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indiacardiacsurg

Dr Rajiv Parakh India Evaluated Women Exhibit More Advanced Disease - 0 views

www.freeprnow.com/...-exhibit-more-advanced-disease

Dr Rajiv Parakh India best vascular surgeon in Medanta hospital Gurgaon Dr Rajiv Parakh vascular surgeon in Medanta

shared by indiacardiacsurg on 12 Oct 21 - No Cached
  • indiacardiacsurg on 12 Oct 21
     
    "It was interesting to see that females were less likely to present with a history of coronary disease," the best vascular surgeon in Medanta hospital Gurgaon said. "That is a finding that is counterintuitive because the vascular disease is in truth a systemic disorder; consequently any patient with PAD has a high probability of concomitant CAD. Email id- dr.rajivparakh@indiacardiacsurgerysite.com Call for Appointment- +91-9370586696
indiacardiacsurg

Dr. Rajiv Parakh Expands Vascular Surgery Services with Updates in Interventional Radiology - 0 views

www.briefingwire.com/...es-in-interventional-radiology

Dr. Rajiv Parakh Vascular Surgery Best Vascular Surgeon Vascular Surgeon Medanta Hospital Gurgaon Delhi Medanta Hospital Gurgaon Delhi

shared by indiacardiacsurg on 23 Apr 22 - No Cached
  • indiacardiacsurg on 23 Apr 22
     
    According to Dr. Rajiv Parakh "Peripheral vascular sickness, also referred to as peripheral arterial disorder most commonly takes place inside the legs and narrows or blocks the vessels that carry blood from the coronary heart to the lower extremities.
indiacardiacsurg

Dr Rajiv Parakh Talk about 3 Things You Can Do Today to Prevent Apoplexy - 0 views

www.briefingwire.com/...n-do-today-to-prevent-apoplexy

Dr. Rajiv Parakh Vascular Surgeon Medanta Gurugram Top Endovascular Surgeon

shared by indiacardiacsurg on 29 Mar 22 - No Cached
  • indiacardiacsurg on 29 Mar 22
     
    Vascular Surgeon in Medanta Gurugram explains "Living a sedentary way of life and consuming the wrong forms of meals puts people at a more risk of having apoplexy." The expert goes on to say that eating a healthy diet and getting sufficient workout routines are two of the most important things people can do to save apoplexy.
indiacardiacsurg

Dr. Rajiv Parakh Expands Services with Updates to Medical Interventional Radiology - 0 views

www.briefingwire.com/...dical-interventional-radiology

Dr. Rajiv Parakh Vascular Surgeon Medanta Hospital Gurgaon Delhi

shared by indiacardiacsurg on 24 Feb 22 - No Cached
  • indiacardiacsurg on 24 Feb 22
     
    Dr. Rajiv Parakh can now perform improved angiographies (the outlet of blocked vessels outside the heart), imaging studies, placement of micro-sized catheters, repair of vessel blockages, and different services. Vascular Surgeon Medanta Gurgaon Delhi Phone No.: +91-9370586696 Email: dr.rajivparakh@indiacardiacsurgerysite.com
indiacardiacsurg

Dr. Rajiv Parakh Medanta Improving Surgical Strategies: PAD and Critical Limb Ischemia - 101 Press Release - 0 views

www.101pressrelease.com/pad-and-critical-limb-ischemia

Dr Rajiv Parakh Dr Rajiv Parakh Medanta Best vascular surgeon in Gurgaon Top Endovascular Surgeon in Gurgaon medanta hospital

shared by indiacardiacsurg on 07 Jan 22 - No Cached
  • indiacardiacsurg on 07 Jan 22
     
    Almost 2 million people dwelling with limb loss in India. Amongst the ones residing with limb loss, the primary causes are vascular ailment (54%) - inclusive of diabetes and peripheral arterial disorder. nearly 185,000 amputations arise in India each year. Write to Doctor - dr.rajivparakh@indiacardiacsurgerysite.com Call for Appointment- +91-9370586696
indiacardiacsurg

Visite médicale de French 2 India: Améliorez votre santé vasculaire avec le Dr Rajiv Parakh, chirurgien vasculaire Medanta Gurgaon - 0 views

french2indiamedicaltour.blogspot.com/...r-surgeon-medanta-gurgaon.html

chirurgien vasculaire Medanta Gurgaon Dr Rajiv Parakh Meilleur chirurgien vasculaire Medanta Hospital Gurugram Numéro de contact du Dr Rajiv Parakh Dr Rajiv Parakh Top chirurgien vasculaire Delhi

shared by indiacardiacsurg on 04 Sep 21 - No Cached
  • indiacardiacsurg on 04 Sep 21
     
