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Nickyz P.

It's Alive! Artificial Life Springs From Manmade DNA : Discovery News - 0 views

  • "This is the first synthetic cell that's been made," said Venter. "We call it synthetic because the cell is totally derived from a synthetic chromosome, made with four bottles of chemicals on a chemical synthesizer, starting with information in a computer."
  • Venter and his colleagues created a special code, similar to Morse code, to "write" within the DNA itself. Instead of dots and dashes, they used the sequence of four DNA nucleotides, thymine (T), guanine (G), cytosine (C), and adenine (A), as a code for any letter, number or punctuation mark. Using the code, the team included the names of the study co-authors, a website, and even several philosophical quotes, complete with punctuation.
Kantham Hongdusit

Gene transfer to human joints: Progress toward a gene therapy of arthritis - 0 views

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    Rheumatoid Arthritis is an incurable disease that is often difficult to treat. The article describes how a transfer of cultured synovial fibroblasts can increase the amount of IL-1Ra receptor, which offers a therapeutic gene that can be used to obtain intra articular transgene expression.
Kantham Hongdusit

Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast i... - 1 views

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    A long term foreign gene expression can be embedded/transferred if a housekeeping gene promoter is present to drive the transcription. A mouse embryo fibroblast implants can be achieved when the embryo is embedded in a collagen matrix, which is a proof of the theory.
Kantham Hongdusit

Inducible gene expression from the plastid genome by a synthetic riboswitch - 0 views

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    Riboswitches, natural RNA sensors that mediate the control of gene expression by beinding with metabolites, are engineered via a simulation to meet the requirements of translational regulation in organelles. These new riboswitches are able facilitate the expression of chloroplast genes
Rafael Chen

Plant Geneticist Identifies Drought-Tolerant Gene - 2 views

  • isolation of the gene that controls drought tolerance in plants
  • enable a plant's leaves to stay green long after the last watering
  • plant hormone abscisic acid triggers the closure of the plant's stomata
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  • controlled by the ERA1
  • By suppressing the gene -- and thereby keeping the stomata closed -- he found it is possible to control water loss so plants last longer
  • useful in applications such as the cut flower industry
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    Genetically engineering plants with a drought resistant gene may be beneficial in creating plants whom leaves would stay green long after the last watering.
Oranicha Jumreornvong

EBSCOhost: "BUT IT DOESN'T RUN IN MY FAMILY" - 1 views

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    health right now Closing the GAPS in your knowledge of YOUR FAMILY TREE can quite literally save your LIFE SARA McGREGOR never worried about getting breast cancer. Neither did her two older sisters. After all, their mother and maternal grandmother never had the disease.
Oranicha Jumreornvong

EBSCOhost: Chicken revisits its dinosaur past - 0 views

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    THIS WEEK If we can rewind evolution to create a "snouted" bird, we might also be able to fast-forward it ARHAT ABZHANOV cuts a square hole in the shell of a chicken egg, drops in a small gelatinous bead and watches the embryo develop.
Oranicha Jumreornvong

EBSCOhost: What Makes Each Brain Unique - 0 views

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    NEUROSCIENCE How can identical twins grow up with different personalities? "Jumping genes" move around in neurons and alter the way they work YOUR BRAIN IS SPECIAL. So is mine. Differences arise at every level of the organ's astonishingly intricate architecture; the human brain contains 100 billion neurons, which come in thousands of types and collectively form an estimate of more than 100 trillion interconnections.
Oranicha Jumreornvong

EBSCOhost: The orchid children - 0 views

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    Features Are you an orchid or a dandelion? Are you a sensitive flower or a hardier type? It may all be down to an intriguing set of genes, as David Dobbs finds out WHY are some children better at sharing than others? One attempt to find out uses what you could call the "Bamba test".
Kantham Hongdusit

