Group items tagged

In 1609, Kepler published a book containing the first two laws. The book also revealed his new model of the solar system, which was against what most scientists back then believed.

He stated that planets moved in elliptical orbits through the solar system, with the Sun located at one focus of the ellipse. Before Kepler, they believed that all orbits in the solar system were perfectly circular.

About ten years later, Kepler added his third law: that square of the orbital period divided by the cube of orbit’s semi-major axis is the same for all planets. Although not immediately accepted, his three laws took science to the next level. Why was he initially not appreciated?

Kepler applied this to the planets and stated that the solar system was built upon geometrical objects called Platonic solids that are a specific type of three-dimensional shape. They have identical sides or surfaces, edges of equal length, and angles of equal extent.

The model Kepler presented was based on a sequence of six spheres and the five Platonic solids, each located between two spheres. Back then, only six planets were discovered as Uranus and Neptune’s discovery took until the 18th and 19th centuries. Thus, each sphere represented one planet.

nitially, it seemed to explain the approximate ratios of the orbits of the six planets. It also gave a reason why there are only six planets—because there are only five Platonic shapes, each of which needs to fit between the orbit of two planets, only once

Kepler published this theory in detail, in his book Mysterium Cosmographicum. Despite all the value he gave to this theory, we now know how wrong it was.

Kepler cherished the theory as his most significant work, long after he had discovered the three laws.

However, the number of planets in the solar system or any other system in the universe is not predictable. Many of the numbers appearing everywhere are out of a mere accident, just like the number of planets.

Kepler thought his greatest achievement was the wrong solar system he drew, but it was the three laws that were so right to survive to date.

which allow the beetle to withstand forces of up to 149 Newtons (approximately 39,000 times the creature's body weight).

To test the potential of this type of structure as a way of joining different materials, such as plastics and metal, the scientists made a series of joints from metal and composites based on those seen in the beetle.

Sean Day is president of the American Synesthesia Association and has been tracking research on this condition for more than three decades

Summarizing the state of current research, Day says the brains of synesthetes do appear to be anatomically different (although he cautions that scientists have only studied a few types of synesthesia so far).

, it seems that the neural connections between different sensory parts of the brain are more myelinated in people with synesthesia

Myelin is a fatty sheath that surrounds neurons and enables neural signals to travel more quickly.

This allows parts of the brain that are responsible for different senses to communicate when they normally wouldn't.

Asian scientists, laboratories and companies are fast becoming a major driver for this innovation – perhaps not a surprise as we are already facing the challenges of an aging population such as growing economic, societal and personal costs.

It is an exciting time to be a neuroscientist and we are closer now than ever to developing breakthrough treatments and technologies that have the potential to make real societal impacts. Neuroscience has advanced more in the last 10 years than the previous 50, and with new perspectives starting to find a voice, I’m quite excited to see what the next 10 years will hold.

Not only that, but the universe appears to be governed by a kind of cosmic censorship: Regions of extreme gravity—where space-time curves so sharply that Einstein’s equations malfunction and the true, quantum nature of gravity and space-time must be revealed—always hide behind the horizons of black holes.

Dyson, who helped develop quantum electrodynamics (the theory of interactions between matter and light) and is professor emeritus at the Institute for Advanced Study in Princeton, New Jersey, where he overlapped with Einstein, disagrees with the argument that quantum gravity is needed to describe the unreachable interiors of black holes. And he wonders whether detecting the hypothetical graviton might be impossible, even in principle. In that case, he argues, quantum gravity is metaphysical, rather than physics.

The ability to detect the “grin” of quantum gravity would seem to refute Dyson’s argument. It would also kill the gravitational decoherence theory, by showing that gravity and space-time do maintain quantum superpositions.

If gravity is a quantum interaction, then the answer is: It depends. Each component of the blue diamond’s superposition will experience a stronger or weaker gravitational attraction to the red diamond, depending on whether the latter is in the branch of its superposition that’s closer or farther away. And the gravity felt by each component of the red diamond’s superposition similarly depends on where the blue diamond is.

Inside 10 Downing Street itself, considered a place of work more than a place of residence, the roughly 250-strong teams of civil servants and political advisers has been stripped back to only essential workers, with approximately 70 people on site at any given time. Johnson's official spokesperson said that inside No 10, staff had been "observing the advice on social distancing" and using video conferencing wherever possible.

