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The Engineering and Systems Design (ESD) program supports research leading to design theory and to tools and methods that enable implementation of the principles of design theory in the practice of design across the full spectrum of engineered products and systems. The program focus is on gaining an understanding of the basic processes and phenomena underlying a holistic, life-cycle view of design where the total system life-cycle context recognizes the need for advanced understanding of the identification and definition of preferences, analysis of alternatives, effective accommodation of uncertainty in decision-making, and the relationship between data and knowledge in a digitally-supported process and environment. The program funds advances in basic design theory, tools, and software to implement design theory and new design methods that span multiple domains, such as design for the environment, for manufacturability, and for systems. 28 28

The System Science (SYS) program funds fundamental research on engineered systems that will support the creation of a mathematically sound framework for systems engineering. The System Science program invites proposals that address fundamental systems issues including system performance prediction, uncertainty quantification in the systems context, theoretical foundations for aggregation in systems, decision-making in the systems context, and operation and maintenance in the systems context. 28 28

CISE's Division of Information and Intelligent Systems (IIS) supports research and education projects that develop new knowledge in three core programs: The Cyber-Human Systems (CHS) program; The Information Integration and Informatics (III) program; and The Robust Intelligence (RI) program. IIS is also responsible for managing the review process for proposals in Computer Graphics and Visualization; these proposals may be submitted to any of the three core programs described above. Proposers are invited to submit proposals in three project classes, which are defined as follows: Small Projects - up to $500,000 total budget with durations up to three years; Medium Projects - $500,001 to $1,200,000 total budget with durations up to four years; and Large Projects - $1,200,001 to $3,000,000 total budget with durations up to five years.

The Engineering and Systems Design (ESD) program supports fundamental research leading to new engineering and systems design methods and practices for specific global contexts.  In particular, ESD seeks intellectual advances in which the theoretical foundations underlying design and systems engineering are operationalized into rigorous and pragmatic methods for a specific context.  In addition, the program funds the rigorous theoretical and empirical characterization of new or existing methods for design and systems engineering, identifying in which global contexts and under which assumptions these methods are effective and efficient.  Such a global context includes both a domain (such as energy systems, consumer products, cyber-physical systems) and an economic, socio-political, environmental and technological context.

The Systems Science (SYS) program supports fundamental research leading to a theoretical foundation for design and systems engineering.   In particular, the Systems Science program seeks intellectual advances in which underlying theories (such as probability theory, decision theory, game theory, organizational sociology, behavioral economics or cognitive psychology) are integrated and abstracted to develop explanatory models for design and systems engineering in a general, domain-independent fashion.  Ideally, the explanatory models, derived from the underlying theoretical foundations will lead to testable hypotheses.  Based on collected evidence supporting or falsifying the hypotheses, new insights are gained allowing the explanatory models to be refined or updated.

CISE's Division of Information and Intelligent Systems (IIS) supports research and education projects that develop new knowledge in three core programs: The Cyber-Human Systems(CHS) program; The Information Integration and Informatics (III)program; and The Robust Intelligence (RI) program

CISE's Division of Computer and Network Systems (CNS) supports research and education projects that take a system-oriented approach to the development of novel computing and networking technologies, or to the enhancement of existing systems in any of several dimensions, or that explore new ways to make use of existing technologies. Proposers are invited to submit proposals in three project classes, which are defined as follows:

This announcement seeks revolutionary research ideas for topics not being addressed by ongoing MTO programs or other published solicitations.

The purpose of this amendment is to correct a typographical error in the abstract details on page 41. See the attached conformed BAA with changes highlighted in yellow. Amendment 01: The purpose of this amendment is to make administrative changes as highlighted in yellow in the attached.Original Synopsis Below:DARPA is soliciting innovative research proposals in the area of novel computing architectures. The Page 3 Architectures thrust of the Electronics Resurgence Initiative (ERI) seeks to demonstrate heterogeneous computing systems that provide the performance advantages of specialized processors, while maintaining the programmability of general purpose processors.The goal of the Software Defined Hardware (SDH) program is to build runtime-reconfigurable hardware and software that enables near ASIC performance without sacrificing programmability for data-intensive algorithms. SDH will create a hardware/software system that allows data-intensive algorithms to run at near ASIC efficiency without the cost, development time or single application limitations associated with ASIC development. The overall goal of the Domain-specific System on Chip (DSSoC) program is to develop a heterogeneous SoC comprised of many cores that mix general-purpose processors, special-purpose processors, hardware accelerators, memory, and input/output (I/O). DSSoC seeks to enable rapid development of multi-application systems through a single programmable device.

The intent of this solicitation is to request proposals from organizations willing to serve as service providers (SPs) within the NSF Innovative High-Performance Computing (HPC) program to provide advanced cyberinfrastructure (CI) capabilities and/or services in production operations to support the full range of computational- and data-intensive research across all of science and engineering (S&E). The current solicitation is intended to complement previous NSF investments in advanced computational infrastructure by provisioning resources, broadly defined in this solicitation to include systems and/or services, in two categories: The first is intended to complement previous NSF investments in advanced computational infrastructure.  Consistent with the ACI Strategic Plan, the current solicitation is focused on expanding the use of high end resources to a much larger and more diverse community.   The second type is devoted to the increasing pressure on the existing infrastructure to store and process very large amounts of data coming from simulation and from experimental resources such as telescopes, genome data banks or sensors.