Niceness, Generosity May Have A Genetic Component - 0 views

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    Psychologists from the Buffalo University and University of California have conducted a survey to find out if DNA can affect how a person perceives the world. They conclude that there is a specific gene, which has not yet been identified, that controls the receptors of oxytocin and vasopressin, hormones that display "niceness".
Kantham Hongdusit

Improved Understanding Of Cancer Progression - 0 views

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    Researchers in IMIM have discovered the function of the enzyme LOXL2, which is one of the factor causing cancer. The enzyme interacts with histone H3, and changes the DNA sequence around that histone, eliminating the lysine 4 amino acid group, which favors tumor development
chanon chiarnpattanodom

Parallel Genetic and Phenotypic Evolution of DNA Superhelicity in Experimental Populati... - 0 views

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    Importance of DNA supercoiling affects on E coli's growth, parallel and creating beneficial mutations.
nidthamsirisup

Epigenetics Seeks Clues to Mental Illness in Genes' Life Story - Science in 2011 - NYTi... - 0 views

  • epigenetics, the study of how people’s experience and environment affect the function of their genes.
  • Studies suggest that such add-on, or epigenetic, markers develop as an animal adapts to its environment, whether in the womb or out in the world — and the markers can profoundly affect behavior.
  • In studies of rats, researchers have shown that affectionate mothering alters the expression of genes, allowing them to dampen their physiological response to stress. These biological buffers are then passed on to the next generation: rodents and nonhuman primates biologically primed to handle stress tend to be more nurturing to their own offspring, and the system is thought to work similarly in humans.
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  • the offspring of parents who experience famine are at heightened risk for developing schizophrenia, some research suggests — perhaps because of the chemical signatures on the genes that parents pass on.
  • in some people with autism, epigenetic markers had silenced the gene which makes the receptor for the hormone oxytocin. Oxytocin oils the brain’s social circuits, and is critical in cementing relationships; a brain short on receptors for it would most likely struggle in social situations.
  • In one large study of people with schizophrenia, researchers at Johns Hopkins are analyzing blood and other data to see whether the degree of epigenetic variation is related to the inherited risk of developing the disorder. In another, researchers at Tufts are studying the genes of animals dependent on opiates to see how epigenetic alterations caused by drug exposure affect the opiate sensitivity of the animals’ offspring.
nidthamsirisup

Mysterious Noncoding DNA: 'Junk' or Genetic Power Player? | PBS NewsHour - 0 views

  • Genes represent only a tiny fraction -- 1 percent -- of our overall genetic material. Then there's the other 99 percent of our DNA -- the stuff that doesn't make protein
  • Researchers have found that some of this noncoding DNA is in fact essential to how our genes function and plays a role in how we look, how we act and the diseases that afflict us.
  • Embedded in this 99 percent is DNA responsible for the mechanics of gene behavior: regulatory DNA. Greg Wray of Duke University's Institute for Genome Sciences and Policy describes the regulatory DNA as the software for our genes, a set of instructions that tells the genome how to use the traditional coding genes.
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  • "It's like a recipe book," Wray said. "It tells you how to make the meal. You need to know the amounts. You need to know the order. The noncoding DNA tells you how much to make, when to make it and under what circumstances."
  • common diseases are probably more influenced by regulatory differences, Harismendy said. These include Type 2 diabetes, Crohn's disease, Alzheimer's Disease and a variety of cancers, including breast, colon, ovarian, prostate and lung.
  • According to Wray, research has shown that diseases like bipolar syndrome and clinical depression may be associated with noncoding mutations that determine whether the brain is producing too much or not enough of a particular neurotransmitter. One noncoding mutation gives a person almost complete protection against the nasty malaria parasite, plasmodium vivax.
  • Another piece of noncoding DNA regulates the enzyme responsible for lactose tolerance, the ability to digest milk. Research by Wray and other scientists has shown that in four populations where dairy consumption is a vital part of the diet, new mutations have appeared that essentially keep the gene that produces the lactase enzyme from switching off.
  • And recent research done by evolutionary biologists suggests that differences in regulatory DNA may represent a major part of what separates us from chimpanzees.
nidthamsirisup

