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This funding opportunity announcement (FOA) invites applications on violence and the HIV care continuum, including: (1) research that will advance understanding of the role of exposure to violence on engagement and retention in HIV care, HIV medication adherence, and viral suppression, and (2) research to develop and test novel interventions to improve HIV care continuum outcomes for individuals who have experienced violence. This FOA uses the R21 grant mechanism, while RFA-MH-20-200 uses the R01 mechanism and RFA-MH-20-202 uses the R34 mechanism. High risk/high payoff projects that lack preliminary data or utilize existing data may be most appropriate for the R21 mechanism. Applications with preliminary data and/or those including longitudinal analysis should consider using the R01 mechanism. Applicants proposing to develop and pilot test an intervention should consider the R34 mechanism.