CISE's Division of Information and Intelligent Systems (IIS) supports research and education projects that develop new knowledge in three core programs: The Cyber-Human Systems (CHS) program; The Information Integration and Informatics (III) program; and The Robust Intelligence (RI) program. Proposals in the area of computer graphics and visualization may be submitted to any of the three core programs described above.

The Campus Cyberinfrastructure (CC*) program invests in coordinated campus-level networking and cyberinfrastructure improvements, innovation, integration, and engineering for science applications and distributed research projects. Learning and workforce development (LWD) in cyberinfrastructure is explicitly addressed in the program. Science-driven requirements are the primary motivation for any proposed activity.

Miami University researchers can provide input about the professional development opportunities they'd like to see OARS offer in the next year by completing this 5-minute survey.

The Dynamics, Control and Systems Diagnostics (DCSD) program supports fundamental research on the analysis, measurement, monitoring and control of dynamic systems. The program promotes innovation in the following areas:

The Mind, Machine and Motor Nexus (M3X) program supports fundamental research at the intersection of mind, machine and motor. A distinguishing characteristic of the program is an integrated treatment of human intent, perception, and behavior in interaction with embodied and intelligent engineered systems and as mediated by motor manipulation. M3X projects should advance the holistic analysis of cognition and of embodiment as present in both human and machine elements. This work will encompass not only how mind interacts with motor function in the manipulation of machines, but also how, in turn, machine response and function may shape and influence both mind and motor function.

CISE's Division of Information and Intelligent Systems (IIS) supports research and education projects that develop new knowledge in three core programs: The Cyber-Human Systems (CHS) program; The Information Integration and Informatics (III) program; and The Robust Intelligence (RI) program. Proposals in the area of computer graphics and visualization may be submitted to any of the three core programs described above. Proposers are invited to submit proposals in three project classes, which are defined as follows: Small Projects - up to $500,000 total budget with durations up to three years; Medium Projects - $500,001 to $1,200,000 total budget with durations up to four years; and Large Projects - $1,200,001 to $3,000,000 total budget with durations up to five years.

The National Institute on Aging is seeking applications on systems biology approaches using non-mammalian laboratory animal models to increase our understanding of the basic biology underpinning neurodegeneration. It is expected that research supported under this FOA will provide new insights into molecular networks that might be involved in causing, amplifying or protecting against neurodegeneration, and that, in turn, might ultimately contribute to Alzheimer's disease or related dementias. Importantly, a major goal of this FOA is to use interaction and regulatory networks produced and analyzed using systems biology to gain these new insights. Because this FOA is directed toward discovery, currently employed genetically modified laboratory animals used to study AD are not required, although they may be used. Because this FOA requires systems biology approaches, data used to build interaction or regulatory networks may also come from humans or other mammals in which AD, related dementias, or aging-related cognitive decline have been observed. This FOA will only support studies using non-mammalian laboratory animal models; studies involving humans or experiments with mammals will not be allowed under this FOA.

The Dynamics, Control and Systems Diagnostics (DCSD) program supports fundamental research on the analysis, measurement, monitoring and control of dynamic systems. The program promotes innovation in the following areas: Modeling: creation of new mathematical frameworks to apply tools of dynamics to physical systems Analysis: discovery and exploration of structure in dynamic behavior Diagnostics: dynamic methods that infer system properties from observations Control: methods that produce desired dynamic behavior

The purpose of this FOA is to promote the development of in vitro microphysiological systems in modeling human diseases and conditions that mimic the pathology in major organs and tissues in the human body, when exposed to the extreme environments of space, and the use of these models at the International Space Station-U.S. National Laboratory (ISS-NL) to facilitate the assessment of biomarkers, bioavailability, efficacy, and toxicity of therapeutic agents prior to entry into clinical trials. Funds from the NIH will be made available through the UG3/UH3 cooperative agreement mechanism. During the initial two-year UG3 phase, support will be provided to develop robust models that recapitulate the progression and pathology of human diseases and conditions exposed to prolonged microgravity environment. Following administrative review, the two-year UH3 phase will build upon successful UG3 models to demonstrate the functional utility of the models for more defined experiments at the ISS-NL. It is anticipated that these studies will lead to identification of novel treatment mechanisms through better understanding of disease biology, drug screening, assessment of candidate therapies for efficacy and safety assessments, and establishing the pre-clinical foundation that will inform clinical trial design on Earth.

This CRISP 2.0 solicitation responds both to national needs on the resilience of critical infrastructures and to increasing NSF emphasis on transdisciplinary research. In this context, the solicitation is one element of the NSF-wide Risk and Resilience activity, with the overarching goal of advancing knowledge in support of improvement of the nation's infrastructure resilience. The devastating effects of recent disasters such as Hurricanes Harvey, Irma and Maria have underscored that a great deal remains to be done. In addition, CRISP 2.0 is aligned with the NSF-wide frontier thinking on convergence, characterized as "deep integration of knowledge, techniques, and expertise from multiple fields to form new and expanded frameworks for addressing scientific and societal challenges and opportunities".