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Purpose NIMH seeks applications for innovative research projects to test strategies to increase the reach, efficiency, effectiveness, and quality of digital mental health interventions which may impact mental health outcomes, including suicide behaviors and serious mental illness. This FOA is intended to support the development of digital health test beds that leverage well-established digital mental health platforms/infrastructure to rapidly refine and optimize existing evidence based digital health interventions and conduct clinical trials testing digital mental health interventions that are statistically powered to provide a definitive answer regarding the intervention's effectiveness. Background The healthcare landscape in the United States is constantly changing, creating new challenges to the delivery of high-quality treatments and services to children, youth, adults, and older adults with unmet or under-met mental health needs. Epidemiological findings suggest that approximately one half of the United States population meets lifetime criteria for a mental disorder, and approximately one quarter of the population meets criteria in any given year. However, only one half of people with any mental health disorder and only two thirds of people with a serious mental health disorder received mental health services in the previous year. Of those that find their way into mental health care, many fall out of care and/or do not receive guideline concordant treatment, including suicide risk assessment and evidence-based preventive interventions. Disparities in population status (e.g., members of racial, ethnic, sexual, and gender minority communities), a fragmented healthcare system, provider shortages, healthcare affordability, and other factors moderate these findings.

The overall goal of this Funding Opportunity Announcement (FOA) is to identify, in animals, in vivo neurophysiological and behavioral measures for use as assays in the early screening phase of treatment development. The FOA will support efforts to optimize and evaluate measures of neurophysiological and behavioral processes that may serve as surrogate markers of neural processes of clinical interest based on available knowledge of the neurobiology of mental illnesses. The screening assays thus developed from this FOA are expected to build upon systems neurobiology and clinical neuroscience to enhance the scientific value of preclinical animal data contributing to a therapeutic development pipeline by assessing the impact of therapeutic targets and treatment candidates on neurobiological mechanisms of clinical relevance to mental illnesses.

The NSF Division of Undergraduate Education (DUE) in collaboration with AAAS will offer an Improving Undergraduate STEM Education: Education and Human Resources (IUSE: EHR) webinar focusing on opportunities for funding in the IUSE: EHR program, specifically associated with the Institutional and Community Transformation (ICT) track of the IUSE program. An audio archive and slides will be posted after the webinar at https://aaas-iuse.org. The IUSE: EHR program "seeks to promote novel, creative, and transformative approaches to generating and using new knowledge about STEM teaching and learning to improve STEM education for all undergraduates." The program supports proposals interested in improving undergraduate education, developing faculty expertise, preparing K-12 teachers, and providing all undergraduate students with STEM competencies and a basic understanding of STEM concepts and principles. All projects must contribute to the body of knowledge about what works in undergraduate STEM education and the conditions that lead to improved STEM teaching and learning. The ICT track seeks to fund innovative work on systemic change that may be measured at the departmental, institutional, or multi-institutional level, or across communities of STEM educators and/or educational researchers. ICT projects are expected to include one or more theories of change to guide the proposed work and this webinar will provide information about expectations for Identifying and incorporating these theories of change.

The Early Career Faculty Innovator Program is inviting a second cohort  of early career faculty in the social and behavioral sciences to co-develop interdisciplinary and actionable research projects in partnership with scientists and engineers at the National Center for Atmospheric Research (NCAR) in Boulder, Colorado. A primary goal of the Innovator Program is to address complex research problems by building partnerships between NCAR scientists and early career faculty. The Innovators Program aims to fund six faculty and one graduate student of each faculty participant for two years, starting in summer 2021. Research themes that align with NSF and NCAR strategic priorities are selected for each two-year cohort. 2021-2022 Research Theme: Actionable Earth System Science Prospective applicants to the Innovators Program are invited to propose an interdisciplinary research project that can leverage expertise at NCAR and occur over a 2-year period.

The OFRN Round 5 Opportunity Announcement is focused on expanding Ohio's research and development capabilities across the state's academic institutions and business in support of Ohio-based federal partner needs, which ultimately promotes Ohio's economic growth. OFRN Round 5 Areas of Interest (AOIs) include topics in Unmanned Aerial Systems (UAS), Artificial Intelligence, Human Factors, Data Analytics and Space Commercialization. This announcement seeks to leverage Ohio's unique research capabilities and its federal partner's expertise to accelerate technology development and innovation by increasing collaboration across government, academic, and industry organizations. The Round 5 Opportunity Announcement is subject to funding availability based upon a pending review and final determination of the Program Objectives from the Ohio Department of Higher Education (ODHE). This is a Pre-Release notification and NOT a formal solicitation.

