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Contents contributed and discussions participated by Dennis OConnor

Dennis OConnor

Free Webinar: How to Be a Statistical Detective - 0 views

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    This is an on-demand webinar. "Statistical errors are all too common in medical literature, and contribute to the reproducibility crisis currently plaguing science. Fortunately, you don't need a degree in statistics to catch these errors. While some errors are impossible to spot without access to the underlying dataset, many are detectable just by reviewing the information available in the paper. In many cases nothing more than common sense and simple arithmetic is required. In addition, there is an ever-increasing number of free, easy-to-use online statistical tools that facilitate error detection."
Dennis OConnor

American Gut by American Gut Project (UC San Diego) - 0 views

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    "The Microsetta Initiative and its subsidiaries, including the American Gut Project, have pivoted to COVID-19 research, and are revising our kits to support this effort. We are working as hard as we can, but please be patient as these changes have required a complete overhaul of our infrastructure. Please check back soon: we are setting up a form to gather information about people who are interested in receiving a kit when they are ready."
Dennis OConnor

Testing ramps up in California - 0 views

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    Source: LA Times 4/8/2020 As of Tuesday, California said it had results for 143,172 tests - or 362 per 100,000 people. That's a sharp increase from two weeks ago when just 39 of every 100,000 residents had been tested. Yet for all its deep sources of innovation, the state is behind the national average of 596 tests per 100,000, according to the COVID Tracking Project. In New York, which has far more people hospitalized with severe symptoms, testing has reached 1,748 of every 100,000.
Dennis OConnor

COVID-19/Coronavirus Real Time Updates With Credible Sources in US and Canada | 1Point3... - 2 views

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    Dr. Michael Kurisu D.O. "This is from a former student at CalIt2 that has a GREAT site connecting people. It has all great interactive data coming in from national sites about COVID Cases. As it says on top... Made with love by first-generation Chinese Americans.. Also has a 'matching' program for hospital that need PPEs and quantity of them AND.. has a matching program for grocery store chains and what they have in stock etc... AND has a 'job posting' arena trying to get people matched up where jobs are available. AWESOME citizen-run project by computer programmers and students… Why oh WHY is our government not running something like this??
Dennis OConnor

Projects / Blog | Eric J. Daza, DrPH, MPS - 0 views

  • Causes and Associations in Single-Individual Analysis (CASIA) [pronounced: ka-sha] | Project
  • The Situation: You have a lot of data from your wearable or implantable device, sensor, or mobile app. You have a recurring outcome you’d like to change (e.g., weight, irritable bowel syndrome, migraine headaches, asthma attacks, chronic pain, blood glucose levels). You’ve identified possible triggers, but their effects may take some time to appear---and it may be expensive or painful to test all or even just a few of them.
  • The Challenge: Design experiments to conduct on yourself to characterize the effects of only the most likely triggers.
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  • Creating Evidence from Real World Patient Digital Data | Project
Dennis OConnor

Coronavirus: Digital Health Projects and Resources | Stats-of-1 - 0 views

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    Recommended by Dr. Michael Kurisu D.O.: ...the owner of the blog is Eric Daza DrPH. He is a biostatitician that does modeling on causal beliefs for Nof1 studies for individuals.
Dennis OConnor

Harnessing wearable device data to improve state-level real-time surveillance of influe... - 0 views

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    "Jennifer M Radin, PhD Nathan E Wineinger, PhD Prof Eric J Topol, MD Steven R Steinhubl, MD"
Dennis OConnor

How To Care For Your Lungs, According To Chinese Medicine - 0 views

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    recommended by Erin Raskin
Dennis OConnor

Coronavirus COVID-19 (2019-nCoV) - 1 views

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    Interactive Map - Global to city range.
Dennis OConnor

COVID19 Research Resources.pdf - 0 views

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    Forwarded by Sharon Wampler. As of April 3, 2020 - Research curated by a librarian at the Gates Foundation
Dennis OConnor

Every Vaccine and Treatment in Development for COVID-19, So Far - 1 views

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    Recommended by DeAunne Denmark, MD, PhD : "The projects these companies are working on can be organized into three distinct groups: Diagnostics: Quickly and effectively detecting the disease in the first place Treatments: Alleviating symptoms so people who have disease experience milder symptoms, and lowering the overall mortality rate Vaccines: Preventing transmission by making the population immune to COVID-19"
Dennis OConnor