    Le Dr Rajiv Parakh propose des méthodes endovasculaires mini-invasives qui obtiennent les meilleurs effets même en diminuant les séjours. Pour un rendez-vous accéléré et une consultation avec le Dr Rajiv Parakh Veuillez appeler le +91-9370586696 ou vous pouvez nous envoyer un courrier Identifiant de l'e-mail : - enquiry@indiacardiacsurgerysite.com
indiacardiacsurg

ডাঃ রাজীব পারখ ভাস্কুলার সার্জন মেদান্ত গুরগাঁওয়ের সাথে আপনার ভাস্কুলার স্বাস্থ্যের উন্নতি করুন - 0 views

healthtourtoindiafrombangladesh.blogspot.com/...r-surgeon-medanta-gurgaon.html

গুরগাঁও ভারতের শীর্ষ এন্ডোভাসকুলার সার্জন শীর্ষ এন্ডোভাসকুলার সার্জন রাজীব পারখ ড ভাস্কুলার সার্জন মেদান্ত গুরগাঁও

shared by indiacardiacsurg on 13 Nov 21 - No Cached
  • indiacardiacsurg on 13 Nov 21
     
    গুরগাঁও ভারতের শীর্ষ এন্ডোভাসকুলার সার্জন ভাস্কুলার রোগের সবচেয়ে জটিল ক্ষেত্রে কার্যকরভাবে চিকিত্সা করার একজন বিশেষজ্ঞ এবং রোগীদের সবচেয়ে কার্যকর চিকিত্সা প্রদানের জন্য নিবেদিত। ডাঃ রাজীব পারখের সাথে ফাস্ট ট্র্যাক অ্যাপয়েন্টমেন্ট এবং পরামর্শের জন্য অনুগ্রহ করে কল করুন +91-9370586696 অথবা আপনি আমাদের মেইল করতে পারেন ইমেল আইডি:- dr.rajivparakh@indiacardiacsurgerysite.com
indiacardiacsurg

Улучшите свое сосудистое здоровье с доктором Радживом Парахом сосудистым хирургом Медантой Гургаон - Россия 2 Индия Медицинская поездка - 0 views

russia2indiamedicaltrip.blogspot.com/...r-surgeon-medanta-gurgaon.html

Доктор Раджив Парах Лучший сосудистый хирург Medanta Hospital Gurugram ведущий эндоваскулярный хирург в Гургаоне Индия

shared by indiacardiacsurg on 19 Nov 21 - No Cached
  • indiacardiacsurg on 19 Nov 21
     
    Доктор Раджив Парах Индия стремится объединить искусство и медицину таким образом, чтобы безопасно, комфортно и надежно лечить различные расстройства. Он дружелюбный и знающий врач, который внимательно выслушает ваши опасения, ответит на все ваши вопросы, а затем подберет индивидуальный пакет лечения, соответствующий вашим потребностям, образу жизни и расписанию. Позвоните по телефону + 91-9370586696 или напишите нам Идентификатор электронной почты: - enquiry@indiacardiacsurgerysite.com
Nathan Goodyear

Tumor regionalization after surgery: Roles of the tumor microenvironment and neutrophil extracellular traps | Experimental & Molecular Medicine - 0 views

