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This is the largest nationally representative study to date of the toll taken by sepsis and pneumonia, two conditions often caused by deadly microbes, including the antibiotic-resistant bacteria MRSA. Such infections can lead to longer hospital stays, serious complications and even death. "In many cases, these conditions could have been avoided with better infection control in hospitals," said Ramanan Laxminarayan, Ph.D., principal investigator for Extending the Cure, a project examining antibiotic resistance based at the Washington, D.C. think-tank Resources for the Future. "Infections that are acquired during the course of a hospital stay cost the United States a staggering amount in terms of lives lost and health care costs," he said. "Hospitals and other health care providers must act now to protect patients from this growing menace." Laxminarayan and his colleagues analyzed 69 million discharge records from hospitals in 40 states and identified two conditions caused by health care-associated infections: sepsis, a potentially lethal systemic response to infection and pneumonia, an infection of the lungs and respiratory tract. The researchers looked at infections that developed after hospitalization. They zeroed in on infections that are often preventable, like a serious bloodstream infection that occurs because of a lapse in sterile technique during surgery, and discovered that the cost of such infections can be quite high: For example, people who developed sepsis after surgery stayed in the hospital 11 days longer and the infections cost an extra $33,000 to treat per person. Even worse, the team found that nearly 20 percent of people who developed sepsis after surgery died as a result of the infection. "That's the tragedy of such cases," said Anup Malani, a study co-author, investigator at Extending the Cure, and professor at the University of Chicago. "In some cases, relatively healthy people check into the hospital for routine surgery. They develop sepsis because of a lapse in infection control—and they can die." The team also looked at pneumonia, an infection that can set in if a disease-causing microbe gets into the lungs—in some cases when a dirty ventilator tube is used. They found that people who developed pneumonia after surgery, which is also thought to be preventable, stayed in the hospital an extra 14 days. Such cases cost an extra $46,000 per person to treat. In 11 percent of the cases, the patient died as a result of the pneumonia infection.

“Nanotubes assemblies of various types are black and highly conductive,” said Dr. Mikhail Kozlov, a research scientist and the study’s lead author. “Their dark, conductive surface can be effectively heated with laser light or electricity to induce variations in the pressure of the air around the nanotubes — which we perceive as sound. It’s called the photo- or thermo-acoustic effect, and it’s the same principle Alexander Graham Bell used to produce sound on the first telephone.” With laser excitation, no electrical contact with the nanotube speaker is required, making the speakers wireless. “Speakers made with carbon nanotube sheets are extremely thin, light and almost transparent,” Kozlov said. “They have no moving parts and can be attached to any surface, which makes the surface acoustically active. They can be concealed in television and computer screens, apartment walls, or in the windows of buildings and cars. The almost invisible strands form films that can ‘talk.’” In addition to filling a room with sound from invisible speakers, nanotube speakers could easily cancel sound from the noisiest neighbor or dim the roar of traffic rushing past a neighborhood, using the same principles as current sound-canceling technologies. “The sound generation by nanotube sheets can help to achieve this effect on very large scales,” Kozlov said.