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In March 2005 High Tech High received a $250,000 grant from the California Department of Education to disseminate project-based learning methods to teachers in non-charter public schools. As part of the project, High Tech High teachers have documented successful projects to share with collaborating teachers from local districts and across the HTH network. The current volume presents the fruits of these labors. The aim is simple: to offer practitioners useful, easily adaptable models of real projects.

This animation depicts the CRISPR-Cas9 method for genome editing - a powerful new technology with many applications in biomedical research, including the potential to treat human genetic disease. Feng Zhang, a leader in the development of this technology, is a faculty member at MIT, an investigator at the McGovern Institute for Brain Research, and a core member of the Broad Institute. Further information can be found on Prof. Zhang's website at http://zlab.mit.edu .

THE prospect of creating intelligent designer babies has been the subject of ethical debate for decades, but we have lacked the ability to actually do it. That may now change, thanks to a new method of testing an embryo's genes that could soon be available in some IVF clinics in the US, New Scientist can reveal.

This case study introduces students to the true story of Caster Semenya, an outstanding female mid-distance runner from South Africa.  Caster won the 800 m race at the 2009 Track and Field World Championships when she was just 18. Since then, she has faced scrutiny about her sex and gender. Due to her high levels of endogenous testosterone, she was banned from running for almost a year by the track and field governing body, the IAAF. In this case study, students use information from news reports and Caster's appearance to determine the possible biological underpinnings likely responsible for her anatomy and physiology.  Students are also asked to consider if using circulating testosterone levels to determine if a female can race is a valid method of exclusion. This case asks students to think about how sex and gender are related, and pushes them to discuss societal implications of labeling both of these constructs as binary when in fact they are much better described as spectra.

This lesson, using segments from the PBS series Faces of America, explores the various types of genetic information contained in the human genome. The Introductory Activity examines the structure and composition of chromosomes and DNA, and can be used as a review or introduction to the topic. Following that, students will participate in a hands-on activity reviewing basic Mendelian genetics and the difference between genotype and phenotype. Students will also learn about different ways of tracing ancestry through DNA, and apply that to patterns of human migration and genetic population sets known as haplogroups. In the Culminating Activity, students will develop methods for determining the genetic heritage of their class, school, or community.

When it's completely unraveled, DNA is known to extend approximately six feet in length, yet is somehow able to cram itself into a cell's nucleus. In a study published today (July 27) in Science, researchers created a novel visualization method that revealed a 3-D glimpse of chromatin as it sits jam-packed within the nuclei of human cells. The researchers found that, contrary to how it's depicted in most textbooks, chromatin does not fold in on itself in an organized manner to create distinct structures. Instead, it forms a pliable, inconsistent chain characterized by a wide variety of folding patterns. 

A paper published today in Science Advances just might change that. By creating a reliable method of studying viruses' long evolutionary history-hitherto nearly impossible-researchers have found new evidence that strongly suggests viruses are indeed living entities.

This directed case study follows the story of "Pauline," a 20-year-old college student who has just received results from a personal genetic testing kit she purchased online. The report shows a negative result for variants of the BRCA 1 and 2 genes, which are associated with a greater risk for breast cancer. Although Pauline has a family history of breast cancer, she concludes that she no longer needs to be concerned, or does she? As students work through the questions in this case study, they review the role of genes and how they code for proteins as well as the effects of proteins on health, especially on cellular growth regulation and cancer. They also learn about the process of genetic testing and consider the ramifications of positive and negative tests for diseases or health conditions, especially with respect to breast cancer. The case is designed for non-science majors in a scientific methods course and could also be used in an introductory biology course. The questions in the case could be adapted for an upper level genetics class.

This flipped case study begins with a video in which a student reveals a family member's diagnosis with breast cancer and then considers the whirlwind of questions that arise in such a situation. Students are asked to relate to the main character and identify what questions they would have and what resources they could consult to seek information.  This sets the context for students to use websites and videos to investigate the nature of cancer, its causes, and progression. Students then learn about the major methods of cancer treatment (surgery, radiation therapy, and chemotherapy), how they work, and the limitations and side effects of each. The case concludes by addressing the claim of one of the characters that there is a conspiracy to hide a cure for cancer. The case would be implemented near the middle of a high school, non-majors, or introductory biology course after discussion of basic cell biology and the cell cycle.

X-Spin Viral RNA Extraction Kit provides a fast an easy isolation method for the extraction and purification of nucleic acid (RNA) in samples. We are top RNA extraction kit manufacturer and offer viral rna extraction kits or rna Isolation kit covering many sample types and throughput needs.

The activity begins with students observing different organisms or phenomena and developing questions based on their observations. They then sort their questions into those that can and cannot be answered using the methods of science. Students practice writing scientific questions, designing experiments to address scientific questions, developing questions that involve cause and effect, and understanding the importance of cause and effect questions in scientific research. At the end of the activity, students determine the research questions being asked from reading journal article titles and parts of a published paper or other reported results. Several possible extension activities are provided for continuing the investigation and research of phenomena.

In the broadest review on this topic that has been carried out to date, we found that, so far, 386 marine fish species are known to have ingested plastic debris, including 210 species that are commercially important. But findings of fish consuming plastic are on the rise. We speculate that this could be happening both because detection methods for microplastics are improving and because ocean plastic pollution continues to increase.

That's the premise behind XPRIZE Feed The Next Billion, a $15 million competition incentivizing teams around the globe to produce chicken breast or fish filet alternatives that outperform conventional chicken and fish in a number of areas - from sustainability to nutrition to animal welfare, as well as taste and texture. To achieve that, teams are leaning into two methods: cultivated meat and plant-based meat alternatives. The multi-year competition is underway right now, and could provide us with the breakthrough we need to change how we eat, for good.

Links for 5 articles covering cancer and cell phones

2:25 video  Scientists have recently discovered that the limbs of some sea stars have been turning into goo, and populations are dying off! Why is this happening, and will this hurt their ecosystem? Join Laci as discusses how this disease is spreading, and why it have some negative consequences.

14:40 min video nature of science, claims and evidence

Japanese knotweed (Fallopia japonica) is an invasive plant that can be very hard to eliminate. This PowerPoint-driven case study briefly describes this plant and asks students to identify possible solutions for its control when a homeowner discovers it growing next to his house. The case was designed for an introductory college course, either a general biology course or a plant biology course, and while it can be used as a regular case, it was actually written to assess the students' ability to solve a problem and write an analysis. If you teach with cases, shouldn't you test with cases as well?

Teacher site with a solid collections of labs