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The Office of Research Integrity (ORI) announces the anticipated availability of funds for Fiscal Year (FY) 2018 for competitive grants under the authority of section 301 of the Public Health Service Act, 42 U.S.C. § 241, as delegated to the Director of ORI and the Public Health Service Policies on Research Misconduct Final Rule, 42 CFR Part 93. The FOA will solicit applications for competing grant awards to fund Phase I of two phases of exploratory developmental research projects designed to foster greater understanding about preventing research misconduct and promoting research integrity. The objective for Phase I awards is to establish project merit and feasibility and generate preliminary data for Phase II proposals. ORI fosters innovative approaches to empirical research on societal, organizational, group, and individual factors that affect, both positively and negatively, integrity in research.

The purpose of this FOA is to stimulate much needed research in an important area of public health significance: prevention of new HIV infections among adolescents at risk, and the identification of, linkage to and retention in care of, and long term viral suppression among youth living with HIV in low-to-middle income countries. These settings must have an HIV epidemic density defined by UNAIDS estimates as either a country 1) in which at least 200,000 people are living with HIV and the number has not decreased by more than 5% over the last 2 consecutive years of available data or 2) has an HIV prevalence of 3% or more. The UG3/UH3 Phased Innovation Awards Cooperative Agreement involves 2 phases. Funding for a UG3 phase will be used to demonstrate sufficient preparation, feasibility and capacity to meet foundational milestone targets specific to the work proposed. A UG3 project that meets its milestones will be administratively considered by NICHD and prioritized for transition to the UH3 award. Applicants responding to this FOA must address objectives for both the UG3 and UH3 phases.

The LRP Impact Award mechanism is being offered for the first time in FY17. The LRP Impact Award encourages applications that support the full spectrum of research projects or ideas that specifically focus on scientific and clinical lupus issues, which, if successfully addressed, have the potential to make a major impact in lupus research. Applications should include a well-formulated, testable hypothesis based on strong scientific rationale that is established through inferential reasoning and/or critical review and analysis of the literature. Inclusion of preliminary data is encouraged. The following are important aspects of the Impact Award: * Impact: The proposed research should impact an area of paramount importance in lupus disease. It is the responsibility of the Principal Investigator (PI) to clearly and explicitly describe the potential impacts of the proposed study on lupus and to convey its level of significance. * Research Strategy: The scientific rationale and experimental methodology should demonstrate critical understanding and in-depth analysis of lupus. Experimental strategies may be novel or may be based on strong rationale derived from a literature review. * Preliminary Data: Inclusion of preliminary data, such as unpublished data from the laboratory of the PI and/or data from published literature that are relevant to lupus and support the proposed research project, is encouraged, but not required. * Focus Areas: The proposed research must address at least one of the FY17 LRP Focus Areas. Clinical trials are not allowed under this Program Announcement.

AIDS United, in collaboration with the Health Resources and Services Administration's HIV/AIDS Bureau and The Fenway Institute, is offering funding through the Using Evidence-Informed Interventions to Improve Health Outcomes among People Living with HIV initiative. The goal of this initiative is to support the implementation of evidence-informed interventions to reduce HIV-related health disparities and improve health outcomes, including increasing retention in care, improving treatment adherence, and improving viral suppression for people living with HIV. Up to 24 intervention sites will receive $170,000 per year to support the development and implementation of interventions. Ryan White HIV/AIDS Program recipients or subrecipients that operate within the United States or its territories are eligible to apply. Proposals must be submitted by January 22, 2018. Visit the AIDS United website to download the RFP.

This Small Research Grant (R03) will support important and innovative projects focused on basic science approaches to elucidate neurodegenerative mechanisms/pathways of Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). Proposed projects should ultimately aim to improve the prevention, diagnosis, treatment, and/or care for individuals with AD/ADRD. The program seeks (i) to facilitate the next generation of researchers in the United States to pursue research and academic careers in neuroscience, AD/ADRD, and healthy brain aging and (ii) to stimulate established researchers who are not currently doing AD/ADRD research to perform pilot studies toward developing new, innovative AD/ADRD research programs that leverage and build upon their existing expertise. Individuals from underrepresented racial and ethnic groups, as well as individuals with disabilities, are always encouraged to apply for NIH support.

