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This Funding Opportunity Announcement (FOA) seeks clinical research on self-management interventions and technologies that improve health and quality of life in persons needing assistance to optimize and maintain existing functional capabilities, prevent/delay disabilities and navigate their environment. The research focus encompasses maintenance/restorative care that can be tailored to individuals' existing functional abilities and interests and is intended to enhance physical, sensory, motor, and mental capabilities. Of particular interest is research designed to maintain functional capabilities in such conditions as cardiac and respiratory insufficiency, movement impairment associated with arthritis, chronic back pain, stroke, and other physical or cognitive disabilities.