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Contents contributed and discussions participated by Dennis OConnor

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Dennis OConnor

Lotus | TCM (Traditional Chinese Medicine) Resources for COVID-19 - 0 views

www.elotus.org/...tcm-resources-covid-19

covid TCM

shared by Dennis OConnor on 26 Mar 20 - No Cached
  • Dennis OConnor on 26 Mar 20
     
    Recommended by Erin Raskin John Chen, PhD, Pharm D, OMD, LAc is a very knowledgeable and generous man.
Dennis OConnor

Help Hope Live v1.0 - Honor Kabir Kadre - Video - 1 views

www.youtube.com/watch

Kabir

shared by Dennis OConnor on 25 Mar 20 - No Cached
  • Dennis OConnor on 25 Mar 20
     
    Kabir speaks from the heart. Big Love.
Dennis OConnor

Donate to Southwest Catastrophic Injury Fund in honor of Kabir Kadre - 2 views

helphopelive.org/1979

Kabir

shared by Dennis OConnor on 25 Mar 20 - No Cached
  • Dennis OConnor on 25 Mar 20
     
    "Thank you for visiting! As you likely know, my name is Kabir Kadre, and I am partnering here with Help Hope Live, a registered 501(c)(3) nonprofit, in part because they provide both tax deductibility and fiscal accountability to those who wish to support the medical costs of my life with Spinal Cord Injury and the resulting quadriplegia and paralysis. Thanks to their efforts, and with your generous support, I am able to offset my substantial medical costs and focus on giving what I can to the world through the gift of my life."
Dennis OConnor

UCSF Emergency COVID-19 Early Detection Research SUPPORT REQUEST - 1 views

diigo.com/0h4fvh

covid testing oura research

shared by Dennis OConnor on 24 Mar 20 - No Cached
  • Dennis OConnor on 24 Mar 20
     
    Click to download the PDF. Oura's primary goal is to help UCSF engage and increase the number of users who have rings and are opting in to early detection efforts. Oura is offering rings at $250 for orders of 1000 rings supporting TemPredict. Immediate impact: Participants are presented every morning with daily personalized insights on heart rate, HRv, respiration, temperature, sleep staging, and activity to empower them to monitor their own health and change their behavior accordingly. This is especially important in medical personnel and high-risk patients. Future impact: UCSF will leverage Oura's backend data to build models that can aid in identifying symptom profiles, pinpointing at risk populations, predicting severity, and validating recovery, containment, and treatment efforts. The data gathered now may be our only chance to measure these changes so we can recognize them and deploy predictive algorithms to minimize the next wave of this outbreak, expected in Fall 2020. We ask all donors to go to OuraRing.com and buy rings for medical personnel so they can join this effort.
Dennis OConnor

Coronavirus Pandemic Update 37: The ACE-2 Receptor - The Doorway to COVID-19 (ACE Inhib... - 0 views

www.youtube.com/watch

covid research ACE-2

shared by Dennis OConnor on 23 Mar 20 - No Cached
  • Dennis OConnor on 23 Mar 20
     
    "Dr. Michael Kurisu D.O." called this video "molecurlar biology 101" It is from the Youtube Channel: MedCram - Medical Lectures Explained CLEARLY
  • Dennis OConnor on 23 Mar 20
     