The purpose of this FOA is to solicit current or recently completed NHLBI K01, K08, and K23 awardees for grant support to expand their current research objectives or to branch out to a study that resulted from the research conducted under the K award. Recently completed NHLBI K01, K08, and K23 awardees are eligible to apply for the R03 if the earliest possible R03 start date falls within 2 years of their prior NHLBI K award Project Period end date. Thus, this FOA is intended to enhance the capability of NHLBI K01, K08, and K23 award recipients to conduct research as they complete their transition to fully independent investigator status. The R03 grant mechanism supports different types of projects, including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. For current and previous K23 awardees, research proposed in the R03 application may or may not include patient-oriented research. The R03 is, therefore, intended to support research projects that can be carried out in a short period of time with limited resources and that provide preliminary data to support a subsequent R01, or equivalent, application.

The objective of the NIDCR Award for Sustaining Outstanding Achievement in Research (SOAR) is to provide longer-term support to NIDCR-funded investigators, who are in their mid-career stage, and have outstanding records of research productivity, mentorship and professional service to the research community. It is expected that the SOAR Award will propel the investigator along this career trajectory and allow him/her to embark on ambitious longer-term projects of extraordinary potential within the mission of NIDCR. This award supports research projects for up to eight years.

The overall goal of this FOA is to support the development of a collaborative research and resource network to synergize the expertise, skills, and resources of investigators within the geriatric emergency medicine and Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD) research communities to identify and address research gaps towards optimizing recognition and emergency care of older adults with AD/ADRD.

The Centers for Disease Control and Prevention's National Center for Injury Prevention and Control (NCIPC) is soliciting investigator-initiated research that will help expand and advance our understanding about what works to prevent violence that impacts children and youth, collectively referred to as Adverse Childhood Experiences (ACEs), including child abuse and neglect, teen dating violence, sexual violence, youth violence, youth/parent suicidal behavior, and exposure to adult intimate partner violence. This initiative is intended to support the evaluation of primary prevention programs, practices or policies that target universal or selected high-risk populations (i.e., populations that have one or more risk factors that place them at heightened risk for violence). Funds are available to conduct such studies focused on preventing child abuse and neglect and at least one other form of violence affecting children and youth, including teen dating violence, sexual violence, youth violence, and exposure to adult intimate partner violence.

The NEI Center Core Grant combines three or more Resource and/or Service Cores for a group of R01 investigators to enhance their research, consolidate resources, avoid duplication of efforts, and/or contribute to cost effectiveness by providing a service with lower costs or higher quality than could be attempted for independent projects by several individual Program Directors/Principal Investigators (PD(s)/PI(s)).

The purpose of this NOFO is to support a mechanism to obtain timely input from nationally representative samples of (a) healthcare providers and (b) the public on critical immunization issues of importance. The objectives of this research are (1) for each year of the project, to conduct multiple surveys of providers and the public to collect immunization-related data using scientifically sound methods with adequate response rates that produce generalizable results, and (2) to disseminate those results broadly to assist in (a) informing recommendations for new vaccines, (b) developing strategies to improve immunization coverage, and (c) instituting contingency plans to address urgent problems (e.g., vaccine supply shortages). Surveyed providers should include pediatricians, family physicians, obstetrician/gynecologists, general internists, or some combination of these physician specialties. Surveyed members of the public should be ≥18 years old and should include subpopulations of special interest for consideration of immunization-related issues such as pregnant women, parents of children aged 0 to 5 years, and persons with chronic medical conditions.

The goal of this FOA is to support basic and clinical research on the influence of alcohol on susceptibility and progression of Alzheimers disease and its related dementias. Recent longitudinal studies have provided strong evidence that alcohol use disorder is associated with the high risk of all types of dementias, and frequent heavy drinking increases risk of both Alzheimers disease and vascular dementia. Even moderate alcohol consumption may be a risk factor for adverse brain outcomes and cognitive decline. Although these studies link heavy and frequent alcohol drinking to dementias in aging populations, mechanisms contributing to this relationship are not well understood. With this FOA, we solicitate research projects that combine diverse expertise and use innovative approaches to investigate mechanisms by which alcohol affects brain aging processes to produce dementias and influences development of Alzheimers disease. This FOA strongly encourages collaborations between alcohol researchers and experts in Alzheimer's disease and its related dementia research.

