Group items matching

in title, tags, annotations or url

At Fred Hutch, we support engaging, challenging and relevant classroom learning experiences for all students by providing access to high-quality instructional materials developed by teachers and scientists. Our free, open-source lessons and units are geared towards high school biotech and biology teachers and focus on giving students opportunities to explore biotechnology and the social dimensions of research science.

Hereditary methemoglobinemia (met-H) is a human genetic disease that is inherited as an autosomal recessive.

TEACHING POPULATION MEANS GLOBAL LEARNING & SUSTAINABILITY It's all about people - how many of us there are, how we shape the world, and how we interact with each other.

n this interrupted case study, students learn about the influence of early fetal nutritional conditions on the expression of genes related to metabolism and growth. Beginning with the true event of a food and fuel embargo that led to famine in the western Netherlands toward the end of World War II, students learn about the historical background of the Dutch Hunger Winter and its social impact. Using real data from the study conducted by Heijmans and coauthors (2008), students then compare the methylation level of a specific gene between individuals conceived during the famine and their unaffected siblings, and how changes in the expression of this metabolically important gene may impact the risk of developing type 2 diabetes. Supported by other studies on mice and in humans, students conclude that in utero events may impact the health of individuals later in life through epigenetic mechanisms. The case is ideally suited for a molecular or cell biology course, but is also appropriate for an introductory biology course in which students have an understanding of descriptive statistics, interpretation of statistical test results, eukaryotic gene structure, and regulation of gene expression.

This "clicker case" tells the story of "Hannah," a baby girl adopted by two loving parents who grows up with an uncontrolled appetite and develops severe early-onset obesity. Students follow Hannah's story as she develops excessive eating early in life, which her health care team is unable to explain. A visit to obesity specialists finally reveals the underlying cause of Hannah's obsession with food: extremely low levels of circulating leptin, a hormone that regulates appetite and body weight. It is further discovered that Hannah's leptin deficiency is due to a mutation in the LEP gene. As the story unfolds, students first work on unit conversions and BMI calculations to practice quantitative skills as well as graph and data interpretation skills. Students then apply their knowledge of DNA transcription, translation, and protein structure to answer questions based on figures from a 2019 study on LEP mutations. The case is best suited for high school and lower-level undergraduate biology courses.

In order to develop complex scientific explanations, students need to have many opportunities to grapple with a concept, look at it from various points of view, and analyze data representing different relationships. I plan the sequence and flow of my AP Environmental Science course strategically to ensure I am making these connections using a concept called "curriculum spiraling."

In this case study, students follow "Mr. Okoro" as he makes the long journey with his sick daughter "Ada" to seek medical attention at the nearest clinic in Enugu, Nigeria. It is the rainy season, and "Dr. Fabian" from the Division of Parasitic Diseases and Malaria has been called in to investigate a suspected outbreak of malaria. Students learn about the circumstances in Ada's background that may have led to her illness, and then adopt the perspective of Dr. Fabian as she investigates the outbreak. They consider the epidemiological triangle, the different stages of the Plasmodium parasite lifecycle and how it leads to malaria, and evaluate the broader societal factors and future implications of malaria in Sub-Saharan Africa. The case was designed for upper-level global health, public health, and human biology courses, but could also be adapted for general biology, health studies, infectious disease, and epidemiology courses.

Symbiotic relationships are interactions between species that live closely with each other and are commonly separated into three types: parasitism, mutualism, and commensalism. Students are often under the impression that these types are distinct and mutually exclusive, but on closer examination some interactions appear to be at times mutualistic, at other times parasitic. Is it perhaps better to think of mutualism and parasitism as two ends of a sliding scale, with commensalism in the middle? In this case study, students consider this question by examining what is often considered to be a classic example of mutualism existing between oxpecker birds and African savanna large mammals. After students examine data from a research study on oxpecker behavior, they then apply a more nuanced understanding of species interactions to a set of additional scenarios. The learning objectives for the case align with the Four-Dimensional Ecology Education Framework. The case was written for an upper-level undergraduate ecology course, but could easily be adapted for an introductory biology course.

Variety of Biology resources from teacher site. Includes PBL and IB resources.

The life science/biology course is divided into 12 instructional segments grouped into four sections. In the first section, From Molecules to Organisms: Structures and Processes, students develop models of how molecules combine to build cells and organisms (IS1 [Structure and Function]; IS2 [Growth and Development of Organisms]; IS3 [Organization for Matter and Energy Flow in Organisms]). In the second section, Ecosystems: Interactions, Energy, and Dynamics, students zoom out to the macroscopic scale to show how organisms interact (IS4 [Interdependent Relationships in Ecosystems]; IS5 [Cycles of Matter and Energy Transfer in Ecosystems]; IS6 [Ecosystem Dynamics, Functioning, and Resilience]; IS7 [Social Interactions and Group Behavior]). Students return to the role that DNA plays in inheritance during the third section, Heredity: Inheritance and Variation of Traits (IS8 [Inheritance of Traits]; IS9 [Variation of Traits]). The class ends tying together interactions at all these scales by explaining evolution and natural selection in Biological Evolution: Unity and Diversity (IS10 [Evidence of Common Ancestry and Diversity]; IS11 [Natural Selection]; IS12 [Adaptation and Biodiversity]). A vignette in IS12 illustrates the level of three-dimensional understanding students are expected to exhibit as a capstone of the course.

