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Padayatty and colleagues showed that high-level ascorbic acid plasma concentrations could only be achieved by intravenous administration

No patient in the low or high dose ascorbic acid treatment arms of this study suffered any identifiable adverse event

a pharmacologic ascorbic acid treatment strategy in critically ill patients with severe sepsis appears to be safe

Inflammation is the most predominant feature during the early (relaping) phases of the disease and declines with aging of the patients and disease duration

in the process of oligodendrocyte destruction and demyelination in MS lesions iron is liberated from its intracellular ferritin bound stores into the extracellular space, where it is taken up by microglia and macrophages and again stored together with ferritin. When this happens in MS lesions in an environment, where free radicals are produced by oxidative burst, iron can be liberated from ferritin and transformed into reactive Fe++[114], which reacts with hydrogen peroxide to generate highly reactive hydroxyl radicals [36] and thus amplifies oxidative damage and associated cellular injury

anti-inflammatory or immunomodulatory treatments are effective in the relapsing stage, but the benefit is lost when the patients have entered the progressive phase

Recent reports indicate that a certain ROS concentration is required for high-dose vitamin C to induce cytotoxicity in cancer cells.

The generation of ascorbyl- and H2O2 radicals by PAA increases ROS stress in cancer cells

In this study, we report that PAA is efficacious in killing MM cells in vitro and in vivo models, which generated levels of 20–40 mM ascorbate and 500 nM ascorbyl radicals after intraperitoneal administration of 4 g ascorbate per kilogram of body weight (Chen et al., 2008Chen et al., 2008), in xenograft MM mice

There is a marked increase in expression of TNF in active multiple sclerosis (MS)

a correlation exists between cerebrospinal fluid levels of TNF and the severity and progression of disease

With cytokine activation, free-radical production increases and this has been demonstrated in MS

mitochondrial aging may be prevented by antioxidants.

CoQ10 can significantly extend survival, delay motor deficits and delay weight loss and attenuate the development of striatal atrophy in a transgenic mouse model of HD

preliminary human studies indicate that α-lipoate may be effective in numerous neurodegenerative disorders

ur data showed that sHT patients exists impaired endothelial function, and antioxidant alpha-lipoic acid can improve endothelial function, through decrease of oxygen- derived free radicals.