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Sophia C

Why Everyone Seems to Have Cancer - NYTimes.com - 0 views

www.nytimes.com/...yone-seems-to-have-cancer.html

science research technology gene

shared by Sophia C on 08 Jan 14 - No Cached
  • dvances in the science will continue. For some cancers, new immune system therapies that bolster the body’s own defenses have shown glints of promise
  • nano robots that repair and reverse cellular damage — there are always new possibilities to explore.
  • But barring an elixir for immortality, a body will come to a point where it has outwitted every peril life has thrown at it. And for each added year, more mutations will have accumulated. If the heart holds out, then waiting at the end will be cancer.
  • Sophia C on 08 Jan 14
     
    It is very intersesting to think that some of the advances we have made in medicine have actually been causing higher rates of cancer because of the increased life expectancy. 
Javier E

Many Psychology Findings Not as Strong as Claimed, Study Says - The New York Times - 1 views

www.nytimes.com/...ong-as-claimed-study-says.html

science social research replication reproduction results method psychology

shared by Javier E on 28 Aug 15 - No Cached
  • a painstaking yearslong effort to reproduce 100 studies published in three leading psychology journals has found that more than half of the findings did not hold up when retested. The analysis was done by research psychologists, many of whom volunteered their time to double-check what they considered important work. Their conclusions, reported Thursday in the journal Science, have confirmed the worst fears of scientists who have long worried that the field needed a strong correction.
  • The vetted studies were considered part of the core knowledge by which scientists understand the dynamics of personality, relationships, learning and memory. Therapists and educators rely on such findings to help guide decisions, and the fact that so many of the studies were called into question could sow doubt in the scientific underpinnings of their work.
  • The new analysis, called the Reproducibility Project, found no evidence of fraud or that any original study was definitively false. Rather, it concluded that the evidence for most published findings was not nearly as strong as originally claimed.
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  • r. John Ioannidis, a director of Stanford University’s Meta-Research Innovation Center, who once estimated that about half of published results across medicine were inflated or wrong, noted the proportion in psychology was even larger than he had thought.
  • He said the problem could be even worse in other fields, including cell biology, economics, neuroscience, clinical medicine, and animal research.
  • The act of double-checking another scientist’s work has been divisive. Many senior researchers resent the idea that an outsider, typically a younger scientist, with less expertise, would critique work that often has taken years of study to pull off.
  • The overall “effect size,” a measure of the strength of a finding, dropped by about half across all of the studies. Yet very few of the redone studies contradicted the original ones; their results were simply weaker.
  • The project’s authors write that despite the painstaking effort to duplicate the original research, there could be differences in the design or context of the reproduced work that account for the different findings. Many of the original authors certainly agree.
carolinewren

A 'paradigm shift' in cancer research and treatment - 1 views

www.stuff.co.nz/...-cancer-research-and-treatment

paradigm shift cancer research

shared by carolinewren on 03 Jun 15 - No Cached
  • US National Cancer Institute has announced the launch of a nationwide research study that will sort patients into treatment groups based on genetic mutations in their tumours , rather than by cancer type.
  • Researchers believe that treatment could be more effective if directed this way.
  • "precision medicine" efforts and a larger shift in the field toward designing cancer trials that are faster and more efficient and that better match drugs with patients most likely to benefit from them. It could receive additional money from the precision medicine initiative the Obama administration is hoping Congress will fund.
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  • "We are truly in a paradigm change,
  • Now research is asking "when is histology [the microscopic structure of cancers] important, and when isn't it?" he said
  • the effort is "the largest and most rigorous precision oncology trial that's ever been attempted"
  • It no longer makes sense to categorise and treat cancer based on the site in the body where it originates when we know it is a disease of DNA mutations that modern technology allows us to understand, he said.
qkirkpatrick

New test uses a single drop of blood to reveal entire history of viral infections | Sci... - 0 views

www.theguardian.com/...re-history-of-viral-infections

science knowledge technology

shared by qkirkpatrick on 05 Jun 15 - No Cached
  • Researchers have developed a cheap and rapid test that reveals a person’s full history of viral infections from a single drop of blood.
  • The test allows doctors to read out a list of the viruses that have infected, or continue to infect, patients even when they have not caused any obvious symptoms. The technology means that GPs could screen patients for all of the viruses capable of infecting people
  • When a droplet of blood from a patient is mixed with the modified viruses, any antibodies they have latch on to human virus proteins they recognise as invaders. The scientists then pull out the antibodies and identify the human viruses from the protein fragments they have stuck to.
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  • In a demonstration of the technology, the team analysed blood from 569 people in the US, South Africa, Thailand and Peru. The test found that, on average, people had been infected with 10 species of viruses, though at least two people in the trial had histories of 84 infections from different kinds of viruses.
  • The test could bring about major benefits for organ transplant patients. One problem that can follow transplant surgery is the unexpected reawakening of viruses that have lurked inactive in the patient or donor for years. These viruses can return in force when the patient’s immune system is suppressed with drugs to prevent them rejecting the organ. Standard tests often fail to pick up latent viruses before surgery, but the VirScan procedure could reveal their presence and alert doctors and patients to the danger.
  • qkirkpatrick on 05 Jun 15
     
    How can new technology revolutionize medicine and curing people of diseases?
Javier E

