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This Funding Opportunity Announcement (FOA) solicits Edward R. Roybal Centers for Translation Research in the Behavioral and Social Sciences of Aging. The purpose of the Roybal Centers is to develop behavioral interventions that improve the health and well-being of people as they are aging and the capacity of institutions to adapt to societal aging. Roybal Centers will conduct Stage 0 through IV pilot studies in accordance with the multidirectional, translational NIH Stage Model, to produce potent and implementable principle-driven behavioral interventions.

The goal of this grant is to hold a one-week program to train girls ages 13-17, and mentors ages 18-25 from two at-risk communities on the north coast and/or the D.R.-Haiti border. The soccer clinics coached by two current or retired US women's soccer players will promote sports as a tool for gender equality and conflict resolution. The program must include life skills, empowerment, health, and/or personal development workshops to help girls create life plans and prevent teenage pregnancy, school dropout and other risky behaviors while promoting healthy choices, good decision making and planning for the future. The program will consist of two two-day clinics (one per community), including both soccer skills clinics and life skills sessions. While the focus for younger participants aged 13-17 would be these soccer and life skills development, young women aged 18-25 would be able to learn from the professional soccer players and other educators to work towards becoming mentors themselves. Alumni of U.S. government exchange programs may be invited to serve as mentors and facilitators.

The overall goal of this funding announcement is to elicit applications for novel strategies to enhance referral, participation, and adherence in cardiac rehabilitation (CR) of older and vulnerable patients who are eligible for CR under current Medicare eligibility criteria. Specifically, NIA seeks clinical trials that address one or more specific age-related factors including patient-related issues, CR program goals and components, and CR program setting-related aspects. These three age-related issues represent distinct, but potentially interrelated, areas that are impacted by advancing age and are not currently addressed in traditional CR programs. Determination of the specific aspects of CR programs that may be better suited to medically complex and vulnerable older adults, such as eligibility, patient-centered goals and outcomes, and novel components and delivery systems may ultimately improve referral, enrollment, completion and overall benefit of this Medicare-supported resource. Successful modified programs should strive to improve function, independence and quality of life while reducing disability, future CV events, readmissions, morbidity and mortality.

This FOA encourages applications at the intersection of HIV and aging by addressing two overarching objectives: 1) to improve understanding of biological, clinical, and socio-behavioral aspects of aging through the lens of HIV infection and its treatment; and 2) to improve approaches for testing, prevention, and treatment of HIV infection, and management of HIV-related comorbidities, co-infections, and complications in different populations and cultural settings by applying our current understanding of aging science Applications appropriate to this FOA should be consistent with the scientific priorities outlined by the NIH Office of AIDS Research (OAR) as described in NOT-OD-15-137.

The purpose of this funding opportunity announcement is to support (1) research to test the efficacy or effectiveness of interventions to prevent initiation and/or escalation of ENDS (electronic nicotine delivery system) use among adolescents; and(2 )research on the impact of tobacco control policies, including ENDS-specific policies, on adolescent ENDS use behavior. Of priority is research that is theoretically based and identifies specific risk and protective factors to target through prevention intervention, or research on policies that can impact adolescent ENDS use. Particularly, for prevention intervention research (e.g., school, community, and clinic-based), collaboration with stakeholders and likely program adopters is required to ensure feasibility for implementation, scalability, dissemination and sustainability. For this funding announcement, individuals as young as 12 and as old as 18 encompass the core target age range. Justification for the specific age or age range of the target population is required, including studies that propose targeting youth outside the core age range.

This Funding Opportunity Announcement (FOA) encourages applications for mechanistic research on age-related changes in emotion regulation and how they may contribute to mental disorders in middle-aged and older adults.In particular, research is sought that will advance understanding of irregularities in the integrative neural-behavioral mechanisms of emotion regulation in adult mood and anxiety disorders, and that will examine whether the irregularities are associated with typical or atypical maturational trajectories of emotion processing. If older adults who suffer episodes of affective dysregulation share the same patterns of improved emotional function with age as have been found to be typical of the older adult population in general. Research that helps to clarify whether they do or do not manifest typical emotion processing trajectories may lead to very different understanding of the irregularities involved their dysregulation.It is anticipated that such studies may identify novel targets for mental health interventions or prevention efforts, or provide clues as to which available intervention strategies might be optimally applied to normalize emotion dysregulation or to strengthen emotional resilience at particular stages of the adult life cycle.

