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This interrupted case study for the flipped classroom introduces the human microbiome from the perspective of one of its occupants, Heidi Helicobacter (Helicobacter pylori).  Heidi lives in the gut of Kristen, a college student, and discusses her fellow microbial inhabitants, functions of these various microbes, and alludes to factors that can disrupt the healthy human microbiome. Students prepare for class by viewing several brief videos and then discuss in class whether Kristen should undergo a fecal microbiota transplant to treat her Clostridium difficile infection.  A lab component has students model, using colored beads, how antibiotics can act as a selective agent for drug-resistant microbes such as C. difficile. The case concludes with Kristen about to give birth to a new baby several years later.  Students listen in as Kristen's microbes discuss the formation of the new baby's microbiome. The case has been used successfully in a general biology class and could easily be adapted for a microbiology, human physiology, ecology, or evolution course.

This PowerPoint-driven, flipped case study begins with a short video about a woman suffering from cystic fibrosis (CF) in the 1970s, a friend of the lead author's, whom she met in college and who died in her twenties. Hooked by this personal story, students then delve into the genetics and biology of cystic fibrosis as they learn about the difference between dominant and recessive genes, make Punnett squares that depict various types of inheritance, distinguish between probability and actual numbers, differentiate types of mutations, and learn about the opportunistic infections that CF patients often succumb to.  Students conclude the case by watching two additional videos on chest compression machines and the contemporary life expectancy of patients with CF.  In addition to the scientific content presented in the case, it is hoped that students will empathize with, and be motivated by, the young people presented in the videos as they struggle with a very real, incurable disease deeply rooted in genetics.

While the "vaccine controversy" has made headlines since the late 1990s, the emergence and popularity of social media has created a public opinion space bursting with pseudoscience, debatable claims and anecdotes regarding the value and importance of childhood vaccines. Because college students get a good deal of news and information from these resources, it is imperative that they distinguish science from pseudoscience and do not perpetuate rumor and falsehoods.  In this case study, written for lower division non-science majors, students will view videos on the scientific method and a mock talk show, analyze data, and scrutinize social media posts.  One of the takeaway points is that if a post/blog/interview identifies a victim, villain, and hero then the student should suspect a story grounded in belief involving pseudoscience.  Following completion of the case, students will hopefully come to conclusions about vaccines based more in the realm of science rather than pseudoscience and continue to apply the scientific method when evaluating social media posts on other scientific topics.

This directed case study was developed in order to present genomic data to students, allow them to interpret the impact of genetic variations on phenotype, and to explore precision medicine. Students are introduced to "Josie," a college sophomore who decides to have her genome sequenced after learning about genome-wide association studies (GWAS) in class. As students work  through the case, they learn about the different technologies that can be used in GWAS studies and interpret Josie's results for a subset of genetic markers that affect a range of traits from pharmacogenetics to disease risk alleles and non-pathogenic traits. Students are confronted with ethical issues such as duty to inform, actionable results, and variants of unknown significance (VUS). Students are also asked to reflect on their feelings about getting genomic testing for themselves. An optional activity for advanced students (included in the teaching notes) involves using the Gene database at NCBI to explore variants of the CYP2C9 gene. The case study is appropriate for use in undergraduate genetics or molecular biology classrooms.

This case study introduces students to the "Red Queen Hypothesis." The hypothesis states that when two species compete for a limited resource or exist in a predator-prey relationship, in order for the antagonists to remain in relative population equilibrium, there must be ongoing and reciprocal adaptation on each side. If one species fails to adapt, it may quickly face extinction. Students are introduced to the Red Queen Hypothesis through an excerpt from Lewis Carroll's novel, Through the Looking Glass, in which Alice meets the Red Queen. They then review experiments from the research literature to evaluate the validity of the hypothesis in extant populations.  Students culminate their learning by contrasting their knowledge of the Red Queen Hypothesis to Darwinian evolutionary theory based on a passage from On the Origin of Species.  Students then craft a letter to Darwin helping to explain his "wedge" theory, a notion he originally developed but removed from later iterations of his book due to a lack of experimental evidence. Originally developed for advanced high school biology students, the case also may be used in a college-level introductory course on evolutionary biology.

Squirrels are frequent and beloved residents of college campuses throughout the United States, but oftentimes less welcomed by campus maintenance officials who report squirrels nesting in buildings, interfering with airflow from heating and cooling units, and destroying gutters. In this laboratory case, students act as members of a fictitious "squirrel task force" appointed by their campus administrators to provide recommendations for how to manage their school's squirrel population.  Students work in groups to assess the habitat suitability of their campus for squirrels by identifying and measuring trees that provide seasonal food for squirrels, and by identifying desirable hunting perches for common squirrel predators.  Students conduct squirrel surveys in designated campus zones to calculate the number of squirrels per acre on their campus and compare it with mean squirrel densities reported in forested areas and at a rival institution.  Students then compile and synthesize class data to provide management recommendations for university maintenance officials for either increasing or decreasing campus squirrel populations. Originally developed for an undergraduate wildlife biology course, the case could also be used in a lower-division biology or environmental studies course.

This directed case study examines the molecular basis of cystic fibrosis to emphasize the relationship between the genetic code stored in a DNA sequence and the encoded protein's structure and function. Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) protein that functions to help maintain salt and water balance along the surface of the lung and gastrointestinal tract. This case introduces students to "Maggie," who has just been diagnosed with cystic fibrosis. The students must identify the mutation causing Maggie's disease by transcribing and translating a portion of the wildtype and mutated CFTR gene. Students then compare the three-dimensional structures of the resulting proteins to better understand the effect a single amino acid mutation can have on the overall shape of a protein. Students also review the concepts of tonicity and osmosis to examine how the defective CFTR protein leads to an increase in the viscosity of mucus in cystic fibrosis patients. This case was developed for use in an introductory college-level biology course but could also be adapted for use in an upper-level cell or molecular biology course.

Session description: The session will provide an introduction to the ethics of research involving human participants. It will ad-dress the history of research ethics, present a contemporary eth-ical framework, and discuss its application to differing kinds of research studies. The ethical framework consists of four principles: respect for persons, beneficence, justice, and respect for communities. Each principle provides the foundation for ethical rules, including requirements for informed consent and confidentiality of health information. Taken together these ethical principles and rules provide a comprehensive framework for the analysis of ethical challenges in health research.

Population simulation involving predator and prey

Here is a list of additional resources for Inquire High School. These inquiry resources include great links to Web sites, articles, videos, and much more that supports inquiry

Made possible through Toyota USA Foundation funding, the REMS curriculum options include nine online lesson plans and interactive activities themed to examine three pressing challenges in the US: preserving sustainable, competitive manufacturing; distributing products and services across the world; and developing and delivering efficient health care services. Each of the lesson plans provides age-appropriate math and science curriculum that tie to the Common Core Learning Standards for elementary, middle and high school students.