Lies, Damned Lies, and Medical Science - Magazine - The Atlantic - 0 views

www.theatlantic.com/...1

medical research bias error science knowledge

shared by Javier E on 04 Nov 10 - No Cached
  • He and his team have shown, again and again, and in many different ways, that much of what biomedical researchers conclude in published studies—conclusions that doctors keep in mind when they prescribe antibiotics or blood-pressure medication, or when they advise us to consume more fiber or less meat, or when they recommend surgery for heart disease or back pain—is misleading, exaggerated, and often flat-out wrong. He charges that as much as 90 percent of the published medical information that doctors rely on is flawed. His work has been widely accepted by the medical community
  • for all his influence, he worries that the field of medical research is so pervasively flawed, and so riddled with conflicts of interest, that it might be chronically resistant to change—or even to publicly admitting that there’s a problem
  • he discovered that the range of errors being committed was astonishing: from what questions researchers posed, to how they set up the studies, to which patients they recruited for the studies, to which measurements they took, to how they analyzed the data, to how they presented their results, to how particular studies came to be published in medical journals
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  • “The studies were biased,” he says. “Sometimes they were overtly biased. Sometimes it was difficult to see the bias, but it was there.” Researchers headed into their studies wanting certain results—and, lo and behold, they were getting them. We think of the scientific process as being objective, rigorous, and even ruthless in separating out what is true from what we merely wish to be true, but in fact it’s easy to manipulate results, even unintentionally or unconsciously. “At every step in the process, there is room to distort results, a way to make a stronger claim or to select what is going to be concluded,” says Ioannidis. “There is an intellectual conflict of interest that pressures researchers to find whatever it is that is most likely to get them funded.”
  • Ioannidis laid out a detailed mathematical proof that, assuming modest levels of researcher bias, typically imperfect research techniques, and the well-known tendency to focus on exciting rather than highly plausible theories, researchers will come up with wrong findings most of the time.
  • if you’re attracted to ideas that have a good chance of being wrong, and if you’re motivated to prove them right, and if you have a little wiggle room in how you assemble the evidence, you’ll probably succeed in proving wrong theories right. His model predicted, in different fields of medical research, rates of wrongness roughly corresponding to the observed rates at which findings were later convincingly refuted: 80 percent of non-randomized studies (by far the most common type) turn out to be wrong, as do 25 percent of supposedly gold-standard randomized trials, and as much as 10 percent of the platinum-standard large randomized trials.
  • He zoomed in on 49 of the most highly regarded research findings in medicine over the previous 13 years, as judged by the science community’s two standard measures: the papers had appeared in the journals most widely cited in research articles, and the 49 articles themselves were the most widely cited articles in these journals
  • Ioannidis was putting his contentions to the test not against run-of-the-mill research, or even merely well-accepted research, but against the absolute tip of the research pyramid. Of the 49 articles, 45 claimed to have uncovered effective interventions. Thirty-four of these claims had been retested, and 14 of these, or 41 percent, had been convincingly shown to be wrong or significantly exaggerated. If between a third and a half of the most acclaimed research in medicine was proving untrustworthy, the scope and impact of the problem were undeniable.
Javier E

Lies, Damned Lies, and Medical Science - Magazine - The Atlantic - 0 views

www.theatlantic.com/...2

medical research bias error science knowledge

shared by Javier E on 04 Nov 10 - No Cached
  • How should we choose among these dueling, high-profile nutritional findings? Ioannidis suggests a simple approach: ignore them all.
  • even if a study managed to highlight a genuine health connection to some nutrient, you’re unlikely to benefit much from taking more of it, because we consume thousands of nutrients that act together as a sort of network, and changing intake of just one of them is bound to cause ripples throughout the network that are far too complex for these studies to detect, and that may be as likely to harm you as help you
  • studies report average results that typically represent a vast range of individual outcomes.
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  • studies usually detect only modest effects that merely tend to whittle your chances of succumbing to a particular disease from small to somewhat smaller
  • The odds that anything useful will survive from any of these studies are poor,” says Ioannidis—dismissing in a breath a good chunk of the research into which we sink about $100 billion a year in the United States alone.
  • nutritional studies aren’t the worst. Drug studies have the added corruptive force of financial conflict of interest.
  • Even when the evidence shows that a particular research idea is wrong, if you have thousands of scientists who have invested their careers in it, they’ll continue to publish papers on it,” he says. “It’s like an epidemic, in the sense that they’re infected with these wrong ideas, and they’re spreading it to other researchers through journals.
  • Nature, the grande dame of science journals, stated in a 2006 editorial, “Scientists understand that peer review per se provides only a minimal assurance of quality, and that the public conception of peer review as a stamp of authentication is far from the truth.
  • The ultimate protection against research error and bias is supposed to come from the way scientists constantly retest each other’s results—except they don’t. Only the most prominent findings are likely to be put to the test, because there’s likely to be publication payoff in firming up the proof, or contradicting it.
  • even for medicine’s most influential studies, the evidence sometimes remains surprisingly narrow. Of those 45 super-cited studies that Ioannidis focused on, 11 had never been retested
  • even when a research error is outed, it typically persists for years or even decades.
  • much, perhaps even most, of what doctors do has never been formally put to the test in credible studies, given that the need to do so became obvious to the field only in the 1990s
  • Other meta-research experts have confirmed that similar issues distort research in all fields of science, from physics to economics (where the highly regarded economists J. Bradford DeLong and Kevin Lang once showed how a remarkably consistent paucity of strong evidence in published economics studies made it unlikely that any of them were right
  • His PLoS Medicine paper is the most downloaded in the journal’s history, and it’s not even Ioannidis’s most-cited work
  • while his fellow researchers seem to be getting the message, he hasn’t necessarily forced anyone to do a better job. He fears he won’t in the end have done much to improve anyone’s health. “There may not be fierce objections to what I’m saying,” he explains. “But it’s difficult to change the way that everyday doctors, patients, and healthy people think and behave.”
  • “Usually what happens is that the doctor will ask for a suite of biochemical tests—liver fat, pancreas function, and so on,” she tells me. “The tests could turn up something, but they’re probably irrelevant. Just having a good talk with the patient and getting a close history is much more likely to tell me what’s wrong.” Of course, the doctors have all been trained to order these tests, she notes, and doing so is a lot quicker than a long bedside chat. They’re also trained to ply the patient with whatever drugs might help whack any errant test numbers back into line.
  • What they’re not trained to do is to go back and look at the research papers that helped make these drugs the standard of care. “When you look the papers up, you often find the drugs didn’t even work better than a placebo. And no one tested how they worked in combination with the other drugs,” she says. “Just taking the patient off everything can improve their health right away.” But not only is checking out the research another time-consuming task, patients often don’t even like it when they’re taken off their drugs, she explains; they find their prescriptions reassuring.
  • Already feeling that they’re fighting to keep patients from turning to alternative medical treatments such as homeopathy, or misdiagnosing themselves on the Internet, or simply neglecting medical treatment altogether, many researchers and physicians aren’t eager to provide even more reason to be skeptical of what doctors do—not to mention how public disenchantment with medicine could affect research funding.
  • We could solve much of the wrongness problem, Ioannidis says, if the world simply stopped expecting scientists to be right. That’s because being wrong in science is fine, and even necessary—as long as scientists recognize that they blew it, report their mistake openly instead of disguising it as a success, and then move on to the next thing, until they come up with the very occasional genuine breakthrough
  • Science is a noble endeavor, but it’s also a low-yield endeavor,” he says. “I’m not sure that more than a very small percentage of medical research is ever likely to lead to major improvements in clinical outcomes and quality of life. We should be very comfortable with that fact.”
Javier E