The only problem is that perfect rulebooks don’t exist, because natural language is far too complex and haphazard to be reduced to a rigid set of specifications.

Researchers simply fed their neural networks massive amounts of written text copied from freely available sources like Wikipedia — billions of words, preformatted into grammatically correct sentences — and let the networks derive next-word predictions on their own. In essence, it was like asking the person inside a Chinese room to write all his own rules, using only the incoming Chinese messages for reference.“The great thing about this approach is it turns out that the model learns a ton of stuff about syntax,”

The nonsequential nature of the transformer represented sentences in a more expressive form, which Uszkoreit calls treelike. Each layer of the neural network makes multiple, parallel connections between certain words while ignoring others — akin to a student diagramming a sentence in elementary school. These connections are often drawn between words that may not actually sit next to each other in the sentence. “Those structures effectively look like a number of trees that are overlaid,” Uszkoreit explained.

But instead of concluding that BERT could apparently imbue neural networks with near-Aristotelian reasoning skills, they suspected a simpler explanation: that BERT was picking up on superficial patterns in the way the warrants were phrased.

Trump never misses an opportunity to make any situation about himself. That's even true during the time of a deadly pandemic that has taken the lives of more than 67,000 Americans and where business shutdowns have resulted in likely the highest unemployment rate since the Great Depression

in the approximately 780 minutes Trump spoke over the past month at press conference he offered less than 300 seconds of empathy to those suffering.

And while Trump has tweeted some recognition for first responders -- on March 19 he thanked them for their "dedication and sacrifice" -- just look at Trump's tweets in the last few days. They're all about Trump. On Sunday morning, right around the time he tweeted his complaint about to former President Bush's impeachment response, Trump also slammed the media for not "showing" polls that he believes make him look good -- "The Fake News doesn't show real polls."

Over the last few days, Trump reminded us time and time again that he sees himself as the victim in this crisis

The human brain has evolved to recognize patterns, perhaps more than any other single function. Our brain is weak at processing logic, remembering facts, and making calculations, but pattern recognition is its deep core capability.

"If you are a US citizen, and you are abroad at the moment, take a look at your circumstances, determine whether this is a place where you'd be willing to hunker down for an indeterminate period of time, as airspace and borders, etc., close down," the senior official said.

The faith of those who believed in Progress was based on the assumption that one could discern a purpose to the human enterprise, even without the theological scaffolding that supported the Christian edifice of belief. Science and technology were the chief instruments of Progress, and · i.Lac_cumulation of reliable in orma on a out nature _1b_n, would bring ignorance, superstition, and suffering to an end.

In T ~chnopoly, we are driven to fill our lives with the quesUo "accesTinformation.

But the genie that came out of the bottle proclaiming that information was the new god of culture was a deceiver. It solved the problez:n of information scarcity, the disadvantages o_f wh~s~ious. But it gave no wami g_ahout the dan_gers of information7rttn,

!:ion of what is called a_ curriculum was a logical step toward 1./ organizing, limiting, and discriminating among available sources of information. Schools became technocracy's first secular bureaucracies, structures for legitimizing some parts of the flow of infgrmatiQD and di"s.ci.e.diling other earts. School;;ere, in short, a ~eans of governing the ecology of information.

it is why in _a TechnoE,.oly there can be no transcendent sense of purpose or meaning, no cultural coherence.

There were several reasons for the rapid growth of the common school, but none was more obvious than that it was a necessary response to the anxiefies and confusion aroused by information on the loose. The inven-

The milieu in which T echnopoly flourishes is one in which the tie between information and human purpose has been severed, i.e., inf~rmation appears indiscriminately, directed at no one in particular, in enormous volume and at high speeds; and disconnected from theory, meaning, or purpose.

Abetted ~~orm of ed~~on that in itself has been em _lie~any co~e~ent world-view, Technopoly deprives us of the social, p·olitical, historical, mefaphys1cal, logical, or spiritual bases for knowing what is beyond belief.