Navigating the New Arctic (NNA) embodies an important forward-looking response by the Foundation to these profound challenges. NNA seeks innovations in fundamental convergence research across the social, natural, environmental, computing and information sciences, and engineering that address the interactions or connections among natural and built environments and social systems, and how these connections inform our understanding of Arctic change and its local and global effects. This solicitation requests proposals that fall within one of three tracks: NNA Planning Grants, dedicated to developing convergence research questions and teams to tackle projects of larger scope in the future; NNA Research Grants, aimed to support creative projects on fundamental research that address convergent scientific and engineering challenges related to the rapidly changing Arctic; and NNA Collaboratory Grants, designed to support collaborative teams undertaking research and training initiatives on critical themes of a broad scope related to the New Arctic.

The purpose of this program is to more effectively respond to the needs of children, youth, and young adults with serious emotional disturbances (SED) and their families by providing information, referrals, and support; and to create a mechanism for families to participate in state and local mental health services planning and policy development. This population of focus will hereafter be referred to as children and youth. SAMHSA expects that this program will be a catalyst for transforming mental health and related systems in the state by strengthening coalitions among family organizations and between family members, policy makers, and service providers.

Our goal is to bend the Keeling Curve. To that end, our team is looking for projects with a proven track record of taking greenhouse gases out of the atmosphere. We've developed five categories, each one addressing a specific sector of climate innovation. We award $25,000 to two projects in each category annually. Capture & Utilization -- Projects in this category are advancing technological and nature-based strategies for capturing and/or utilizing heat-trapping gases from the air or oceans. Energy -- Projects in this category decarbonize energy, support zero-carbon energy innovations, and lead the way in improving the supply, distribution, and access of low or zero-emissions energy systems worldwide. Finance -- Projects in this category are making financial mechanisms and economics work for greenhouse gas reduction and/or reversal ventures. Social & Cultural Pathways -- Projects in this category are changing the way people consider, understand, and act concerning human impacts on planet Earth. They are trying to answer the question: what does it take, socially and culturally, to develop beyond fossil fuels? Transport & Mobility -- Projects that apply in this category are reimagining and reinventing all types of vehicles, fuels, and mobility options for both people and products. These projects will confront the carbon footprint of the vehicles themselves and the routes traveled.

The goal of the NOSI is to develop strategies and interventions to address vaccine hesitancy, uptake, and implementation among populations who experience health disparities in the US. The NOSI will solicit research to help understand and address misinformation, distrust, and hesitancy regarding vaccines (e.g., SARS-CoV-2, human papilloma virus, pneumococcal, influenza, hepatitis B, and herpes zoster) that target adults in the United States and territories, especially among populations who are at increased risk for morbidity and mortality due to long-standing systemic health and social inequities and chronic medical conditions. The program will solicit community-engaged research to: 1) evaluate innovative interventions (e.g., expand reach, access) to facilitate vaccination uptake in clinical and community contexts; and 2) address the barriers to increasing reach, access, and uptake of vaccinations among health disparity populations.

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative research proposals in the areas of physical sciences, engineering, materials, mathematics, biology, computing, informatics, social science, and manufacturing of interest to DARPA's Defense Sciences Office (DSO), Microsystems Technology Office (MTO), and Biological Technologies Office (BTO).

The Defense Advanced Research Projects Agency (DARPA) is soliciting innovative research proposals in the areas of physical sciences, engineering, materials, mathematics, biology, computing, informatics, social science, and manufacturing of interest to DARPA's Defense Sciences Office (DSO), Microsystems Technology Office (MTO), and Biological Technologies Office (BTO).

The Lesbian Health Fund (LHF), a program of GLMA: Health Professionals Advancing LGBT Equality, was established in 1992 to define, study, and educate lesbians and their health care providers about lesbian health issues. LHF's mission is to improve the health of lesbians, other sexual minority women (SMW) and their families through research. Research areas include: Understanding social, family, and interpersonal influences as sources of stress or support Eliminating inequalities in health care, including barriers to care, and improving quality of care and utilization rates Development and testing of interventions to address mental and physical health needs of lesbians and other SMW, including but not limited to depression, identity related issues, eating disorders, substance abuse, obesity, cancer risks, cardiovascular disease and sexually transmitted infections Sexual and reproductive health, including family & parenting issues The deadlines for receipt of applications are May 15 and October 15.

