter of recognizing the right patterns faster than anyone else, and machines just have so much processing power these days it's easy to see them becoming the future doctors and lawyers of the world.
  • The future of intelligence is in making our patterns better, our heuristics stronger.
  • One thing is clear – being able to recognize patterns is what gave humans their evolutionary edge over animals.
  • How we refine, shape and improve our pattern recognition is the key to how much longer we'll have the evolutionary edge over machines.
18More

Consumer Updates > Coping With Memory Loss - 0 views

  • Frequent memory lapses are likely to be noticeable because they tend to interfere with daily living.
  • What’s being forgotten?
  • may cause individuals to get lost in a familiar place or put something in an inappropriate place because they can’t remember where it goes (think car keys in the refrigerator).
  • ...15 more annotations...
  • —the process of thinking, learning, and remembering—can affect memory.
  • Anything that affects cognition
  • Depression, which is common with aging, causes a lack of attention and focus that can affect memory.
  • Brain imaging – either using computerized axial tomography (CAT) scans or magnetic resonance imaging (MRI) – can help to identify strokes and tumors, which can sometimes cause memory loss.
  • Heavy alcohol use can cause deficiencies in vitamin B1 (
  • Stress, particularly because of emotional trauma, can cause memory loss. I
  • Doctors evaluate memory loss by taking a medical history, asking questions to test mental ability
  • repeated head trauma, as in boxers and footballers can result in progressive loss of memory and other effects.
  • Research has shown that the combination of shifting estrogen and progestin levels increased the risk of dementia in women older than 65. There is no evidence that the herb ginkgo biloba prevents memory loss.
  • vascular diseases (heart disease and stroke) that result from elevated cholesterol and blood pressure may contribute to the development of Alzheimer’s disease,
  • Don’t smoke or abuse alcohol.
  • Get regular exercise.
  • Maintain healthy eating habits.
  • Maintain social interactions,
  • Keep your brain active
9More

A.I. Comes to the Operating Room - The New York Times - 0 views

  • Brain surgeons are bringing artificial intelligence and new imaging techniques into the operating room, to diagnose tumors as accurately as pathologists, and much faster, according to a report in the journal Nature Medicine.
  • The traditional method, which requires sending the tissue to a lab, freezing and staining it, then peering at it through a microscope, takes 20 to 30 minutes or longer. The new technique takes two and a half minutes.
  • In addition to speeding up the process, the new technique can also detect some details that traditional methods may miss, like the spread of a tumor along nerve fibers
  • ...6 more annotations...
  • The new process may also help in other procedures where doctors need to analyze tissue while they are still operating, such as head and neck, breast, skin and gynecologic surgery, the report said. It also noted that there is a shortage of neuropathologists, and suggested that the new technology might help fill the gap in medical centers that lack the specialty. Video Advertisement LIVE 00:00 1:05
  • Algorithms are also being developed to help detect lung cancers on CT scans, diagnose eye disease in people with diabetes and find cancer on microscope slides.
  • The diagnoses were later judged right or wrong based on whether they agreed with the findings of lengthier and more extensive tests performed after the surgery.The result was a draw: humans, 93.9 percent correct; A.I., 94.6 percent.
  • At some centers, he said, brain surgeons do not even order frozen sections because they do not trust them and prefer to wait for tissue processing after the surgery, which may take weeks to complete.
  • Some types of brain tumor are so rare that there is not enough data on them to train an A.I. system, so the system in the study was designed to essentially toss out samples it could not identify.
  • “It won’t change brain surgery,” he said, “but it’s going to add a significant new tool, more significant than they’ve stated.”
4More