FAQs on Diagnostic Testing for SARS-CoV-2 | FDA - 0 views

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    Explanation from DeAunne Denmark, MD, PhD : And just to clarify for all, since all of the testing jargon and landscape can be *extremely* confusing, especially now: The FDA has currently relaxed regulations for COVID diagnostics under "Emergency Use" (EUA). This authorizes, not approves, test kits, machines and devices to run those kits, and all other aspects involved in diagnostic testing. Authorize vs approve are very different animals under FDA. And you will see this repeatedly emphasized on the FDA site. But most often neglected, skipped over, mistaken in the wider press. Many articles and press releases use "approve" which is technically wrong - they mean authorize, or "grant use", or "use will not be objected to by FDA." If you have the stamina, I highly recommended reading as much of this as you can: https://www.fda.gov/medical-devices/emergency-situations-medical-devices/faqs-diagnostic-testing-sars-cov-2 "Validation" is yet an additional aspect that is probably the grayest zone of all, since it is left to each company/testing entity how exactly this is done. Validation can range from excellent to pretty cruddy science and still meet FDA "standards". These will be the devilish details we need to sort out re: collaborating with partners. And will unfortunately likely be a big mess for many outpatient Drs trying to figure out which test to order.
Dennis OConnor

Supplies Needed - Biocom - 0 views

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    "To contribute supplies to one of the below organizations, please click directly on their corresponding links."
Dennis OConnor

Recommended Twitter Feeds for Expert Advice on Science and Medicine - 1 views

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    Recommended by DeAunne Denmark, MD, PhD & Meg Sweeney
Dennis OConnor

What This Chart Actually Means for COVID-19 - YouTube - 0 views

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    Recommended by Sharon Wampler
Dennis OConnor

We need #masks4all - YouTube - 0 views

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    Recommended by Sharon Wampler
Dennis OConnor