There is not a single line written by Jefferson, Adams, Paine, Hamilton, or Franklin that does not take for granted that when information is made available to citizens they are capable of managing it. This is not to say that the Founding Fathers believed information could not be false, misleading, or irrelevant. But they believed that the marketplace of infonpation and ideas was sufficiently ordered so that citizens could make sense of what they read and heard and, through reason, judge ·its μsefulness to their lives. Jefferson's proposals for education, Paine'~ arguments for self-governance, Franklin's arrangements for community affairs assume coherent, commonly shared principles.that allow us to debate such questions as: What are the responsibilities of citizens? What is the nature of education? What constitutes human progress? What are the limitations of social structures?

New forms of public discourse came into being through newspapers, pamphlets, broadsides, and books.

First Amendment to the United States Constitution stands as a monument to the ideolo_g~~ print. It says: "Congress shall make no law respecting the establishment of religion, or prohibiting the free exercise thereof; or abridging freedom of speech or of the press; or of the right of the people peaceably to assemble, and to petition the government for a redress of grievances." In these forty-five words we may find the fundamental values of the literate, reasoning_giind as fostered by the print revolution: a belief in privacy, individuality, intellectual freedom, open criticism, and ~.' adio .

telegraphy created the idea of context-free . 1 informatig_n::= that fs'~the idea that the value of information need ;;~t be ti~ to any function it might serve in social and political

decision-making and action. The telegraph made information into a commodity, a "thing" that could be bought and sold irrespective of its uses or meaning. 2

a new definition qf information came into being. Here was information that rejected the necessit ·of interco~nectedness, proceeded without conte~rgued for instancy against historic continuity, and offere · ascination· in place of corn !exit and cohe ence.

the fourth stage of the information revolution occurred, broadcasting. And then the fifth, computer technology. Each of these brought with it new forms of information, unpre~edented amounts of it, and increased speeds

photography was invented at approximately the same time a~phy, and initiated the Ehi:rd stage of the information revolution. Daniel Boorstin has called it "the graphic revolution," bec~use the photograph and other ico~ogr~phs br~ on a massive intrusion of ima es into the symbolic environment:

~ the beginning of the seventeenth century, an entirely new information environment had been created by_12rint

It is an improbable world. It is a world in which the idea of human progress, as Bacon ex~sed it, has been g~ by the idea of technological progress.

echnopoly is a state of cttlture., It is also a st~te of mind. It consists in the deification of technology, which means that the culture seeks its authorization in te0,~logy, finds · .atisf~tions in technolo , and takes its orders from technolog-¥,

Th_e relationship between information and the mechanisms ( for its control is fairly simple ~ec · ·ology increases the available supply of information. As the supply is increased, \ control mechanisms are strained. Additional control mech\ anisms ~re needed to cope with new information. When addi1 tional control mechanisms are themselves technical, they in tum I further increase the supply of information. When the supply of information is no longer controllable, a general breakdown in psychic tranquillity and social purpose occurs. Without defenses, people have no way of finding meaning in their experiences, lose their capacity to remember, and have difficulty imagining reasonable futures.

any decline in the force of i~~~ti'?n_s makes people vulnerable to information chaos. 1 To say that life is destabilized by weakened institutions is merely to say that information loses its use and therefore becomes a source of confu;~n rather than coherence.

T echnop_oly, then, is to say it is what h~pens to society when the defe~ainst informati;~ glut have broken down.

the school as a mechanism for information control. What its standards are can usually be found in, a curriculum or, with even more clarity, in a course catalogue. A college catalogue lists courses, subjects, and fields of study that, taken together, amount to a certified statement of what a serious student ought to think about.

In the West, the family as an institution for the management of nonbiological information began with the ascendance of print. As books on every conceivable subject become available, parent_~ were forced int°._the roles of guard-· ians'... protectors, nurturers, and arbiters of taste and rectitude. \ Their function was to define what it means to be a child by \ excluding from the family's domain information that would 1. undermine its purpose.

all_ theories are oversimplifications, or at least lead to oversimplification. The rule of law is an oversimplification. A curriculum is an oversimplification. So is a family's conception of a child. T~~t is the funt!ion _o._Ltheories-_ to o~~~~ip:lp}}_fy, and thus to assist believers in_ organiziDg, weighting, _ _an~_ excluding information. Therein lies the power of theories.

The political party is another.

