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People who have type 2 diabetes are about twice as likely to get Alzheimer’s, and people who have diabetes and are treated with insulin are also more likely to get Alzheimer’s, suggesting elevated insulin plays a role in Alzheimer’s. In fact, many studies have found that elevated insulin, or “hyperinsulinemia,” significantly increases your risk of Alzheimer’s. On the other hand, people with type 1 diabetes, who don’t make insulin at all, are also thought to have a higher risk of Alzheimer’s. How could these both be true?

Schilling posits this happens because of the insulin-degrading enzyme, a product of insulin that breaks down both insulin and amyloid proteins in the brain—the same proteins that clump up and lead to Alzheimer’s disease. People who don’t have enough insulin, like those whose bodies’ ability to produce insulin has been tapped out by diabetes, aren’t going to make enough of this enzyme to break up those brain clumps. Meanwhile, in people who use insulin to treat their diabetes and end up with a surplus of insulin, most of this enzyme gets used up breaking that insulin down, leaving not enough enzyme to address those amyloid brain clumps.

this can happen even in people who don’t have diabetes yet—who are in a state known as “prediabetes.” It simply means your blood sugar is higher than normal, and it’s something that affects roughly 86 million Americans.

In a 2012 study, Roberts broke nearly 1,000 people down into four groups based on how much of their diet came from carbohydrates. The group that ate the most carbs had an 80 percent higher chance of developing mild cognitive impairment—a pit stop on the way to dementia—than those who ate the smallest amount of carbs.

“It’s hard to be sure at this stage, what an ‘ideal’ diet would look like,” she said. “There’s a suggestion that a Mediterranean diet, for example, may be good for brain health.”

there are several theories out there to explain the connection between high blood sugar and dementia. Diabetes can also weaken the blood vessels, which increases the likelihood that you’ll have ministrokes in the brain, causing various forms of dementia. A high intake of simple sugars can make cells, including those in the brain, insulin resistant, which could cause the brain cells to die. Meanwhile, eating too much in general can cause obesity. The extra fat in obese people releases cytokines, or inflammatory proteins that can also contribute to cognitive deterioration, Roberts said. In one study by Gottesman, obesity doubled a person’s risk of having elevated amyloid proteins in their brains later in life.

even people who don’t have any kind of diabetes should watch their sugar intake, she said.

as these and other researchers point out, decisions we make about food are one risk factor we can control. And it’s starting to look like decisions we make while we’re still relatively young can affect our future cognitive health.

“Alzheimer’s is like a slow-burning fire that you don’t see when it starts,” Schilling said. It takes time for clumps to form and for cognition to begin to deteriorate. “By the time you see the signs, it’s way too late to put out the fire.”

Some changes are hard, but the family is learning to love Greg as he is — not as he was yesterday, or as he might have been if he'd never gotten Alzheimer's.

"You're still funny," his son Conor told him recently. "You're slightly different, but you're still funny."

The cerebrum has two halves, or hemispheres, that are further divided into four regions, or lobes. The frontal lobes, located behind the forehead, are involved with speech, thought, learning, emotion, and movement.

Behind them are the parietal lobes, which process sensory information such as touch, temperature, and pain.

At the rear of the brain are the occipital lobes, dealing with vision

Lastly, there are the temporal lobes, near the temples, which are involved with hearing and memory.

The second-largest part of the brain is the cerebellum, which sits beneath the back of the cerebrum.

diencephalon, located in the core of the brain. A complex of structures roughly the size of an apricot, its two major sections are the thalamus and hypothalamus

The brain is extremely sensitive and delicate, and so it requires maximum protection, which is provided by the hard bone of the skull and three tough membranes called meninges.

Want more proof that the brain is extraordinary? Look no further than the blood-brain barrier.

This led scientists to learn that the brain has an ingenious, protective layer. Called the blood-brain barrier, it’s made up of special, tightly bound cells that together function as a kind of semi-permeable gate throughout most of the organ. It keeps the brain environment safe and stable by preventing some toxins, pathogens, and other harmful substances from entering the brain through the bloodstream, while simultaneously allowing oxygen and vital nutrients to pass through.

One in five Americans suffers from some form of neurological damage, a wide-ranging list that includes stroke, epilepsy, and cerebral palsy, as well as dementia.

Alzheimer’s disease, which is characterized in part by a gradual progression of short-term memory loss, disorientation, and mood swings, is the most common cause of dementia. It is the sixth leading cause of death in the United States

50 million people suffer from Alzheimer’s or some form of dementia. While there are a handful of drugs available to mitigate Alzheimer’s symptoms, there is no cure.

Unfortunately, negative attitudes toward people who suffer from mental illness are widespread. The stigma attached to mental illness can create feelings of shame, embarrassment, and rejection, causing many people to suffer in silence.

In the United States, where anxiety disorders are the most common forms of mental illness, only about 40 percent of sufferers receive treatment. Anxiety disorders often stem from abnormalities in the brain’s hippocampus and prefrontal cortex.

Attention-deficit/hyperactivity disorder, or ADHD, is a mental health condition that also affects adults but is far more often diagnosed in children.

ADHD is characterized by hyperactivity and an inability to stay focused.

Depression is another common mental health condition. It is the leading cause of disability worldwide and is often accompanied by anxiety. Depression can be marked by an array of symptoms, including persistent sadness, irritability, and changes in appetite.

The good news is that in general, anxiety and depression are highly treatable through various medications—which help the brain use certain chemicals more efficiently—and through forms of therapy

In other words, welcome to the club: If you plan to live a long time, then you, too, belong to the high-risk group. Now what are you going to do about it?

