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"a group of researchers in MIT's Education Arcade are trying to harness the power of MMO games to teach high school students to think like scientists and mathematicians. Their game, The Radix Endeavor, is designed to be an educational game, and capitalizes on the interactions students can have as a way to build their knowledge and skills. Radix, as it's known, is aligned to the Next Generation Science Standards for biology, focusing on topics like genetics, evolution, ecology and human body systems. In math, the game is aligned to the Common Core and has particular focuses on algebra, probability and statistics, as well as geometry. The researchers worked with Filament Games and are funded by the Gates Foundation for the three-year project."

Interactive activities that work directly in the browser, broken apart by subject, topic, and grade level. The US history map and the ecology simulator are very good.

website from the British Pharmaceutical industry. Interactive sims for chemistry and biology. Periodic table activities and population studies are two good ones here.