    Forwarded to the Project Apollo listserve by "Dr. Michael Kurisu D.O." from Christina Mnatzaganian. This is from the UCSD Family Medicine Faculty Listserve. Hi Deepa, The statement below is from ACC/HFSA/AHA on March 17th. Essentially, there is no human data yet and data is evolving. See below, particularly the red area: *The following joint statement from the ACC, American Heart Association and Heart Failure Society of America was posted online on March 17 and addresses using renin angiotensin aldosterone system (RAAS) antagonists in COVID-19. "The continued highest standard of care for cardiovascular disease patients diagnosed with COVID-19 is top priority, but there are no experimental or clinical data demonstrating beneficial or adverse outcomes among COVID-19 patients using ACE-I or ARB medications," said Richard J. Kovacs, MD, FACC. "We urge urgent, additional research that can guide us to optimal care for the millions of people worldwide with cardiovascular disease and who may contract COVID-19. These recommendations will be adjusted as needed to correspond with the latest research." Patients with underlying cardiovascular diseases appear to have an increased risk for adverse outcomes with coronavirus disease 2019 (COVID-19). Although the clinical manifestations of COVID-19 are dominated by respiratory symptoms, some patients also may have severe cardiovascular damage. Angiotensin converting enzyme 2 (ACE2) receptors have been shown to be the entry point into human cells for SARS-CoV-2, the virus that causes COVID-19. In a few experimental studies with animal models, both angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) have been shown to upregulate ACE2 expression in the heart. Though these have not been shown in human studies, or in the setting of COVID-19, such potential upregulation of ACE2 by ACE inhibitors or ARBs has resulted in a speculation of potential increased risk for COVID-19 infection in patients with
Dennis OConnor

Doctors on the Frontlines of the Coronavirus Fight - The Atlantic - 0 views

www.theatlantic.com/...608509

covid research testing first-responders

shared by Dennis OConnor on 23 Mar 20 - No Cached
  • Yui had always counted herself lucky to be among a family of doctors. Now the family is facing the greatest challenge of their lives as they wrestle with the dilemma of caring for their patients even though this risks exposing their loved one
  • Will her family survive the crisis intact?
  • Doctors across America are facing similar predicaments, made all the more acute by the government’s failure to protect them—to warn the public, to provide tests, and to supply enough protective equipment.
  • ...13 more annotations...
  • When it comes to us being doctors, I worry about [family members] Stephanie and Alex and Jennifer and Pam—about their health, and about the eventual burnout due to everything that’s going on,”
  • As a primary-care physician, she’s the first point of contact with the medical system for many patients.
  • Pam recommended a hospital visit to be tested. “It was already too late for me and my family,” Pamela told me—she had been potentially exposed. Her patient got tested on March 12, and is still waiting for results. “My patient’s test was sent from Baltimore to a lab in Utah, then due to a reagent shortage [a substance needed to process the tests] sent from Utah to Arizona, Arizona back to a lab in North Carolina,” she said.
  • This is a mirror of the dysfunction and delays surrounding the country’s testing crisis, a major factor hamstringing the fight against the virus.
  • Meanwhile, she started feeling sick on Tuesday, and took the test herself. Self-quarantined at home, she thinks it’s only a matter of time, if she does have the virus, before she infects her two children—totally isolating from them would be all but impossible.
  • As a health-care provider, if I test positive, it has big implications for my office, my staff, and all the patients,”
  • Emergency-room doctors, he noted, are among those most at risk.
  • Her emergency room has been seeing more and more patients who have symptoms
  • She wears protective equipment but knows that the hospital could run out.
  • It’s not lost on Koo and her family that medical professionals worldwide have been dying fighting the coronavirus.
  • the main dilemma they’re grappling with is not so much getting sick themselves but spreading the virus to their families, their patients, and the public.
  • his might be the greatest fear of doctors across the country—that they’ll move from being part of the solution to part of the problem.
  • should. It weighs heavily on people.”Yui, for her part, told me she’d never let her fears over the virus stop her from doing her job.
  • Dennis OConnor on 23 Mar 20
     
    Dr. Michael Kurisu D.O.: Another article capturing the dialogue that i hear from a lot of my colleagues and others. We have doctors as well In my family : -My sister is Neuro ICU and director of stroke at Tri city hospital in Oceanside -Her husband is ER doc -My little sister is the PhD in sociology. (She specializes in education programs for the incarcerated and has interest on health access for prisons - which is a frightful place during this pandemic)
  • Dennis OConnor on 23 Mar 20
     