This Funding Opportunity Announcement (FOA) is a phased innovation initiative to facilitate multi-omics/integrative approaches to identify omics profiles associated with protection against multiple aging conditions, with exceptional health span, and to refine strategies for utilizing these profiles for therapeutics development. Specifically, a phased innovation cooperative agreement mechanism (UH2/UH3) involving an interdisciplinary research team will be used to support a single project that will conduct integrative analysis of person-specific multiple omics measurements (e.g., transcriptomics, proteomics, metabolomics) generated across multiple tissues; the multi-omic profiling should be conducted on individuals from extensively phenotyped cohorts with substantial numbers of long-lived individuals with characteristics of exceptionally healthy aging and appropriate controls.

This FOA invites applications from qualified institutions to create a Roybal Center Coordinating Center (CC), serving the needs of the Roybal Centers for Translational Research on Aging program as well as the Roybal Centers for Translational Research on Dementia Care Provider Support program. The Roybal Coordinating Center will serve as a hub for the Roybal Center grant program. Roybal Center programs conduct translational in the behavioral and social sciences of aging, structured in accordance with the NIH Stage Model. Roybal Center program resources are intended for pilot and preliminary translational, multi-directional research at Stages 0 through IV of the behavioral intervention development pipeline with the goal of creating principle-driven interventions that improve the lives of mid-life and older people and the capacity of institutions to adapt to societal aging. The Roybal Coordinating Center will facilitate and coordinate trans-Roybal activities. The Center will work closely with the NIA Program Officer and, in coordination with all Roybal sites, will be responsive to requests generated by key Roybal site personnel, NIA, NIH, the scientific community, and the general public.

This Funding Opportunity Announcement (FOA) invites applications for the next 5-year cycle of the National Longitudinal Study of Adolescent to Adult Health (Add Health) to include a sixth wave of data collection (Wave VI). Add Health is a nationally representative, longitudinal study of individuals primarily born from 1976 through 1982 who were first interviewed as adolescents in grades 7-12 (ages 12-19) in 1994-1995. Add Health respondents are now entering middle age. The goals for Add Health Wave VI are to: Re-interview Add Health cohort members in a combination of web-based and in-person modes, including aggressive non-response follow-up and oversamples of race/ethnic-minority and low-socioeconomic-status individuals. Re-visit cohort members for an in-home health exam that includes venous blood collection. Assay biological specimens for biomarkers of disease. Enrich measures in domains that may elucidate mid- and later-life health and disparities therein (e.g., cumulative stress, discrimination, work-life balance, caregiving). Clean, document, disseminate, archive (including storage of biological specimens for future study), and promote the Wave VI data to the scientific community for aging research.

Despite significant scientific advancements made in substance use disorder research over the last century, the causes and consequences of drug use in later life remain poorly understood. The intent of this funding opportunity announcement is to support innovative research that examines aspects of marijuana and prescription opioid and benzodiazepine use in adults aged 50 and older. This FOA encourages research that examines the determinants of these types of drug use and/or characterizes the resulting neurobiological alterations, associated behaviors, and public health consequences. This initiative will focus on two distinct populations of older adults: individuals with earlier onset of drug use who are now entering this stage of adult development or individuals who initiate drug use after the age of 50. Applications are encouraged to utilize broad methodologies ranging from basic science, clinical, and epidemiological approaches. The insights gleaned from this initiative are critical to our understanding of the determinants of drug use in later life, as well as its consequences in the aging brain and on behavior. This knowledge may have the potential to identify risk factors and to guide clinical practices in older populations.

The Health and Aging Policy Fellows Program is a unique opportunity for professionals in health and aging to receive the experience and skills necessary to make a positive contribution to the development and implementation of health policies that affect older Americans. The year-long program offers fellows the opportunity to participate in a residential track or a non-residential track. The residential track allows fellows to participate in the policymaking process on either the Federal or state level as legislative assistants in Congress, professional staff members in executive branch agencies or policy organizations. The non-residential track allows fellows to remain at their home institution but work on a policy project that involves brief placement(s) throughout the year at relevant sites. Core program components focused on career development and professional enrichment are provided for fellows in both tracks. Fellows also have the opportunity to apply for second-year funding to continue components of their fellowship experience/project either at their placement sites, at the state/local levels, or with non-governmental organizations.

The National Institute on Aging is seeking applications to develop systems biology approaches to understand the basic biology underpinning neurodegeneration which might ultimately contribute to Alzheimer's disease or related dementias, using non-mammalian laboratory animal models. It is expected that research carried under the auspices of this FOA will lead to discovery of new mechanisms that provoke neurodegeneration and to new molecular pathways that might be involved in causing, amplifying or protecting against neurodegeneration. Applications should propose to use established non-mammalian laboratory animals which have a history of contributions to our understanding of neurobiology or aging biology.  