Coronavirus Will Change the World Permanently. Here's How. - POLITICO - 0 views

  • Instead of asking, “Is there a reason to do this online?” we’ll be asking, “Is there any good reason to do this in person?”
  • saluting our doctors and nurses, genuflecting and saying, “Thank you for your service,”
  • give them guaranteed health benefits and corporate discounts
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  • it will force us to reconsider who we are and what we value, and, in the long run, it could help us rediscover the better version of ourselves.
  • has the potential to break America out of the 50-plus year pattern of escalating political and cultural polarization
  • the “common enemy” scenario, in which people begin to look past their differences when faced with a shared external threat
  • second reason is the “political shock wave” scenario
  • enduring relational patterns often become more susceptible to change after some type of major shock destabilizes them
  • now is the time to begin to promote more constructive patterns in our cultural and political discourse. The time for change is clearly ripening.
  • The COVID-19 crisis
  • has already forced people back to accepting that expertise matters.
  • move them back toward the idea that government is a matter for serious people.
  • the end of our romance with market society and hyper-individualism.
  • We could turn toward authoritarianism
  • reorient our politics and make substantial new investments in public goods—for health, especially—and public services.
  • to allowing partial homeschooling or online learning for K-12 kids has been swept away by necessity.
  • the social order it helps support—will collapse if the government doesn’t guarantee income for the millions of workers who will lose their jobs in a major recession or depression
  • de-militarization of American patriotism and love of community will be one of the benefits to come out of this whole awful mess.
  • But how do an Easter people observe their holiest day if they cannot rejoice together on Easter morning?
  • How do Jews celebrate their deliverance from bondage when Passover Seders must take place on Zoom
  • Can Muslim families celebrate Ramadan if they cannot visit local mosques for Tarawih prayers
  • All faiths have dealt with the challenge of keeping faith alive under the adverse conditions of war or diaspora or persecution—but never all faiths at the same time.
  • Contemplative practices may gain popularity
  • One group of Americans has lived through a transformational epidemic in recent memory: gay men. Of course, HIV/AIDS
  • Plagues drive change.
  • awakened us to the need for the protection of marriage
  • People are finding new ways to connect and support each other in adversity
  • demand major changes in the health-care system
  • COVID-19 will sweep away many of the artificial barriers to moving more of our lives online
  • uptake on genuinely useful online tools has been slowed by powerful legacy players,
  • collaboration with overcautious bureaucrats
  • Medicare allowing billing for telemedicine was a long-overdue change
  • s was revisiting HIPAA to permit more medical providers to use the same tools the rest of us use every day to communicate, such as Skype, Facetime and email.
  • The resistance
  • we will be better able to see how our fates are linked.
  • near-impossible to put that genie back in the bottle in the fall
  • college
  • forcing massive changes in a sector that has been ripe for innovation for a long time.
  • Once companies sort out their remote work dance steps, it will be harder—and more expensive—to deny employees those options.
  • Yo-Yo Ma
  • Perhaps we can use our time with our devices to rethink the kinds of community we can create through them
  • This is a different life on the screen from disappearing into a video game or polishing one’s avatar.
  • breaking open a medium with human generosity and empathy
  • Not only alone together, but together alone.
  • The rise of telemedicine
  • Out of necessity, remote office visits could skyrocket in popularity as traditional-care settings are overwhelmed by the pandemic
  • they’ve been forced to make impossible choices among their families, their health and financial ruin.
  • This crisis should unleash widespread political support for Universal Family Care
  • single public federal fund that we all contribute to, that we all benefit from, that helps us take care of our families while we work, from child care and elder care to support for people with disabilities and paid family leave.
  • potlight on unmet needs of the growing older population
  • The reality of fragile supply chains for active pharmaceutical ingredients coupled with public outrage over patent abuses that limit the availability of new treatments has led to an emerging, bipartisan consensus that the public sector must take far more active and direct responsibility for the development and manufacture of medicines.
  • resilient government approach will replace our failed, 40-year experiment with market-based incentives
  • Science reigns again.
  • Truth and its most popular emissary, science, have been declining in credibility for more than a generation
  • Quickly, however, Americans are being reacquainted with scientific concepts like germ theory and exponential growth
  • Unlike with tobacco use or climate change, science doubters will be able to see the impacts of the coronavirus immediately
  • for the next 35 years, I think we can expect that public respect for expertise in public health and epidemics to be at least partially restored
  • Congress can finally go virtual.
  • We need Congress to continue working through this crisis, but given advice to limit gatherings to 10 people or fewer, meeting on the floor of the House of Representatives is not an especially wise option right now
  • nstead, this is a great time for congresspeople to return to their districts and start the process of virtual legislating—permanently
  • Lawmakers will be closer to the voters they represent
  • sensitive to local perspectives and issues
  • A virtual Congress is harder to lobby
  • Party conformity also might loosen with representatives remembering local loyalties over party ties.
  • Big government makes a comeback.
  • Not only will America need a massive dose of big government
  • we will need big, and wise, government more than ever in its aftermath.
  • The widely accepted idea that government is inherently bad won’t persist after coronavirus.
  • functioning government is crucial for a healthy society
  • most people are desperately hoping
  • a rebirth of the patriotic honor of working for the government.
  • the coronavirus crisis might sow the seeds of a new civic federalism, in which states and localities become centers of justice, solidarity and far-sighted democratic problem-solving.
  • we will see that some communities handled the crisis much better than others.
  • success came in states where government, civic and private-sector leaders joined their strengths together in a spirit of self-sacrifice for the common good.
  • The coronavirus is this century’s most urgent challenge to humanity.
  • a new sense of solidarity, citizens of states
  • The rules we’ve lived by won’t all apply
  • pandemic has revealed a simple truth:
  • many policies that our elected officials have long told us were impossible and impractical were eminently possible and practical all along.
  • student loans and medical debt
  • evictions were avoidable; the homeless could’ve been housed
  • Trump has already put a freeze on interest for federal student loans
  • Governor Andrew Cuomo has paused all medical and student debt owed to New York State
  • Democrats and Republicans are discussing suspending collection on—or outright canceling—student loans as part of a larger economic stimulus package
  • It’s clear that in a crisis, the rules don’t apply
  • an unprecedented opportunity to not just hit the pause button and temporarily ease the pain, but to permanently change the rules so that untold millions of people aren’t so vulnerable to begin with.
  • Revived trust in institutions.
  • oronavirus pandemic, one hopes, will jolt Americans into a realization that the institutions and values Donald Trump has spent his presidency assailing are essential to the functioning of a democracy—and to its ability to grapple effectively with a national crisis.
  • government institutions
  • need to be staffed with experts (not political loyalists),
  • decisions need to be made through a reasoned policy process and predicated on evidence-based science and historical and geopolitical knowledge
  • we need to return to multilateral diplomacy,
  • to the understanding that co-operation with allies—and adversaries, too—is especially necessary when it comes to dealing with global problems like climate change and viral pandemics.
  • t public trust is crucial to governance
  • 1918 flu pandemic
  • the main lesson from that catastrophe is that “those in authority must retain the public’s trust” and “the way to do that is to distort nothing, to put the best face on nothing, to try to manipulate no one.”
  • Expect a political uprising.
  • Occupy Wall Street 2.0, but this time much more massive and angrier.
  • Electronic voting goes mainstream.
  • how to allow for safe voting in the midst of a pandemic, the adoption of more advanced technology
  • To be clear, proven technologies now exist that offer mobile, at-home voting while still generating paper ballots.
  • This system is not an idea; it is a reality that has been used in more than 1,000 elections for nearly a decade by our overseas military and disabled voters.
  • hould be the new normal.
  • Election Day will become Election Month.
  • The change will come through expanded early voting and no-excuse mail-in balloting, effectively turning Election Day into Election Month
  • Once citizens experience the convenience of early voting and/or voting by mail, they won’t want to give it up.
  • . Some states, such as Washington, Oregon and Utah, already let everyone vote at home.
  • Voters already receive registration cards and elections guides by mail. Why not ballots?
  • First, every eligible voter should be mailed a ballot and a self-sealing return envelope with prepaid postage.
  • Elections administrators should receive extra resources to recruit younger poll workers, to ensure their and in-person voters’ health and safety, and to expand capacity to quickly and accurately process what will likely be an unprecedented volume of mail-in votes.
  • In the best-case scenario, the trauma of the pandemic will force society to accept restraints on mass consumer culture as a reasonable price to pay to defend ourselves against future contagions and climate disasters alike.
  • In the years ahead, however, expect to see more support from Democrats, Republicans, academics and diplomats for the notion that government has a much bigger role to play in creating adequate redundancy in supply chains—resilient even to trade shocks from allies. This will be a substantial reorientation from even the very recent past.
  • pressure on corporations to weigh the efficiency and costs/benefits of a globalized supply chain system against the robustness of a domestic-based supply chain.
  • other gap that has grown is between the top fifth and all the rest—and that gap will be exacerbated by this crisis.
  • In this crisis, most will earn steady incomes while having necessities delivered to their front doors.
  • other 80 percent of Americans lack that financial cushion.
  • will struggle
  • A hunger for diversion.
  • After the disastrous 1918-19 Spanish flu and the end of World War I, many Americans sought carefree entertainment, which the introduction of cars and the radio facilitated.
  • The economy quickly rebounded and flourished for about 10 years, until irrational investment tilted the United States and the world into the Great Depression.
  • human beings will respond with the same sense of relief and a search for community, relief from stress and pleasure.
  • Less communal dining—but maybe more cooking
  • many people will learn or relearn how to cook over the next weeks.
  • ikely there will be many fewer sit-down restaurants in Europe and the United States. We will be less communal at least for a while.
  • A revival of parks.
  • Urban parks—in which most major cities have made significant investments over the past decade—are big enough to accommodate both crowds and social distancing.
  • Society might come out of the pandemic valuing these big spaces even more,
  • A change in our understanding of ‘change.’
  • Americans have said goodbye to a society of frivolity and ceaseless activity in a flash
  • Our collective notions of the possible have changed already
  • The tyranny of habit no more.
  • Maybe, as in Camus’ time, it will take the dual specters of autocracy and disease to get us to listen to our common sense, our imaginations, our eccentricities—and not our programming.
  • and environmentally and physiologically devastating behaviors (including our favorites: driving cars, eating meat, burning electricity)
  • echarged commitment to a closer-to-the-bone worldview that recognizes we have a short time on earth
Dennis OConnor

