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This Funding Opportunity Announcement (FOA) supports Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that will develop and/or validate devices or electronic systems that can: 1) monitor biologically- or behaviorally-based processes applicable to mind and body interventions or 2) be used to assist in optimizing the practice or increasing the efficacy of mind and body interventions.  The applications should: 1) lead to the development of new technologies, 2) adapt existing innovative technologies, devices and/or electronic systems, 3) repurpose existing devices and electronic systems, or 4) conduct testing of single or combined components of an integrated, long term, automated, wearable monitoring, stimulation device or electronic system in order to monitor or enhance the mechanistic processes or functional outcomes of mind and body interventions. For the purposes of this FOA, mind and body interventions are defined as non-pharmacological approaches that include mind/brain focused interventions (e.g., meditation, hypnosis), body-based approaches (e.g., acupuncture, massage, spinal manipulation/mobilization), or combined mind and body meditative movement approaches (e.g., yoga, tai-chi, qigong).  

Partnerships for Innovation: Building Innovation Capacity (PFI:BIC) supports academe-industry partnerships, which are led by an interdisciplinary academic research team collaborating with at least one industry partner in order to carry out research to advance, adapt, and integrate technology(ies) into a specified, human-centered smart service system. The selected service system should function as a technology test bed. Partnership projects are unrestricted as to domain knowledge and application areas and should be in the translational, pre-commercialization space, building on fundamental research discoveries with the objective of creating or transforming a "smart(er)" service system that has the potential for significant social and economic impact.

The HPEM Modeling & Effects research and development effort consists of the following areas: understanding the connectivity of infrastructure and mobile targets; understanding the phenomenology of front door effects; developing a predictive effects model; developing a theoretical and empirical basis for HPEM effects ranging from the basic circuit level to the system level effects; empirical effects testing on operational targets as a function of frequency, pulsed duration, and power of the incident HPEM pulse; battle damage assessment; rapid modeling of HPEM system sources and components; improving particle-in-cell code (PIC) capabilities; first principles materials modeling; improving models for electron emission, gas desorption to enhance the predictive capability of virtual prototyping; and developing electromagnetic (EM) algorithms to propagate radio frequency (RF) from platform-specific high power RF systems to targets to assess the performance measures of effective HPEM sources. Sound software engineering and development principles must be employed for all developed software and documentation. Robust software testing, validation, and verification are critical to software development efforts. As appropriate, software must scale to large simulation sizes and be portable to massively parallel computer architecture.

The Advanced Manufacturing (AM) program supports the fundamental research needed to revitalize American manufacturing to grow the national prosperity and workforce, and to reshape our strategic industries. The AM program accelerates advances in manufacturing technologies with emphasis on multidisciplinary research that fundamentally alters and transforms manufacturing capabilities, methods and practices. Advanced manufacturing research proposals should address issues related to national prosperity and security, and advancing knowledge to sustain global leadership. Areas of research, for example, include manufacturing systems; materials processing; manufacturing machines; methodologies; and manufacturing across the length scales. Researchers working in the areas of cybermanufacturing systems, manufacturing machines and equipment, materials engineering and processing, and nanomanufacturing are encouraged to transcend and cross domain boundaries. Interdisciplinary, convergent proposals are welcome that bring manufacturing to new application areas, and that incorporate challenges and approaches outside the customary manufacturing portfolio to broaden the impact of America's advanced manufacturing research. Proposals of all sizes will therefore be considered as justified by the project description. Investigators are encouraged to discuss their ideas with AM program directors well in advance of submission at AdvancedManufacturing@nsf.gov.

This funding opportunity announcement (FOA) is intended to support Small Business Innovation Research (SBIR) grants that develop novel technologies for the purpose of advancing the National Action Alliance for Suicide Prevention's "Zero Suicide" goal of preventing suicide events (attempts, deaths) among individuals receiving treatment within health care systems. Zero Suicide is a commitment to the prevention of suicide among individuals served by health care systems and is also a specific set of health care strategies and tools intended to eliminate suicide events. Research is still needed, however, to implement these goals effectively, and the incorporation of health information technology (health IT) products into this care program is critical. As such, this FOA specifically supports SBIR grants to develop technologies that enable healthcare settings to improve the development, management and/or delivery of services under the Zero Suicide framework.

