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Adam Ruben's tongue-in-cheek column about the common difficulties and frustrations of reading a scientific paper broadly resonated among Science Careers readers. Many of you have come to us asking for more (and more serious) advice on how to make sense of the scientific literature, so we've asked a dozen scientists at different career stages and in a broad range of fields to tell us how they do it. Although it is clear that reading scientific papers becomes easier with experience, the stumbling blocks are real, and it is up to each scientist to identify and apply the techniques that work best for them. The responses have been edited for clarity and brevity.

"Reading and understanding scientific literature can be a daunting task for students in introductory science courses. This decision/dilemma case study helps ease them into the process by using a short scientific article with a simple experimental design that compares two types of ACL (anterior cruciate ligament) surgery, autograft and allograft. The case tells the story of Todd, a martial artist who recently tore his ACL in competition. With the help of the article, Todd discusses the potential surgical options provided by his doctor with his friend, Sam, a medical student. The case has the added value of demonstrating how one can use scientific literature to make informed healthcare decisions based on clinical evidence. Please note that the required article (Kane et al., Knee Surgery, Sports Traumatology, Arthroscopy 24(11): 3627-33) is not provided with this case; prior to assigning this material, instructors should confirm that students can access the article, since access may vary by institution."

The activity begins with students observing different organisms or phenomena and developing questions based on their observations. They then sort their questions into those that can and cannot be answered using the methods of science. Students practice writing scientific questions, designing experiments to address scientific questions, developing questions that involve cause and effect, and understanding the importance of cause and effect questions in scientific research. At the end of the activity, students determine the research questions being asked from reading journal article titles and parts of a published paper or other reported results. Several possible extension activities are provided for continuing the investigation and research of phenomena.