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In spite of being a minor cellular subset, cancer stem cells (CSCs) fundamentally contribute to intra-tumor heterogeneity. With the biological features of self-renewal and differentiation, CSCs confer a driving force for malignant recurrence and anti-cancer drug resistance in oncologic patients, which highlight an unmet clinical need calling for innovative medicine to Come up. Due to the elusiveness of specific biomarkers and biological regulation for CSCs, a number of precisely targeted therapeutic approaches against CSCs are at their infancy far from reaching the clinic. However, we have herein been able to sort out three groups of CSC inhibitors which are clinically available, and proposed to take the advantages of these drugs to improve the therapeutic efficacy of existing anti-cancer treatments. For more info : http://scidoc.org/JBR-TCEO-01-201.php

The epidemic of Zika Virus (ZV) drastically affected the health of more than one million people in Brazil resulting in twenty-fold increase of microcephaly (head circumference of newborn baby being less than or equal to thirty-two cms) in infected pregnant women. ZV crosses the placental barrier between maternal and fetal compartments. ZV has been found in amniotic fluid and fetal brain tissue of the human pregnancies complicated with ZV infection and microcephaly supporting cause and effect relationship between ZV and microcephaly. New knowledge about how ZV enters into the cells is mandatory for preventive and therapeutic research. ZV is a Flavivirus, therefore the Flavivirus receptors are candidate receptors for ZV too. ZV has been associated with high level of TYRO3 and AXL component of TAM, a Tyrosine Kinase receptor family, expression in the infected skin cells and neuronal stem cells. It predicts that AXL receptors may facilitate ZV entry into the trophoblasts and endothelial cells lining the fetal vessels present in the placenta. This hypothesis stems from the reported studies on ZV and AXL receptor expression, both in human tissues and animal models. If our hypothesis proves to be valid, it would be a great step towards the drug and therapeutic development to prevent ZV crossing the placental barrier and resulting in complications. For more info : http://scidoc.org/IJVR-03-401.php

Evaluation of histopathological factors for women with radical hysterectomy a.m. Okabayashi for cervical cancer in stage 1bwith similar pre- and postoperative treatment. For more info @ http://scidoc.org/IJCR-2167-9118-05-301.php

This study is concerned with the aeroelastic behavior of a laminated composite rectangular plate with temperature dependent material properties. Plate equations for homogenous linear elastic material and small deformations are derived in the frame of the Kirchhoff theory. Uniform and linear temperature distributions are considered on the layered composite plate and it is assumed that the material properties of fiber and matrix vary with the temperature. For more info : http://scidoc.org/IJASAR-2470-4415-03-401.php

Root Rescue offers varieties of mycorrhizal fungi. Our fungi are native to soil and crop rhizoplane thus making them as an essential mechanism for sustainability in agricultural. Mycorrhizal fungi is helpful for soil health, as an integral part of the living soil food web and the living soil community.

Cerbera odollam is a powerful toxic plant that is responsible both for suicide and homicide. The seeds are excessively toxic, containing cerberin as the main active cardenolide. Cerberin is difficult to detect in autopsies and its taste can be masked with strong spices. Therefore it is often used in homicide and suicide especially in India. Pathologists would not be able to identify Cerbera poisoning unless there is evidence the victim had eaten the plant. In this article we want to highlight the recent incidence of poisoning, present analytical techniques used as well the recent advances in identification of the cereberin toxin. For more information : http://scidoc.org/IJCPT-2167-910X-05-801.php

Nanomedicine is an application of nanotechnology which made its debut with greatly increased possibilities in the field of medicine. Nanomedicine desires to deliver research tools and clinically reformative devices in the near future. With the advance of nanomedicine technology, scientists face a new realm in biotherapeutics and drug development that includes vaccines, antibodies, gene therapies and Nanoparticles such as liposomes, polymeric micelles, Nanoparticles, dendrimers, and nanocrystals for drug delivery and contrast agents. For more info : http://scidoc.org/IJNSTSpecialIssues.php

Congenital insensitivity to pain (CIP) is a rarely syndrome and is characterized by unresponsiveness to painful stimulants, anhydrous, mental retardation, and recurring feverish episodes. In this case report we presented our anesthesia management in a patient with congenital insensitivity to pain for lower extremity surgery due to osteomyelitis. For more details : http://scidoc.org/IJAR-2332-2780-04-1001.php

International Journal of Clinical Pharmacology & Toxicology (IJCPT) ISSN:2167-910X aims to develop coherent means to modify drug therapy, with respect to the patients genotype, and to ensure maximum efficiency with minimal contrary effects. Clinical Pharmacology & Toxicology is the all-encompassing and becoming an increasingly important discipline for the identification of disease targets and drug designing with their toxicological effects and means to eradicate diseases. For more details : http://scidoc.org/clinical-pharmacology-and-toxicology.php

