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Many newly diagnosed prostate cancers present as low Gleason score tumors that require no treatment intervention. Distinguishing the many indolent tumors from the minority of lethal ones remains a major clinical challenge. We now show that low Gleason score prostate tumors can be distinguished as indolent and aggressive subgroups on the basis of their expression of genes associated with aging and senescence. Using gene set enrichment analysis, we identified a 19-gene signature enriched in indolent prostate tumors. We then further classified this signature with a decision tree learning model to identify three genes-FGFR1, PMP22, and CDKN1A-that together accurately predicted outcome of low Gleason score tumors. Validation of this three-gene panel on independent cohorts confirmed its independent prognostic value as well as its ability to improve prognosis with currently used clinical nomograms. Furthermore, protein expression of this three-gene panel in biopsy samples distinguished Gleason 6 patients who failed surveillance over a 10-year period. We propose that this signature may be incorporated into prognostic assays for monitoring patients on active surveillance to facilitate appropriate courses of treatment.

Early results of cost analysis by the Augustine human spaceflight panel have found no good options for continuing human exploration of space within the constraints set by the Obama administration's fiscal 2010 budget plan for NASA.

"For 20 years, researchers have reported a potential link between gum disease and atherosclerotic heart disease from hardening of the arteries or stroke. "The message sent out by some in health-care professions, that heart attack and stroke are directly linked to gum disease, can distort the facts, alarm patients and perhaps shift the focus on prevention away from well-known risk factors for these diseases," said Dr. Peter Lockhart, a professor and chair of oral medicine at the Carolinas Medical Center in Charlotte, N.C. Lockhart wrote the heart group's new position statement in the journal Circulation. The statement was prepared after a three-year analysis of about 600 studies by an expert panel led by a dentist and a cardiologist."

A giant asteroid smashing into Earth is the only plausible explanation for the extinction of the dinosaurs, a global scientific team said on Thursday, hoping to settle a row that has divided experts for decades. A panel of 41 scientists from across the world reviewed 20 years' worth of research to try to confirm the cause of the so-called Cretaceous-Tertiary (KT) extinction, which created a "hellish environment" around 65 million years ago and wiped out more than half of all species on the planet. Scientific opinion was split over whether the extinction was caused by an asteroid or by volcanic activity in the Deccan Traps in what is now India, where there were a series of super volcanic eruptions that lasted around 1.5 million years. The new study, conducted by scientists from Europe, the United States, Mexico, Canada and Japan and published in the journal Science, found that a 15-kilometre (9 miles) wide asteroid slamming into Earth at Chicxulub in what is now Mexico was the culprit. "We now have great confidence that an asteroid was the cause of the KT extinction. This triggered large-scale fires, earthquakes measuring more than 10 on the Richter scale, and continental landslides, which created tsunamis," said Joanna Morgan of Imperial College London, a co-author of the review.

It's possible to get the mental equivalent of whiplash from the latest medical findings, as risk factors are identified one year and exonerated the next. According to a panel at the American Association for the Advancement of Science, this isn't a failure of medical research; it's a failure of statistics, and one that is becoming more common in fields ranging from genomics to astronomy. The problem is that our statistical tools for evaluating the probability of error haven't kept pace with our own successes, in the form of our ability to obtain massive data sets and perform multiple tests on them. Even given a low tolerance for error, the sheer number of tests performed ensures that some of them will produce erroneous results at random.

Future Mars outposts or colonies may seem more distant than ever with NASA's exploration plans in flux, but the rocket technology that could someday propel a human mission to the red planet in as little as 40 days may already exist. A company founded by former NASA astronaut Franklin Chang-Diaz has been developing a new rocket engine that draws upon electric power and magnetic fields to channel superheated plasma out the back. That stream of plasma generates steady, efficient thrust that uses low amounts of propellant and builds up speed over time. "People have known for a long time, even back in the '50s, that electric propulsion would be needed for serious exploration of Mars," said Tim Glover, director of development at the Ad Astra Rocket Company.

Quantum dots are man-made atoms that confine electrons to a small space. They have atomic-like behavior that results in unusual electronic properties on a nanoscale. These unique properties may be particularly valuable in tailoring the way light interacts with matter.

Coastline Sediment Control offers the best tree fence protection services and erosion control systems in Australia. The construction of tree protection fencing comprises weldmesh panels or close boarded supported on a framework.

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