    We are in a war against this virus. First responders are the first line of defense. There is a lack of supplies and central leadership. However, there is no shortagage of courage. When you meet a first responder, say, "Thank you for your service."
Dennis OConnor

What We Know So Far About SARS-CoV-2 - The Atlantic - 0 views

www.theatlantic.com/...608338

covid research testing

shared by Dennis OConnor on 23 Mar 20 - No Cached
  • March 20, 2020
  • One of the few mercies during this crisis is that, by their nature, individual coronaviruses are easily destroyed.
  • These viruses don’t endure in the world. They need bodies.
  • ...30 more annotations...
  • To be clear, SARS-CoV-2 is not the flu. It causes a disease with different symptoms, spreads and kills more readily,
  • his family, the coronaviruses, includes just six other members that infect humans
  • OC43, HKU1, NL63, and 229E—have been gently annoying humans for more than a century, causing a third of common colds
  • MERS and SARS (or “SARS-classic,” as some virologists have started calling it)—both cause far more severe disease.
  • hy was this seventh coronavirus the one to go pandemic?
  • The structure of the virus provides some clues about its success. In shape, it’s essentially a spiky ball. Those spikes recognize and stick to a protein called ACE2
  • This is the first step to an infection
  • he exact contours of SARS-CoV-2’s spikes allow it to stick far more strongly to ACE2 than SARS-classic did
  • But in SARS-CoV-2, the bridge that connects the two halves can be easily cut by an enzyme called furin, which is made by human cells and—crucially—is found across many tissues. “This is probably important for some of the really unusual things we see in this virus,” says Kristian Andersen of Scripps Research Translational Institute.
  • SARS-CoV-2 seems to infect both upper and lower airways,
  • his double whammy could also conceivably explain why the virus can spread between people before symptoms show up
  • All of this is plausible but totally hypothetical; the virus was only discovered in January, and most of its biology is still a mystery.
  • The closest wild relative of SARS-CoV-2 is found in bats, which suggests it originated in a bat, then jumped to humans either directly or through another species.
  • Another coronavirus found in wild pangolins also resembles SARS-CoV-2
  • Indeed, why some coronaviruses are deadly and some are not is unclear. “There’s really no understanding at all of why SARS or SARS-CoV-2 are so bad but OC43 just gives you a runny nose,” Frieman says.
  • Once in the body, it likely attacks the ACE2-bearing cells that line our airways.
  • The immune system fights back and attacks the virus; this is what causes inflammation and fever
  • in extreme cases, the immune system goes berserk
  • These damaging overreactions are called cytokine storms.
  • they’re probably behind the most severe cases of COVID-19.
  • During a cytokine storm, the immune system isn’t just going berserk but is also generally off its game, attacking at will without hitting the right targets.
  • But why do some people with COVID-19 get incredibly sick, while others escape with mild or nonexistent symptoms
  • Age is a factor.
  • other factors—a person’s genes, the vagaries of their immune system, the amount of virus they’re exposed to, the other microbes in their bodies
  • “it’s a mystery why some people have mild disease, even within the same age group,”
  • Coronaviruses, much like influenza, tend to be winter viruses.
  • In the heat and humidity of summer, both trends reverse, and respiratory viruses struggle to get a foothold.
  • irus is tearing through a world of immunologically naive people, and that vulnerability is likely to swamp any seasonal variations.
  • And one recent modeling study concluded that “SARS-CoV-2 can proliferate at any time of year.
  • Unless people can slow the spread of the virus by sticking to physical-distancing recommendations, the summer alone won’t save us.
  • Dennis OConnor on 23 Mar 20
     
    Dr. Michael Kurisu D.O.: We've known about SARS-CoV-2 for only three months, but scientists can make some educated guesses about where it came from and why it's behaving in such an extreme way.
Dennis OConnor

