Group items tagged

language skills.

Researchers tested memory skills of the people with primary progressive aphasia by showing them pictures of common objects. After waiting 10 minutes, they were shown the same pictures along with others and had to indicate whether they had seen the picture before. This test was given once and then again an average of 2.4 years later.

They were tested once and then again an average of 1.7 years later.

their verbal memory and language skills declined with equal severity during the study.

Left sided asymmetry of brain shrinkage and a lower incidence of brain proteins known as ApoE4 and TDP-43 were identified as potential contributors to the preservation of memory in this rare type of Alzheimer's disease.

Limitations of the study are the relatively small sample size and that autopsies were not available for all of the primary progressive aphasia cases.

Some changes are hard, but the family is learning to love Greg as he is — not as he was yesterday, or as he might have been if he'd never gotten Alzheimer's.

"You're still funny," his son Conor told him recently. "You're slightly different, but you're still funny."

In this study, a higher consumption of fish seemed to make a big difference in keeping your brain young.

People who ate a diet close to the MIND diet saw a 53% lower risk of developing Alzheimer's.

Even people who ate the MIND diet "most" (as opposed to "all") of the time saw a 35% reduced chance of developing the disease.

It has also been shown as a key to helping you live longer. It helps you manage your weight better and can lower your risk for cancer, and cardiovascular diseases.

this coherence process is disrupted in Alzheimer's disease.

β-amyloid plaques

these plaques directly impair the slow wave activity.

this balance was disturbed by the protein deposits, so that inhibition was reduced.

Low doses of sleep-inducing drugs as possible therapy

hippocampus,

Electrodes implanted in these patients' brains help their surgeons precisely identify the seizure foci and also provide valuable information on the brain's inner workings, Lega says.

new treatments to combat memory loss from conditions such as traumatic brain injury or Alzheimer's disease.

In addition, while rats are actively exploring an environment, place cells are further organized into "mini-sequences" that represent a virtual sweep of locations ahead of the rat. These radar-like sweeps happen roughly 8-10 times per second and are thought to be a brain mechanism for predicting immediately upcoming events or outcomes.

it was unclear how the hippocampus was able to produce such sequences.

hocolate milk

However, taking a closer look at the data, the researchers found something new: As the rats moved through these spaces, their neurons not only exhibited forward, predictive mini-sequences, but also backward, retrospective mini-sequences. The forward and backward sequences alternated with each other, each taking only a few dozen milliseconds to complete.

"In the past few decades, there's been an explosion in new findings about memory,"

(50.4 percent) of cases are mild

the pooled percentage was 45.2 percent for the combined group of mild AD dementia and MCI that later progressed to AD.

We found that approximately 45 percent of all those who are cognitively impaired or diagnosed with AD-dementia had early AD.

Diagnosis and severity were assessed by consensus dementia review.

According to the researchers the finding that half of the people living with AD have mild disease underscores the need for research and interventions to slow decline or prevent progression of this burdensome disease.

The researchers believe that most people who have AD are still at a stage when there is still some preserved quality of life.

I have never seen this (brain) pathology in someone under the age of 30"

he had more than 10 concussions

He lost consciousness, suffered headaches, neck pain, insomnia and anxiety. He couldn't remember things or concentrate.

ventually saw a neurologist, who prescribed him a muscle relaxant and anti-seizure medication, but they did little and the symptoms continued

he stopped playing football because the symptoms were so strong

he had great opportunities, and he had to turn these opportunities down because of something that was taking over his brain

teach proper technique

Keck believed he suffered from CTE, but it cannot be diagnosed in living people.

Keck died from cardiac arrest in 2013, and it does appear his life was lost to CTE.

Usually there's a latent period. He seemed to develop it while he was playing. Even after he quit playing, it seemed to get worse."

factors such as environment and genetics may have a role.

I think its becoming more and more clear that the developing brain is more susceptible to concussion; it has a delayed recovery from concussion,"

"We really need to limit the amount of head contact that young children and adolescents are experiencing

became increasingly depressed and suicidal

We are taking out unnecessary head contact out of the sport, out of practice. We're enforcing rule changes

This kind of modeling is already in use to study individual cellular processes like metabolism. But Dr. Covert said: “Where I think our work is different is that we explicitly include all of the genes and every known gene function. There’s no one else out there who has been able to include more than a handful of functions or more than, say, one-third of the genes.”

The simulation, which runs on a cluster of 128 computers, models the complete life span of the cell at the molecular level, charting the interactions of 28 categories of molecules — including DNA, RNA, proteins and small molecules known as metabolites, which are generated by cell processes.

They called the simulation an important advance in the new field of computational biology, which has recently yielded such achievements as the creation of a synthetic life form — an entire bacterial genome created by a team led by the genome pioneer J. Craig Venter. The scientists used it to take over an existing cell.