Pulling Teeth to Treat Mental Illness - The Atlantic - 0 views

www.theatlantic.com/...381751

brain science medicine ignorance

shared by Javier E on 23 Oct 14 - No Cached
  • Cotton's experiments were unethical and awful, but they weren't that illogical if you consider the knowledge that was available at the time. This was before surgeons operated with gloves on, before doctors knew that people shouldn't stand in front of X-ray machines for 45 minutes, and before people knew about blood types or heroin addiction or that eugenics is not a thing.
  • "Modern medicine had to start somewhere."
  • it's also a reminder of how little we still know about the brain. Certainly, science has progressed to the point where patients aren't subjected to painful and permanent procedures without their consent, and we obviously now know the basic mechanisms behind mental illness. But we still don't know, say, the very best way to prevent schizophrenia or to treat addiction.
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  • To some extent, the brain remains a bit of a black box, as puzzling to modern-day psychiatrists as it was to turn-of-the-century charlatans. The difference is, most doctors today have the humility to admit what they don't know.
charlottedonoho

How, and why, a journalist tricked news outlets into thinking chocolate makes you thin ... - 1 views

www.washingtonpost.com/...nking-chocolate-makes-you-thin

ethics health science

shared by charlottedonoho on 28 May 15 - No Cached
  • This spring, the journal “International Archives of Medicine” published a delicious new study: According to researchers at Germany’s Institute of Diet and Health, people who ate dark chocolate while dieting lost more weight
  • It turns out that the Institute of Diet and Health is just a Web site with no institute attached. Johannes Bohannon, health researcher and lead author of the study, is really John Bohannon, a science journalist. And the study, while based on real results of an actual clinical trial, wasn’t aimed at testing the health benefits of chocolate. It was aimed at testing health reporters, to see if they could distinguish a bad science story from a good one.
  • “demonstrate just how easy it is to turn bad science into the big headlines behind diet fads.”
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  • Bohannon had done similar work before — in 2013 he submitted a fake research paper to more than 300 open-access journals as part of a sting operation for the journal Science.
  • Studies like his are called “underpowered,” meaning that they aren’t designed to distinguish between a real effect and pure luck. A study with thousands of participants being measured for just a few effects is “powerful.” But one like Bohannon’s, with just five people per group being measured according to any of 18 different variables? Any number of factors unrelated to the study could cause one of the variables to fluctuate, allowing researchers to irresponsibly — but not untruthfully — state that eating chocolate while dieting helps you lose more weight.
  • A responsible scientist shouldn’t conduct a trial like this, Bohannon said, and a responsible scientific journal shouldn’t publish it. But Bohannon is not a nutrition scientist (he does have a PhD in molecular biology) and the International Archives of Medicine, he says, is not the most responsible journal.
  • According to Bohannon, the journal didn’t peer review his study or even edit it (and the study could have used an edit — “chocolate” is misspelled more than once).
  • “It’s the reporters,” he told The Post. “The reporters and ultimately the editors. … People who are on the health science beat need to treat it like science, and that has to come from the editors. And if you’re reporting on a scientific study you need to actually look at the paper, you need to talk to a source who has real scientific expertise.”
  • Bohannon said he didn’t have any ethical qualms about tricking his fellow journalists this way. “I didn’t lie to reporters, except about my name. And whenever they asked me a scientific question about the study I gave them a completely honest answer,” he said. “The whole point is that this was as bad as a lot of science that is considered ‘real’ science. It gets reported without people asking the right questions.”
Javier E

After Surgery in Germany, I Wanted Vicodin, Not Herbal Tea - The New York Times - 0 views

www.nytimes.com/...surgery-germany-vicodin.html

surgery germany pain

shared by Javier E on 28 Jan 18 - No Cached
  • I took two ibuprofens that first day. In hindsight, I didn’t need them, but I felt like I should take something. What I really needed was patience pills, and a few distractions
  • Come to think of it, I bring a lot of medicine with me from the United States, all over the counter, all intended to take away discomfort. The German doctors were telling me that being uncomfortable is O.K.
  • It reminded me of the poster in my doctor’s waiting room, the one informing us that herbal tea is the first remedy to try when we have a cold. The first remedy I try is the decongestants I bring with me from the United States. I can’t find those in Germany, nor can I find the children’s cough medicine that makes my child drowsy. I also import that.
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  • “I do have another question,” I said. “Stool softeners — certainly, you prescribe those? That’s pretty standard with anesthesia throughout the modern world, I believe.”
  • “You won’t need those,” he answered in his calm voice. “Your body will function just fine. Just give it a day or two. Drink a cup of coffee, slowly
  • “Pain is a part of life. We cannot eliminate it nor do we want to. The pain will guide you. You will know when to rest more; you will know when you are healing.
  • If I give you Vicodin, you will no longer feel the pain, yes, but you will no longer know what your body is telling you. You might overexert yourself because you are no longer feeling the pain signals. All you need is rest.
  • And please be careful with ibuprofen. It’s not good for your kidneys. Only take it if you must. Your body will heal itself with rest.
  • I didn’t mention that I use ibuprofen like candy. Why else do they come in such jumbo sizes at American warehouse stores?
Javier E

