These mRNA vaccines represented a new type of vaccine that comprises synthetic mRNA molecules that contain the coding sequence necessary to build the SARS-CoV-2 Spike protein, which is encased in the lipid nanoparticles (LNPs) to allow for the delivery of mRNA to cells.
proteins are synthesized within the host cells
they can induce significant neutralizing anti-spike IgG and IgA response
Lethal COVID-19 cases have been linked to higher levels of IgG4 antibodies
mRNA vaccines trigger their synthesis
provide the scientific rationale suggesting that repeated vaccination with mRNA vaccines could generate an immune tolerance mechanism, thereby favoring unopposed SARS-CoV-2 replication.