This Funding Oopportunity Aannouncement (FOA) invites pilot feasibility studies testing rapid-acting interventions to reduce severe suicide risk through clinical trials that are based in appropriate/specialized healthcare settings(e.g., emergency departments [ED], psychiatric inpatient units, other settings that meet Risk Evaluation and Mitigation Strategy approaches).

NIMH seeks applications for innovative research projects to test strategies to increase the reach, efficiency, effectiveness, and quality of digital mental health interventions. This FOA is intended to support the development of digital health test beds that leverage well-established digital mental health platforms ,to rapidly refine and optimize existing evidence-based digital health interventions and conduct clinical trials testing digital mental health interventions that are statistically powered to provide a definitive answer regarding the intervention's effectiveness.

To support projects that apply new or existing tools to monitor and/or manipulate the 4D nucleome in the context of human health and disease. Any human disease or biological process relevant to NIHs mission may be proposed including environmental exposures (e.g. addictive substances, toxins, psychosocial stress), or studies across development or lifespan. Other relevant timeframes may include but are not limited to: circadian rhythms, fasting and feeding cycles, reproductive cycles, and sleep/wake cycles.

This initiative will provide two years of support for planning activities necessary for initiating a Phase III clinical trial designed to validate VCID biomarkers and/or treat patients with VCID. The full spectrum of VCID is in scope, and the one or more VCID disorders(s) to be targeted in the trial must be clearly specified in the application, for example (but not limited to): vascular insults including clinical stroke, silent infarcts and microinfarcts, leukoaraiosis, cerebral amyloid angiopathy (CAA), transient ischemic attack (TIA), micro-bleeds, CADASIL, and vascular contributions to Alzheimers dementia. Planning activities may include identifying trial sites/collaborations, designing trial protocols and procedures, and addressing regulatory approvals.

To support projects from NIH-defined New Investigators that apply new or existing tools to monitor and/or manipulate the 4D nucleome (4DN) in the context of human health and disease. Any human disease or biological process relevant to NIHs mission may be proposed including environmental exposures (e.g. addictive substances, toxins, psychosocial stress), or studies across development or lifespan. Other relevant time frames may include but are not limited to: circadian rhythms, fasting and feeding cycles, reproductive cycles, and sleep/wake cycles.

This FOA invites applications that propose to develop novel research infrastructure that will advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations. This FOA will use the NIH Phased Innovation Award (R21/R33) mechanism to provide up to 2 years of R21 support for initial developmental activities, and up to 3 years of R33 support for expanded activities. Through this award, investigators will develop a sustainable research infrastructure to support projects that address key interdisciplinary aging research questions.

This NCIPC Mentored Research Scientist Development Award (K01) seeks to provide support for an intensive, supervised (mentored) career development experience in violence prevention research leading to research independence. Applicants must identify an experienced mentor and, co-mentor(s) as applicable to supervise the proposed career development and research experience. Applicants must have a qualifying (relevant to the field of study) research or health- professional doctoral or medical degree (specifically PhD, ScD, DO, DrPH, MD, DVMD) and less than five years of experience as a researcher in the injury and/or violence prevention field. Applicants must propose violence prevention research to 1) assess the effectiveness of an intervention to prevent one or more forms of violence impacting children and youth ages 0-17 years (i.e., child abuse and neglect, youth violence, teen dating violence, or sexual violence) or to prevent intimate partner violence, sexual violence, or self-directed violence; 2) assess violence outcomes (e.g., victimization or perpetration) or key risk or protective factors; and 3) focus on one of the interpersonal violence prevention research gaps in the NCIPC Research Priorities (https://www.cdc.gov/injury/researchpriorities/index.html).

This NOFO has two components, A and B. Component A (Natural Experiment Research Centers): To support a 5-year multi-center network of independent research centers to evaluate innovative, health system and non-health system-based natural experimental approaches to alter the diabetogenic characteristics of US communities. Applicants will select one of the following two tracks: Track 1 Evaluation of population-level programs or policies that affect population-level risk factors for type 2 diabetes (such as diet or physical activity, as well as other health behaviors; glucose; prediabetes), or Track 2 Evaluation of programs or policies aimed at improving care and management of diabetes, and the risk for diabetes complications. Component B (Coordinating Center): To fund a Coordinating Center (CC) to provide organizational, logistic and communication support to enhance the efficiency, productivity, and public health impact of the Natural Experiments research centers that are funded as part of Component A.