www.nature.com/...s12276-022-00784-2

TME NETosis metastasis surgery cancer tumor microenvironment

shared by Nathan Goodyear on 20 Apr 23 - No Cached
  • tumor surgery must be carefully considered because the risk of metastasis could be increased by the surgical procedure.
  • NETosis, which is the process of forming neutrophil extracellular traps (NETs)
  • surgery-induced metastasis
  • ...61 more annotations...
  • surgery per se can promote cancer metastasis through a series of local and systemic events
  • surgery results in a serious wound that disrupts the structural barrier preventing the outspreading of cancer cells, change the properties of the cancer cells and stromal cells remaining in the tumor microenvironment, or impairs the host defense systems against cancers
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Key point; add to presentation on surgery and metastasis
  • After the primary tumor is surgically removed, the metastases can start to grow vigorously via neoangiogenesis because the circulating inhibitors disappear
  • infection and inflammation during the postoperative period have been reported to increase the risk of cancer recurrence in patients
  • Surgeons have long suspected that surgery, even if it is a necessary step in cancer treatment, facilitates cancer metastasis
  • Surgery-induced cancer metastasis has been well established in animal models
  • tumor cell dissemination, tumor-favoring immune responses, and neoangiogenesis
  • the surgical resection of primary tumors is beneficial is controversial
  • CTCs abruptly increase just after surgery
  • Even externally palpitating tumors for diagnosis could increase the numbers of CTCs in skin cancer and breast cancer
  • excessive glucocorticoids negatively modulate immune functions
  • immune surveillance against tumors is considered to be impaired by surgical stress
  • In addition to glucocorticoids, during stimulation of the HPA axis, the catecholamine hormones epinephrine and norepinephrine are released from the adrenal medulla
  • NK cell suppression may be attributed to increased levels of catecholamines as well as glucocorticoids
  • In mice bearing a primary tumor, it was observed that the removal of the primary tumor facilitated the growth of highly vascularized metastases
  • primary tumors may secrete angiogenic inhibitors as well as angiogenic activators
  • second phase of tumor recurrence and metastasis, which are newly acquired events, rather than just outcomes of incomplete treatment.
    • Nathan Goodyear
      Nathan Goodyear on 23 Apr 23
       
      Another key point
  • double-edged sword
  • HIF-1 in neutrophils plays a critical role in NETosis and bacteria-killing activity
  • neutrophils play various roles in the initiation and progression of cancer
  • NETosis
  • many inflammatory and neoplastic diseases
  • formation of neutrophil extracellular traps (NETs), which are large extracellular complexes composed of chromatin and cytoplasmic/granular proteins1
  • NETosis has been highlighted as an inflammatory event that promotes cancer metastasis
  • Once activated, neutrophils produce intracellular precursors by using DNA, histones, and granular and cytoplasmic proteins and then spread the mature form of NETs out around themselves
  • A series of these events is called NETosis.
  • neutrophil elastase, myeloperoxidase, cathepsin G, proteinase 3, lactoferrin, gelatinase, lysozyme C, calprotectin, neutrophil defensins, and cathelicidins
  • innate immune response against infection
  • Neutrophils are the most abundant type of granulocytes, comprising 40–70% of all white blood cells
  • two types of NEToses, suicidal (or lytic) NETosis and vital NETosis
  • Suicidal NETosis mainly depends on the production of reactive oxygen species (ROS)
  • Since neutrophils die during this process, it is called suicidal NETosis.
  • vital NETosis
  • vital NETosis occurs independently of ROS production
  • Vital NETosis can be induced by Gram-negative bacteria. LPS
  • NETs are present in a variety of cancers, such as lung cancer, colon cancer, ovarian cancer, and leukemia
  • neutrophils actively undergo NETosis in the tumor microenvironment
  • Hypoxia
  • NETosis plays a pivotal role in noninfectious autoimmune diseases,
  • cytokines
  • tumor-derived proteases
  • tumor exosomes
  • NETosis generally actively progresses in the tumor microenvironment.
  • the proliferative cytokines TGFβ and IL-10 and the angiogenic factor VEGF are representative of neutrophil-derived tissue repair proteins.
  • NETosis is a defense system to protect the body from invading pathogens
  • when neutrophils are excessively stimulated, they produce excess NETs, thereby leading to pathological consequences
  • plasma levels of NETosis markers are elevated after major surgeries
  • local invasion, intravasation into the blood or lymphatic vessels, escape from the immune system, anchoring to capillaries in target organs, extravasation into the organs, transformation from dormant cells to proliferating cells, colonization to micrometastases, and growth to macrometastases
  • NETs promote metastasis at multiple steps
  • NETs loosen the ECM and capillary wall to promote the intravasation of cancer cells
  • NETs and platelets wrap CTCs, which protects them from attack by immune cells and shearing force by blood flow
  • NETs promote the local invasion of cancer cells by degrading the extracellular matrix (ECM)
  • neutrophil elastase, matrix metalloproteinase 9, and cathepsin G
  • NETs also promote the intravasation of cancer cells
  • millions of tumor cells are released into the circulation every day,
  • NETs can wrap up CTCs with platelets
  • β1-integrin plays an important role in the interaction between CTCs and NETs
  • NET-platelet-CTC aggregates.
  • After metastasizing to distant tissues, tumor cells are often found to remain dormant for a period of time and unexpectedly regrow late
  • NETs are believed to participate in the reactivation of dormant cancer cells in metastatic regions
  • NET-associated proteases NE and MMP-9 were found to be responsible for the reactivation of dormant cancer cells
  • Nathan Goodyear on 20 Apr 23
     
    Surgery induced metastasis: it is real and steered by NETosis.
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