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Loss of species richness is often due to anthropogenic activity. The global decline of amphibians is one such example. This case study examines the impact of road deicing agents on amphibians living near bridges and roads treated heavily with salt during the winter months. Concepts explored in this case include changes to the aquatic environment as a result of road deicing applications, bioaccumulation, osmoregulation in amphibians living in clean freshwater, and the impact of increased aquatic salinity levels on the ability of amphibians to adequately osmoregulate in an environment for which they are not adapted. Three short videos created by the author can be shown in class or assigned for viewing in advance for a "flipped" classroom approach. Originally developed for a general education/introductory biology course, the case could also be used with introductory level animal anatomy and physiology courses as part of a deeper exploration of the renal system.