The most imposing institutions for the control of information are religio!1 ~nd the st~J:f, .. They do their work in a somewhat more abstract way than do courts, schools, families, or political parties. The_y m?n~g~__Ji;1formation throug~ creation of mytJ:is and stories that express theories about funq1m1entaf question_s_:_ __ 10:_hy are we here, where have we come from, and where are we headed?

any educational institution, if it is to function well in the mana~~nt of information, must have a theory about its purpose and meaning-'. .!n'!::!Sl. have the means to give clear expression to its_ theory, and must do so, to a large extent, by excluding information.

Those who reject the Bible's theory and who believe, let us say, in the theory of Science are also protected from unwanted information. Their theory, for example, instructs them to disregard information about astrology, dianetics, and creationism, which they usually label as medieval superstition or subjective opinion.

thought-world that functions not only without a transcendent; narrative to provide moral underpinnings but also without strong social institutions to control the flood of information produced by technology.

In the r case of the United States, the great eighteenth-century revolution was not indifferent to commodity capitalism but was nonetheless infused with profound moral content. The U~!ed States was not merely an experiment in a new form of governance; it wai1nefu1fillmenl-oFGocf s plan. True, Adams, Jeffe;son, and Painere1ected-fne supernatural elements in the Bible,· but they never doubted that their experiment had the imprimatur of \ Providence. People were to be free but for a eurp_9se. Their [ God~giv_e~ig[ifs im li~_? obli ations and responsibilities, not L onfytoGod but to other nations, to which the new republic would be a guide and a showcase of what is possible-w~en reason and spirituality commingle.

American Technopoly must rel,y, to an obsessive extent, on technica( ~ethods to control the flow of information. Three such means merit speci attention.

Francis Fukuyama is wrong. There is another ideological conflict to be fought-between "liberal democracy" as conceived in the eighteenth century, with all its transcendent moral underpinnings, and T echnopoly, a twentieth-century

in at- ~ tempting to make the most rational use of information, bureaucracy ignores all information and ideas that do not contribute to efficiency

in principle a bureaucracy is simply a coordinated series of techniques for reducing the amount of information that requires processing.

The transformation of bureaucracy from a set of techniques·> designecfto serve social ~tutions to an auton-;;mous metainstitution that largely serves itself came as a result of several developments in the mid-andlate-nineteenth century: rapid ../ industrial growth, improvements in transportation and commu- ·✓ nication, the extension of government into ever-larger realms of V public and business affairs, the increasing centralization of gov- v ernmental structures.

Along the way, it ceased to be merely a servant of social institutions an

became ~ their master. Bureaucracy now not only solves problems but creates them. More important, it defines what our problems are---and they arec!.lways, in the bureaucra!!c view, problems of l . , efficiency.

Th_~-role of t!;_e ~xpert is to concentrate o_l}_one_ .H~ld of knowledge, sift through all that is available, eliminate that -.--:-: __ __:~---------which has no bearing on a problem, and use what is left !Q. !!§Sist in solving a probl~.

Institutions ca~~aked~cisions on the basis of scores and. sfatistics, and. there certainly may be occasions where there is no reasonable alternative. But unless such decisions are made with profound skepticism-that is, acknowledged as being made for administrative convenience-they are delusionary.

The god they serve does not speak \ of righteousness or goodness or mercy or grace. Their god speaks of efficiency, precision, objectivity. And that is why such concepts as sin and evil disappear in Technopoly. They come from a moral universe that is irrelevant to the theology of expertise. And so the priests of Technopoly call sin "social deviance," which is a statistical concept, and they call evil "psychopathology," which is a medical concept. Sin and evil disappear because they cannot be measured and objectified, and therefore cannot be dealt with by experts.

That allows quantum computers to make many calculations in one pass, while digital ones have to perform each calculation separately. By speeding up computation, quantum computers could potentially solve big, complex problems in fields like chemistry and materials science that are out of reach today.

When Google researchers made their supremacy claim in 2019, they said their quantum computer performed a calculation in 3 minutes 20 seconds that would take about 10,000 years on a state-of-the-art conventional supercomputer.

The IBM researchers in the new study performed a different task, one that interests physicists. They used a quantum processor with 127 qubits to simulate the behavior of 127 atom-scale bar magnets — tiny enough to be governed by the spooky rules of quantum mechanics — in a magnetic field. That is a simple system known as the Ising model, which is often used to study magnetism.

This problem is too complex for a precise answer to be calculated even on the largest, fastest supercomputers.