Epigenetics: DNA Isn't Everything - 0 views

  • Research into epigenetics has shown that environmental factors affect characteristics of organisms. These changes are sometimes passed on to the offspring.
  • A certain laboratory strain of the fruit fly Drosophila melanogaster has white eyes. If the surrounding temperature of the embryos, which are normally nurtured at 25 degrees Celsius, is briefly raised to 37 degrees Celsius, the flies later hatch with red eyes.
  • crossed the flies for six generations. In this experiment, they were able to prove that the temperature treatment changes the eye colour of this specific strain of fly, and that the treated individual flies pass on the change to their offspring over several generations. However, the DNA sequence for the gene responsible for eye colour was proven to remain the same for white-eyed parents and red-eyed offspring.
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  • Epigenetics examines the inheritance of characteristics that are not set out in the DNA sequence.
  • important factors are the histones, a kind of packaging material for the DNA, in order to store DNA in an ordered and space-saving way. It is now clear that these proteins have additional roles to play. Depending on the chemical group they carry, if they are acetylated or methylated, they permanently activate or deactivate genes.
  • New methods now allow researchers to sometimes directly show which genes have been activated or deactivated by the histones
  • The genetic information of the DNA is passed on along with the relevant epigenetic information for the respective cell type.
  • A similar question remains for the inheritance of the epigenetic characteristics from parents to offspring. They now know that when the gametes are formed, certain epigenetic markers remain and are passed on to the offspring. The questions, which are currently being researched, are how much and which part of the epigenetic information is preserved and subsequently inherited.
  • Diet and epigenetics appear to be closely linked. The most well known example is that of the Agouti mice: they are yellow, fat and are prone to diabetes and cancer. If Agouti females are fed with a cocktail of vitamin B12, folic acid and cholin, directly prior to and during pregnancy, they give birth to mainly brown, slim and healthy offspring. They in turn mainly have offspring similar to themselves.
  • Environmental factors, which change the characteristics of an individual and are then passed on to its offspring, do not really fit into Darwin’s theory of evolution. According to his theory, evolution is the result of the population and not the single individual. “Passing on the gained characteristics fits more to Lamarck’s theory of evolution”, says Paro.
nidthamsirisup

Engineered stem cells seek out and kill HIV in living mice - 0 views

  • human stem cells can be genetically engineered into HIV-fighting cells
  • surrogate model
  • CD8 cytotoxic T lymphocytes -- the "killer" T cells that help fight infection -- from an HIV-infected individual and identified the molecule known as the T cell receptor, which guides the T cell in recognizing and killing HIV-infected cells.
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  • cloned the receptor and used this to genetically engineer human blood stem cells.
  • mature T cells that can attack HIV in tissues where the virus resides and replicates.
  • CD4 cells are white blood cells that are an important component of the immune system, helping to fight off infections.
  • CD4 "helper" T cells
  • engineering stem cells to form immune cells that target HIV is effective in suppressing the virus in living tissues in an animal model
  • increased
  • HIV in the blood decreased.
    • wasin kusakabe
       
      Using mice as lab rats, researchers are able to produce a large amount of T cells that can fight off HIV more effectively.
  • The engineered stem cells developed into a large population of mature, multi-functional HIV-specific CD8 cells that could specifically target cells containing HIV proteins. The researchers also discovered that HIV-specific T cell receptors have to be matched to an individual in much the same way an organ is matched to a transplant patient.
  • Expanding on previous research providing proof-of-principle that human stem cells can be genetically engineered into HIV-fighting cells
  • In this current study, the researchers similarly engineered human blood stem cells and found that they can form mature T cells that can attack HIV in tissues where the virus resides and replicates. They did so by using a surrogate model, the humanized mouse, in which HIV infection closely resembles the disease and its progression in humans.
  • increased, while levels of HIV in the blood decreased. CD4 cells are white blood cells that are an important component of the immune system, helping to fight off infections. These results indicated that the engineered cells were capable of developing and migrating to the organs to fight infection there.
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    Stem cells that are engineered to produce T cells that can help fight off HIV.
Rafael Chen