The purpose of this Funding Opportunity Announcement (FOA) is to provide dissertation awards in all areas of research within NIA's strategic priorities to increase diversity of the scientific research workforce engaged in research on aging and aging-related health conditions.

The National Institute on Aging is pursuing this initiative to recruit talented new investigators who have begun to establish research programs and who, through this award, will be ready to assume leadership roles in their field of expertise and who will be poised to change theory, practice and health outcomes related to the health of older individuals. Unlike other mentored K awards, candidates for this award must have received competitively awarded research support as a PD/PI at the faculty level and have had prior leadership responsibilities in the clinical or research domain.

The National Institute on Aging is pursuing this initiative to recruit talented new investigators who have begun to establish research programs and who, through this award, will be ready to assume leadership roles in their field of expertise and who will be poised to change theory, practice and health outcomes related to the health of older individuals. Unlike other mentored K awards, candidates for this award must have received competitively awarded research support as a PD/PI at the faculty level and have had prior leadership responsibilities in the clinical or research domain.

Purpose This FOA is intended to support research on lupus through a longitudinal study designed to follow an established, US-based., population-based cohort with lupus (systemic lupus erythematosus {SLE} and skin lupus) of all ages to determine over time: o The treatment, health care access, and natural history (severity, morbidity, mortality, etc.) of cohort members, o Factors (including genetic and other biological factors such as antibody levels) associated with these outcomes, and o The above by categories of research interest (e.g., age, gender, race/ethnic group). Knowledge of such information for lupus, which is associated with strong age/sex/race disparities and has had little public health research, can help identify missed opportunities for better treatment, help identify new disease phenotypes based on progression of disease, and help identify factors associated with progression that may play a role in secondary and tertiary prevention. 

Despite current data supporting the importance of circadian regulation of DI, molecular components that couple circadian systems with metabolic control, epigenetic modification and age-associated pathologies are not fully understood. In addition, little is known about the contributions of central clocks versus peripheral clocks for regulating circadian homeostasis in the context of aging and metabolism. Several DI modifications such as amino acid restriction, intermittent fasting, and fasting-mimicking diets have been shown to improve healthspan in animals and in human trials. Therefore, this FOA aims to examine how each of these dietary interventions entrains peripheral clocks and how circadian regulation integrates with various dietary strategies to achieve optimal health benefits.

This funding opportunity announcement (FOA) invites applications for the next five-year cycle of the National Health and Aging Trends Study (NHATS), the leading nationally representative, longitudinal data resource in the US for research on trends, dynamics, and disparities in late-life disability, and for studies of the social and economic consequences of late-life disability for individuals, families and society, including caregiving and end-of-life issues. NHATS has conducted seven annual rounds of data collection to date (an eighth round is in process) and is linked to the separately funded National Study of Caregiving (NSOC). The goals of the next cycle are to: 1) Continue the current structure and design elements of NHATS; 2) Permit studies of long-term trends in disability prevalence; 3) Enrich measurement of cognitive capacity; 4) Enhance measurement of physical activity and sedentary behavior; 5) Continue linkages with administrative records; and 6) Augment data dissemination and user support.

The purpose of this Funding Opportunity Announcement (FOA) is to stimulate research to address gaps in our knowledge related to the risk factors, access barriers, oral health promotion and disease prevention strategies, and clinical management of dental, oral, and craniofacial (DOC) diseases associated with aging. To stimulate scientific advances, research supported by this FOA should consider interdisciplinary research and interprofessional approaches focused on improving DOC health in adults age 65 and older. Collaborations between researchers focused on aging and researchers focused on DOC health will be strongly encouraged.

This FOA invites applications that propose to support advanced-stage development and utilization of novel research infrastructure to advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations. This FOA will use the NIH Exploratory/Developmental Grants Phase II mechanism to provide support for expanded activities. Applicants are expected to have an existing research infrastructure developed either through PA-12-064, or with other NIH or non-NIH support. Through this award, investigators will develop a mature and sustainable research infrastructure to support projects that address key interdisciplinary aging research questions.

This FOA invites applications that propose to develop novel research infrastructure that will advance the science of aging in specific areas requiring interdisciplinary partnerships or collaborations. This FOA will use the NIH Phased Innovation Award (R21/R33) mechanism to provide up to 2 years of R21 support for initial developmental activities, and up to 3 years of R33 support for expanded activities. Through this award, investigators will develop a sustainable research infrastructure to support projects that address key interdisciplinary aging research questions.