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Cyberinfrastructure for Phylogenetic Research (CIPRES) project is an open collaboration funded by the National Science Foundation. The group is led by Tandy Warnow and involves researchers (biologists, computer scientists, statisticians, and mathematicians) at sixteen institutions. The goal of the CIPRES project is to enable large-scale phylogenetic reconstructions on a scale that will enable analyses of huge data sets containing hundreds of thousands of bio molecular sequences. To achieve this goal we have brought together a group of researchers involved in phylogeny estimation, statistics, and computer science to create new solutions for the difficult computational problems that arise in inferring evolutionary relationships.