The Substance Abuse andMental Health Services Administration (SAMHSA), Center for Substance AbuseTreatment (CSAT), isaccepting applications for fiscal year (FY) 2019 Provider's Clinical SupportSystem - Universities (Short Title: PCSS-Universities) grants. The purpose of this program is toexpand/enhance access to medication-assisted treatment (MAT) services forpersons with an opioid use disorder (OUD) seeking or receiving MAT throughensuring the education and training of students in the medical, physicianassistant and nurse practitioner fields. This program's focus is to ensure students fulfill the trainingrequirements needed to obtain a DATA waiver to prescribe MAT in office-basedsettings. The desired outcomes include: 1) an increase in the number of individuals completing the trainingrequirements for the DATA waiver, 2) an increase the number of individuals witha DATA waiver, and 3) an ultimate increase in those prescribing.

With this solicitation, NIJ seeks applications for funding for multidisciplinary research projects addressing four topics: impact of fatigue and stress on officer performance; impact of occupational prestige and job satisfaction on officer stress resilience; enhancing strategies for officer interaction with mentally ill individuals; and reducing traffic-related officer fatalities and injuries through technology enhancement and policy.

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites applications to evaluate the cumulative and progressive effects on brain structure and cognitive/behavioral function of combined HIV infection and alcohol abuse on older patients cohorts.

This program calls for innovative, convergent, boundary-crossing proposals that can best capture those opportunities and map out new research frontiers. NSF seeks proposals that are bold and risky, and transcend the perspectives and approaches typical of disciplinary research efforts. This cross-directorate program is one element of NSF’s broader effort directed at Understanding the Brain, a multi-year activity

A central goal of the BRAIN Initiative is to understand how electrical and chemical signals code information in neural circuits and give rise to sensations, thoughts, emotions and actions. While currently available technologies can provide some understanding, they may not be sufficient to accomplish this goal. For example, non-invasive technologies are low resolution and/or provide indirect measures such as blood flow, which are imprecise; invasive technologies can provide information at the level of single neurons producing the fundamental biophysical signals, but they can only be applied to tens or hundreds of neurons, out of a total number in the human brain estimated at 85 billion. Other BRAIN FOAs seek to develop novel technology (RFA-NS-17-003) or to optimize existing technology ready for in-vivo proof-of-concept testing and collection of preliminary data (RFA-NS-17-004) for recording or manipulating neural activity on a scale that is beyond what is currently possible. This FOA seeks applications for unique and innovative technologies that are in an even earlier stage of development than that sought in other FOAs, including new and untested ideas that are in the initial stages of conceptualization.

The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites applications to evaluate the cumulative and progressive effects on brain structure and cognitive/behavioral function of combined HIV infection and alcohol abuse. This project has recruited and longitudinally tracked a large cohort of individuals with HIV infection, or alcohol abuse, or the comorbid condition. As members of this cohort are growing older and living well longer due to antiretroviral medications, this project is well suited to address several questions of current interest in the HIV-AIDS research community. These questions include the effects of coinfection with the Hepatitis C virus, the involvement of peripheral neuropathy as a factor in frailty, potential neurotoxic effects of antiretroviral medications, and interactive effects with advancing age on sensory and motor functioning.

The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry, or at the Development stage, to advance a development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Projects that enter at the Discovery stage and meet their milestones may continue on through Development. BPN awardee Institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program.

The Blueprint Neurotherapeutics Network (BPN) encourages applications from small businesses seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry, or at the Development stage, to advance a development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Projects that enter at the Discovery stage and meet their milestones may continue on through Development. BPN awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program.

The purpose of this Funding Opportunity Announcement (FOA) is to support investigators who have interest and capability to join efforts for the discovery of in vivo chemical probes for novel brain targets. It is expected that applicants will have, in hand, the starting compounds ("validated hits") for chemical optimization and bioassays for testing new analog compounds. Through this FOA, NIH wishes to stimulate research in 1) discovery and development of novel, small molecules for their potential use in understanding biological processes relevant to the missions of NIMH, NIDA, NEI, and/or NIA and 2) discovery and/or validation of novel, biological targets that will inform studies of brain disease mechanisms. Emphasis will be placed on projects that provide new insight into important disease-related biological targets and biological processes. The main emphasis of projects submitted under this FOA should be the discovery of in vivo chemical probes. Applicants interested in developing cell-based chemical probes may wish to apply using the companion R21 mechanism, (PAR-21-028).