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Janos Haits

CATALYST project - FP7 - 0 views

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    MAJOR COMMUNITY NETWORKS & LEADING RESEARCH INSTITUTES IN COLLECTIVE INTELLIGENCE Have joined forces
Janos Haits

CHB - 0 views

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    Come work with us Interested in working with researchers from different disciplines within the Harvard, MIT and Broad community and an unique opportunity to participate in world-class research to make an impact on human health? Come work with us! We are looking for a computational biologists to handle data from a wide variety of experimental methods, focusing on next-gen sequencing technologies. Keep Reading...  SCDE is live The Stem Cell Discovery Engine (SCDE) is an integrated platform that allows users to consistently describe, share and compare cancer and tissue stem cell data. It is made up of an online database of curated experiments coupled to a customized instance of the Galaxy analysis engine with tools for gene list manipulation and molecular profile comparisons. The SCDE currently contains more than 50 stem cell-related experiments. Each has been manually curated and encoded using the ISA-Tab standard to ensure the quality of the data and its annotation. Keep Reading...  The Center for Health Bioinformatics at the Harvard School of Public Health provides consults to researchers for the management, integration and contextual analysis of biological high-throughput data. We are a member of the Center for Stem Cell Bioinformatics, the Environmental Statistics and Bioinformatics Core at the Harvard NIEHS Center for Environmental Health and the Genetics & Bioinformatics Consulting group for Harvard Catalyst and work closely with our colleagues in the Department of Biostatistics and the Program in Quantitative Genomics to act as a single point of contact for computational biology,
Mike Chelen

RNA world easier to make : Nature News - 0 views

  • John Sutherland and his colleagues from the University of Manchester, UK
  • ribonucleotide
  • building block of RNA
  • ...29 more annotations...
  • Donna Blackmond, a chemist at Imperial College London.
  • strong evidence for the RNA world
  • 'RNA world' hypothesis, which suggests that life began when RNA, a polymer related to DNA that can duplicate itself and catalyse reactions
  • chemists had thought the subunits would probably assemble themselves first, then join to form a ribonucleotide
  • three distinct parts: a ribose sugar, a phosphate group and a base
  • RNA polymer is a string of ribonucleotides
  • efforts to connect ribose and base together have met with frustrating failure
  • researchers have now managed to synthesise
  • ribonucleotides
  • remedy is to avoid producing separate ribose-sugar and base subunits
  • makes a molecule whose scaffolding contains a bond that will
  • be the key ribose-base connection
  • atoms are then added around this skeleton
  • final connection is to add a phosphate group
  • influences the entire synthesis
  • acting as a catalyst, it guides small organic molecules into making the right connections
  • What we have ended up with is molecular choreography
  • objectors to the RNA-world theory say the RNA molecule as a whole is too complex to be created using early-Earth geochemistry
  • flaw is in the logic — that this experimental control by researchers in a modern laboratory could have been available on the early Earth
  • Robert Shapiro, a chemist at New York University
  • early-Earth scenarios
  • heating molecules in water, evaporating them and irradiating them with ultraviolet light
  • results showing that they can string nucleotides together
  • ultimate goal is to get a living system (RNA) emerging from a one-pot experiment
  • need to know what the constraints on the conditions are first
  • Shapiro sides with
  • another theory of life's origins
  • because RNA is too complex to emerge from small molecules, simpler metabolic processes
  • eventually catalysed the formation of RNA and DNA
anonymous

C-H-N-S-O Analysis - Trivedi Science - 0 views

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    CHNSO elemental analyses of treated products. Total nitrogen, carbon, nitrogen, sulfur and oxygen are determined with significant improvements. Read Trivedi Science report here
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