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Dennis OConnor

A serological assay to detect SARS-CoV-2 seroconversion in humans | medRxiv - 0 views

www.medrxiv.org/...2020.03.17.20037713v1

covid research testing

shared by Dennis OConnor on 20 Mar 20 - No Cached
  • While molecular assays to directly detect the viral genetic material are available for the diagnosis of acute infection, we currently lack serological assays suitable to specifically detect SARS-CoV-2 antibodies.
  • Methods: Here we describe serological enzyme-linked immunosorbent assays (ELISA) that we developed using recombinant antigens derived from the spike protein of SARS-CoV-2.
  • Conclusion: Serological assays are of critical importance to determine seroprevalence in a given population, define previous exposure and identify highly reactive human donors for the generation of convalescent serum as therapeutic.
  • Dennis OConnor on 20 Mar 20
     
    Recommended by DeAunne Denmark, MD, PhD: This study is under peer review. Published via the medRxiv preprint server for health sciences.
Dennis OConnor

Pursuing Safe and Effective Anti-Viral Drugs for COVID-19 - NIH Director's Blog - 0 views

directorsblog.nih.gov/...-anti-viral-drugs-for-covid-19

covid testing

shared by Dennis OConnor on 20 Apr 20 - No Cached
  • Remdesivir
  • when an RNA virus attempts to replicate, its polymerase is tricked into incorporating remdesivir into its genome as a foreign nucleotide, or anomalous letter.
  • undecipherable, extra letter brings the replication process to a crashing halt
  • ...4 more annotations...
  • An important step was just posted as a preprint yesterday—a small study showed infusion of remdesivir was effective in limiting the severity of lung disease in rhesus macaques [2]. That’s encouraging news. But the only sure way to find out if remdesivir will actually help humans who are infected with SARS-CoV-2 is to conduct a randomized, controlled clinical trial.
  • NIAID’s Division of Microbiology and Infectious Diseases, has already enrolled 805 patients at 67 testing sites.
  • All trial participants must have laboratory-confirmed COVID-19 infections and evidence of lung involvement, such as abnormal chest X-rays, rattling sounds when breathing (rales) with a need for supplemental oxygen, or a need for mechanical ventilation.
  • the study is double-blind, meaning
Dennis OConnor

COVID-19 Testing Project - Pre-print manuscript - 0 views

covidtestingproject.org

covid antibodies testing preprint

shared by Dennis OConnor on 26 Apr 20 - No Cached
  • April 24, 2020: Read our pre-print manuscript. This is a preliminary report of work that has not been certified by peer review. This should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as established information.
  • Dennis OConnor on 26 Apr 20
     
    "We are a multidisciplinary team of researchers and physicians at UCSF, UC Berkeley, Chan Zuckerberg Biohub, and Innovative Genomics Institute."
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