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Nathan Goodyear

Tumor targeting by conjugation of DHA to paclitaxe... [J Control Release. 2001] - PubMed result - 0 views

www.ncbi.nlm.nih.gov/...11489499

DHA chemotherapy Taxol Omega-3

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Nathan Goodyear on 11 Feb 11
     
    Not only does DHA, Omega 3, increase effectiveness of chemotherapy drug Taxol, but it reduces the toxicity too.  Why doesn't every chemo regimen with Taxol, now include DHA?
Nathan Goodyear

The Potential Utility of Curcumin in the Treatment of HER-2-Overexpressed Breast Cancer: An In Vitro and In Vivo Comparison Study with Herceptin - 0 views

www.ncbi.nlm.nih.gov/...PMC3162976

curcumin HER-2 breast cancer NF-KappaB

shared by Nathan Goodyear on 19 Jan 12 - No Cached
  • Nathan Goodyear on 19 Jan 12
     
    Curcumin downregulates HER-2 oncoprotein in breast cancer in vitro and in vivo.  IN this study, the combination of taxol and curcumin was comparable to that of taxol and perceptin.
Nathan Goodyear

Paclitaxel therapy promotes breast cancer metastasis in a TLR4-dependent manner - 0 views

www.ncbi.nlm.nih.gov/...PMC4185415

Chemotherapy "chemotherapy metastasis" metastasis cancer taxol

shared by Nathan Goodyear on 23 Jan 19 - No Cached
  • Nathan Goodyear on 23 Jan 19
     
    Taxol can promote tumor metastasis through TLR4 mechanism.
Nathan Goodyear

British Journal of Cancer - Phase I//II study of DHA-paclitaxel in combination with carboplatin in patients with advanced malignant solid tumours - 0 views

www.nature.com/...6602196a.html

DHA Omega-3 Taxol paclitaxel hair loss chemotherapy

shared by Nathan Goodyear on 11 Feb 11 - No Cached
  • Preclinical studies have demonstrated increased activity, relative to paclitaxel, with the potential for an improved therapeutic ratio.
  • No alopecia was seen
  • Nathan Goodyear on 11 Feb 11
     
    DHA, omega-3,  improves effectiveness of Taxol therapy; but without HAIR LOSS
Nathan Goodyear

Searching For an Old New Cure: Ivermectin Deficiency Syndrome? « The Healthy Planet - 0 views

thehealthyplanet.com/...ivermectin-deficiency-syndrome

Ivermectin cancer PAK1 oncogene oncogenes

shared by Nathan Goodyear on 21 Mar 18 - No Cached
  • Ivermectin can inactivate the protein kinase PAK1 and blocks the PAK1-dependent growth of human ovarian cancer and NF2 tumor cell lines
  • PAK proteins encoded by the PAK1 gene are critical for cytoskeleton reorganization and nuclear signaling.
  • PAK-1 kinase is required for the growth of more than 70% of human cancers such as pancreatic, colon, breast and prostate cancers, and neurofibromatosis
  • ...5 more annotations...
  • The p21 activated Kinase PAK1 is implicated in tumor genesis.
  • Inhibiting PAK1 signals induce tumor cell apoptosis (cell death)
  • PAK1 has also been implicated for maintenance of glucose homeostasis in pancreatic beta cells and skeletal muscle
  • Ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells (Blood, November 4, 2010, vol.115). The paper states Ivermectin synergizes with chemo agents cytarabine and daunorubicin to induce cell death in leukemia cells.
  • Praziquantel , my other favorite parasite medication for liver flukes, synergistically enhances Paclitaxel (Taxol) efficacy to inhibit cancer cell growth
  • Nathan Goodyear on 21 Mar 18
     
    Just a commentary but with important information on ivermectin in its inhibitory activity against another oncogene PAK1.
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