CDC - Recommended Guidance for Extended Use and Limited Reuse of N95 Filtering Facepiec... - 0 views

www.cdc.gov/...recommendedguidanceextuse.html

testing covid first-responders safety

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • This document recommends practices for extended use and limited reuse of NIOSH-certified N95 filtering facepiece respirators (commonly called “N95 respirators”). The recommendations are intended for use by professionals who manage respiratory protection programs in healthcare institutions to protect health care workers from job-related risks of exposure to infectious respiratory illnesses.
  • Minimize the number of individuals who need to use respiratory protection through the preferential use of engineering and administrative controls;
  • Use alternatives to N95 respirators (e.g., other classes of filtering facepiece respirators, elastomeric half-mask and full facepiece air purifying respirators, powered air purifying respirators) where feasible;
  • ...5 more annotations...
  • mplement practices allowing extended use and/or limited reuse of N95 respirators, when acceptable; and
  • Prioritize the use of N95 respirators for those personnel at the highest risk of contracting or experiencing complications of infection.
  • Respirator Reuse Recommendations
  • There is no way of determining the maximum possible number of safe reuses for an N95 respirator as a generic number to be applied in all cases. Safe N95 reuse is affected by a number of variables that impact respirator function and contamination over time.
  • Risks of Extended Use and Reuse of Respirators
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Jessica Block
Dennis OConnor

Substantial undocumented infection facilitates the rapid dissemination of novel coronav... - 0 views

science.sciencemag.org/...science.abb3221

covid research testing

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • AbstractEstimation of the prevalence and contagiousness of undocumented novel coronavirus (SARS-CoV2) infections is critical for understanding the overall prevalence and pandemic potential of this disease. Here we use observations of reported infection within China, in conjunction with mobility data, a networked dynamic metapopulation model and Bayesian inference, to infer critical epidemiological characteristics associated with SARS-CoV2, including the fraction of undocumented infections and their contagiousness. We estimate 86% of all infections were undocumented (95% CI: [82%–90%]) prior to 23 January 2020 travel restrictions. Per person, the transmission rate of undocumented infections was 55% of documented infections ([46%–62%]), yet, due to their greater numbers, undocumented infections were the infection source for 79% of documented cases. These findings explain the rapid geographic spread of SARS-CoV2 and indicate containment of this virus will be particularly challenging.
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Jessica Block
Dennis OConnor

Up-to-Date Coronavirus (SARS-CoV-2 / COVID-19) Information - Peter Attia MD - 0 views

peterattiamd.com/covid-19

covid research testing

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • Currently, my entire clinical and research team are working on trying to make sense of the SARS-CoV-2 / COVID-19 pandemic.
  • We’re constantly in contact with leading experts and doctors working on this issue around the world,
  • We will tell you what we know, when we know it, and what we don’t know.
  • ...1 more annotation...
  • Information will continue to be passed through podcasts, patient memos, and videos.
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Vicky Newman & Erin Raskin
Dennis OConnor

How to Protect Yourself from COVID-19: Supporting Your Immune System When You May Need ... - 0 views

drhyman.com/...protect-yourself-from-covid-19

covid research immune-system

shared by Dennis OConnor on 21 Mar 20 - No Cached
  • How Can I Protect Myself, My Family, and My Community
  • How to Avoid Infection with COVID-19 
  • How to Support Your Immune System: Remember, Let Food Be Your Medicine! 
  • ...1 more annotation...
  • How to Supplement for Immune Function 
  • Dennis OConnor on 21 Mar 20
     
    Recommended by Erin Raskin, DACM, L.Ac
Dennis OConnor

Anthony S. Fauci, M.D., NIAID Director | NIH: National Institute of Allergy and Infecti... - 0 views

www.niaid.nih.gov/director

covid research reliable-sources

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • Dr. Fauci was appointed Director of NIAID in 1984.
  • Dr. Fauci has advised six Presidents on HIV/AIDS and many other domestic and global health issues.
  • Dennis OConnor on 20 Mar 20
     
    DeAunne Denmark, MD, PhD - Recommends Dr. Anthony Fauci as a highly credible source of information.
Dennis OConnor