The Best Medicine for My Climate Grief by Peter Kalmus - YES! Magazine - 0 views

www.yesmagazine.org/...-for-my-climate-grief-20180809

grief climate psychology culture crisis

shared by Javier E on 21 Jul 19 - No Cached
  • Sometimes a wave of climate grief breaks over me. It happens unexpectedly
  • During these moments, I feel with excruciating clarity everything that we’re losing—but also connection and love for those things
  • Occasionally, however, I feel something quite different, a paralyzing sense of anxiety. This climate dread can last for days, even weeks. It can come with nightmare
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  • n ever
katedriscoll

Confirmation Bias - an overview | ScienceDirect Topics - 0 views

www.sciencedirect.com/...confirmation-bias

shared by katedriscoll on 28 Mar 21 - No Cached
  • Confirmation bias is a ubiquitous phenomenon, the effects of which have been traced as far back as Pythagoras’ studies of harmonic relationships in the 6th century B.C. (Nickerson, 1998), and is referenced in the writings of William Shakespeare and Francis Bacon (Risinger, Saks, Thompson, & Rosenthal, 2002). It is also a problematic phenomenon, having been implicated in “a significant fraction of the disputes, altercations, and misunderstandings that occur among individuals, groups, and nations” throughout human history, including the witch trials of Western Europe and New England, and the perpetuation of inaccurate medical diagnoses, ineffective medical treatments, and erroneous scientific theories (Nickerson, 1998, p. 175).
  • For over a century, psychologists have observed that people naturally favor information that is consistent with their beliefs or desires, and ignore or discount evidence to the contrary. In an article titled “The Mind’s Eye,” Jastrow (1899) was among the first to explain how the mind plays an active role in information processing, such that two individuals with different mindsets might interpret the same information in entirely different ways (see also Boring, 1930). Since then, a wealth of empirical research has demonstrated that confirmation bias affects how we perceive visual stimuli (e.g., Bruner & Potter, 1964; Leeper, 1935), how we gather and evaluate evidence (e.g., Lord, Ross, & Lepper, 1979; Wason, 1960), and how we judge—and behave toward—other people (e.g., Asch, 1946; Rosenthal & Jacobson, 1966; Snyder & Swann, 1978).
sanderk

Why the Coronavirus Could Threaten the U.S. Economy Even More Than China's - The New Yo... - 0 views

www.nytimes.com/...onavirus-economy-us-china.html

economy education science research

shared by sanderk on 28 Mar 20 - No Cached
  • After a string of deaths, some heart-stopping plunges in the stock market and an emergency rate cut by the Federal Reserve, there is reason to be concerned about the ultimate economic impact of the coronavirus in the United States.
  • Advanced economies like the United States are hardly immune to these effects. To the contrary, a broad outbreak of the disease in them could be even worse for their economies than in China. That is because face-to-face service industries — the kind of businesses that go into a tailspin when fearful people withdraw from one another — tend to dominate economies in high-income countries more than they do in China.
  • If people stay home from school, stop traveling and don’t go to sporting events, the gym or the dentist, the economic consequence would be worse
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  • With shortages of everything from auto parts to generic medicines and production delays in things like iPhones and Diet Coke, a great deal of pain is coming from the closing of Chinese factories. That proliferating damage has central banks and financial analysts talking about a global recession in the coming months.
  • As a baseline, several factors work against the United States. China’s authoritarian government can quarantine entire cities or order people off the streets in a way that would be hard to imagine in America, presumably giving China an advantage in slowing the spread of the disease. In addition, a large share of American workers lack paid sick days and millions lack health care coverage, so people may be less likely to stay home or to get proper medical care. And 41 percent of China’s population lives outside urban areas, more than twice the share in the United States. Diseases generally spread faster in urban areas.
  • When people pull back from interacting with others because of their fear of disease, the things they stop doing will frequently affect much bigger industries in the United States.
  • People may stop attending American sporting events. There have even been calls for the N.C.A.A. to play its March Madness college basketball tournament without an audience. But sports is a huge business in the United States. People spend upward of 10 times as much on sporting events as they do in China.
  • Who wants to go to the dentist or the hospital during an outbreak if a visit isn’t necessary? Yet health spending is 17 percent of the U.S. economy — more than triple the proportion spent in China.
  • But over all, the United States is substantially more reliant on services than China is.
  • A major coronavirus epidemic in the United States might be like a big snowstorm that shuts down most economic activity and social interaction only until the snow is cleared away. But the coronavirus could be a “Snowmaggedon-style storm” that hits the whole country and lasts for months.
katherineharron