This opportunity aims to facilitate the translation of NSF's technology investments in Engineering Research Centers (ERC) and in Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) projects into the market place. Furthermore, in instances where an ERC is funded with a mission to support the public good through the implementation of critical public engineering systems (the infrastructure), this includes facilitating implementations that realize the intended public benefit. The specific goals of this opportunity are to: Speed the translation of ERC-generated research and technology advances to the marketplace or its implementation into critical public engineered systems and engage undergraduate and graduate students more directly in the innovation process through collaboration between an ERC and a small business concern, (OPTION 1) and Strengthen the research capacity of active NSF SBIR/STTR Phase II awardees to speed the entry of their innovations into the marketplace and broaden its portfolio of marketable products through collaboration with an ERC (OPTION 2).

This opportunity aims to facilitate the translation of NSF's technology investments in Engineering Research Centers (ERC) and in Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) projects into the market place. Furthermore, in instances where an ERC is funded with a mission to support the public good through the implementation of critical public engineering systems (the infrastructure), this includes facilitating implementations that realize the intended public benefit. The specific goals of this opportunity are to: Speed the translation of ERC-generated research and technology advances to the marketplace or its implementation into critical public engineered systems and engage undergraduate and graduate students more directly in the innovation process through collaboration between an ERC and a small business concern, (OPTION 1) and Strengthen the research capacity of active NSF SBIR/STTR Phase II awardees to speed the entry of their innovations into the marketplace and broaden its portfolio of marketable products through collaboration with an ERC (OPTION 2).

This opportunity aims to facilitate the translation of NSF's technology investments in Engineering Research Centers (ERC) and in Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) projects into the market place. Furthermore, in instances where an ERC is funded with a mission to support the public good through the implementation of critical public engineering systems (the infrastructure), this includes facilitating implementations that realize the intended public benefit.The specific goals of this opportunity are to:Speed the translation of ERC-generated research and technology advances to the marketplace or its implementation into critical public engineered systems and engage undergraduate and graduate students more directly in the innovation process through collaboration between an ERC and a small business concern, (OPTION 1) andStrengthen the research capacity of active NSF SBIR/STTR Phase II awardees to speed the entry of their innovations into the marketplace and broaden its portfolio of marketable products through collaboration with an ERC (OPTION 2).

REAP provides grants to agricultural producers and rural small businesses to conduct feasibility study for a renewable energy system as well as to purchase and install renewable energy systems or make energy efficiency improvements. The program is designed to help agricultural producers and rural small businesses reduce energy costs and consumption and help meet the Nation's critical energy needs.

The National Human Genome Research Institute (NHGRI) solicits SBIR (R43/R44) grant applications to develop novel technologies that will enable extremely low-cost, high quality DNA sequencing. The goal of this initiative is to reduce the cost of sequencing a mammalian-sized genome to approximately $1000. Applicants may propose to develop full-scale sequencing systems or to investigate challenges underlying key system components. Exploration of methods other than those currently being pursued as potential $1,000 genome technologies is encouraged. High-risk/high-payoff applications are appropriate to achieve the goals of this FOA.

The Partnerships for Innovation: Building Innovation Capacity (PFI:BIC) program supports academe-industry partnerships, which are led by an interdisciplinary academic research team with a least one industry partner, to collaborate in building technological and human innovation capacity [4]. This innovation capacity is intended to endure beyond the initial award. Partnerships that build the capacity to innovate are expected to be effective at innovating and able to continue to innovate. They are highly intentional about creating an environment that fosters innovation. These partnerships not only develop new technology but also foster the development of human capital that embraces a culture of change, nurtures the generation of new ideas, and considers feedback an integral part of the innovation processes. Partnership members are diverse, representing a spectrum of backgrounds, perspectives, and skills. Partnership activities that drive sustained innovation include the targeted allocation of resources such as capital, time, facilities; and sharing of knowledge in a cross-organizational and interdisciplinary context. The PFI:BIC partnership team should focus on technological innovations with potential for significant economic/societal impact. The team collaborates on research, focusing on novel applications motivated by existing research discoveries and based on a platform technology with the potential to achieve transformational change in existing service systems or to spur entirely new service systems.