Integrative Considerations during the COVID 3.18.20.pdf - 1 views

diigo.com/0h3ryg

covid Integrative-spaces

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • Dennis OConnor on 20 Mar 20
     
    Recommended by Dr. Michael Kurisu D.O.: There is a high level of interest in integrative strategies to augment public health measures to prevent COVID-19 infection and associated pneumonia. Unfortunately, no integrative measures have been validated in human trials. Notwithstanding, this is an opportune time to be proactive. Using available in-vitro evidence, an understanding of the virulence of COVID-19, as well as data from similar, but different, viruses, we offer the following strategies to consider. Again, we stress that these are supplemental considerations to the current recommendations that emphasize regular hand washing, social distancing, stopping non-essential travel, and getting tested if you develop symptoms.
Dennis OConnor

Exporting Your Data with Oura on the Web - Oura Help - 0 views

support.ouraring.com/...ownloading-Your-Data-from-Oura

oura data data visualization

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • Dennis OConnor on 20 Mar 20
     
    Here is how you login to Oura to see your data: https://cloud.ouraring.com/account/login
Dennis OConnor

This Is How We Beat the Coronavirus - The Atlantic - 1 views

www.theatlantic.com/...608389

covid testing research

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • We’re closing schools and businesses and committing to social (really, physical) distancing. But as the sobering charts from the analysis show, this isn’t enough.
  • Asian countries have engaged in suppression; we are only engaging in mitigation.
  • At the moment, we can’t even test everyone who is sick.
  • ...15 more annotations...
  • Testing will allow us to isolate the infected so they can’t infect others. We need to be vigilant, and willing to quarantine people with absolute diligence.
  • To achieve this, we need to test many, many people, even those without symptoms.
  • Our primary approach is social distancing—asking people to stay away from one another.
  • Our efforts are good, temporizing measures.
  • Social distancing cannot prevent these infections, as they’ve already happened. Therefore, things will appear to get worse for some time, even if what we’re doing is making things better in the long run.
  • buried in the Imperial College report is reason for optimism. The analysis finds that in the do-nothing scenario, many people die and die quickly. With serious mitigation, though, many of the measures we’re taking now slow things down. By the summer, the report calculates, the number of people who become sick will eventually reduce to a trickle.
  • We can create a third path. We can decide to meet this challenge head-on. It is absolutely within our capacity to do so. We could develop tests that are fast, reliable, and ubiquitous. If we screen everyone, and do so regularly, we can let most people return to a more normal life. We can reopen schools and places where people gather. If we can be assured that the people who congregate aren’t infectious, they can socialize.
  • We can build health-care facilities that do rapid screening and care for people who are infected, apart from those who are not.
  • We can even commit to housing infected people apart from their healthy family members, to prevent transmission in households.
  • We will need to massively strengthen our medical infrastructure. We will need to build ventilators and add hospital beds. We will need to train and redistribute physicians, nurses, and respiratory therapists to where they are most needed. We will need to focus our factories on turning out the protective equipment—masks, gloves, gowns, and so forth—to ensure we keep our health-care workforce safe.
  • most importantly, we need to pour vast sums of intellectual and financial resources into developing a vaccine that would finally bring this nightmare to a close
  • If we commit to social distancing, however, at some point in the next few months the rate of spread will slow. We’ll be able to catch our breath. We’ll be able to ease restrictions, as some early hit countries are doing. We can move toward some semblance of normalcy.
  • The temptation then will be to think we have made it past the worst. We cannot give in to that temptation. That will be the time to redouble our efforts. We will need to prepare for the coming storm. We’ll need to build up our stockpiles, create strategies, and get ready.
  • We need to keep time on the clock, time to find a treatment or a vaccine.
  • We all have a choice to make. We can look at the coming fire and let it burn. We can hunker down, and hope to wait it out—or we can work together to get through it with as little damage as possible.
Dennis OConnor