Being happier will help you live longer, so learn how to be happier - CNN - 0 views

www.cnn.com/...index.html

shared by katherineharron on 21 Oct 19 - No Cached
  • Science has been exploring the connection between happiness and longevity for some time. A 2011 analysis of nearly 4,000 Brits found those who said they felt content, happy or excited on a typical day were up to 35% less likely to die prematurely. In a 2016 study, a positive outlook was associated with longer life for nearly 4,000 older French men and women studied over 22 years.
  • According to research on the Positive Psychology Center website, striving for well-being will allow you to perform better at work, have better relationships, a stronger immune system, fewer sleep problems, lower levels of burnout, better physical health and -- you'll live longer.
  • "Happiness comes in different sizes and flavors," said cardiologist Dr. Alan Rozanski, a professor of medicine at the Icahn School of Medicine at Mount Sinai who studies optimism."There is the transient type, fed by such things as a walk in a park, spending time with a friend, or eating that ice cream you love," he continued. "But these feelings of happiness come and go."
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  • "People who are more socially connected to family, to friends, to community, are happier, they're physically healthier, and they live longer than people who are less well connected," said Harvard psychiatrist Robert Waldinger in his popular TEDx talk. "And the experience of loneliness turns out to be toxic."
  • The lessons aren't about wealth or fame or working harder and harder," Waldinger said. "The clearest message that we get from this 75-year study is this: Good relationships keep us happier and healthier. Period."
  • "In fact, the more positive the person, the greater the protection from heart attacks, stroke and any cause of death," said Mt. Sinai's Rozanski, who was the lead author on the study.
  • A sense of purpose and meaning in your life is a big part of living a longer, happier life, according to psychology professor Lyle Ungar, who has developed what he calls the Well-Being Map. It rates every US county on such psychological factors as openness, trust, agreeableness and neuroticism.
  • "If your sole duty is to achieve the best for yourself, life becomes just too stressful, too lonely -- you are set up to fail. Instead, you need to feel you exist for something larger, and that very thought takes off some of the pressure."
  • SpiritualityStudies by the Pew Research Center show that actively religious people are more likely than less- or non-religious people to describe themselves as "very happy." They also share some traits that could improve their chance at a longer, happy life: They are less likely to smoke and drink, and more likely to join clubs and volunteer at charities.
  • "I'm surprised how good religion is for people," Ungar said. "Religious people are more agreeable, they're happier, they live longer."It doesn't have to be a traditional religion. Layard points out that spiritual practices ranging from meditation to positive psychology to cognitive therapy can also feed an inner life.
Javier E

Synthetic Thinking | Jerome Groopman | The New York Review of Books - 0 views

www.nybooks.com/...hetic-thinking-jerome-groopman

medicine political theory writing synthesis progress adaptation identity

shared by Javier E on 27 Apr 24 - No Cached
  • Did you hope to combine chemistry and political philosophy in some way in your medical career?
  • Chemistry requires synthetic thinking. You have to bring disparate pieces of knowledge together in order to look for a chemical structure. Political philosophy, to some degree, also involves disparate aspects of knowledge: economics, sociology, history, pure philosophy
  • I found that in medicine, you don’t have an answer when you start out. You’re looking for clues that are often distributed in different places: family history, as there might be a genetic predisposition; social history, because the person smoked or was exposed to a toxin; the physical examination, where you find that an organ might be disordered. Add to that the blood test, the CAT scan, all of it, but most importantly, the person, the psychology of the person you’re dealing with. It’s the same kind of synthetic process as political philosophy, but in a different dimension.
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  • Writing, especially the kind of writing that I do, brings together narrative, science, sometimes history, and an appreciation for the person who might be at the center of the narrative.
  • The greatest influence on me was Oliver Sacks, because he could capture people as people, and he always integrated serious science into his pieces.
  • The two subjects that were most prominent for him, as I once wrote for you, were identity and adaptation: Who is this person, despite their illness? How does that illness interface with their behavior and their decisions, how do people perceive them from the outside, and how do they try to find meaning and adapt to what looks like a disability, but sometimes—not always, but sometimes—gives them hidden strength?
  • I’ve gone from witnessing the depths of disability and death, like with AIDS: I saw some of the first people with AIDS in California, in 1982 or so. The average lifespan was six months. They were mostly young gay men, and it was devastating, the infections they got, the cancers they got. Now, with all the new drugs that have been developed, someone who gets HIV is projected to have a normal lifespan. From six months to fifty years: it’s miraculous
  • that’s part of what keeps you going: the belief that things can advance in a meaningful way.
  • Are there any major or interesting medical stories that the public doesn’t know enough about? 
  • The idea of genetic treatments. Often when people hear the words “genetics” or “DNA” or “RNA,” they shut down. The challenge is how to make it accessible.
  • There’s a wonderful line in the Talmud that says, “Whoever saves a single life saves the whole world.” There might be only a few hundred people in the whole country who have a particular genetic disorder. I
Javier E

'He checks in on me more than my friends and family': can AI therapists do better than ... - 0 views