Trump's Gut Collides With Science on Coronavirus Messaging : NPR - 0 views

  • President Trump is known to say what's on his mind, to go with his gut and accentuate the positive. That approach is now colliding with a public health emergency in the form of coronavirus.
  • The challenge posed by Trump's breezy style was on full display Wednesday night in an interview in which he disputed the World Health Organization's recent coronavirus death rate estimate of 3.4%. "Well, I think the 3.4% is really a false number," Trump told Sean Hannity on Fox News. "Now, this is just my hunch, and — but based on a lot of conversations with a lot of people that do this, because a lot of people will have this, and it's very mild. They will get better very rapidly. They don't even see a doctor."
  • It's a challenge for any politician to accurately convey public health messages: to encourage preparedness and avoid inciting fear without underplaying or overselling the risks. That challenge is particularly acute for Trump given his free-flowing communications style. During the interview, Trump also revealed that he was concerned that repatriating Americans from the Diamond Princess cruise ship that was held in Japan last month would "look bad" because it would increase the total number of coronavirus cases in the United States. "I felt we had to do it. And, in one way, I hated to do it statistically," Trump said.
  • ...1 more annotation...
  • "In these kinds of public health emergencies, we need to be able to trust our leaders, be it public health, scientific or political leaders," Omer said. This will become particularly important in the coronavirus outbreak if there comes a time when the government needs to recommend major lifestyle adjustments to curtail the spread of the disease.
3More

Mysterious repeating fast radio burst traced to nearby galaxy - CNN - 0 views

  • Astronomers have traced the signal of an enigmatic repeating fast radio burst for only the second time -- and it's in a spiral galaxy similar to our own, not so far away.
  • Multiple individual fast radio bursts in past years have been traced back to their sources in other galaxies, although those have yet to shed light on what created them.But this newly discovered repeating FRB has a different source from the first one that was found in 2019, deepening the mystery of how these radio waves are created.
  • "The FRB is among the closest yet seen, and we even speculated that it could be a more conventional object in the outskirts of our own galaxy," said Mohit Bhardwaj, study co-author and McGill University doctoral student. "However, the observation proved that it's in a relatively nearby galaxy, making it still a puzzling FRB but close enough to now study using many other telescopes."
3More

Do You Use Only 10% of Your Brain? | Mental Floss - 0 views

  • We may be biased, but we think the human brain is pretty special.
  • This myth is so prevalent that it is unquestioningly accepted as a pivotal plot point in movies, a motivational tactic for self-improvement, or justification for claims about ESP and other supposed untapped abilities of the human mind. A 2013 poll surveying over 2000 Americans found that 65 percent believed the 10 percent myth. A 2007 study in the British Medical Journal (BMJ) found that even some doctors weren't immune to the fallacy. But the truth is that everyone uses 100 percent of their brain.
  • Decades later, the myth has persevered because of the attractive possibility it seems to present. It absolves us for not reaching our full potential, offers a persistent insecurity for self-help gurus to appeal to, and provides a pseudo-scientific explanation for the limits of human comprehension. 
34More