On the quantum computer, the calculation took less than a thousandth of a second to complete. Each quantum calculation was unreliable — fluctuations of quantum noise inevitably intrude and induce errors — but each calculation was quick, so it could be performed repeatedly.

Indeed, for many of the calculations, additional noise was deliberately added, making the answers even more unreliable. But by varying the amount of noise, the researchers could tease out the specific characteristics of the noise and its effects at each step of the calculation.“We can amplify the noise very precisely, and then we can rerun that same circuit,” said Abhinav Kandala, the manager of quantum capabilities and demonstrations at IBM Quantum and an author of the Nature paper. “And once we have results of these different noise levels, we can extrapolate back to what the result would have been in the absence of noise.”In essence, the researchers were able to subtract the effects of noise from the unreliable quantum calculations, a process they call error mitigation.

Altogether, the computer performed the calculation 600,000 times, converging on an answer for the overall magnetization produced by the 127 bar magnets.

Although an Ising model with 127 bar magnets is too big, with far too many possible configurations, to fit in a conventional computer, classical algorithms can produce approximate answers, a technique similar to how compression in JPEG images throws away less crucial data to reduce the size of the file while preserving most of the image’s details

Certain configurations of the Ising model can be solved exactly, and both the classical and quantum algorithms agreed on the simpler examples. For more complex but solvable instances, the quantum and classical algorithms produced different answers, and it was the quantum one that was correct.

Thus, for other cases where the quantum and classical calculations diverged and no exact solutions are known, “there is reason to believe that the quantum result is more accurate,”

Mr. Anand is currently trying to add a version of error mitigation for the classical algorithm, and it is possible that could match or surpass the performance of the quantum calculations.

In the long run, quantum scientists expect that a different approach, error correction, will be able to detect and correct calculation mistakes, and that will open the door for quantum computers to speed ahead for many uses.

Error correction is already used in conventional computers and data transmission to fix garbles. But for quantum computers, error correction is likely years away, requiring better processors able to process many more qubits

“This is one of the simplest natural science problems that exists,” Dr. Gambetta said. “So it’s a good one to start with. But now the question is, how do you generalize it and go to more interesting natural science problems?”

Those might include figuring out the properties of exotic materials, accelerating drug discovery and modeling fusion reactions.

Most A.I. researchers agree that models trained using R.L.H.F. are better behaved than models without it. But some argue that fine-tuning a language model this way doesn’t actually make the underlying model less weird and inscrutable. In their view, it’s just a flimsy, friendly mask that obscures the mysterious beast underneath.

In a nutshell, the joke was that in order to prevent A.I. language models from behaving in scary and dangerous ways, A.I. companies have had to train them to act polite and harmless. One popular way to do this is called “reinforcement learning from human feedback,” or R.L.H.F., a process that involves asking humans to score chatbot responses, and feeding those scores back into the A.I. model.

Shoggoths are fictional creatures, introduced by the science fiction author H.P. Lovecraft in his 1936 novella “At the Mountains of Madness.” In Lovecraft’s telling, Shoggoths were massive, blob-like monsters made out of iridescent black goo, covered in tentacles and eyes.

@TetraspaceWest said, wasn’t necessarily implying that it was evil or sentient, just that its true nature might be unknowable.

And it reinforces the notion that what’s happening in A.I. today feels, to some of its participants, more like an act of summoning than a software development process. They are creating the blobby, alien Shoggoths, making them bigger and more powerful, and hoping that there are enough smiley faces to cover the scary parts.

“I was also thinking about how Lovecraft’s most powerful entities are dangerous — not because they don’t like humans, but because they’re indifferent and their priorities are totally alien to us and don’t involve humans, which is what I think will be true about possible future powerful A.I.”

when Bing’s chatbot became unhinged and tried to break up my marriage, an A.I. researcher I know congratulated me on “glimpsing the Shoggoth.” A fellow A.I. journalist joked that when it came to fine-tuning Bing, Microsoft had forgotten to put on its smiley-face mask.

@TetraspaceWest, the meme’s creator, told me in a Twitter message that the Shoggoth “represents something that thinks in a way that humans don’t understand and that’s totally different from the way that humans think.”