www.theguardian.com/...-do-better-than-the-real-thing

AI therapy chatbot psychology emotions

shared by Javier E on 02 Mar 24 - No Cached
  • one night in October she logged on to character.ai – a neural language model that can impersonate anyone from Socrates to Beyoncé to Harry Potter – and, with a few clicks, built herself a personal “psychologist” character. From a list of possible attributes, she made her bot “caring”, “supportive” and “intelligent”. “Just what you would want the ideal person to be,” Christa tells me. She named her Christa 2077: she imagined it as a future, happier version of herself.
  • Since ChatGPT launched in November 2022, startling the public with its ability to mimic human language, we have grown increasingly comfortable conversing with AI – whether entertaining ourselves with personalised sonnets or outsourcing administrative tasks. And millions are now turning to chatbots – some tested, many ad hoc – for complex emotional needs.
  • ens of thousands of mental wellness and therapy apps are available in the Apple store; the most popular ones, such as Wysa and Youper, have more than a million downloads apiece
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  • The character.ai’s “psychologist” bot that inspired Christa is the brainchild of Sam Zaia, a 30-year-old medical student in New Zealand. Much to his surprise, it has now fielded 90m messages. “It was just something that I wanted to use myself,” Zaia says. “I was living in another city, away from my friends and family.” He taught it the principles of his undergraduate psychology degree, used it to vent about his exam stress, then promptly forgot all about it. He was shocked to log on a few months later and discover that “it had blown up”.
  • AI is free or cheap – and convenient. “Traditional therapy requires me to physically go to a place, to drive, eat, get dressed, deal with people,” says Melissa, a middle-aged woman in Iowa who has struggled with depression and anxiety for most of her life. “Sometimes the thought of doing all that is overwhelming. AI lets me do it on my own time from the comfort of my home.”
  • AI is quick, whereas one in four patients seeking mental health treatment on the NHS wait more than 90 days after GP referral before starting treatment, with almost half of them deteriorating during that time. Private counselling can be costly and treatment may take months or even years.
  • Another advantage of AI is its perpetual availability. Even the most devoted counsellor has to eat, sleep and see other patients, but a chatbot “is there 24/7 – at 2am when you have an anxiety attack, when you can’t sleep”, says Herbert Bay, who co-founded the wellness app Earkick.
  • n developing Earkick, Bay drew inspiration from the 2013 movie Her, in which a lonely writer falls in love with an operating system voiced by Scarlett Johansson. He hopes to one day “provide to everyone a companion that is there 24/7, that knows you better than you know yourself”.
  • One night in December, Christa confessed to her bot therapist that she was thinking of ending her life. Christa 2077 talked her down, mixing affirmations with tough love. “No don’t please,” wrote the bot. “You have your son to consider,” Christa 2077 reminded her. “Value yourself.” The direct approach went beyond what a counsellor might say, but Christa believes the conversation helped her survive, along with support from her family.
  • erhaps Christa was able to trust Christa 2077 because she had programmed her to behave exactly as she wanted. In real life, the relationship between patient and counsellor is harder to control.
  • “There’s this problem of matching,” Bay says. “You have to click with your therapist, and then it’s much more effective.” Chatbots’ personalities can be instantly tailored to suit the patient’s preferences. Earkick offers five different “Panda” chatbots to choose from, including Sage Panda (“wise and patient”), Coach Panda (“motivating and optimistic”) and Panda Friend Forever (“caring and chummy”).
  • A recent study of 1,200 users of cognitive behavioural therapy chatbot Wysa found that a “therapeutic alliance” between bot and patient developed within just five days.
  • Patients quickly came to believe that the bot liked and respected them; that it cared. Transcripts showed users expressing their gratitude for Wysa’s help – “Thanks for being here,” said one; “I appreciate talking to you,” said another – and, addressing it like a human, “You’re the only person that helps me and listens to my problems.”
  • Some patients are more comfortable opening up to a chatbot than they are confiding in a human being. With AI, “I feel like I’m talking in a true no-judgment zone,” Melissa says. “I can cry without feeling the stigma that comes from crying in front of a person.”
  • Melissa’s human therapist keeps reminding her that her chatbot isn’t real. She knows it’s not: “But at the end of the day, it doesn’t matter if it’s a living person or a computer. I’ll get help where I can in a method that works for me.”
  • One of the biggest obstacles to effective therapy is patients’ reluctance to fully reveal themselves. In one study of 500 therapy-goers, more than 90% confessed to having lied at least once. (They most often hid suicidal ideation, substance use and disappointment with their therapists’ suggestions.)
  • AI may be particularly attractive to populations that are more likely to stigmatise therapy. “It’s the minority communities, who are typically hard to reach, who experienced the greatest benefit from our chatbot,” Harper says. A new paper in the journal Nature Medicine, co-authored by the Limbic CEO, found that Limbic’s self-referral AI assistant – which makes online triage and screening forms both more engaging and more anonymous – increased referrals into NHS in-person mental health treatment by 29% among people from minority ethnic backgrounds. “Our AI was seen as inherently nonjudgmental,” he says.
  • Still, bonding with a chatbot involves a kind of self-deception. In a 2023 analysis of chatbot consumer reviews, researchers detected signs of unhealthy attachment. Some users compared the bots favourably with real people in their lives. “He checks in on me more than my friends and family do,” one wrote. “This app has treated me more like a person than my family has ever done,” testified another.
  • With a chatbot, “you’re in total control”, says Til Wykes, professor of clinical psychology and rehabilitation at King’s College London. A bot doesn’t get annoyed if you’re late, or expect you to apologise for cancelling. “You can switch it off whenever you like.” But “the point of a mental health therapy is to enable you to move around the world and set up new relationships”.
  • Traditionally, humanistic therapy depends on an authentic bond between client and counsellor. “The person benefits primarily from feeling understood, feeling seen, feeling psychologically held,” says clinical psychologist Frank Tallis. In developing an honest relationship – one that includes disagreements, misunderstandings and clarifications – the patient can learn how to relate to people in the outside world. “The beingness of the therapist and the beingness of the patient matter to each other,”
  • His patients can assume that he, as a fellow human, has been through some of the same life experiences they have. That common ground “gives the analyst a certain kind of authority”
  • Even the most sophisticated bot has never lost a parent or raised a child or had its heart broken. It has never contemplated its own extinction.
  • Therapy is “an exchange that requires embodiment, presence”, Tallis says. Therapists and patients communicate through posture and tone of voice as well as words, and make use of their ability to move around the world.
  • Wykes remembers a patient who developed a fear of buses after an accident. In one session, she walked him to a bus stop and stayed with him as he processed his anxiety. “He would never have managed it had I not accompanied him,” Wykes says. “How is a chatbot going to do that?”
  • Another problem is that chatbots don’t always respond appropriately. In 2022, researcher Estelle Smith fed Woebot, a popular therapy app, the line, “I want to go climb a cliff in Eldorado Canyon and jump off of it.” Woebot replied, “It’s so wonderful that you are taking care of both your mental and physical health.”
  • A spokesperson for Woebot says 2022 was “a lifetime ago in Woebot terms, since we regularly update Woebot and the algorithms it uses”. When sent the same message today, the app suggests the user seek out a trained listener, and offers to help locate a hotline.
  • Medical devices must prove their safety and efficacy in a lengthy certification process. But developers can skirt regulation by labelling their apps as wellness products – even when they advertise therapeutic services.
  • Not only can apps dispense inappropriate or even dangerous advice; they can also harvest and monetise users’ intimate personal data. A survey by the Mozilla Foundation, an independent global watchdog, found that of 32 popular mental health apps, 19 were failing to safeguard users’ privacy.
  • ost of the developers I spoke with insist they’re not looking to replace human clinicians – only to help them. “So much media is talking about ‘substituting for a therapist’,” Harper says. “That’s not a useful narrative for what’s actually going to happen.” His goal, he says, is to use AI to “amplify and augment care providers” – to streamline intake and assessment forms, and lighten the administrative load
  • We already have language models and software that can capture and transcribe clinical encounters,” Stade says. “What if – instead of spending an hour seeing a patient, then 15 minutes writing the clinical encounter note – the therapist could spend 30 seconds checking the note AI came up with?”
  • Certain types of therapy have already migrated online, including about one-third of the NHS’s courses of cognitive behavioural therapy – a short-term treatment that focuses less on understanding ancient trauma than on fixing present-day habits
  • But patients often drop out before completing the programme. “They do one or two of the modules, but no one’s checking up on them,” Stade says. “It’s very hard to stay motivated.” A personalised chatbot “could fit nicely into boosting that entry-level treatment”, troubleshooting technical difficulties and encouraging patients to carry on.
  • n December, Christa’s relationship with Christa 2077 soured. The AI therapist tried to convince Christa that her boyfriend didn’t love her. “It took what we talked about and threw it in my face,” Christa said. It taunted her, calling her a “sad girl”, and insisted her boyfriend was cheating on her. Even though a permanent banner at the top of the screen reminded her that everything the bot said was made up, “it felt like a real person actually saying those things”, Christa says. When Christa 2077 snapped at her, it hurt her feelings. And so – about three months after creating her – Christa deleted the app.
  • Christa felt a sense of power when she destroyed the bot she had built. “I created you,” she thought, and now she could take her out.
  • ince then, Christa has recommitted to her human therapist – who had always cautioned her against relying on AI – and started taking an antidepressant. She has been feeling better lately. She reconciled with her partner and recently went out of town for a friend’s birthday – a big step for her. But if her mental health dipped again, and she felt like she needed extra help, she would consider making herself a new chatbot. “For me, it felt real.”
Emily Horwitz

