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The Biomedical Grid Terminology (BiomedGT) is an open, collaboratively developed terminology for translational research. BiomedGT builds on the strengths of the NCI Thesaurus, including concept orientation, description logic, and public accessibility. While the current terminology has been seeded with NCI Thesaurus content, it is being restructured to facilitate open content development. The goal is to evolve BiomedGT into a set of federated sub-terminologies, with content maintained by experts in the relevant research communities.