Reasons for COVID-19 Optimism on T-Cells and Herd Immunity - 0 views

  • It may well be the case that some amount of community protection kicks in below 60 percent exposure, and possibly quite a bit below that threshold, and that those who exhibit a cross-reactive T-cell immune response, while still susceptible to infection, may also have some meaningful amount of protection against severe disease.
  • early returns suggest that while the maximalist interpretation of each hypothesis is not very credible — herd immunity has probably not been reached in many places, and cross-reactive T-cell response almost certainly does not functionally immunize those who have it — more modest interpretations appear quite plausible.
  • Friston suggested that the truly susceptible portion of the population was certainly not 100 percent, as most modelers and conventional wisdom had it, but a much smaller share — surely below 50 percent, he said, and likely closer to about 20 percent. The analysis was ongoing, he said, but, “I suspect, once this has been done, it will look like the effective non-susceptible portion of the population will be about 80 percent. I think that’s what’s going to happen.”
  • ...31 more annotations...
  • one of the leading modelers, Gabriela Gomes, suggested the entire area of research was being effectively blackballed out of fear it might encourage a relaxation of pandemic vigilance. “This is the very sad reason for the absence of more optimistic projections on the development of this pandemic in the scientific literature,” she wrote on Twitter. “Our analysis suggests that herd-immunity thresholds are being achieved despite strict social-distancing measures.”
  • Gomes suggested, herd immunity could happen with as little as one quarter of the population of a community exposed — or perhaps just 20 percent. “We just keep running the models, and it keeps coming back at less than 20 percent,” she told Hamblin. “It’s very striking.” Such findings, if they held up, would be very instructive, as Hamblin writes: “It would mean, for instance, that at 25 percent antibody prevalence, New York City could continue its careful reopening without fear of another major surge in cases.”
  • But for those hoping that 25 percent represents a true ceiling for pandemic spread in a given community, well, it almost certainly does not, considering that recent serological surveys have shown that perhaps 93 percent of the population of Iquitos, Peru, has contracted the disease; as have more than half of those living in Indian slums; and as many as 68 percent in particular neighborhoods of New York City
  • overshoot of that scale would seem unlikely if the “true” threshold were as low as 20 or 25 percent.
  • But, of course, that threshold may not be the same in all places, across all populations, and is surely affected, to some degree, by the social behavior taken to protect against the spread of the disease.
  • we probably err when we conceive of group immunity in simplistically binary terms. While herd immunity is a technical term referring to a particular threshold at which point the disease can no longer spread, some amount of community protection against that spread begins almost as soon as the first people are exposed, with each case reducing the number of unexposed and vulnerable potential cases in the community by one
  • you would not expect a disease to spread in a purely exponential way until the point of herd immunity, at which time the spread would suddenly stop. Instead, you would expect that growth to slow as more people in the community were exposed to the disease, with most of them emerging relatively quickly with some immune response. Add to that the effects of even modest, commonplace protections — intuitive social distancing, some amount of mask-wearing — and you could expect to get an infection curve that tapers off well shy of 60 percent exposure.
  • Looking at the data, we see that transmissions in many severely impacted states began to slow down in July, despite limited interventions. This is especially notable in states like Arizona, Florida, and Texas. While we believe that changes in human behavior and changes in policy (such as mask mandates and closing of bars/nightclubs) certainly contributed to the decrease in transmission, it seems unlikely that these were the primary drivers behind the decrease. We believe that many regions obtained a certain degree of temporary herd immunity after reaching 10-35 percent prevalence under the current conditions. We call this 10-35 percent threshold the effective herd immunity threshold.
  • Indeed, that is more or less what was recently found by Youyang Gu, to date the best modeler of pandemic spread in the U.S
  • he cautioned again that he did not mean to imply that the natural herd-immunity level was as low as 10 percent, or even 35 percent. Instead, he suggested it was a plateau determined in part by better collective understanding of the disease and what precautions to take
  • Gu estimates national prevalence as just below 20 percent (i.e., right in the middle of his range of effective herd immunity), it still counts, I think, as encouraging — even if people in hard-hit communities won’t truly breathe a sigh of relief until vaccines arrive.