Bulk smokeless gunpowder is manufactured in a large variety of shapes, sizes, and textures, many different types look similar, making it challenging to differentiate between types of powders. One chemical discriminating parameter is the presence of nitroglycerin, which often requires expensive instrumentation to be detected. By using the Hanging drop technique, whereby a sample is induced to react inside a drop hanging over it after, it is possible to differentiate between single and double-base smokeless powders. The method resulted in a successful, time effective, and non-destructive result for the detection of nitroglycerin. For more info : http://scidoc.org/IJFP-2332-287X-04-901.php

NASA Aviation. NASA X Technology Program, The Boeing X-48 UAV. Future of Aeronautics HD. FSX Boeing B-797 Flying Wing Super Liner On March 19, 2010, NASA and Boeing successfully completed the initial flight testing phase of the X-48B. Fay Collier, manager of the ERA Project in NASA's Aeronautics Research Mission Directorate commented on the completion of the first phase of testing saying, "This project is a huge success. Bottom line: the team has proven the ability to fly tailless aircraft to the edge of the low-speed envelope safely." 39 Days to Mars! NASA's New Plasma Following the installation of a new flight computer in 2010, the X-48B was to continue a new phase of flights tests to investigate controlability aspects. The second phase of flight tests with the X-48B began in September 2010. The X-48C first flew on August 7, 2012. Engine yaw control was among the aspects to be studied.] The X-48C completed its 8-month flight test program with its 30th flight on 9 April 2013. The Boeing X-48 is an experimental unmanned aerial vehicle (UAV) for investigation into the characteristics of blended wing body (BWB) aircraft, a type of flying wing. Boeing designed the X-48 and two examples were built by Cranfield Aerospace in the UK. Boeing began flight testing the X-48B version for NASA in 2007. The X-48B was later modified into the X-48C version. It was flight tested from August 2012 to April 2013. Boeing and NASA plan to develop a larger BWB demonstrator.

The radicular cysts developed on primary teeth are infrequent compared to their evolution in permanent teeth. However, dentigerous cysts are ranked second in frequency after inflammatory cysts. They surround the crown of a tooth erupting while the radiculo- inflammatory dental cysts are hanging from the roots of the mortified teeth. This is the probable coexistence of these two entities that we have been faced in a patient aged 10 years with mixed dentition who presented a radiolucent lesion surrounding infected roots of a mandibular second primary molar in the vicinity of the tooth successor. In our presentation, we discuss problem diagnosis but also treatment. Indeed, we proceeded to avulsion of deciduous molar and we opted for a cystotomy or marsupialisation to preserve the replacement tooth. For more info : http://scidoc.org/IJDOS-2377-8075-03-903.php

We conducted a meta-analysis to evaluate current research that aims to map the neural correlates of two typical conditions of moral judgment: right-wrong moral judgments and decision-making in moral dilemmas. Utilizing the activation likelihood estimation (ALE) method, we conducted a meta-analysis using neuroimaging data obtained from twenty-one previous studies that measured responses in one or the other of these conditions. We found that across the studies (n = 400), distinct neural circuits correlated with a distinction in the type of moral question used as stimulus. For right-wrong moral judgments, the significantly active regions were identified in the right medial frontal gyrus, the bilateral anterior cingulates, the left inferior frontal gyrus, the right middle temporal gyrus, the left superior frontal gyrus and the left posterior cingulate. For more info : http://scidoc.org/IJCNE-03-201.php

Violation of nasal breathing mostly related to nasal septum deformation, which is an indication to perform septoplasty. This article represents our observations about the possible cause of aesthetic complications after nasal septum resection; the technique we us for prevention of such complications, clinical cases and treatment results. For more details : http://scidoc.org/IJCEO-02-501.php

PIONEER's independently-developed and produced PSA-CO adsorbent PU-1 was granted the Chinese, USA and Canadian patents. PU-1 has ultra-high adsorption capacity and selectivity for CO, which are the key features for PSA-CO technology which reaches the advanced level in the world.

Inspire3 made Hypnosis Boot-Camp benefits many users with its Live MP3. By listening to this MP3 for a longer period (approx 6 months to 1 year) they are able to overcome the longtime limiting attitude in their life which has brought a great turning point for them. The stream of happiness and satisfaction has come in the eye and soul of many regular users who have crossed more than 1 year with the Hypnosis Live Mp3. You can have so many satisfactory Inspire3 reviews on the Inspire3 website.

Inspire3 made Hypnosis Boot-Camp benefits many users with its Live MP3. By listening to this MP3 for a longer period (approx 6 months to 1 year) they are able to overcome the longtime limiting attitude in their life which has brought a great turning point for them. The stream of happiness and satisfaction has come in the eye and soul of many regular users who have crossed more than 1 year with the Hypnosis Live Mp3. You can have so many satisfactory Inspire3 reviews on the Inspire3 website.