Keeping the Coronavirus from Infecting Health-Care Workers | The New Yorker - 0 views

  • #StayHome
  • Wuhan
  • The city began to run out of doctors and nurses. Forty-two thousand more had to be brought in from elsewhere to treat the sick.
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  • methods were found that protected all the new health-care workers: none—zero—were infected.
  • methods were Draconian
  • health-care workers seeing at-risk patients were housed away from their families
  • They wore full-body protective gear,
  • goggles, complete head coverings, N95 particle-filtering masks, and hazmat-style suits
  • So what happens if you are exposed to a coronavirus patient and you don’t have the ability to go full Wuhan?
  • Partners HealthCare, has already sent more than a hundred staff members home for fourteen days of self-quarantine because they were exposed to the coronavirus without complete protection.
  • The success that Hong Kong and Singapore achieved by screening for people with fever- or flu-like symptoms suggests that the risk of asymptomatic contagion could be much lower than we thought.
Dennis OConnor

Stop, collaborate and listen - Crowdsourcing to fight covid-19 | International | The Ec... - 0 views

  • , the World Health Organisation (WHO) is crowdsourcing what hospitals are learning.
  • submit anonymised covid-19 patient records to its global database
  • isting the drugs prescribed, procedures carried out and outcomes.
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  • Clinicians who treat covid-19 patients in 30 countries chime in at a twice-weekly virtual gathering run by the WHO.
  • Their input, plus the clinical studies that are being published at a steady clip, are distilled into the WHO’s standards of care.
  • these standards have been revised five times in less than two months.
  • On March 12th eight Chinese doctors, led by Liang Zongang, a professor of cardiopulmonary reanimation, arrived in Italy on a charter flight that brought medical equipment supplied by the Chinese Red Cross.
  • ollowed on March 18th by around 300 Chinese intensive-care doctors.
  • Online learning about covid-19 is gathering speed, especially in developing countries.
  • To save the lives of gravely ill patients, doctors are trying many drugs
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