The eyes may be the windows to the soul, but they're also the keepers of all kinds of secrets-secrets our eye doctors are in on but we typically aren't. Those little tidbits of info our baby blues (or greens or browns) are hiding are actually chock-full of important details, not only about our eyes and vision, but about our overall health.
This interrupted case study for the flipped classroom introduces the human microbiome from the perspective of one of its occupants, Heidi Helicobacter (Helicobacter pylori). Heidi lives in the gut of Kristen, a college student, and discusses her fellow microbial inhabitants, functions of these various microbes, and alludes to factors that can disrupt the healthy human microbiome. Students prepare for class by viewing several brief videos and then discuss in class whether Kristen should undergo a fecal microbiota transplant to treat her Clostridium difficile infection. A lab component has students model, using colored beads, how antibiotics can act as a selective agent for drug-resistant microbes such as C. difficile. The case concludes with Kristen about to give birth to a new baby several years later. Students listen in as Kristen's microbes discuss the formation of the new baby's microbiome. The case has been used successfully in a general biology class and could easily be adapted for a microbiology, human physiology, ecology, or evolution course.
Say a red gummy bear has a baby with a yellow gummy bear - what percentage of red and yellow do the parents give to their children?
Well, assuming gummy bear genetics works the same way we do, they'll have one set of chromosomes from their mum and one from their dad - so 50 percent from each - easy!
This "clicker case" tells the story of "Hannah," a baby girl adopted by two loving parents who grows up with an uncontrolled appetite and develops severe early-onset obesity. Students follow Hannah's story as she develops excessive eating early in life, which her health care team is unable to explain. A visit to obesity specialists finally reveals the underlying cause of Hannah's obsession with food: extremely low levels of circulating leptin, a hormone that regulates appetite and body weight. It is further discovered that Hannah's leptin deficiency is due to a mutation in the LEP gene. As the story unfolds, students first work on unit conversions and BMI calculations to practice quantitative skills as well as graph and data interpretation skills. Students then apply their knowledge of DNA transcription, translation, and protein structure to answer questions based on figures from a 2019 study on LEP mutations. The case is best suited for high school and lower-level undergraduate biology courses.
The Visible Embryo is a visual guide through fetal development from fertilization through pregnancy to birth. As the most profound physiologic changes occur in the "first trimester" of pregnancy, these Carnegie stages are given prominence on the birth spiral.