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Erich Feldmeier

Holger Sondermann: biofilms - 0 views

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    "Bacterial signaling controlling biofilm formation and pathogenicity Opportunistic bacterial pathogens cause a variety of infectious diseases. Their ability to sense and respond to different microenvironments, particularly during the transition from a free-living to an indwelling pathogenic lifestyle, is largely dependent on a variety of adaptational strategies (Hall-Stoodley et al., 2004). Examples include phenotypic variation, biofilm formation, resistance to antibiotic treatments and virulence gene expression, suggested to be interlinked phenotypes largely dependent on bacterial signaling and changes in their transcription profiles "
Skeptical Debunker

Sensitive nano oscillator can detect pathogens - 0 views

  • The researchers, led by professor of applied and engineering physics Harold Craighead, made a device just 200 nanometers thick and a few microns long with an oscillating cantilever hanging off one end. (A nanometer is one-billionth of a meter; a micron is one-millionth of a meter.) They identified exactly how to tune its sensitivity -- a breakthrough that could lead to advanced sensing technologies. The experiments detailed online Feb. 8 in Journal of Applied Physics show how these oscillators, which are nanoelectromechanical systems (NEMS), could one day be made into everyday devices by lining up millions of them and treating each cantilever with a certain molecule. "The big purpose is to be able to drive arrays of these things all in direct synchrony," said first author Rob Ilic, a research associate at the Cornell NanoScale Science and Technology Facility. "They can be functionalized with different chemistries and biomolecules to detect various pathogens -- not just one thing."
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    By watching how energy moves across a tiny device akin to a springing diving board, Cornell researchers are a step closer to creating extraordinarily tiny sensors that can instantly recognize harmful substances in air or water.
Erich Feldmeier

@biogarage Sick Bees - Part 3: The Bee Immune System @ Scientific Beekeeping - 0 views

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    "Note that the antimicrobial peptides are produced largely in the fat bodies-so there would be less of this sort of response in forager bees, which don't maintain their fat bodies. This makes sense, since foragers aren't expected to live for long. However, keep in mind that the bees in protein-hungry colonies are unable to develop their fat bodies fully-this one point where nutrition ties in to immunity. Surprisingly, Jay Evans found that these genes are not upregulated in bees from CCD colonies, even though the bees are full of pathogens! There are a few potential explanations for this finding that come to mind: The bee hemocytes are not recognizing the pathogens as foreign (suppression of recognition systems, perhaps by viruses?). The colonies could be protein-starved. Something is suppressing the transcription of the genes, or their translation to peptides. Note that viruses can do this very thing, which I feel may be a big clue!"
Erich Feldmeier

uBiome -- Sequencing Your Microbiome | Indiegogo - 0 views

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    "uBiome is a citizen science project that allows the public access to cutting edge sequencing technology to understand their health through the microbiome. How does the microbiome affect my health? We are all covered in trillions of microbes -- in fact, they outnumber human cells 10:1. The trillions of bacteria live on and in us are collectively called the microbiome. Like the rainforest, the healthy human microbiome is a balanced ecosystem. The correct balance of microbes keeps potential pathogens in check and regulates our immune system. Microbes also perform essential functions such as digesting food and synthesizing vitamins. Studies have also linked the microbiome to human mood and behavior, as well as many gut disorders, eczema, and chronic sinusitis."
Erich Feldmeier

John Cryan: Mind-Altering Bugs - ScienceNOW - 0 views

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    "Hundreds of species of bacteria call the human gut their home. This gut "microbiome" influences our physiology and health in ways that scientists are only beginning to understand. Now, a new study suggests that gut bacteria can even mess with the mind, altering brain chemistry and changing mood and behavior. In recent years, researchers have become increasingly interested in how gut bacteria might influence the brain and behavior, says John Cryan, a neuroscientist at University College Cork in Ireland. So far, most of the work has focused on how pathogenic bugs influence the brain by releasing toxins or stimulating the immune system, Cryan says. One recent study suggested that even benign bacteria can alter the brain and behavior, but until now there has been very little work in this area, Cryan says."
Erich Feldmeier

Michael Marletta: Mystery of bacterial growth and resistance solved: Findings shed ligh... - 0 views

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    "explains how nitric oxide, a signaling molecule involved in the immune system, leads to biofilm formation. "It is estimated that about 80 percent of human pathogens form biofilms during some part of their life cycle," said Scripps Research president and CEO Michael Marletta, PhD, who led the work."
Erich Feldmeier

Mind-Altering Bugs - ScienceNOW - 0 views

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    "Hundreds of species of bacteria call the human gut their home. This gut "microbiome" influences our physiology and health in ways that scientists are only beginning to understand. Now, a new study suggests that gut bacteria can even mess with the mind, altering brain chemistry and changing mood and behavior. In recent years, researchers have become increasingly interested in how gut bacteria might influence the brain and behavior, says John Cryan, a neuroscientist at University College Cork in Ireland. So far, most of the work has focused on how pathogenic bugs influence the brain by releasing toxins or stimulating the immune system, Cryan says. One recent study suggested that even benign bacteria can alter the brain and behavior, but until now there has been very little work in this area, Cryan says."
thinkahol *

Biodiversity's 'holy grail' is in the soil : Soil-borne pathogens drive tree diversity ... - 0 views

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    ScienceDaily (June 28, 2010) - Why are tropical forests so biologically rich? Smithsonian researchers have new evidence that the answer to one of life's great unsolved mysteries lies underground, according to a study published in the journal, Nature.
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