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JoAnn Burkholder and her associates at North Carolina State University were the pioneer investigators in the Pfiesteria research, which our group of Old Dominion colleagues has since pursued. Burkholder was the first scientist to link the 1991 fish deaths to Pfiesteria, based on her team's on-site investigations and controlled laboratory studies. In addition, she observed a complicated life cycle in the organism, including numerous morphological forms such as motile flagellated cells, amoebae and cysts that are able to survive in the sediment of estuaries until activated by the presence of fish to produce toxic motile cells. 

When watermen find wounded fish along a lonely river in Maryland, they kick off a scientific debate and an environmental crisis focused on a mysterious microbe that may -- or may not -- cause sick fish and sick people. Watch the title sequence from this award-winning, hour-long film.