In any case, the Shoggoth is a potent metaphor that encapsulates one of the most bizarre facts about the A.I. world, which is that many of the people working on this technology are somewhat mystified by their own creations. They don’t fully understand the inner workings of A.I. language models, how they acquire new capabilities or why they behave unpredictably at times. They aren’t totally sure if A.I. is going to be net-good or net-bad for the world.

That some A.I. insiders refer to their creations as Lovecraftian horrors, even as a joke, is unusual by historical standards. (Put it this way: Fifteen years ago, Mark Zuckerberg wasn’t going around comparing Facebook to Cthulhu.)

If it’s an A.I. safety researcher talking about the Shoggoth, maybe that person is passionate about preventing A.I. systems from displaying their true, Shoggoth-like nature.

A great many people are dismissive of suggestions that any of these systems are “really” thinking, because they’re “just” doing something banal (like making statistical predictions about the next word in a sentence). What they fail to appreciate is that there is every reason to suspect that human cognition is “just” doing those exact same things. It matters not that birds flap their wings but airliners don’t. Both fly. And these machines think. And, just as airliners fly faster and higher and farther than birds while carrying far more weight, these machines are already outthinking the majority of humans at the majority of tasks. Further, that machines aren’t perfect thinkers is about as relevant as the fact that air travel isn’t instantaneous. Now consider: we’re well past the Wright flyer level of thinking machine, past the early biplanes, somewhere about the first commercial airline level. Not quite the DC-10, I think. Can you imagine what the AI equivalent of a 777 will be like? Fasten your seatbelts.

@thomas h. You make my point perfectly. You’re observing that the way a plane flies — by using a turbine to generate thrust from combusting kerosene, for example — is nothing like the way that a bird flies, which is by using the energy from eating plant seeds to contract the muscles in its wings to make them flap. You are absolutely correct in that observation, but it’s also almost utterly irrelevant. And it ignores that, to a first approximation, there’s no difference in the physics you would use to describe a hawk riding a thermal and an airliner gliding (essentially) unpowered in its final descent to the runway. Further, you do yourself a grave disservice in being dismissive of the abilities of thinking machines, in exactly the same way that early skeptics have been dismissive of every new technology in all of human history. Writing would make people dumb; automobiles lacked the intelligence of horses; no computer could possibly beat a chess grandmaster because it can’t comprehend strategy; and on and on and on. Humans aren’t nearly as special as we fool ourselves into believing. If you want to have any hope of acting responsibly in the age of intelligent machines, you’ll have to accept that, like it or not, and whether or not it fits with your preconceived notions of what thinking is and how it is or should be done … machines can and do think, many of them better than you in a great many ways. b&

@BLA. You are incorrect. Everything has nature. Its nature is manifested in making humans react. Sure, no humans, no nature, but here we are. The writer and various sources are not attributing nature to AI so much as admitting that they don’t know what this nature might be, and there are reasons to be scared of it. More concerning to me is the idea that this field is resorting to geek culture reference points to explain and comprehend itself. It’s not so much the algorithm has no soul, but that the souls of the humans making it possible are stupendously and tragically underdeveloped.

When even tech companies are saying AI is moving too fast, and the articles land on page 1 of the NYT (there's an old reference), I think the greedy will not think twice about exploiting this technology, with no ethical considerations, at all.

@nome sane? The problem is it isn't data as we understand it. We know what the datasets are -- they were used to train the AI's. But once trained, the AI is thinking for itself, with results that have surprised everybody.

The unique feature of a shoggoth is it can become whatever is needed for a particular job. There's no actual shape so it's not a bad metaphor, if an imperfect image. Shoghoths also turned upon and destroyed their creators, so the cautionary metaphor is in there, too. A shame more Asimov wasn't baked into AI. But then the conflict about how to handle AI in relation to people was key to those stories, too.

onic constipation, a functional bowel disorder, affects approximately 14% of adults worldwide [1]. Slow transit constipation (STC) is the major cause of chronic constipation which is characterized by markedly prolonged colonic transit time as a result of the colonic motility function disorde

Usually, patients with STC suffer from a common sense of abdominal pain, nausea, depression and sickness, which seriously influence their social ability and health-related quality of life [4–6

Current clinical treatments include cathartics, prokinetics and aggressive surgery which can increase bowel movement frequency to a certain degree.

