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Congenital insensitivity to pain (CIP) is a rarely syndrome and is characterized by unresponsiveness to painful stimulants, anhydrous, mental retardation, and recurring feverish episodes. In this case report we presented our anesthesia management in a patient with congenital insensitivity to pain for lower extremity surgery due to osteomyelitis. For more details : http://scidoc.org/IJAR-2332-2780-04-1001.php