A decade ago, scientists developed simulations of metabolism that are now being used to study a wide array of cells, including bacteria, yeast and photosynthetic organisms. Other models exist for processes like protein synthesis.

“Right now, running a simulation for a single cell to divide only one time takes around 10 hours and generates half a gigabyte of data,” Dr. Covert wrote. “I find this fact completely fascinating, because I don’t know that anyone has ever asked how much data a living thing truly holds. We often think of the DNA as the storage medium, but clearly there is more to it than that.”

scientists chose an approach called object-oriented programming, which parallels the design of modern software systems. Software designers organize their programs in modules, which communicate with one another by passing data and instructions back and forth.

“The major modeling insight we had a few years ago was to break up the functionality of the cell into subgroups, which we could model individually, each with its own mathematics, and then to integrate these submodels together into a whole,”

Poor sleep may be contributing to the buildup of the brain plaques that drive the disease

“Sleep is a great early warning beacon, a distress call that we can latch onto, to potentially alert us to the beginnings of Alzheimer’s,” says Walker.

The result: reassurance and relief. Everything was in the normal range for her age, and she registered as superior on the ability to perform tasks and solve problems.

Simple tests done in eight to 12 minutes in a doctor’s office can determine whether memory issues are normal for one’s age or are problematic and warrant a more thorough evaluation.

more than half of older adults with signs of memory loss never see a doctor about it

“Early evaluation and identification of people with dementia may help them receive care earlier,”

“It can help families make plans for care, help with day-to-day tasks, including medication administration, and watch for future problems that can occur.”

Both tests measure orientation to time, date and place; attention and concentration; ability to calculate; memory; language; and conceptual thinking.

its score can be skewed by a person’s level of education, cultural background, a learning or speech disorder, and language fluency

How did immune cells get in, and how did they leave? No one knew.

The new study stands to resolve this and lead to new understanding of and treatments for vexing diseases.

For now, the researchers are hard at work on two major follow-up questions to try to figure out how the research might be relevant and useful. First, does this system definitely exist in humans? And second, what is the potential role of these vessels in Alzheimer's, MS, and meningitis?

The idea that an entire part of the lymphatic system was hiding in plain sight should ensure that these potentially crucial areas are ignored no longer. With any luck, this might help us solve more mysteries behind the brain — and fight some of its greatest foes.

People who have type 2 diabetes are about twice as likely to get Alzheimer’s, and people who have diabetes and are treated with insulin are also more likely to get Alzheimer’s, suggesting elevated insulin plays a role in Alzheimer’s. In fact, many studies have found that elevated insulin, or “hyperinsulinemia,” significantly increases your risk of Alzheimer’s. On the other hand, people with type 1 diabetes, who don’t make insulin at all, are also thought to have a higher risk of Alzheimer’s. How could these both be true?

Schilling posits this happens because of the insulin-degrading enzyme, a product of insulin that breaks down both insulin and amyloid proteins in the brain—the same proteins that clump up and lead to Alzheimer’s disease. People who don’t have enough insulin, like those whose bodies’ ability to produce insulin has been tapped out by diabetes, aren’t going to make enough of this enzyme to break up those brain clumps. Meanwhile, in people who use insulin to treat their diabetes and end up with a surplus of insulin, most of this enzyme gets used up breaking that insulin down, leaving not enough enzyme to address those amyloid brain clumps.

this can happen even in people who don’t have diabetes yet—who are in a state known as “prediabetes.” It simply means your blood sugar is higher than normal, and it’s something that affects roughly 86 million Americans.

In a 2012 study, Roberts broke nearly 1,000 people down into four groups based on how much of their diet came from carbohydrates. The group that ate the most carbs had an 80 percent higher chance of developing mild cognitive impairment—a pit stop on the way to dementia—than those who ate the smallest amount of carbs.

“It’s hard to be sure at this stage, what an ‘ideal’ diet would look like,” she said. “There’s a suggestion that a Mediterranean diet, for example, may be good for brain health.”

there are several theories out there to explain the connection between high blood sugar and dementia. Diabetes can also weaken the blood vessels, which increases the likelihood that you’ll have ministrokes in the brain, causing various forms of dementia. A high intake of simple sugars can make cells, including those in the brain, insulin resistant, which could cause the brain cells to die. Meanwhile, eating too much in general can cause obesity. The extra fat in obese people releases cytokines, or inflammatory proteins that can also contribute to cognitive deterioration, Roberts said. In one study by Gottesman, obesity doubled a person’s risk of having elevated amyloid proteins in their brains later in life.

even people who don’t have any kind of diabetes should watch their sugar intake, she said.

as these and other researchers point out, decisions we make about food are one risk factor we can control. And it’s starting to look like decisions we make while we’re still relatively young can affect our future cognitive health.