Despite the availability of increasingly effective treatment modalities, including insulin analogues, continuous glucose monitors (CGMs), and continuous subcutaneous insulin infusion (CSII) devices, a substantial proportion of patients with type 1 diabetes (T1D) cannot achieve adequate glycemic control and avoid acute complications such as hypoglycemia.  NIDDK has long supported this area of research, especially through small business projects, and this support has contributed substantially to the development of new devices that are increasingly used in clinical practice.  Nonetheless, the approved devices and current technologies still have significant limitations, and it is important to put renewed emphasis on the creation of the next generation of devices that will further the goals of relieving patients of the burden of diabetes self-management and achieving daily euglycemia to prevent acute and chronic complications. However, given the pace of technical progress in this field and the substantial room for improvement in reliability, accuracy, and patient burden of current devices, NIDDK considers it important to continue supporting research in this field. This FOA is intended to support cutting edge research conducted by small business leading to the development of innovative technologies that may advance progress toward an integrated, long term, wearable/implantable, glucose regulated open and closed loop insulin/pancreatic hormone delivery systems.  This announcement has two main purposes: a) promote technical innovation and b) pre-clinical testing of single or combined components of open and closed loop systems

This Funding Opportunity Announcement (FOA) encourages Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) that propose to develop or improve technologies for obtaining, characterizing and testing animal and human stem cells and their derivatives as models for stem cell-based regenerative medicine using animal models. The program is intended to support projects devoted to the creation of informative animal models for regenerative medicine, which will facilitate testing the safety and therapeutic potential of animal and human stem cells and their derivatives for pre-clinical evaluation. The initiative focuses on the following areas: 1) comparative analysis of animal and human stem cells to provide information for selection of the most predictive and informative model systems; 2) development of new technologies for stem cells and their derivatives, including production, characterization and transplantation; and 3) improvement of animal disease models for stem cell-based therapeutic applications. The ultimate objective of these efforts should be to provide commercial products and technologies that can help develop future clinical therapies.

This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to develop or improve technologies for obtaining, characterizing and testing animal and human stem cells and their derivatives as models for stem cell-based regenerative medicine using animal models. The program is intended to support projects devoted to the creation of informative animal models for regenerative medicine, which will facilitate testing the safety and therapeutic potential of animal and human stem cells and their derivatives for pre-clinical evaluation. The initiative focuses on the following areas: 1) comparative analysis of animal and human stem cells to provide information for selection of the most predictive and informative model systems; 2) development of new technologies for stem cells and their derivatives, including production, characterization and transplantation; and 3) improvement of animal disease models for stem cell-based therapeutic applications. The ultimate objective of these efforts should be to provide commercial products and technologies that can help develop future clinical therapies.

The Instrument Development for Biological Research (IDBR) Program supports the development, production, and distribution of novel instrumentation that addresses demonstrated needs in biological research in areas supported by NSF Biology programs (see http://www.nsf.gov/bio). These systems would benefit a broad user community through mass distribution of the technology. Interdisciplinary collaborations are strongly encouraged, as are partnerships with U.S. industries that can facilitate knowledge transfer, commercialization and broad utilization in the research community. The program accepts two types of proposals:Type A - Innovation: Proposals for the development of novel instrumentation that provides new research capabilities or, where appropriate, that significantly improves current technologies by at least an order of magnitude in fundamental aspects such as accuracy, precision, resolution, throughput, flexibility, breadth of application, costs of construction or operation, or user-friendliness.Type B - Bridging: Proposals for transforming ‘one of a kind' prototypes or high-end instruments into devices that are broadly available and utilizable without loss of capacity. If appropriate, PIs should seek SBIR/STTR Program, or similar support mechanism for implementation of broad distribution following an IDBR award.