Squirrels are frequent and beloved residents of college campuses throughout the United States, but oftentimes less welcomed by campus maintenance officials who report squirrels nesting in buildings, interfering with airflow from heating and cooling units, and destroying gutters. In this laboratory case, students act as members of a fictitious "squirrel task force" appointed by their campus administrators to provide recommendations for how to manage their school's squirrel population.  Students work in groups to assess the habitat suitability of their campus for squirrels by identifying and measuring trees that provide seasonal food for squirrels, and by identifying desirable hunting perches for common squirrel predators.  Students conduct squirrel surveys in designated campus zones to calculate the number of squirrels per acre on their campus and compare it with mean squirrel densities reported in forested areas and at a rival institution.  Students then compile and synthesize class data to provide management recommendations for university maintenance officials for either increasing or decreasing campus squirrel populations. Originally developed for an undergraduate wildlife biology course, the case could also be used in a lower-division biology or environmental studies course.

Every year during the foodless winter months, bears enter their den and lapse into a state of extended dormancy and slumber (called hibernation). For the next 130+ consecutive days they do not drink, eat, defecate, or urinate. Rarely do they die from starvation, dehydration, or poisoning from waste buildup while hibernating. How do bears prepare for this period of starvation coupled with significant weight loss? Bears are not only the champions of winter rest, but are also the undisputed champions of non-stop summer eating. They are constantly on the move during late spring and all summer long into late autumn oftentimes covering great distances over diverse habitats in their incessant search for locally and seasonally available food. In this case study, students learn the basics about bear denning, hibernation energetics, the differences in size of bear home ranges, and the nutritional landscape they must navigate to prepare for the long months of winter inactivity and caloric deprivation. The case is suitable for a wide audience, including majors or non-majors in lower- or upper-level undergraduate courses in environmental science, ecology, biology, or wildlife science.

Although rabies still causes thousands of deaths globally every year, it has essentially been eradicated from most industrialized countries. Part of the success story is due to an unusual project undertaken by the Swiss prompted by a series of large outbreaks in the 1970s: the large-scale vaccination of wild foxes to stop the epidemic. In this directed case study, students use an easily accessible MS Excel-based model to understand key epidemiological parameters of rabies outbreaks in wild foxes. The simple model allows students also to predict what proportion of foxes needs to be vaccinated to eradicate the virus from the population. The case fits into both ecological and microbiological (epidemiological) courses and offers opportunities to explore zoonotic diseases and "One Health" questions. The mathematical basis of the differential equations in the models is explained, although prior knowledge of calculus is not essential. A key learning outcome is the critical understanding of both the power and limitations of simple epidemiological models. This case was written for an online course but could also be used as a face-to-face activity if students have access to computers in class.

inquiryHub high school and middle school curricula are aligned to the Framework and guided by the Next Generation Science Standards (NGSS). Using research-based approaches to teaching Science in a deeply digital environment, students contribute resources, observations, data, and analyses to solve larger scientific problems.  inquiryHub curricula are designed to go beyond traditional Science content. By focusing on phenomena relevant to students' lives and communities, the coursesprovides opportunities to authentically engage with Science and engineering practices.

This case study is designed to teach basic concepts of genetics by focusing on a rare disease, pseudoxanthoma elasticum (PXE).  Chromosome 16 is the narrator at the beginning of the case and introduces students to genes, chromosomes and mutations. The focus then shifts to the patient and his mother as she finds out about her son's disease and her subsequent efforts to connect with patient advocacy groups for support. The case concludes with students watching a TED talk given by Sharon Terry, the real-life mother on whom this story is loosely based, so that students can connect on an emotional and human level with someone who has intimate experience as a parent of children with a rare genetic disease. The case is suitable for high school general biology classes, but it can also be used by biology major or non-major undergraduates in a lower-division biology class, or in any lower-division non-major class focused on human disease.

The data comes from the open Tree of Life Project, a collaboration among biologists and other scientists around the world. It contains decades' worth of work in phylogeny, evolutionary history of and relationships among groups of organisms. The project is about a year away from a complete tree of all life, Rosindell said. He wanted a system in place that could visualize it as soon as it's ready. Right now, OneZoom only contains mammals, but that's still more than 5,000 species, all correlated with each other and color-coded according to their threat levels. Rosindell has big plans for the rest, and he even wants to build a searchable app for smartphones, showcasing the history and relationships between all life on Earth.

In the broadest review on this topic that has been carried out to date, we found that, so far, 386 marine fish species are known to have ingested plastic debris, including 210 species that are commercially important. But findings of fish consuming plastic are on the rise. We speculate that this could be happening both because detection methods for microplastics are improving and because ocean plastic pollution continues to increase.

The Underrepresentation Curriculum (URC) is a free, flexible curriculum for STEM instructors to teach about injustice and change the culture of STEM. Using tools such as data analysis, hypothesis creation, and investigation, students look critically at science through the lenses of equity and inclusion. By comparing the general population to similar data describing scientists, students can explore issues of social justice in STEM.

Our students will face decisions about health, science, and medicine that we can hardly imagine.   How can we keep student needs and science first, yet still create a safe and affirming space for intellectual curiosity? Teaching biology creates many opportunities to authentically incorporate student curiosity. The Next-Generation science Standards (NGSS) expect students to ask questions about natural phenomena and then explain their answers using models. This website offers examples of adapting curriculum to NGSS and gender-inclusive standards, as well as resources for advocating to administration and others.