However, pharmacological interventions is prone to drug dependency and relapse after drug withdrawal [3]

Surgical treatments such as subtotal colectomy and total colectomy in STC patients may adversely affect the quality of life due to the risk of postoperative diarrhea or incontinence, and result in a heavy healthcare burden

The enteric nervous system (ENS), located in the intestinal wall, regulates various functions including contraction of intestine, homeostasis and blood flow [10]. As the ‘second brain’, the ENS contains large amounts of neurons working independently from the central nervous system [11]. Researches have identified that STCs are mostly caused by disorders of the relevant nerves, especially the ENS [12,13].

McCallum et al. [35] found that gastric electrical stimulation in combination with pharmacological treatment could also enhance emptying in patients with gastroparesis. Especially, gastric electrical stimulation has been approved as a clinical therapy method for gastroparesis and obesity in European and American countries [36].

we employed pulse train stimulation and implanted electrodes at the proximal colon in dogs.

After CES treatment, we observed the colonic transit time of the sham treatment group was longer than that of CES treatment and control groups, and electrical stimulation significantly enhanced the colonic electromyogram (EMG) signal.

histopathology and TEM analysis showed increased ganglia and synaptic vesicles existing in the colon myenteric plexus of the CES treatment group as compared with that of the sham CES group

Our results suggested that CES might reduce the degeneration of the myenteric plexus neurons, thereby contributing to the therapeutic effect on STC beagles.

the defecating frequency and the feces characteristics of STC beagles returned to normal after CES treatment. The result indicated that CES could improve the symptoms of STC.

The colonic EMG signal was strongly promoted by CES

Especially, the colonic EMG signal of the beagles with STC was remarkably enhanced by CES (Figure 3), indicating that CES could not only improve the colonic content emptying, but also enhance the EMG signal to promote colonic motility.

Colonic electrical stimulation (CES), a valuable alternative for the treatment of STC, was reported to improve the colon motility by adjusting the bioelectrical activity in animal models or patients with STC [17]. However, little report focuses on the underlying nervous mechanism to normalize the delayed colonic emptying and relieve symptoms. We hypothesized that CES may also repair the disorders of the relevant nerves and then improve the colonic motility.

The first study regarding the CES to modulate colonic motility was performed by Hughes et al. [37]. Since then, many researchers employed short-pulse CES in canine descending colon or pig cecum [20,21,38]. Researchers also applied long-pulse CES to stimulate the colon of human or animals [39]

Recently, studies showed that the prokinetic effect of pulse train CES is better than that of short-pulse CES or long-pulse CES [25]

Our study indicated that CES could enhance the colonic motility, and then accelerate the colonic content emptying. Thereafter, we investigated the underlying mechanism and presumed that CES might improve the STC symptom through the repairment of the ENS.

The neuropathy in ENS is considered to be responsible for various kinds of disordered motility including STC and the related pathophysiologic symptoms [40]. In agreement with this view, our study discovered the decreased number of ganglia in the myenteric plexus, as well as the destruction of the enteric nerve axon terminals and synaptic vesicles in the sham CES group beagles

The present study proves that CES with pulse trains has curative effects on the colonic motility and content emptying in STC beagles. The up-regulation of intestinal nerve related proteins such as SYP, PGP9.5, CAD and S-100B in the colonic myenteric plexus suggests that CES might reduce the degeneration of the myenteric plexus neurons, thereby producing the therapeutic effect on STC beagles. Further investigation for the underlying mechanism of nerve regeneration is necessary to better understand how CES promotes the recovery of delayed colonic motility induced by STC.

Before the introduction of Botox and hyaluronic acid dermal fillers in 2002 and 2003, respectively, aesthetic work was serious, expensive. Nose jobs and face lifts required general anesthesia, not insignificant recovery time, and cost thousands of dollars (in 2000, a facelift was $5,416 on average, and a rhinoplasty $4,109, around $9,400 and $7,000 adjusted).

In contrast, the average price of a syringe of hyaluronic acid filler today is $684, while treating, for example, the forehead and eyes with Botox will put you out anywhere from $300 to $600

We copied the beautiful and the rich, not in facsimile, but in homage.

In 2018, use of Botox and fillers was up 18% and 20% from five years prior. Philosophies of prejuvenation have made Botox use jump 22% among 22- to 37-year-olds in half a decade as well. By 2030, global noninvasive aesthetic treatments are predicted to triple.