  • If you can get real protection starting at 35 percent, it means that even a mediocre vaccine, administered much more haphazardly to a population with some meaningful share of vaccination skeptics, could still achieve community protection pretty quickly. And that is really significant — making both the total lack of national coordination on rollout and the likely “vaccine wars” much less consequential.
  • At least 20 percent of the public, and perhaps 50 percent, had some preexisting, cross-protective T-cell response to SARS-CoV-2, according to one much-discussed recent paper. An earlier paper had put the figure at between 40 and 60 percent. And a third had found an even higher prevalence: 81 percent.
  • The T-cell story is similarly encouraging in its big-picture implications without being necessarily paradigm-changing
  • These numbers suggest their own heterogeneity — that different populations, with different demographics, would likely exhibit different levels of cross-reactive T-cell immune response
  • The most optimistic interpretation of the data was given to me by Francois Balloux, a somewhat contrarian disease geneticist and the director of the University College of London’s Genetics Institute
  • According to him, a cross-reactive T-cell response wouldn’t prevent infection, but would probably mean a faster immune response, a shorter period of infection, and a “massively” reduced risk of severe illness — meaning, he guessed, that somewhere between a third and three-quarters of the population carried into the epidemic significant protection against its scariest outcomes
  • the distribution of this T-cell response could explain at least some, and perhaps quite a lot, of COVID-19’s age skew when it comes to disease severity and mortality, since the young are the most exposed to other coronaviruses, and the protection tapers as you get older and spend less time in environments, like schools, where these viruses spread so promiscuously.
  • Balloux told me he believed it was also possible that the heterogeneous distribution of T-cell protection also explains some amount of the apparent decline in disease severity over time within countries on different pandemic timelines — a phenomenon that is more conventionally attributed to infection spreading more among the young, better treatment, and more effective protection of the most vulnerable (especially the old).
  • Going back to Youyang Gu’s analysis, what he calls the “implied infection fatality rate” — essentially an estimated ratio based on his modeling of untested cases — has fallen for the country as a whole from about one percent in March to about 0.8 percent in mid-April, 0.6 percent in May, and down to about 0.25 percent today.
  • even as we have seemed to reach a second peak of coronavirus deaths, the rate of death from COVID-19 infection has continued to decline — total deaths have gone up, but much less than the number of cases
  • In other words, at the population level, the lethality of the disease in America has fallen by about three-quarters since its peak. This is, despite everything that is genuinely horrible about the pandemic and the American response to it, rather fantastic.
  • there may be some possible “mortality displacement,” whereby the most severe cases show up first, in the most susceptible people, leaving behind a relatively protected population whose experience overall would be more mild, and that T-cell response may play a significant role in determining that susceptibility.
  • That, again, is Balloux’s interpretation — the most expansive assessment of the T-cell data offered to me
  • The most conservative assessment came from Sarah Fortune, the chair of Harvard’s Department of Immunology
  • Fortune cautioned not to assume that cross-protection was playing a significant role in determining severity of illness in a given patient. Those with such a T-cell response, she told me, would likely see a faster onset of robust response, yes, but that may or may not yield a shorter period of infection and viral shedding
  • Most of the scientists, doctors, epidemiologists, and immunologists I spoke to fell between those two poles, suggesting the T-cell cross-immunity findings were significant without necessarily being determinative — that they may help explain some of the shape of pandemic spread through particular populations, but only some of the dynamics of that spread.
  • he told me he believed, in the absence of that data, that T-cell cross-immunity from exposure to previous coronaviruses “might explain different disease severity in different people,” and “could certainly be part of the explanation for the age skew, especially for why the very young fare so well.”
  • the headline finding was quite clear and explicitly stated: that preexisting T-cell response came primarily via the variety of T-cells called CD4 T-cells, and that this dynamic was consistent with the hypothesis that the mechanism was inherited from previous exposure to a few different “common cold” coronaviruses
  • “This potential preexisting cross-reactive T-cell immunity to SARS-CoV-2 has broad implications,” the authors wrote, “as it could explain aspects of differential COVID-19 clinical outcomes, influence epidemiological models of herd immunity, or affect the performance of COVID-19 candidate vaccines.”
  • “This is at present highly speculative,” they cautioned.
5More