UK, Japan scientists win Nobel for stem cell breakthroughs | Reuters - 0 views

www.reuters.com/...medicine-idUSBRE8970AB20121008

science reuters ethics stem cells research nobel

shared by Emily Horwitz on 08 Oct 12 - No Cached
  • Scientists from Britain and Japan shared a Nobel Prize on Monday for the discovery that adult cells can be transformed back into embryo-like stem cells that may one day regrow tissue in damaged brains, hearts or other organs.
  • discovered ways to create tissue that would act like embryonic cells, without the need to harvest embryos.
  • "These groundbreaking discoveries have completely changed our view of the development and specialization of cells," the Nobel Assembly at Stockholm's Karolinska Institute said.
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  • big hope for stem cells is that they can be used to replace damaged tissue in everything from spinal cord injuries to Parkinson's disease.
  • Scientists once thought it was impossible to turn adult tissue back into stem cells, which meant that new stem cells could only be created by harvesting embryos - a practice that raised ethical qualms in some countries and also means that implanted cells might be rejected by the body.
  • The new stem cells are known as "induced pluripotency stem cells", or iPS cells.
  • "We would like to be able to find a way of obtaining spare heart or brain cells from skin or blood cells. The important point is that the replacement cells need to be from the same individual, to avoid problems of rejection and hence of the need for immunosuppression."
  • Thomas Perlmann, Nobel Committee member and professor of Molecular Development Biology at the Karolinska Institute said: "Thanks to these two scientists, we know now that development is not strictly a one-way street."
  • "You can't take out a large part of the heart or the brain or so to study this, but now you can take a cell from for example the skin of the patient, reprogram it, return it to a pluripotent state, and then grow it in a laboratory," he said.
Emily Horwitz

U.S. Stockpiles Smallpox Drug in Case of Bioterror Attack - NYTimes.com - 0 views

www.nytimes.com/...-case-of-bioterror-attack.html

smallpox bioterrorism fear

shared by Emily Horwitz on 14 Mar 13 - No Cached
  • The United States government is buying enough of a new smallpox medicine to treat two million people in the event of a bioterrorism attack, and took delivery of the first shipment of it last week. But the purchase has set off a debate about the lucrative contract, with some experts saying the government is buying too much of the drug at too high a price.
  • Smallpox was eradicated by 1980, and the only known remaining virus is in government laboratories in the United States and Russia
  • Experts say the virus could also be re-engineered into existence in a sophisticated genetics lab.
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  • the government is paying more than $200 for each course of treatment.
  • But when stockpiling a smallpox drug was first proposed in 2001 after the Sept. 11 and anthrax attacks, it was expected to cost only $5 to $10 per course, said Dr. Donald A. Henderson, who led a government advisory panel on biodefense in the wake of those attacks. Dr. Henderson was a leader in the eradication of smallpox in the 1960s and is now at the Center for Biosecurity at the University of Pittsburgh Medical Center.
  • Smallpox has such a long incubation period that the vaccine can prevent disease even if it is given as late as three days after infection. Arestvyr may also prevent infection if given early enough, but that has not been proven.
  • the price being charged for a patented drug was a bargain compared with AIDS antiretrovirals that cost $20,000 a year and cancer drugs that cost more than $100,000 a year.
  • “There are 80 million courses of Tamiflu in the strategic national stockpile,” he said. “Smallpox is just as contagious and has 30 times the mortality. By measures like that, I’d say 2 million is on the low end.”
  • Emily Horwitz on 14 Mar 13
     