The Volpe National Transportation System Center, (Volpe Center) is issuing a solicitation pursuant to the Small Business Innovation Development Act of 1982, PL 27-219, as amended by PL 99-443 and LPL 102-564 and reauthorized by PL 106-554, as amended and reauthorized by PL 112-81 which was signed into law on December 31, 2011, extending the SBIR program through September 30, 2017. The solicitation will be issued on or about February 4, 2014. The purpose of this solicitation is to invite small businesses with their valuable resources and creative capabilities to submit innovative research proposals that address high priority requirements of the U.S. Department of Transportation.

This Funding Opportunity Announcement (FOA) invites Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) for funding to perform research leading to the development of innovative technologies that may advance progress toward integrated long term glucose regulated insulin/pancreatic hormones delivery systems (artificial pancreas).

FSMIP provides matching funds on a competitive basis to assist eligible entities explore new market opportunities and to encourage research and innovation aimed at improving the efficiency and performance of the U.S. agricultural marketing system. The 2016 allocation for grants is approximately $1 million. Proposals may focus on addressing barriers, overcoming challenges or realizing opportunities manifesting at any stage of the marketing chain including direct, wholesale, and retail. Proposals must have a strong marketing focus, must involve research, and the primary beneficiaries must be agricultural producers and agribusinesses. Proposals that involve training or education programs must include a research component that tests the effects of the program on the marketing goals. Proposals may involve small, medium or large scale agricultural entities but should benefit multiple producers or agribusinesses. Proposals that benefit one agribusiness or individual will not be considered. Proposals that address issues of importance at the State, multi-State, or national level are appropriate for FSMIP. Of particular interest are proposals that reflect a collaborative approach between the States, academia, the farm sector and other appropriate entities and stakeholders. FSMIP will also consider unique proposals on a smaller scale that may serve as pilot projects or case studies useful as models for others. Such proposals should include an objective to analyze opportunities and formulate recommendations with regard to how the project could be scaled up or expanded to other regions. FSMIP will hold a teleconference to review the Request for Applications and answer questions on Thursday, March 24 at 2:00 pm Eastern time. If you would like to participate in the teleconference, please send an email to janise.zygmont@ams.usda.gov to receive instructions.

The goal of the Rapid Innovation Fund is to facilitate the rapid insertion of innovative technologies into military systems or programs that meet critical national security needs. The DoD seeks mature prototypes for final development, testing, evaluation, and integration. Those selected for award may receive up to $3 million in Rapid Innovation Funding and will have up to two years to perform the work. There is a source selection preference for technologies from small businesses. There are two phases in the source selection process: White paper submission and proposal submission. Proposal submissions are by invitation only.

This Broad Agency Announcement (BAA) with procurement instrument identification number HQ0034-17-BAA-RIF-0001 constitutes the solicitation of offers for research and development for the Rapid Innovation Fund. The goal of the Rapid Innovation Fund is to facilitate the rapid insertion of innovative technologies into military systems or programs that meet critical national security needs. The DoD seeks mature prototypes for final development, testing, evaluation, and integration. Those selected for award may receive up to $3 million in Rapid Innovation Funding and will have up to two years to perform the work. There is a source selection preference for technologies from small businesses. There are two phases in the source selection process: White paper submission and proposal submission. Proposal submissions are by invitation only. All responsible firms and academic institutions capable of satisfying the Government's needs may submit a White Paper under this BAA. Historically Black Colleges and Universities (HBCUs) and Minority Institutions (MIs) are encouraged to submit White Papers and/or participate in teaming arrangements in submitting White Papers; however, no portion of this announcement will be set aside for HBCU and MI participation.