The trouble is that a status symbol, without status, is common.

Beauty has always been exclusive. When someone strikes you as pretty, it means they are something that everyone else is not.

It’s a zero-sum game, as relative as our morals. Naturally, we hoard of beauty what we can. It’s why we call grooming tips “secrets.”

Largely the secrets started with the wealthy, who possess the requisite money and leisure to spare on their appearances

Botox and filler only accelerated a trend that began in the ’70s and ’80s and is just now reaching its saturation point.

we didn’t have the tools for anything more than emulation. Fake breasts and overdrawn lips only approximated real ones; a birthmark drawn with pencil would always be just that.

Instagram Face, on the other hand, distinguishes itself by its sheer reproducibility. Not only because of those new cosmetic technologies, which can truly reshape features, at reasonable cost and with little risk.

built in to the whole premise of reversible, low-stakes modification is an indefinite flux, and thus a lack of discretion.

Instagram Face has replicated outward, with trendsetters giving up competing with one another in favor of looking eerily alike. And obviously it has replicated down.

Eva looks like Eva. If she has procedures in common with Kim K, you couldn’t tell. “I look at my features and I think long and hard of how I can, without looking different and while keeping as natural as possible, make them look better and more proportional. I’m against everything that is too invasive. My problem with Instagram Face is that if you want to look like someone else, you should be in therapy.”

natural looks have always been, and still are, more valuable than artificial ones. Partly because of our urge to legitimize in any way we can the advantages we have over other people. Hotness is a class struggle.

As more and more women post videos of themselves eating, sleeping, dressing, dancing, and Only-Fanning online, in a logical bid for economic ascendance, the women who haven’t needed to do that gain a new status symbol.

Privacy. A life which is not a ticketed show. An intimacy that does not admit advertisers. A face that does not broadcast its insecurity, or the work undergone to correct it.

Upper class, private women get discrete work done. The differences aren’t in the procedures themselves—they’re the same—but in disposition

Eva, who lives between central London, Geneva, and the south of France, says: “I do stuff, but none of the stuff I do is at all in my head associated with Instagram Face. Essentially you do similar procedures, but the end goal is completely different. Because they are trying to get the result of looking like another human being, and I’m just beautifying myself.”

But the more rapidly it replicates, and the clearer our manuals for quick imitation become, the closer we get to singularity—that moment Kim Kardashian fears unlike any other: the moment when it becomes unclear whether we’re copying her, or whether she is copying us.

what he restores is complicated and yet not complicated at all. It’s herself, the fingerprint of her features. Her aura, her presence and genealogy, her authenticity in space and time.

Dr. Taktouk’s approach is “not so formulaic.” He aims to give his patients the “better versions of themselves.” “It’s not about trying to be anyone else,” he says, “or creating a conveyor belt of patients. It’s about working with your best features, enhancing them, but still looking like you.”

“Vulgar” says that in pursuing indistinguishability, women have been duped into another punishing divide. “Vulgar” says that the subtlety of his work is what signals its special class—and that the women who’ve obtained Instagram Face for mobility’s sake have unwittingly shut themselves out of it.

While younger women are dissolving their gratuitous work, the 64-year-old Madonna appeared at the Grammy Awards in early February, looking so tragically unlike herself that the internet launched an immediate postmortem.

The folly of Instagram Face is that in pursuing a bionic ideal, it turns cosmetic technology away from not just the reality of class and power, but also the great, poignant, painful human project of trying to reverse time. It misses the point of what we find beautiful: that which is ephemeral, and can’t be reproduced

Age is just one of the hierarchies Instagram Face can’t topple, in the history of women striving versus the women already arrived. What exactly have they arrived at?

Youth, temporarily. Wealth. Emotional security. Privacy. Personal choices, like cosmetic decisions, which are not so public, and do not have to be defended as empowered, in the defeatist humiliation of our times

Maybe they’ve arrived at love, which for women has never been separate from the things I’ve already mentioned.

I can’t help but recall the time I was chatting with a plastic surgeon. I began to point to my features, my flaws. I asked her, “What would you do to me, if I were your patient?” I had many ideas. She gazed at me, and then noticed my ring. “Nothing,” she said. “You’re already married.”