In the Footsteps of Thich Nhat Hanh Online Summit - 0 views

promo.lionsroar.com/t-thich-nhat-hanh-aff-00urvpxn

mindfulness

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • Cultivate joy and transform suffering with wisdom from leading teachers in the Plum Village tradition of mindfulness, compassion, and peace.
  • Discover the beauty and brilliance of Thich Nhat Hanh’s wisdom with guidance from some of those who know him best. Join 9 incredible teachers from his lineage as they offer intimate insights inspired by his most powerful teachings.
  • “We have more possibilities available in each moment than we realize.”~ Thich Nhat Hanh
  • Dennis OConnor on 20 Mar 20
     
    Recommended by Erin Raskin: Free Online Event - March 25-26, 2020
Dennis OConnor

A serological assay to detect SARS-CoV-2 seroconversion in humans | medRxiv - 0 views

www.medrxiv.org/...2020.03.17.20037713v1

covid research testing

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • While molecular assays to directly detect the viral genetic material are available for the diagnosis of acute infection, we currently lack serological assays suitable to specifically detect SARS-CoV-2 antibodies.
  • Methods: Here we describe serological enzyme-linked immunosorbent assays (ELISA) that we developed using recombinant antigens derived from the spike protein of SARS-CoV-2.
  • Conclusion: Serological assays are of critical importance to determine seroprevalence in a given population, define previous exposure and identify highly reactive human donors for the generation of convalescent serum as therapeutic.
  • Dennis OConnor on 20 Mar 20
     
    Recommended by DeAunne Denmark, MD, PhD: This study is under peer review. Published via the medRxiv preprint server for health sciences.
Dennis OConnor

First U.S. Company Announces an Upcoming Home COVID-19 Test | Time - 0 views

time.com/...home-covid-19-test-everlywell

covid research testing EverlyWell

shared by Dennis OConnor on 19 Mar 20 - No Cached
  • Food and Drug Administration allowed certified labs, including commercial lab testing companies, to develop and distribute COVID-19 tests on Feb. 29.
  • People can order the Everlywell COVID-19 test on the company’s website, after first answering questions about their basic health, symptoms and risk factors for the coronavirus disease. A doctor still needs to prescribe the test, so telemedicine doctors from PWNHealth, a national network of physicians who prescribe diagnostic tests, then reviews these answers to determine if a person qualifies for testing, based on criteria established by the Centers for Disease Control and Prevention.
  • Currently, because COVID-19 tests are not plentiful in the U.S., doctors are trying to rule out other respiratory diseases like flu first, and only ordering tests for people with symptoms who also have other risk factors for infection, such as being in close contact with others who have been diagnosed.
  • ...7 more annotations...
  • If the telemedicine doctor decides to prescribe an Everlywell COVID-19 test, the company says it will send the $135 test kit in two days (customers can pay $30 more to receive the kit overnight).
  • As with many of the commercially available tests, this one extracts SARS-CoV-2, the virus behind COVID-19, from the sample and then probes for specific genetic signatures of the virus.
  • If the test is positive, the company also provides a full telemedicine consultation with one of around 200 physicians that is included in the cost of the test.
  • Everlywell says it is ready to ship 30,000 COVID-19 tests, and plans to expand the number of labs processing the sample
  • kits will depend on the availability of swabs for collecting samples
  • global shortage of swabs for any lab performing the test.
  • We’re working hard to ramp up weekly capacity to test 250,000 Americans,” says Cheek
  • Dennis OConnor on 20 Mar 20
     
    DeAunne Denmark, M.D. Phd - I was just reading about this last night. Dr forum blowing up about it. It could be a gigantic win for EverlyWell (and at-home D-T-C Direct-to-Consumer) if they do it right. But *must* do it right, e.g. including transparency re: methods, interfacing with HCP/EMRs, etc. The big issue may be collection variability, not unlike the microbiome. Nasal swab not trivial, more talk now about collection variability possibly accounting for a large proportion of "negs" turning positive. Hate to see a lot of false confidence running around at large infecting others.
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