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Lottie Peppers

DNA breakage underlies both learning, age-related damage | MIT News - 0 views

newsoffice.mit.edu/...arning-age-related-damage-0604

dna learning damage MIT memories memory formation DNA breakage Alzheimer's

shared by Lottie Peppers on 23 Jun 15 - No Cached
  • Lottie Peppers on 23 Jun 15
     
    Early-response genes, which are important for synaptic plasticity, are "switched off" under basal conditions by topological constraints. Neuronal activity triggers DNA breaks in a subset of early-response genes, which overrides these topological constraints, and "switches on" gene expression.
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