For instance, if adenosine puts us under at the moment of transition from wakefulness to sleep, where does it come from? “Nobody knows,” remarks Michael Lazarus, a researcher at the institute who studies adenosine. Some people say it’s coming from neurons, some say it’s another class of brain cells. But there isn’t a consensus. At any rate, “this isn’t about storage,” says Yanagisawa. In other words, these substances themselves don’t seem to store information about sleep pressure. They are just a response to it.