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Autism and the Body Although much research has been devoted to the study of the brain in autism, it is now becoming evident that in many cases, ASD may be a multi-organ system disorder. We now know that many individuals on the spectrum experience gastrointestinal dysfunction and that there is growing evidence of a possible connection with the immune system. Further, research has determined a possible connection to mitochondrial disorders (energy metabolism). Sleep disorders are fairly common and hormonal imbalances have been reported in some cases.