New Plant Mutation Produces Tap Root With Large Amounts Of Oil, Proteins, And Starch - 1 views

  • The discovery could lead to genetically engineered plants that store commercially useful substances in an enlarged root
  • The pickle mutation mimics what happens in seeds, which typically are the major structures accumulating and storing proteins and oil
  • In this mutation the cells destined to become primary root cells retain the character of embryonic cells
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  • They fail to make the switch from embryonic to adult
  • The mutation has its greatest effect when gibberellin is not present during the first 24 hours of growth
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    A mutation in plants that makes the tap root accumulate large amounts of oils, proteins, and starch was discovered by scientist, this could lead to genetically engineered plants that store commercially useful substances in an enlarged root.
nidthamsirisup

Stem Cell Treatment Spurs Cartilage Growth - Science News - 0 views

  • A small molecule dubbed kartogenin encourages stem cells to take on the characteristics of cells that make cartilage, a new study shows
  • And treatment with kartogenin allowed many mice with arthritis-like cartilage damage in a knee to regain the ability to use the joint without pain.
  • Kartogenin steers the stem cells to wake up and take on cartilage-making duties. This is an essential step in the cartilage repair that falls behind in people with osteoarthritis, the most common kind of arthritis, which develops from injury or long-term joint use.
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  • The molecule turned on genes that make cartilage components called aggrecan and type II collagen. Tests of mice with cartilage damage similar to osteoarthritis showed that kartogenin injections lowered levels of a protein called cartilage oligomeric matrix protein. People with osteoarthritis have an excess of the protein, which is considered a marker of disease severity.
  • kartogenin inhibits a protein called filamin A in the mesenchymal stem cells
Sea Maskulrath

The Ice Age Elephant - Mammuthus primigenius | Scitech | The Earth Times - 0 views

  • preserved remains of a shaggy monster that lived in Siberia at -40°C 10,000 years ago have been uncovered;
  • The frozen and p
  • Only microscopic amounts of DNA are left on the skeletons, including all the bacteria that lived on the animals. No usable DNA is therefore often found in bone, but mammoth hair is plentiful. Shampooed and bleached and digested, the hair, even at 18,000 years old, can have 90% of the DNA left. The genome shows 4 different "races" of this species. Research has also shown the recreated blood of mammoth. It doesn't decrease its oxygen capacity at the low temperatures the mammoth had to endure. That increased oxygen-offloading ability was one of the essential physiological changes evolved especially for this species, just like the Yuka kidney.
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  • reserved remains of a shaggy monster that lived in Siberia at -40°C 10,000 years ago have been uncovered;
  • Cloning the mammoth has been an aim of Japanese scientists for several years. They discovered almost intact bone marrow from a thigh bone in Yakutsk and hope to use a female elephant for what is obviously more than a simple experiment within the next 5 years.
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    The return of the giant, not a long wait :) 
Sea Maskulrath

Why having sex really IS the best thing to do: Gene mapping finally proves mating is be... - 0 views

  • Why having sex really IS the best thing to do
  • is better for evolution than self-reproduction
  • Having sex allows us to evolve more effectively than species which reproduce without a partner, according to tests that claim to finally prove the long-held theory.
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  • cording to the study by the University of Edinburgh.
  • Combining the genes of two parents – rather than one in the case of fruit flies, stick insects and other animals – allows for damaging DNA to be removed within a few generations.
  • Meanwhile, creatures who reproduce asexually are more likely to be lumbered with disease-causing genes
  • h longer, a
  • or muc
  • This is because individuals who inherit healthy genes tend to flourish and pass on their DNA to the next generatio
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    well, I guess SEX is the best way to develop a super human for the future + I know everyone gonna love it :) 
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