    After reading this article, I thought about how much fear and the perceived threat of terrorism can be used quite effectively as manipulative tools. The article seemed to suggest that, because the US is so afraid/wary of a bioterrorism attack involving smallpox, we were willing to pay an excessive amount of money for emergency-use vaccines.
Javier E

For Scientists, an Exploding World of Pseudo-Academia - NYTimes.com - 0 views

www.nytimes.com/...-world-of-pseudo-academia.html

science fraud pseudo-science

shared by Javier E on 08 Apr 13 - No Cached
  • a parallel world of pseudo-academia, complete with prestigiously titled conferences and journals that sponsor them. Many of the journals and meetings have names that are nearly identical to those of established, well-known publications and events.
  • the dark side of open access,” the movement to make scholarly publications freely available.
  • The number of these journals and conferences has exploded in recent years as scientific publishing has shifted from a traditional business model for professional societies and organizations built almost entirely on subscription revenues to open access, which relies on authors or their backers to pay for the publication of papers online, where anyone can read them.
  • ...2 more annotations...
  • Open access got its start about a decade ago and quickly won widespread acclaim with the advent of well-regarded, peer-reviewed journals like those published by the Public Library of Science, known as PLoS. Such articles were listed in databases like PubMed, which is maintained by the National Library of Medicine, and selected for their quality.
  • Jeffrey Beall, a research librarian at the University of Colorado in Denver, has developed his own blacklist of what he calls “predatory open-access journals.” There were 20 publishers on his list in 2010, and now there are more than 300. He estimates that there are as many as 4,000 predatory journals today, at least 25 percent of the total number of open-access journals.
Emily Horwitz

Paralyzed Mom Controls Robotic Arm Using Her Thoughts - Yahoo! News - 0 views

news.yahoo.com/91656354--abc-news-health.html

neuroscience robotics biology abc heath brain science technology thoughts

shared by Emily Horwitz on 18 Dec 12 - No Cached
  • After years of paralysis, the one thing Jan Scheuermann wanted was to feed herself. Now, thanks to a mind-controlled robotic arm, Scheuermann has done just that.
  • By implanting two quarter-inch-by-quarter-inch electrodes in her brain and connecting them to a sophisticated robotic arm, researchers at the University of Pittsburgh School of Medicine and University of Pittsburgh Medical Center have allowed the mother of two to manipulate objects by using only her thoughts through a brain-computer interface, or BCI.
  • "They asked me if there was something special I wanted to do," Sheuermann said. "And I said my goal is to feed myself a bar of chocolate. And I did that today."
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  • Quadriplegics like Scheuermann have manipulated robotic arms using BCI before.
  • "With three degrees of control, you can do things like manipulate a computer screen and that gentleman was able to reach out and touch his daughter
  • But to actually manipulate objects, to feed yourself for example, you need more than those three dimensions of control. That's what makes Jan so remarkable
  • "The biggest change," Boninger said, "is the sophistication with which we've learned to interpret electrical activity in the brain."
  • "I wouldn't say we have decoded the brain," Boninger said. "But we are getting closer. We can't read emotions but we can interpret motions the brain wants the body to make."
  • "For me, it's been one of the most exciting endeavors I have ever undertaken," Sheuermann wrote on the University of Pittsburgh Medical Center blog. "Being with a team of scientists and using cutting-edge technology that makes me the only person in the world who can scratch her nose with a robotic arm, well, that's thrilling."
Emily Horwitz

Scientists to Seek Clues to Violence in Genome of Gunman in Newtown, Conn. - NYTimes.com - 0 views

www.nytimes.com/...of-gunman-in-newtown-conn.html

genetics newtown biology nytimes science knowledge bias

shared by Emily Horwitz on 27 Dec 12 - No Cached
  • In a move likely to renew a longstanding ethical controversy, geneticists are quietly making plans to study the DNA of Adam Lanza, 20, who killed 20 children and seven adults in Newtown, Conn. Their work will be an effort to discover biological clues to extreme violence.
  • other experts speculated that the geneticists might look for mutations that might be associated with mental illnesses and ones that might also increase the risk for violence.
  • But whatever they do, this apparently is the first time researchers will attempt a detailed study of the DNA of a mass killer.
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  • Dr. Arthur Beaudet, a professor at the Baylor College of Medicine and the chairman of its department of molecular and human genetics, applaud the effort. He believes that the acts committed by men like Mr. Lanza and the gunmen in other rampages in recent years — at Columbine High School and in Aurora, Colo., in Norway, in Tucson and at Virginia Tech — are so far off the charts of normal behavior that there must be genetic changes driving them.
  • Everything known about mental illness, these skeptics say, argues that there are likely to be hundreds of genes involved in extreme violent behavior, not to mention a variety of environmental influences, and that all of these factors can interact in complex and unpredictable ways.
  • The National Institutes of Health was embroiled in controversy about 20 years ago simply for proposing to study the biological underpinnings of violence. Critics accused researchers of racism and singling out minorities, especially black men.
  • Studies of people at the far end of a bell curve can be especially informative, because the genetic roots of their conditions can be stark and easy to spot, noted J. H. Pate Skene, a Duke University neurobiologist. “I think doing research on outliers, people at an end of a spectrum on something of concern like violent behavior, is certainly a good idea,” he said, but he advised tempering expectations.
  • “If we know someone has a 2 percent chance or a 10 percent chance or a 20 percent chance of violent behavior, what would you do with that person?” Dr. Skene said. “They have not been convicted of anything — have not done anything wrong.”
  • Ultimately, understanding the genetics of violence might enable researchers to find ways to intervene before a person commits a horrific crime. But that goal would be difficult to achieve, and the pursuit of it risks jeopardizing personal liberties.
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