“Alzheimer’s is like a slow-burning fire that you don’t see when it starts,” Schilling said. It takes time for clumps to form and for cognition to begin to deteriorate. “By the time you see the signs, it’s way too late to put out the fire.”

For many affected patients, brain function improves as they recover. But some are likely to face long-term disability,

The injuries resembled those from a series of tiny strokes occurring in many different areas of the brain,

To understand other, less obvious mechanisms, though, scientists needed brain tissue from patients with COVID-19 who died.

"What we found was that the very small blood vessels in the brain were leaking,"

Some patients also suffer brain damage when their lungs can no longer provide enough oxygen.

What's more, the inflammation and leaky blood vessels associated with all these symptoms may make a person's brain more vulnerable to another type of damage."We know that those are important in Alzheimer's disease and we're seeing them play a key role here in COVID-19,"

Researchers will assess patients' "behavior, their memory, their overall function" at six-month intervals, she says.

Though it remains unclear at what point the ancestors of modern humans first started to develop spoken language, we know that our Homo sapiens predecessors emerged around 150,000–200,000 years ago. So, Prof. Pagel explains, complex speech is likely at least as old as that

A study led by researchers from Lund University in Sweden found that committed language students experienced growth in the hippocampus, a brain region associated with learning and spatial navigation, as well as in parts of the cerebral cortex, or the outmost layer of the brain.

In fact, researchers have drawn many connections between bilingualism or multilingualism and the maintenance of brain health

Multiple studies, for instance, have found that bilingualism can protect the brain against Alzheimer’s disease and other forms of dementia.

Being bilingual has other benefits, too, such as training the brain to process information efficiently while expending only the necessary resources on the tasks at hand.

Research now shows that her assessment was absolutely correct — the language that we use does change not only the way we think and express ourselves, but also how we perceive and interact with the world.

Language holds such power over our minds, decision-making processes, and lives, so Broditsky concludes by encouraging us to consider how we might use it to shape the way we think about ourselves and the world.

“The findings need to be replicated under clinical trial conditions, with larger numbers of participants and with robust blinding of subjects and outcome assessors.

induced improvements in working memory might come at the price of worsening of other areas of cognitive function.”

it could also have applications in treating disorders linked to poor working memory, such as schizophrenia and Alzheimer’s disease.

The cerebrum has two halves, or hemispheres, that are further divided into four regions, or lobes. The frontal lobes, located behind the forehead, are involved with speech, thought, learning, emotion, and movement.

Behind them are the parietal lobes, which process sensory information such as touch, temperature, and pain.

At the rear of the brain are the occipital lobes, dealing with vision

Lastly, there are the temporal lobes, near the temples, which are involved with hearing and memory.

The second-largest part of the brain is the cerebellum, which sits beneath the back of the cerebrum.

diencephalon, located in the core of the brain. A complex of structures roughly the size of an apricot, its two major sections are the thalamus and hypothalamus

The brain is extremely sensitive and delicate, and so it requires maximum protection, which is provided by the hard bone of the skull and three tough membranes called meninges.

Want more proof that the brain is extraordinary? Look no further than the blood-brain barrier.

This led scientists to learn that the brain has an ingenious, protective layer. Called the blood-brain barrier, it’s made up of special, tightly bound cells that together function as a kind of semi-permeable gate throughout most of the organ. It keeps the brain environment safe and stable by preventing some toxins, pathogens, and other harmful substances from entering the brain through the bloodstream, while simultaneously allowing oxygen and vital nutrients to pass through.

One in five Americans suffers from some form of neurological damage, a wide-ranging list that includes stroke, epilepsy, and cerebral palsy, as well as dementia.

Alzheimer’s disease, which is characterized in part by a gradual progression of short-term memory loss, disorientation, and mood swings, is the most common cause of dementia. It is the sixth leading cause of death in the United States

50 million people suffer from Alzheimer’s or some form of dementia. While there are a handful of drugs available to mitigate Alzheimer’s symptoms, there is no cure.

Unfortunately, negative attitudes toward people who suffer from mental illness are widespread. The stigma attached to mental illness can create feelings of shame, embarrassment, and rejection, causing many people to suffer in silence.

In the United States, where anxiety disorders are the most common forms of mental illness, only about 40 percent of sufferers receive treatment. Anxiety disorders often stem from abnormalities in the brain’s hippocampus and prefrontal cortex.

Attention-deficit/hyperactivity disorder, or ADHD, is a mental health condition that also affects adults but is far more often diagnosed in children.

ADHD is characterized by hyperactivity and an inability to stay focused.

Depression is another common mental health condition. It is the leading cause of disability worldwide and is often accompanied by anxiety. Depression can be marked by an array of symptoms, including persistent sadness, irritability, and changes in appetite.

The good news is that in general, anxiety and depression are highly treatable through various medications—which help the brain use certain chemicals more efficiently—and through forms of therapy