New cancer treatment destroys tumours in terminally ill, finds trial | Cancer | The Gua... - 0 views

  • In a landmark trial, a cocktail of immunotherapy medications harnessed patients’ immune systems to kill their own cancer cells and prompted “a positive trend in survival”, according to researchers at the Institute of Cancer Research (ICR), London, and the Royal Marsden NHS foundation trust.
  • Scientists found the combination of nivolumab and ipilimumab medications led to a reduction in the size of tumours in terminally-ill head and neck patients. In some, their cancer vanished altogether, with doctors stunned to find no detectable sign of disease.
  • the immunotherapy treatment also triggered far fewer side-effects compared with the often gruelling nature of “extreme” chemotherapy,
  • ...2 more annotations...
  • The results from the phase 3 trial, involving almost 1,000 dying head and neck cancer patients, were early and not statistically significant but were still “clinically meaningful”, the ICR said, with some patients living months or years longer and suffering fewer side effects.
  • When the research nurses called to tell me that, after two months, the tumour in my throat had completely disappeared, it was an amazing moment,” said Ambrose. “While there was still disease in my lungs at that point, the effect was staggering.”
7More

I Was Powerless Over Diet Coke - The New York Times - 0 views

  • What makes it so hard to quit?
  • two culprits: aspartame and caffeine. Or, to be more precise: addiction to sweetness and to caffeine. Individually, they’re bad; together, they’re an addict’s nightmare.
  • A 12-ounce can of regular Coke has 34 milligrams of caffeine, whereas Diet Coke has 11 milligrams more, according to Coca-Cola. (An 8-ounce cup of coffee has about 95 mg.) Artificial sweeteners activate the brain’s reward system, but only about half as much as regular sugar, said Dr. Peeke. Faux sugar doesn’t pack the same wallop as the real stuff, so it keeps you wanting more and more.
  • ...4 more annotations...
  • Not only is this tied to weight gain, especially in the belly, but it also leaves you with cravings. Aspartame is 200 times sweeter than table sugar. Serious drinkers are so used to the super-sweet taste that everything else seems bland in comparison.
  • Coca-Cola has a different take on what people refer to as an addiction. “Food and beverages, like chocolate, for example, can trigger what scientists call ‘reward centers’ in the brain, but so can other things like music or laughter,” said Daphne Dickerson, a spokeswoman for Coca-Cola. “Regularly consuming food and beverages that taste good and that you enjoy is not the same as being addicted to them.”
  • In September 2020, Ms. Beller was diagnosed with breast cancer. She didn’t quit Diet Coke until after surgery, when doctors found more cancer and she realized she’d have to undergo chemotherapy.
  • She used the Quitzilla app, a habit breaker and sobriety counter, which tracked her progress. “Every time I had a craving, just looking at the app did something good in my brain,” she said. She didn’t have a lot of physical side effects, but she did long for the drink. She credits the app with helping her stay on track.
3More

Did Francesca Gino and Dan Ariely Fabricate Data for the Same Study? - The Atlantic - 0 views

  • Had the doctoring been done by someone from the insurer, as Ariely implied? There didn’t seem to be a way to dispute that contention, and the company itself wasn’t saying much. Then, last week, NPR’s Planet Money delivered a scoop: The company, called The Hartford, informed the show that it had finally tracked down the raw numbers that were provided to Ariely—and that the data had been “manipulated inappropriately” in the published study.
  • The analysis of insurance data from The Hartford appeared as “Experiment 3” in the paper. On the preceding page, an analysis of a different dataset—the one linked to Gino—was written up as “Experiment 1.” The scientists who say they discovered issues with both experiments—Leif Nelson, Uri Simonsohn, and Joe Simmons—dubbed the apparent double fraud a “clusterfake.” When I spoke with the scientific-misconduct investigator and Atlantic contributor James Heathers, he had his own way of describing it: “This is some kind of mad, fraudulent unicorn.”
  • When they set about reviewing Ariely’s work on the 2012 paper, a few quirks in the car-insurance data tipped them off that something might be amiss. Some entries were in one font, some in another. Some were rounded to the nearest 500 or 1,000; some were not. But the detail that really caught their attention was the distribution of recorded values. With such a dataset, you’d expect to see the numbers fall in a bell curve—most entries bunched up near the mean, and the rest dispersed along the tapering extremes. But the data that Ariely said he’d gotten from the insurance company did not form a bell curve; the distribution was completely flat. Clients were just as likely to have claimed that they’d driven 1,000 miles as 10,000 or 50,000 miles. It’s “hard to know what the distribution of miles driven should look like in those data,” the scientists wrote. “It is not hard, however, to know what it should not look like.”
6More

'I don't even remember what I read': People enter a 'dissociative state' when using soc... - 0 views

  • “I think people experience a lot of shame around social media use,” said lead author Amanda Baughan, a UW doctoral student in the Paul G. Allen School of Computer Science & Engineering. “One of the things I like about this framing of ‘dissociation’ rather than ‘addiction’ is that it changes the narrative. Instead of: ‘I should be able to have more self-control,’ it’s more like: ‘We all naturally dissociate in many ways throughout our day – whether it’s daydreaming or scrolling through Instagram, we stop paying attention to what’s happening around us.'”
  • “Having a stop built into a list meant that it was only going to be a few minutes of reading and then, if they wanted to really go crazy, they could read another list. But again, it’s only a few minutes. Having that bite-sized piece of content to consume was something that really resonated.”
  • Over the course of the month, 42% of participants (18 people) agreed or strongly agreed with that statement at least once. After the month, the researchers did in-depth interviews with 11 participants. Seven described experiencing dissociation while using Chirp.
  • ...3 more annotations...
  • “But people only realize that they’ve dissociated in hindsight. So once you exit dissociation there’s sometimes this feeling of: How did I get here? It’s like when people on social media realize: ‘Oh my gosh, how did 30 minutes go by? I just meant to check one notification.'”
  • The problem with social media platforms, the researchers said, is not that people lack the self-control needed to not get sucked in, but instead that the platforms themselves are not designed to maximize what people value.
  • These platforms need to create an end-of-use experience, so that people can have it fit in their day with their time-management goals.”
18More