This kind of modeling is already in use to study individual cellular processes like metabolism. But Dr. Covert said: “Where I think our work is different is that we explicitly include all of the genes and every known gene function. There’s no one else out there who has been able to include more than a handful of functions or more than, say, one-third of the genes.”

The simulation, which runs on a cluster of 128 computers, models the complete life span of the cell at the molecular level, charting the interactions of 28 categories of molecules — including DNA, RNA, proteins and small molecules known as metabolites, which are generated by cell processes.

They called the simulation an important advance in the new field of computational biology, which has recently yielded such achievements as the creation of a synthetic life form — an entire bacterial genome created by a team led by the genome pioneer J. Craig Venter. The scientists used it to take over an existing cell.

A decade ago, scientists developed simulations of metabolism that are now being used to study a wide array of cells, including bacteria, yeast and photosynthetic organisms. Other models exist for processes like protein synthesis.

“Right now, running a simulation for a single cell to divide only one time takes around 10 hours and generates half a gigabyte of data,” Dr. Covert wrote. “I find this fact completely fascinating, because I don’t know that anyone has ever asked how much data a living thing truly holds. We often think of the DNA as the storage medium, but clearly there is more to it than that.”

scientists chose an approach called object-oriented programming, which parallels the design of modern software systems. Software designers organize their programs in modules, which communicate with one another by passing data and instructions back and forth.

“The major modeling insight we had a few years ago was to break up the functionality of the cell into subgroups, which we could model individually, each with its own mathematics, and then to integrate these submodels together into a whole,”

In stage 1, they submit the introduction, methods, proposed analysis, and if necessary, pilot data. This manuscript then goes through the usual peer review process, and is assessed on criteria such as the soundness of the methods and analysis, and overall plausibility of the stated hypotheses.

Once researchers have passed through stage 1, they can then move on to data collection. In stage 2, they then submit the full manuscript – the introduction and agreed methods from stage 1, plus results and discussion sections. The results must include the outcome of the analyses agreed in stage 1, but the researchers are allowed to include additional analyses in a separate, ‘exploratory’ section (as long as they are justified).

Pre-registering scientific articles in this way helps to protect against a number of undesirable practices (such as p-hacking and HARKing) that can exaggerate statistical findings and make non-existent effects seem real. While this is a problem across psychology generally, it is a particularly extreme problem for violent video game research.

By outlining the intended methods and analysis protocols beforehand, Registered Reports protect against these problems, as the review process concentrates on the robustness of the proposed methods. And Registered Reports offer an additional advantage: because manuscripts are never accepted based on the outcome of the data analysis, the process is immune to researcher party lines. It doesn’t matter which research ‘camp’ you are in; your data – and just as importantly, your methods - will speak for themselves.

Poor sleep may be contributing to the buildup of the brain plaques that drive the disease

“Sleep is a great early warning beacon, a distress call that we can latch onto, to potentially alert us to the beginnings of Alzheimer’s,” says Walker.

Meanwhile, the Office of National Statistics in the UK has found that rates of depression have doubled. Both depression and anxiety are known to have an impact on memory.

Although levels of anxiety peaked when lockdown started and have gradually reduced, average levels have remained higher than in usual times, especially in people who are young, living alone, living with children, living on a low income or in urban areas

Repetition of stories helps us to consolidate our memories of what happened to us – so-called episodic memories. If we can’t socialise as much, perhaps it’s not surprising that those memories don’t feel as crystal clear as usual.

This is all made more difficult by a lack of cues to aid our memories. If you go out to work then your journey, the change of scenery and breaks you take punctuate the day, giving you time points to anchor your memorie

Then there’s a general fatigue, which also doesn’t help our memories. Zoom meetings are tiring, some work is much harder from home and holidays are getting cancelled. A lack of routine and anxiety about the pandemic can disturb our sleep. Put all that together – basically we’re consistently tired.

So with the combination of fatigue, anxiety, a lack of cues, and fewer social interactions, it’s no wonder that some of us feel our memories are letting us down.

The good news is that there are things we can do about it. Going for a walk, especially along unfamiliar streets, will bring your brain back to attention

Making sure the weekdays and the weekends are different enough not to merge into one can help with the distortions our new life can have on our perception of time.

When we learn something—even as simple as someone’s name—we form connections between neurons in the brain. These synapses create new circuits between nerve cells, essentially remapping the brain.

The sheer number of possible connections gives the brain unfathomable flexibility—each of the brain’s 100 billion nerve cells can have 10,000 connections to other nerve cells.

Huganir and his team discovered that when mice are exposed to traumatic events, the level of neuronal receptors for glutamate increases at synapses in the amygdala, the fear center of the brain, and encodes the fear associated with the memory. Removing those receptors, however, reduces the strength of these connections, essentially erasing the fear component of the trauma but leaving the memory.

Now Huganir and his lab are developing drugs that target those receptors. The hope is that inactivating the receptors could help people with post-traumatic stress syndrome by reducing the fear associated with a traumatic memory, while strengthening them could improve learning, particularly in people with cognitive dysfunction or Alzheimer’s disease.

Dementia (di-men-sha): A loss of brain function that can be caused by a variety of disorders affecting the brain. Symptoms include forgetfulness, impaired thinking and judgment, personality changes, agitation and loss of emotional control. Alzheimer’s disease, Huntington’s disease and inadequate blood flow to the brain can all cause dementia. Most types of dementia are irreversible.

Post-traumatic stress disorder (PTSD): A disorder in which your “fight or flight,” or stress, response stays switched on, even when you have nothing to flee or battle. The disorder usually develops after an emotional or physical trauma, such as a mugging, physical abuse or a natural disaster. Symptoms include nightmares, insomnia, angry outbursts, emotional numbness, and physical and emotional tension.