What Do We Lose If We Lose Twitter? - The Atlantic - 0 views

  • What do we lose if we lose Twitter?
  • At its best, Twitter can still provide that magic of discovering a niche expert or elevating a necessary, insurgent voice, but there is far more noise than signal. Plenty of those overenthusiastic voices, brilliant thinkers, and influential accounts have burned out on culture-warring, or have been harassed off the site or into lurking.
  • many of the most hyperactive, influential twitterati (cringe) of the mid-2010s have built up large audiences and only broadcast now: They don’t read their mentions, and they rarely engage. In private conversations, some of those people have expressed a desire to see Musk torpedo the site and put a legion of posters out of their misery.
  • ...15 more annotations...
  • Perhaps the best example of what Twitter offers now—and what we stand to gain or lose from its demise—is illustrated by the path charted by public-health officials, epidemiologists, doctors, and nurses over the past three years.
  • They offered guidance that a flailing government response was too slow to provide, and helped cobble together an epidemiological picture of infections and case counts. At a moment when people were terrified and looking for any information at all, Twitter seemed to offer a steady stream of knowledgeable, diligent experts.
  • But Twitter does another thing quite well, and that’s crushing users with the pressures of algorithmic rewards and all of the risks, exposure, and toxicity that come with virality
  • t imagining a world without it can feel impossible. What do our politics look like without the strange feedback loop of a Twitter-addled political press and a class of lawmakers that seems to govern more via shitposting than by legislation
  • What happens if the media lose what the writer Max Read recently described as a “way of representing reality, and locating yourself within it”? The answer is probably messy.
  • here’s the worry that, absent a distributed central nervous system like Twitter, “the collective worldview of the ‘media’ would instead be over-shaped, from the top down, by the experiences and biases of wealthy publishers, careerist editors, self-loathing journalists, and canny operators operating in relatively closed social and professional circles.”
  • Twitter is, by some standards, a niche platform, far smaller than Facebook or Instagram or TikTok. The internet will evolve or mutate around a need for it. I am aware that all of us who can’t quit the site will simply move on when we have to.
  • Many of the past decade’s most polarizing and influential figures—people such as Donald Trump and Musk himself, who captured attention, accumulated power, and fractured parts of our public consciousness—were also the ones who were thought to be “good” at using the website.
  • the effects of Twitter’s chief innovation—its character limit—on our understanding of language, nuance, and even truth.
  • “These days, it seems like we are having languages imposed on us,” he said. “The fact that you have a social media that tells you how many characters to use, this is language imposition. You have to wonder about the agenda there. Why does anyone want to restrict the full range of my language? What’s the game there?
  • in McLuhanian fashion, the constraints and the architecture change not only what messages we receive but how we choose to respond. Often that choice is to behave like the platform itself: We are quicker to respond and more aggressive than we might be elsewhere, with a mindset toward engagement and visibility
  • it’s easy to argue that we stand to gain something essential and human if we lose Twitter. But there is plenty about Twitter that is also essential and human.
  • No other tool has connected me to the world—to random bits of news, knowledge, absurdist humor, activism, and expertise, and to scores of real personal interactions—like Twitter has
  • What makes evaluating a life beyond Twitter so hard is that everything that makes the service truly special is also what makes it interminable and toxic.
  • the worst experience you can have on the platform is to “win” and go viral. Generally, it seems that the more successful a person is at using Twitter, the more they refer to it as a hellsite.
« First ‹ Previous 141 - 160 of 169 Next ›
Showing 20 items per page